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Jin Tae Hong, Dohee Won1, Mi Hee Park, Sun Mi Kown, Miran Jo, Sang-Yoon Nam, Beom Jun Lee, Young Won Yun, Ki-Wan Oh, Sang Bae Han 충북대학교 동물의학연구소 2011 Journal of Biomedical and Translational Research Vol.12 No.4
The objective of this study was to determine the effect of macrophages on growth of human colon cancer cells. The results showed that co-culture of colon cancer cells with macrophages inhibited the growth of colon cancer cells (HCT116 and SW620) depending on the number of macrophages, RAW 264.7 cells, and activated THP-1 cells accompanied by down regulation of pSTAT3 in cancer cells. We also found that expression and release of cancer cell growth inhibitory cytokines, IL-1 receptor antagonist (IL-1ra) and IL-10, was increased in macrophages. Blocking of the STAT3 pathway with specific inhibitor and siRNA of STAT3 abolished the growth of colon cancer cells and expression of IL-1ra and IL-10. In addition, neutralization of IL-1ra and IL-10 with antibodies resulted in reversal of macrophage-induced inhibition of cancer cell growth. These data showed that IL-1ra and IL-10 released from macrophages inhibit growth of colon cancer cells through inhibition of the STAT3 pathway
장애학생 관련 변인에 따른 비장애 학생의 통합태도 연구
오원석 ( Won Seok Oh ),남경숙 ( Kyung Sook Nam ),허명진 ( Myung Jin Huh ) 한국특수교육문제연구소 2006 특수교육저널 : 이론과 실천 Vol.7 No.3
장애학생 관련 변인에 따른 비장애 학생의 통합교육에 대한 태도 및 장애학생에 대한 친근감을 알아보기 위하여 본 연구를 수행하였으며, 연구 대상은 대구광역시 초등학교 5개교15학급 477명을 선정하였다. 연구 결과 장애학생의 통합에 대한 비장애 학생의 태도에 영향을 미치는 변인은 장애유형, 장애학생 성별, 장애학생의 청결상태이며, 영향을 미치지 않는 변인으로는 장애학생 부모의 관심도, 장애아 가정의 경제적 수준 그리고 장애학생의 학습 능력인 것으로 나타났다. The purpose of this study is to determine the attitudes for integration education and the intimacy with disabled students of Nondisabled students influenced by disabled students. For such purpose, 477 students of 15 classes from 5 elementary schools located in Daegu Metropolitan City were selected as the object of this study. Integrated Attitudes was measured through an investigation equipment by Oh Won-Seok and Seo-Yeong Ran which adapted and modified a testing document called Inclusion of Students who are Deaf or Hard of Hearing Inventory (ISDHH) invented by Hsin-Ling Hung(2005). The result indicated that the factors which influence the Attitudes of nondisabled students regarding integration with disabled students are the type of injury, the gender and the cleanness of the disabled student. The factors which do not influence the above are interests of the disabled student``s parents, economic level of the family and the learning ability of the disabled student.
Electrical quadruple hysteresis in Pd-doped vanadium pentoxide nanowires due to water adsorption
Kim, Byung Hoon,Oh, Soon-Young,Yu, Han Young,Hong, Won G,Yun, Yong Ju,Kim, Yark Yeon,Kim, Hae Jin Elsevier 2010 SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS Vol.11 No.6
<P>Humidity-dependent current–voltage (<I>I–V</I>) characteristics of Pd-doped vanadium pentoxide nanowires (Pd-VONs) were investigated. Electrical quadruple hysteresis (QH) was observed and attributed to the large amount of water molecules adsorbed on the nanowires. Using QH in Pd-VONs, the reaction of water with PdO was interpreted as the water molecules are desorbed and then dissociated with increasing bias voltage. Owing to the dissociated H<SUP>+</SUP> and OH<SUP>−</SUP> ions, PdO is reduced and oxidized. As a result, water molecules recombine as the bias voltage is decreased.</P>
임현민,이진호,김원진,오승환,서동혁,이동희,김륜나,김우병,Yim, Hyeonmin,Lee, Jinho,Kim, Won Jin,Oh, Seung-Hwan,Seo, Dong Hyeok,Lee, Donghee,Kim, Ryun Na,Kim, Woo-Byoung 한국재료학회 2022 한국재료학회지 Vol.32 No.9
A spin coating process for RRAM, which is a TiN/TiO<sub>2</sub>/FTO structure based on a PTC sol solution, was developed in this laboratory, a method which enables low-temperature and eco-friendly manufacturing. The RRAM corresponds to an OxRAM that operates through the formation and extinction of conductive filaments. Heat treatment was selected as a method of controlling oxygen vacancy (V<sub>O</sub>), a major factor of the conductive filament. It was carried out at 100 ℃ under moisture removal conditions and at 300 ℃ and 500 ℃ for excellent phase stability. XRD analysis confirmed the anatase phase in the thin film increased as the heat treatment increased, and the Ti<sup>3+</sup> and OH- groups were observed to decrease in the XPS analysis. In the I-V analysis, the device at 100 ℃ showed a low primary SET voltage of 5.1 V and a high ON/OFF ratio of 10<sup>4</sup>. The double-logarithmic plot of the I-V curve confirmed the device at 100 ℃ required a low operating voltage. As a result, the 100 ℃ heat treatment conditions were suitable for the low voltage driving and high ON/OFF ratio of TiN/TiO<sub>2</sub>/FTO RRAM devices and these results suggest that the operating voltage and ON/OFF ratio required for OxRAM devices used in various fields under specific heat treatment conditions can be compromised.
