자가면역 췌장염의 동반증상 없이 발생한 IgG4 연관 경화성 담관염

천송욱 ( Song Wook Chun ),최자성 ( Ja Sung Choi ),강버들 ( Beo Deul Kang ),김유진 ( Yu Jin Kim ),한기준 ( Ki Jun Han ),조현근 ( Hyeon Geun Cho ),오화은 ( Hwa Eun Oh1 ),조재희 ( Jae Hee Cho ) 대한소화기학회 2013 대한소화기학회지 Vol.62 No.1

IgG4-related systemic diseases are characterized by a diffuse or mass forming inflammatory reaction rich in lymphocytes and IgG4-positive plasma cells (lymphoplasmacytic infiltration), fibrosclerosis of variable organs and obliterative phlebitis. They usually involve various organs including the pancreas, bile duct, gallbladder, salivary gland, retroperitoneum, kidney, lung, and prostate. However, most of them are accompanied by autoimmune pancreatitis, and good response to steroid treatment is one of the hallmarks of this disease. We report a case of an 67-year-old man with IgG4 associated sclerosing cholangitis, who was diagnosed by endoscopic retrograde cholangiopancreatography and successfully treated with steroid therapy. (Korean J Gastroenterol 2013; 62:69-74)

Surgical Clues of Distal Anterior Cerebral Artery(DACA) Aneurysms

김승범,이형중,김재민,백광흠,김충현,오석전,Kim, Sung Bum,Yi, Hyeong Joong,Kim, Jae Min,Bak, Koang Hum,Kim, Choong Hyun,Oh, Suck Jun The Korean Neurosurgical Society 2000 Journal of Korean neurosurgical society Vol.29 No.12

목 적 : 원위부 전대뇌 동맥에 발생하는 동맥류는 모동맥의 확보가 힘들고 재출혈 및 수술중 조기출혈의 빈도가 높으며, 익숙치 않은 수술적 접근법이 필요하다든지 하는 몇 가지 독특한 문제점이 있다. 따라서 전대뇌 반구간열 주변의 해부학적 구조물과 박리 시작점에 대한 수술전 지식을 요한다. 저자들은 박리 시작점에 대한 일관된 외부표식자를 이용하여 전두 기저부 대뇌반구간열 접근법 수술을 시행하였고 이를 심부 구조물들에 대한 접근 지표로 삼고자 하였다. 대상 및 방법 : 1995년 11월부터 1999년 6월까지 동맥류경을 결찰한 총 131명의 뇌동맥류파열 환자 중에서 원위부 전대뇌 동맥류 9명에 대하여 혈관조영술, 의무기록지, 수술소견을 통해 임상적, 수술소견을 조사하였다. 결 과 : 원위부 전대뇌동맥류의 빈도는 6.3%였고, 6례에서 뇌량 연변 동맥이 기시하는 뇌량 주위 동맥에서 발생하였고, 3례에서는 전두극동맥이 기시하는 뇌량 주위 동맥에서 발생하였다. 동반된 다른 혈관기형 및 다른 동맥류는 각각 3예에서 발견되었다. 술전 환자 상태는 일반적으로 불량했다. 조기수술은 7예에서 실시되었으며, 전두 기저부 대뇌반구간열 접근법으로 동맥류 결찰을 시행한 경우도 7예였다. 술후 심한 혈관연축과 흡인성 폐렴으로 인한 사망이 각각 1례씩이었으며 그 이외에는 신경학적 소견은 정상이었다. 결 론 : 원위부 전대뇌 동맥류의 조기수술시에 전두 기저부 대뇌반구간열 접근법이 유용하였다. 이 방법으로 뇌견인을 최소화할 수 있었으며 동맥류의 조기파열을 방지할 수 있었다. 저자들은 대뇌반구 간열의 박리 시작점으로 첫번째 교정맥(전두극 정맥)이 상시상 정맥동으로 유출되는 지점을 기준으로 하여 뇌량 및 뇌량 주변부 원위부 전대뇌동맥류에 접근할 수 있었다. Objects : Surgical management of the distal anterior cerebral artery(DACA) aneurysms presents several unique problems to surgeons, such as difficulty in early identification of parent arteries, high incidence of rebleeding and premature rupture, and requirement of unfamiliar approach other than conventional frontotemporal craniotomy. Therefore, preoperative anatomical knowledge of anterior interhemispheric fissure and entry point of dissection is prerequisite. Authors utilized a frontobasal approach for DACA aneurysms by using consistent external landmark for guidance to the deep structure. Materials and Methods : From Nov. 1995 to Jun. 1999, a surgical clipping of DACA aneurysms was carried out in 9 patients among a total 131 patients with intracranial aneurysms. In each case, the clinical and aneurysmal features were carefully reviewed through the angiograms, medical records, and intraoperative findings. Results : The incidence of DACA aneurysms was 6.9% from our series. All cases were arisen from juxtacallosal por-tion ; 6 cases from pericallosal-callosomarginal(PC-CM) junction and 3 from pericallosal-frontopolar(PC-FP) junction. Associated vascular anomalies were noted in 3 cases and multiple aneurysms in 3 cases, respectively. The preoperative clinical grades were generally poor. An early surgery was performed in 7 cases and frontobasal interhemispheric approaches in 7 cases. Postoperatively, two patients died of complications ; one delayed ischemic vasospasm and one aspiration pneumonia but remaining patients recovered well. Conclusion : The frontobasal interhemispheric approach was useful for DACA aneurysms in early surgery. Division of superior sagittal sinus(SSS) enabled a minimal retraction of brain on both sides, and prevention of intraoperative rupture was possible. Authors suggest the frontopolar(first frontal bridging) vein as a constant external landmark for approaching the genu of the corpus callosum and juxtacallosal DACA aneurysms.

