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오승태(Seung-Tae Oh),이범희(Beom-Hee Lee),옥지효(Ji-Hyo Ock),김국태(Kuk-Tae Kim),이배한(Bae-Han Lee) 대한기계학회 2013 대한기계학회 춘추학술대회 Vol.2013 No.12
The purpose of this research is to explain the characteristics of vibration for hydraulic turbine generator of shaft system. In design procedure, reviewing the dynamics of shaft vibration for Hydro generator including thrust and upper guide bearing, lower guide bearing, the shaft vibration has effect on an important dynamic characteristics of Francis Turbine Generator with vertical structure running at the rated speed 514rpm (8.57Hz) and the runaway speed. The main thrust of this work is to study the theoretical figures of hydro-generator with salient poles which is driven by hydraulic turbines running at lower speeds less than 1000rpm. Each pole is built thin silicon steel laminations of 0.35~0.5mm to 0.8mm thickness to reduce eddy current laminations. Low speeds are built with vertical shaft design which has suspended type where in the bearing is mounted above the rotor. So, this research is very useful for a practical designers and workers who are engaged in the shaft design for the development of the large hydro generator.
Oh, Gi-Su,Pae, Hyun-Ock,Choi, Byung-Min,Kwon, Ji-Wung,Yun, Yeong-Ho,Choi, Jeong-Ho,Kwon, Tae-Oh,Park, Young-Chul,Chung, Hun-Teag The Korean Association of Immunobiologists 2003 Immune Network Vol.3 No.3
Background: The mushroom Phellinus linteus (PL) has been shown to have the anti-tumor and immunostimulatory effects. We hypothesized that the hot water extract of PL (WEPL) exerts its significant immunostimulatory effect by inducing production of the Th1-derived cytokine interferon-${\gamma}$ (IFN-${\gamma}$) by T lymphocytes. Methods: T lymphocytes were isolated from the mice fed with 200 mg/kg of WEPL once a day for 4 weeks, and then stimulated with the mitogen concanavaline A (Con A). IFN-${\gamma}$ gene and intracellular protein expressions were analyzed by RT-PCR and flow cytometry, respectively. The production of IFN-${\gamma}$ was measured by enzyme-linked immunosorbent assay. Results: WEPL significantly enhanced the transcription of IFN-${\gamma}$ mRNA. The effect of WEPL on IFN-${\gamma}$ expression was further supported by a concomitant increase in the number of cells with intracellular IFN-${\gamma}$ protein as well as the secretion of IFN-${\gamma}$. However, WEPL did not modulate either gene expression or protein secretion of interleukin-4, a Th2-associated cytokine, by Con A-stimulated T lymphocytes. Conclusion: Our results demonstrate that one of the potentially beneficial anti-tumor and immunostimulatory effects of WEPL may be mediated through the enhancement of IFN-${\gamma}$ secretion by T lymphocytes.
Na, Tae-Young,Lee, Hyo-Jeong,Oh, Hyeon-Jeong,Huh, Seung,Lee, In-Kyu,Lee, Mi-Ock Ovid Technologies Wolters Kluwer -American Heart A 2011 Arteriosclerosis, thrombosis, and vascular biology Vol.31 No.12
<P>Atherosclerosis is a chronic and progressive inflammatory disease of the arteries that is characterized by subendothelial accumulation of lipid-rich macrophages, called foam cells. We sought to identify the molecular details of cross-talk between liver X receptor α (LXRα) and hypoxia-inducible factor 1α (HIF-1α) for the formation of triglyceride-rich foam cells under hypoxic conditions.</P>
Anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma
Kwak, Tae Won,Shin, Hee Jae,Jeong, Young-Il,Han, Myoung-Eun,Oh, Sae-Ock,Kim, Hyun-Jung,Kim, Do Hyung,Kang, Dae Hwan Dove Medical Press 2015 Drug design, development and therapy Vol.9 No.-
<P><B>Background</B></P><P>The aim of this study is to investigate the anticancer activity of streptochlorin, a novel antineoplastic agent, in cholangiocarcinoma.</P><P><B>Methods</B></P><P>The anticancer activity of streptochlorin was evaluated in vitro in various cholangiocarcinoma cell lines for apoptosis, proliferation, invasiveness, and expression of various protein levels. A liver metastasis model was prepared by splenic injection of HuCC-T1 cholangiocarcinoma cells using a BALB/c nude mouse model to study the systemic antimetastatic efficacy of streptochlorin 5 mg/kg at 8 weeks. The antitumor efficacy of subcutaneously injected streptochlorin was also assessed using a solid tumor xenograft model of SNU478 cells for 22 days in the BALB/c nude mouse.