올레산의 비율에 따른 아데노신의 경피 투과의 영향

남현빈,정세진,구민석,오예진,김용민,이훈희,윤수정,임정균 순천향대학교 부설 산업기술연구소 2021 순천향 산업기술연구소논문집 Vol.27 No.2

In addition to the development of functional cosmetics, technology to increase percutaneous absorption rate when applied to the skin is an important task. In this experiment, oleic acid was used as a skin absorption promoter, and its effect on transdermal permeability of adenosine was studied and analyzed using a skin-like membrane. As a result of the experiment, it was investigated that the permeability coefficient and concentration of adenosine are proportional to the content of oleic acid. This indicates that a high proportion of oleic acid is effective as a skin absorption promoter.

ROS 기반 이동 로봇 강화학습을 위한 시뮬레이션 환경 구축

오세현(Se-Hyeon Oh),박주환(Joo-Hwan Park),최홍용(Hong-Yong Choi),옥승호(Seung-Ho Ok) 한국정보기술학회 2022 Proceedings of KIIT Conference Vol.2022 No.12

최근 실내 이동 로봇 등 로봇의 자율주행에 관한 연구가 활발히 이루어지고 있으며 일반적으로 SLAM을 통한 맵 제작 후 네비게이션을 수행하는 방법이 주로 사용된다. 하지만 해당 방법은 새로운 환경에서 매번 맵핑을 해야 한다는 한계점이 있어 강화학습을 이용한 Mapless Navigation에 관한 연구가 증가하고 있다. 본 논문에서는 가상 시뮬레이션 툴인 Unity와 강화학습 플러그인인 ML-Agents를 기반으로 이동 로봇 강화학습 알고리즘을 구현하고 현실 로봇에 적용을 위해 ROS(Robot Operating System) 기반 모바일 로봇인 Turtlebot3 및 Unity 간의 통신환경을 구축하였다. 실험 결과 DDPG(deep deterministic policy gradient) 알고리즘으로 모바일 로봇을 강화 학습하여 보상 값의 수렴성을 통해 학습의 유효함을 확인하였고 ROS 기반 Turtlebot3와 통신하여 정상적으로 동작함을 확인하였다. Recently, research on autonomous driving of robots such as indoor transfer robots has been actively conducted, and in general, a method of performing navigation after making a map through SLAM is mainly used. However, this method has a limitation in that it must be mapped every time in a new environment, so research on Mapless Navigation using reinforcement learning is increasing. In this paper, we implement a mobile robot reinforcement learning algorithm based on the virtual simulation tool Unity and the reinforcement learning plug-in ML-Agents, and establish a communication environment between Unity and Turtlebot3, a ROS-based mobile robot, for application as a real robot. Experiments confirmed that the mobile robot is effective through convergence of reward values by reinforcing learning with a deep deterministic policy gradient (DDPG) algorithm, and that it operates normally by communicating with ROS-based Turtlebot3.