성인기의 생애주기별 사회적지지망 연구

정추자(Jeong, Chu-Ja),이선옥(Lee, Sun-Ock),강정희(Kang, Jung-Hee),김정아(Kim, Jeong Ah),김혜령(Kim, Hye-Ryoung),오경옥(Oh, Kyong-Ok),이숙자(Lee, Sook-Ja),전화연(Jun, Hoa-Yun),홍성경(Hong, Sung Kyung) 한국간호교육학회 2012 한국간호교육학회지 Vol.18 No.3

Purpose: The purpose of this study was to identify social support networks for each life-cycle stage of adults. Method: A total of 1,047 subjects included 454 young adults, 262 middle-aged adults and 331 senior adults. Data were collected using Oh’s Korean Version Norbeck’s Social Support Questionnaire (NSSQ), and analyzed using descriptive statistics, t-test, and ANOVA. Result: For the young adults, parents were the top and second priority as important social support resources, the third was siblings, and then friends. For the middle-aged, spouse was the first priority as an important social support resource, while the second and the third were children. For the senior adults, children ranked from the top to the seventh priority. The mean number of social support resources was 13.23 for the young adult, 12.93 for the middle-aged and 5.30 for the senior adults. Social support networks of the young adults significantly differed according to gender and marital status. That of the middle-aged significantly differed according to family size. In addition, that of the senior adults was significantly different according to marital status, economic status, religion and family size. Conclusion: It is essential to consider social support networks for each life-cycle stage of adults when making a social support intervention program.

Opuntia humifusa Ameliorated Cerulein-Induced Acute Pancreatitis

Choi, Sun Bok,Bae, Gi-Sang,Park, Kyoung-Chel,Jo, Il-Joo,Seo, Seung-Hee,Song, Kyung,Lee, Dong-Sung,Oh, Hyuncheol,Kim, Youn-Chul,Kim, Jong-Jin,Shin, Yong Kook,Park, Jin-Han,Seo, Min-Jun,Song, Ho-Joon,Pa by Lippincott Williams Wilkins. 2014 PANCREAS Vol.43 No.1

OBJECTIVE: The aim of this study was to evaluate the effects of Opuntia humifusa (OH) on cerulein-induced acute pancreatitis (AP). METHODS: Acute pancreatitis was induced via intraperitoneal injection of cholecystokinin analog cerulein (50 μg/kg). In the OH pretreatment group, OH was administered intraperitoneally (100, 250, or 500 mg/kg) 1 hour before first cerulein injection. In the posttreatment group, OH was administered intraperitoneally (500 mg/kg) 1 hour after the first cerulein injection. Furthermore, we isolated the pancreatic acinar cells using collagenase method, then investigated the acinar cell viability, cytokine productions, and the regulating mechanisms. RESULTS: The both pretreatment and posttreatment of OH treatment attenuated the severity of AP, as shown by the histology of the pancreas and lung, and inhibited neutrophil infiltration; serum amylase and lipase activities; proinflammatory cytokine expression such as interleukin 1, interleukin 6, and tumor necrosis factor α; and cell death including apoptosis and necrosis. Furthermore, OH inhibited the activation of c-Jun N-terminal kinases. CONCLUSIONS: These results suggest that OH reduces the severity of AP by inhibiting acinar cell death through c-Jun N-terminal kinases.