</P><P><B>Results</B></P><P>Streptochlorin inhibited growth and secretion of vascular endothelial growth factor by cholangiocarcinoma cells in a dose-dependent manner and induced apoptosis in vitro. In addition, streptochlorin effectively inhibited invasion and migration of cholangiocarcinoma cells. Secretion of vascular endothelial growth factor and activity of matrix metalloproteinase-9 in cholangiocarcinoma cells were also suppressed by treatment with streptochlorin. Streptochlorin effectively regulated metastasis of HuCC-T1 cells in a mouse model of liver metastasis. In a tumor xenograft study using SNU478 cells, streptochlorin significantly inhibited tumor growth without changes in body weight when compared with the control.</P><P><B>Conclusion</B></P><P>These results reveal that streptochlorin is a promising chemotherapeutic agent to the treatment of cholangiocarcinoma.</P>
Koo, Tae-Hyeon,Jun, Hyung-Oh,Bae, Soo-Kyung,Kim, Su-Ryun,Moon, Chang-Pyo,Jeong, Seong-Kyoon,Kim, Woo-Sik,Kim, Gyoo-Cheon,Jang, Hye-Ock,Yun, Il,Kim, Kyu-Won,Bae, Moon-Kyoung 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.1
Porphyromonas gingivalis is a major periodontal pathogen. The lipopolysaccharide (LPS) secreted from P. gingivalis is implicated in the initiation and progression of periodontitis. Aberrant angiogenesis is often associated with lesion formation in chronic periodontitis. In this study, we report that P. gingivalis LPS activates angiogenic cascade, migration, invasion and tube formation in human umbilical vein endothelial cells (HUVECs). Furthermore, P. gingivalis LPS potently stimulated in vivo neovascularization in chick chorioallantoic membrane (CAM) and the mouse Matrigel plug assay. P. gingivalis LPS had no effect on the expression of vascular endothelial growth factor (VEGF) or its receptor, Flk-1, implying that P. gingivalis LPS-induced angiogenesis may result from its direct action on endothelial cells. P. gingivalis LPS evoked activation of the mitogen-activated protein kinase ERK1/2 in HUVECs, which is closely linked to angiogenesis. Taken together, these results strongly suggest P. gingivalis LPS plays an important role in the pathological angiogenesis for periodontal diseases, such as periodontitis.
Na, Tae‐,Young,Shin, Young Kee,Roh, Kyung Jin,Kang, Shin‐,Ae,Hong, Il,Oh, Sae Jin,Seong, Je Kyung,Park, Cheol Keun,Choi, Yoon La,Lee, Mi‐,Ock Wiley Subscription Services, Inc., A Wiley Company 2009 Hepatology Vol.49 No.4
<P><B>Abstract</B></P><P>Although hepatitis B virus X protein (HBx) has been implicated in abnormal lipid metabolism in hepatitis B virus (HBV)–associated hepatic steatosis, its underlying molecular mechanism remains unclear. Liver X receptor (LXR) plays an important role in regulating the expression of genes involved in hepatic lipogenesis. Here we demonstrate that LXRα and LXRβ mediate HBV‐associated hepatic steatosis. We have found that HBx induces the expression of LXR and its lipogenic target genes, such as sterol regulatory element binding protein‐1c (SREBP‐1c), fatty acid synthase (FAS), and peroxisome proliferator‐activated receptor, and this is accompanied by the accumulation of lipid droplets. RNA interference with LXR expression decreases the amount of lipid droplets as well as the expression of the lipogenic genes, and this indicates that HBx‐induced lipogenesis is LXR‐dependent. LXRα and HBx colocalize in the nucleus and are physically associated. HBx induces the transactivation function of LXRα by recruiting CREB binding protein to the promoter of the target gene. Furthermore, we have observed that expression of LXR is increased in the livers of HBx‐transgenic mice. Finally, there is a significant increase in the expression of LXRβ (<I>P</I> = 0.036), SREBP‐1c (<I>P</I> = 0.008), FAS, and stearoyl–coenyzme A desaturase‐1 (<I>P</I> = 0.001) in hepatocellular carcinoma (HCC) in comparison with adjacent nontumorous nodules in human HBV‐associated HCC specimens. <I>Conclusion:</I> Our results suggest a novel association between HBx and LXR that may represent an important mechanism explaining HBx‐induced hepatic lipogenesis during HBV‐associated hepatic carcinogenesis. (H<SMALL>EPATOLOGY</SMALL> 2009.)</P>