조선후기 경상도 尙州학풍의 일면

오세현(Oh, Se-Hyeon) 역사실학회 2017 역사와실학 Vol.64 No.-

조선후기 경상도 尙州는 영남학파의 영향과 함께 지리적 특징으로 인해 율곡학파와 화담학파의 영향력이 공존하는 지역이었다. 상주 출신의 재야 학자 申東永(1753-1818)은 그러한 상주의 다양한 학문적 특징 중에서 율곡학파의 영향력을 반영하는 인물이다. 신동영의 본관은 平山으로 고려말 조선초의 문인 申槩(1374-1446)를 派祖로 하는 平山申氏 文僖公派의 일원이다. 신동영의 11대조 申叔彬(1457-1520)이 戊午士禍 이후 경상도 聞慶에 은거하면서 평산 신씨 문희공파의 경상도 거주가 시작되었다. 9대조 申裕(1496-1541)가 문희 공파 안에서 小宗의 분기를 이룩하며 상주에 기반을 마련했고, 申碩蕃(1596-1675)과 申碩亨(1605-1660) 형제가 17세기 중반 예송논쟁을 전후하여 서인의 학문적 지향에 동참했다. 신동영 역시 가학으로 전수되었던 서인 학문에 상당한 친연성을 보였는데, 그러한 모습을 확인할 수 있는 것이 그의 문집 『存齋遺稿』이다. 『존재유고』는 제1-2책에 해당하는 ‘箚疑’와 제3책에 해당하는 상소와 편지의 두 부분으로 구성되어 있다. 문집의 구성에서 알 수 있듯이 신동영은 앞 세대의 학문적 성과를 그대로 답습하지 않고 의심이 드는 부분에 대해 역대의 학설을 근거로 자신의 견해를 밝히는 방법인 箚疑를 강조했다. 箚記를 작성한 근본 이유가 程朱의 학설에 대한 의문 때문임을 강조한 신동영은 주희의 中和說에 대한 논의에서도 영남학파와는 다른 논의를 제시했다. 신동영은 『大學章句』 중에서 주희가 직접 지어서 보충한 傳文 5장인 補亡章에 대해 의문을 지녔다. 그런데 자신과 마찬가지로 주희의 『대학장구』에 의문을 지녔던 李彦迪의 문집 『晦齋集』을 열람하다가 「大學章句補遺序」를 접한 후 이언적의 취지에 상당한 공감을 표현했다. 신동영에 대한 율곡학파의 영향력은 李珥의 理氣論에 대한 비판적 지지를 통해 확인할 수 있다. 이이가 제시한 이기론의 세부 표현에 대한 수정을 통해 더욱 완벽한 논의를 기대한 신동영은 이황의 이기론이 기반하고 있는 이기호발론에 대한 근본적 비판과 달리 이이의 이기론을 적극 지지했다. Gyeongsang Provinces Sangju(尙州) in Late Joseon Period existed the influence of Yeongnam academic groups and also coexisted of the influence of Yulgok(栗谷) academic groups and Hwadam(花潭) academic groups by the physical geography. Shin Dong-young(申東永) who was born in Sangju is the scholar represent the influence of Yulgok academic groups. His family clan is Pyungsan(平山). Sin Gae(申槩, 1374-1446) who was the nobleman between late goryeo and the Early Choson Dynasty was progenitor of Pyungsan Shin clan(平山申氏) Munhigongpa(文僖公派) and Shin Dong-young was the member of that group. Shin Suk-bin(申叔彬,1457-1520) started the residence in Gyeongsang Provinces after the Muoh(戊午) massacre of scholars. Shin Yu(申裕,1496-1541) ramify in the Pyungsan Shin clan Munhigongpa and laid the groundwork in Sangju. Shin Suk-bun(申碩蕃, 1596-1675) and Shin Suk-hyung(申碩亨, 1605-1660) brothers actively participated in Seoin(西人) study through Yesong(禮訟) argument in mid-seventeenth century. Shin Dong-young also was close Seoin study that have been passed down the generations, and the evidence that show such circumstances is Jonjaeyugo(存齋遺稿). Jonjaeyugo consisted of two parts that volume 1-2 that was made up of chaui(箚疑) and volume 3 that was made up of appeal and letter. Shin Dong-young emphasize chaui that express one´s intention by raising a question whether the words of ancient sages wrong or right. He wrote chagi(箚記) and that’s fundamental reason is the question about Zhu Xi(朱熹)’s theory. He suggested a different discussion about Zhu Xi’s Jungwha(中和) theory from Yeongnam academic groups. Shin Dong-young suggested a question about Daehak-Janggu(大學章句)’s volume 5(補亡章) that Zhu Xi wrote. He read Daehak-Jangguboyu-seo(大學章句補遺序), that Lee Un-jeok(李彦迪) wrote by browsing Hoejae-jip(晦齋集) and he actively express sympathy about Lee-unjeok’s theory. Shin Dong-young also express critical sympathy about Lee-Yi(李珥)’s Lichi(理氣) theory. He looked forward to be more perfect theory by modification in detail expression. But Shin Dong-young show the basic criticism to Lee-Hwang(李滉).

증례 : 순환기 ; 폐렴간균에 의한 감염성 대동맥류와 동반된 내인성 안내염 1예

오세훈 ( Se Hoon Oh ),이미래 ( Mi Rae Lee ),백경란 ( Kyong Ran Peck ),강세웅 ( Se Woong Kang ),최연현 ( Yeon Hyeon Choe ),김영욱 ( Young Wook Kim ),김덕경 ( Duk Kyung Kim ) 대한내과학회 2010 대한내과학회지 Vol.78 No.3

감염성 대동맥류는 세균성 감염에 의한 동맥벽의 미란과 파괴로 생긴 동맥류를 말한다. 그 원인 병원체로는 그람 양성균, 그람 음성균, 진균, 항산균 등이 있다. 폐렴막대균은 비뇨생식기계 감염, 지역사회 폐렴, 간농양, 내인성 안내염 등을 흔하게 발병시키나 감염성 동맥류의 원인으로는 드물다. 최근 들어, 특히 동부 아시아 지역에서 폐렴막대균으로 인한 간농양의 발생과 이에 동반된 내인성 안내염의 보고가 증가하고 있는 추세이지만 아직까지 폐렴막대균 감염성 동맥류 A mycotic aneurysm is a localized, irreversible arterial dilatation resulting from destruction of the vessel wall by infection. Pathogens causing mycotic aneurysms include Gram-positive and -negative bacteria, mycobacteria, and fungi. Klebsiella pneumoniae

충격성 잡음이 포함된 신호의 포락선을 이용한 불량 검출 방법

이동현(Dong-Hyeon Lee),김연우(Yeon-Woo Kim),오현수(Hyeon-Su Oh),여주현(Ju-Hyeon Yeo),안세진(Se-Jin Ahn),정의봉(Weui-Bong Jeong) 한국소음진동공학회 2018 한국소음진동공학회 학술대회논문집 Vol.2018 No.4