Effects of sun exposure and dietary vitamin D intake on serum 25-hydroxyvitamin D status in hemodialysis patients

Yeon Joo Lee,Il Hwan Oh,Hee Jun Baek,Chang Hwa Lee,Sang Sun Lee 한국영양학회 2015 Nutrition Research and Practice Vol.9 No.2

BACKGROUND/OBJECTIVES: Vitamin D deficiency is common in hemodialysis patients. The aim of this study was to identify whether or not sun exposure and dietary vitamin D intake have effects on serum 25-hydroxyvitamin D (25(OH)D) status in hemodialysis (HD) patients. The objective was to identify the main determinants of serum vitamin D status in the study subjects. SUBJECTS/METHODS: A cross-sectional study of 47 HD patients (19 males and 28 females) was performed. We assessed serum 25(OH)D and 1,25(OH)2D levels between August and September 2012 and analyzed the prevalence of vitamin D deficiency in HD patients. To evaluate the determinants of serum 25(OH)D levels, we surveyed dietary vitamin D intake, degree of sun exposure, and outdoor activities. To compare biological variables, serum 25(OH)D was stratified as below 15 ng/ml or above 15 ng/ml. RESULTS: Mean 25(OH)D and 1,25(OH)2D levels were 13.5 ± 5.8 ng/ml and 20.6 ± 11.8 pg/ml, respectively. The proportions of serum 25(OH)D deficiency (< 15 ng/ml), insufficiency (15-< 30 ng/ml), and sufficiency (≥ 30 ng/ml) in subjects were 72.4%, 23.4%, and 4.3%, respectively. Prevalence of vitamin D deficiency in female patients was 78.6%, whereas that in males was 63.2% (P = 0.046). Vitamin D intake and sun exposure time were not significantly different between the two stratified serum 25(OH)D levels. Dietary intake of vitamin D did not contribute to increased serum 25(OH)D levels in HD patients. The main effective factors affecting serum 25(OH)D status were found to be the sun exposure and active outdoor exercise. CONCLUSIONS: Hypovitaminosis D is common in HD patients and is higher in females than in males. Sun exposure is the most important determinant of serum 25(OH)D status in HD patients.

만성 콩팥병 환자에서 추정 사구체 여과율에 따른 25-Hydroxyvitamin D의 특성

고정희 ( Jung Hee Koh ),곽임수 ( Ihm Soo Kwak ),송상헌 ( Sang Heon Song ),이수봉 ( Soo Bong Lee ),이하린 ( Harin Rhee ),성은영 ( Eun Young Seong ),박창준 ( Chang Jun Park ),김태균 ( Tae Kyun Kim ),오상보 ( Sang Bo Oh ) 대한내과학회 2012 대한내과학회지 Vol.83 No.6

Background/Aims: Accumulating data suggest that vitamin D deficiency is prevalent in patients with chronic kidney disease (CKD). However, comprehensive data are lacking for Koreans. The aim of this study was to survey vitamin D deficiency among patients with CKD in Korea and to identify the relationships among various factors. Methods: We conducted a retrospective cohort study of 444 patients who were divided into four subgroups by estimated glomerular filtration rate (eGFR) for comparisons of mean 25-hydroxyvitamin D [25(OH)D] level and other parameters. In addition, non-dialyzed patients were categorized into four groups based on 25(OH)D levels (<10, 10-19, 20-29, and ≥ 30 ng/mL), and risk factors for severe vitamin D deficiency (<10 ng/mL) were investigated. Results: Of patients with an eGFR ≥ 60 mL/min/1.73 m2, 43% (34/79) showed severe 25(OH)D deficiency, and the mean 25(OH)D level was 11.7±5.3 ng/mL. In CKD3 group, 53.2% (41/77) showed severe 25(OH)D deficiency, with a mean level of 11.3±7.2 ng/mL. In CKD4 group, 53.3% (49/92) had severe 25(OH)D deficiency, with a mean level of 11.0±6.2 ng/mL. Approximately 71% (139/196) of patients in CKD5 group showed severe deficiency, and the mean level was 9.2±5.9 ng/mL. Severe 25(OH)D deficiency was affected by winter season, renal function, diabetes, and low-density lipoprotein cholesterol. The serum parathyroid hormone level was inversely correlated with the 25(OH)D level, such that 25(OH)D < 20 ng/mL were associated with a steep increase in parathyroid hormone. Conclusions: Vitamin D deficiency is highly prevalent in the Korean population. Few patients met a sufficient 25(OH)D concentration, even in the early stages of CKD. Our data suggest that 25(OH)D level of 20 ng/mL is a threshold for a rapid increase in parathyroid hormone levels. (Korean J Med 2012;83:740-751)