Cho, Joon-Hyung,Jeon, Soo-Bin,Kang, Min-Kyoung,Kim, Jin-Seop,Cho, Sang-Won,Oh, Kwang-Joong Elsevier 2017 Separation and purification technology Vol.184 No.-
<P><B>Abstract</B></P> <P>Ion exchange technology is the most effective and economical to remove heat stable salts (HSS) in CO<SUB>2</SUB> absorption processes. However, the disadvantage of high waste generation remains an unsolved problem. This study attempted to reduce the amount of waste generated during the Zr(OH)<SUB>5</SUB> <SUP>−</SUP> regeneration process through resource recovery by using ZrCl<SUB>4</SUB> coagulant, then recycling the recovered Zr(OH)<SUB>4</SUB> precipitate to produce Zr(OH)<SUB>5</SUB> <SUP>−</SUP> regenerant. The experimental results showed a waste coagulant efficiency of about 75%. The coagulation mechanism was suggested based on the conductivity and zeta potential analysis. The recovered Zr(OH)<SUB>4</SUB> had no differences in terms of chemical composition and regeneration efficiency, when compared with virgin material. These results indicate that the recovery and recycling of Zr(OH)<SUB>4</SUB> from the waste stream using ZrCl<SUB>4</SUB> as a coagulant reduced a large amount of the waste generated from the ion exchange process.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Reduction efficiency using ZrCl<SUB>4</SUB> coagulant from ion exchange waste is about 75.0%. </LI> <LI> Coagulation mechanism of four stages with respect to the coagulant dose is proposed. </LI> <LI> Recovery efficiency of hydroxide, as Zr(OH)<SUB>4</SUB>, from the waste is about 99.2%. </LI> <LI> The recovered Zr(OH)<SUB>4</SUB> has no difference in regeneration efficiency of virgin material. </LI> </UL> </P>
Regulation of insulin response in skeletal muscle cell by caveolin status
Oh, Yoon Sin,Cho, Kyung A.,Ryu, Sung Jin,Khil, Lee-Yong,Jun, Hee-Sook,Yoon, Ji-Won,Park, Sang Chul Wiley Subscription Services, Inc., A Wiley Company 2006 Journal of cellular biochemistry Vol.99 No.3
<P>Recent studies on the role of caveolin-1 in adipocytes showed that caveolin has emerged as an important regulatory element in insulin signaling but little is known on its role in skeletal muscle cells. In this study, we demonstrate for the first time that caveolin-1 plays a crucial role in insulin dependent glucose uptake in skeletal muscle cells. Differentiation of L6 skeletal muscle cells induce the expression of caveolin-1 and caveolin-3 with partial colocalization. However in contrast to adipocytes, phosphorylation of insulin receptor β (IRβ) and Akt/Erk was not affected by the respective downregulation of caveolin-1 or caveolin-3 in the muscle cells. Moreover, the phosphorylation of IRβ was detected not only in the caveolae but also in the non-caveolae fractions of the muscle cells despite the interaction of IRβ with caveolin-1 and caveolin-3. These data implicate the lack of relationship between caveolins and IRβ pathway in the muscle cells, different from the adipocytes. However, glucose uptake was reduced specifically by downregulation of caveolin-1, but not that of caveolin-3. Taken together, these observations suggest that caveolin-1 plays a crucial role in glucose uptake in differentiated muscle cells and that the regulation of caveolin-1 expression may be an important mechanism for insulin sensitivity, implying the role of muscle cells for type 2 diabetes. J. Cell. Biochem. 99: 747–758, 2006. © 2006 Wiley-Liss, Inc.</P>
[P051] Nail involvement of lichen striatus successfully treated with intralesional steroid injection
( Won Seon Koh ),( Dong Uk Cheon ),( Su Jin Oh ),( Jeong Eun Kim ),( Joo Yeon Ko ),( Young Suck Ro ) 대한피부과학회 2017 대한피부과학회 학술발표대회집 Vol.69 No.1
Lichen striatus (LS) is a rare inflammatory dermatosis, characterized by linear papules, mainly along the Blaschko lines of limbs in children. Nail involvement of LS occurs in about 2.6% of patients. Despite various treatment modalities for nail involvement in LS, the efficacies are controversial. Cases treated with intralesional injection (ILI) of steroid have been rarely reported. A 15-year-old boy presented with linear erythematous papules and plaques on left lower leg which has been for 1 month. A biopsy specimen showed lymphocytic infiltration in the upper dermis with epidermal changes including irregular acanthosis and exocytosis of lymphocyte. Based on these findings, he was diagnosed with LS. After 12 weeks of treatment with topical steroid and tacrolimus, the skin lesion was dramatically improved. However, onychodystrophy newly developed at left great toenail (TN) and was getting worse despite of maintenance of treatment with topical tacrolimus. We began to treat his TN with ILI of triamcinolone acetonide (TA) 2.5mg/ml with 2 weeks interval. After 2 months of treatment, clear TN was noted at the proximal portion of TN and almost complete recovery of nail lesion was achieved at 6 months. Herein, we report a case of nail involvement in LS successfully treated with ILI of TA and propose that active treatment could be an effective therapeutic option for nail LS.