Effect of Electromagnetic Fields on Growth of Human Cell Lines

(Se Jong Oh),(Mi Kyung Lee),(Seo Ho Lee),(Jin Ha Lee),(Dai Jong Kim),(Young Shik Park),(Hyeon Yong Lee) 한국미생물생명공학회 2001 Journal of microbiology and biotechnology Vol.11 No.5

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Synergistic Effect of Minoxidil and Retinol on Hair Growth in Human Dermal Papilla Cells

( Hyeon Gyeong Yoo ),( In Young Chang ),( Se Rah Lee ),( Soon Jin Choi ),( Hyun Keol Pyo ),( Ji Yun Kim ),( Oh Sang Kwon ),( Jin Ho Chung ),( Kwang Hyun Cho ),( Hee Chul Eun ),( Kyu Han Kim ) 대한피부과학회 2005 초록집 Vol.43 No.20

Acoustic data condensation to enhance pipeline leak detection

Oh, Se Won,Yoon, Doo-Byung,Kim, Gwan Joong,Bae, Ji-Hoon,Kim, Hyeon Soo Elsevier 2018 Nuclear engineering and design Vol.327 No.-

<P><B>Abstract</B></P> <P>Acoustic monitoring techniques are widely adopted for identifying various leaks from plant facilities to prevent loss of resources and any further structural damages. As the conventional sensing devices have measured acoustic signals at predesignated positions inside or very close to the object being observed, the need for more sophisticated and automated monitoring of more complex infrastructure has increased both the number of sensors to be installed and the amount of data to be analyzed. Thus, in order to diagnose the high-pressure steam leakage efficiently, this research proposes a novel method to find and condense the distinguishable features from the acoustic signals, which are captured by remotely dispersed microphone sensor nodes around a laboratory scale nuclear power plant coolant system. The performance of the proposed method is evaluated by several quantitative metrics resulting from the five state-of-the-art machine learning algorithms, together with the condensed data ratio. Experimental results show that the proposed method can transform the original acoustic signals into a smaller number of featured predictors, even less than ten-thousandths of the original data amount, while improving classification accuracy despite loud machine-driven noises nearby.</P> <P><B>Highlights</B></P> <P> <UL> <LI> For pipeline leak detection air-borne acoustic signals are remotely captured. </LI> <LI> A method to find the key predictors that affect leak distinction is presented. </LI> <LI> Data conversion of the acoustic signals facilitates distinguishing pipeline leaks. </LI> <LI> Performance metrics are derived by several learning algorithms for classification. </LI> <LI> Experiments show leaks can be better distinguished using less amount of predictors. </LI> </UL> </P>

Establishment of particulate matter-induced lung injury model in mouse

Se Yong Park,Kyu Sup An,Buhyun Lee,Ju-Hee Kang,Hyun Jin Jung,Min Woo Kim,Hyeon Yeol Ryu,Kyu-Suk Shim,Ki Taek Nam,Yeo Sung Yoon,Seung Hyun Oh 한국실험동물학회 2021 한국실험동물학회 학술발표대회 논문집 Vol.2021 No.7

Particulate matter (PM) is one of the principal causes of human respiratory disabilities resulting from air pollution. Animal models have been applied to discover preventive and therapeutic drugs for lung diseases caused by PM. However, the induced severity of lung injury in animal models using PM varies from study to study due to disparities in the preparation of PM, and the route and number of PM administrations. In this study, we established an in vivo model to evaluate PM-induced lung injury in mice. PM dispersion was prepared using SRM2975. Reactive oxygen species were increased in MLE 12 cells exposed to this PM dispersion. In vivo studies were conducted in the PM single challenge model, PM multiple challenge model, and PM challenge with ovalbumin-induced asthma using the PM dispersion. No histopathological changes were observed in lung tissues after a single injection of PM, whereas mild to moderate lung inflammation was obtained in the lungs of mice exposed to PM three times. However, fibrotic changes were barely seen, even though transmission electron microscopy (TEM) studies revealed the presence of PM particles in the alveolar macrophages and alveolar capillaries. In the OVA-PM model, peribronchial inflammation and mucous hypersecretion were more severe in the OVA+PM group than the OVA group. Serum IgE levels tended to increase in OVA+PM group than in OVA group. In this study, we established a PM-induced lung injury model to examine the lung damage induced by PM. Based on our results, repeated exposures of PM are necessary to induce lung inflammation by PM alone. PM challenge, in the presence of underlying diseases such as asthma, can also be an appropriate model for studying the health effect of PM.

A Broken Railway: A Subclavian Arterial Stent Fracture

Se-Jung Yoon,Jong-Kwan Park,Seok Jong Ryu,Hancheol Lee,Ji-Yong Jang,Kyeong-Hyeon Chun,Hyeongsoo Kim,Seung-Jin Oh 대한심장학회 2022 Korean Circulation Journal Vol.52 No.5