Implant Drill Characteristics: Thermal and Mechanical Effects of Two-, Three-, and Four-Fluted Drills

Oh, Hyun Jun,Kim, Beom Ik,Kim, Hae-Young,Yeo, In-Sung,Wikesjö,, Ulf Me,Koo, Ki-Tae QUINTESSENCE PUBLISHING CO, INC 2017 The International journal of oral & maxillofacial Vol.32 No.3

Genetically Optimized Hybrid Fuzzy Set-based Polynomial Neural Networks with Polynomial and Fuzzy Polynomial Neurons

Sung-Kwun Oh,Seok-Beom Roh,Keon-Jun Park 한국지능시스템학회 2005 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.5 No.4

We investigatea new fuzzy-neural networks-Hybrid Fuzzy set based polynomial Neural Networks (HFSPNN). These networks consist of genetically optimized multi-layer with two kinds of heterogeneous neurons thatare fuzzy set based polynomial neurons (FSPNs) and polynomial neurons (PNs). We have developed a comprehensive design methodology to determine the optimal structure of networks dynamically. The augmented genetically optimized HFSPNN (namely gHFSPNN) results in a structurally optimized structure and comes with a higher level of flexibility in comparison to the one we encounter in the conventional HFPNN. The GA-based design procedure being applied at each layer of gHFSPNN leads to the selection leads to the selection of preferred nodes (FSPNs or PNs) available within the HFSPNN. In the sequel, the structural optimization is realized via GAs, whereas the ensuing detailed parametric optimization is carried out in the setting of a standard least square method-based learning. The performance of the gHFSPNN is quantified through experimentation where we use a number of modeling benchmarkssynthetic and experimental data already experimented with in fuzzy or neurofuzzy modeling.

Preliminary PET Study of ¹⁸F-FC119S in Normal and Alzheimer’s Disease Models

Oh, Se Jong,Kim, Min Hwan,Han, Sang Jin,Kang, Kyung Jun,Ko, In Ok,Kim, YoungSoo,Park, Ji-Ae,Choi, Jae Yong,Lee, Kyo Chul,Chi, Dae Yoon,Lee, Yong Jin,Kim, Kyeong Min American Chemical Society 2017 MOLECULAR PHARMACEUTICS Vol.14 No.9

<P>To evaluate the efficacy of F-18-FC119S as a positron emission tomography (PET) radiopharmaceutical for the imaging of Alzheimer's disease (AD), we studied the drug absorption characteristics and distribution of F-18-FC119S in normal mice. In addition, we evaluated the specificity of F-18-FC119S for beta-amyloid (A beta) in the AD group of an APP/PS1 mouse model and compared it with that in the wild-type (WT) group. The behavior of F-18-FC119S in the normal mice was characteristic of rapid brain uptake and washout patterns. In most organs, including the brain, F-18-FC119S reached its maximum concentration within 1 min and was excreted via the intestine. Brain PET imaging of F-18-FC119S showed highly specific binding of the molecule to A beta in the cortex and hippocampus. The brain uptake and binding values for the AD group were higher than those for the WT group. These results indicated that F-18-FC119S would be a candidate PET imaging agent for targeting A beta plaque.</P>

A retrospective analysis of second-Line chemotherapy in patients with advanced gastric cancer (초)

( Sang Hoon Ji ),( Do Hyoung Lim ),( Min Jae Park ),( Seong Yoon Yi ),( Kyoung Ha Kim ),( Hyo Song Kim ),( Hyun Jung Jun ),( Ji Eun Uhm ),( Jee Yun Lee ),( Se Hoon Park ),( Joon Oh Park ),( Young Suk 대한내과학회 2008 대한내과학회지 Vol.75 No.1S