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Ning Zhu,Yi Gong,Jian He,Jingwen Xia,Xiaodong Chen 연세대학교의과대학 2013 Yonsei medical journal Vol.54 No.6
Purpose: Methylenetetrahydrofolate reductase (MTHFR) has been implicated in lung cancer risk and response to platinum-based chemotherapy in advanced non-small cell lung cancer (NSCLC). However, the results are controversial. We performed meta-analysis to investigate the effect of MTHFR C677T polymorphism on lung cancer risk and response to platinum-based chemotherapy in advanced NSCLC. Materials and Methods: The databases of PubMed, Ovid, Wanfang and Chinese Biomedicine were searched for eligible studies. Nineteen studies on MTHFR C677T polymorphism and lung cancer risk and three articles on C677T polymorphism and response to platinum-based chemotherapy in advanced NSCLC, were identified. Results: The results indicated that the allelic contrast, homozygous contrast and recessive model of the MTHFR C677T polymorphism were associated significantly with increased lung cancer risk. In the subgroup analysis,the C677T polymorphism was significantly correlated with an increased risk of NSCLC, with the exception of the recessive model. The dominant model and the variant T allele showed a significant association with lung cancer susceptibility of ever smokers. Male TT homozygote carriers had a higher susceptibility, but the allelic contrast and homozygote model had a protective effect in females. No relationship was observed for SCLC in any comparison model. In addition, MTHFR 677TT homozygote carriers had a better response to platinum-based chemotherapy in advanced NSCLC in the recessive model. Conclusion: The MTHFR C677T polymorphism might be a genetic marker for lung cancer risk or response to platinum-based chemotherapy in advanced NSCLC. However, our results require further verification.
Quality of Life of Male Spouse Caregivers for Breast Cancer Patients in China
Zhu, Ping,Fu, Ju-Fang,Wang, Bo,Lin, Jing,Wang, Yan,Fang, Ning-Ning,Wang, Dan-Dan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.10
Background: The aim of this study was to describe the characteristics of male spouse caregivers of breast cancer patients in China, assess their quality of life (QOL), and investigate the influencing factors. Materials and Methods: A total of 243 breast cancer patient-spouse caregiver dyads were recruited from four hospitals in Shanxi and Anhui province of China. A cross-sectional design was applied to collect data and the Chinese version of the Medical Outcomes Study 36-item Short Form (SF-36) was used to measure caregivers' QOL, and the Chinese version of M.D. Anderson Symptom Inventory (MDASI-C) was applied to measure patient symptom severity and interference. Pearson's correlation was used to examine the correlations between caregiver burden and QOL. The multiple regression analysis was used to determine the most predictive factors influencing QOL. Results: The scores of all SF-36 scales were above 50.0, which were much lower than that of general mainland Chinese males. Mental QOL was significantly worse than physical QOL. Spouses demographic characteristics, caregiving-related variables and patient symptoms were related to spouse QOL. Caregiver burden has a negative relationship with QOL. Conclusions: A decrease in life events and patient symptoms, as well as increase in spouse sleeping time and family income, ought to improve QOL.
Antennal UDP-glycosyltransferase genes in the coffee white stemborer, Xylotrechus quadripes
Ning-Na Yin,Yu-Jie Zhao,Jia-Ying Zhu,Nai-Yong Liu 한국응용곤충학회 2019 Journal of Asia-Pacific Entomology Vol.22 No.4
The antenna of Xylotrechus quadripes is the principle olfactory organ that is subjected to a large number of endogenous and exogenous compounds. The gene families associated with the detoxification of these compounds are essential for the adaptive evolution of insect defensive strategies. However, knowledge on uridine diphosphate (UDP)-glycosyltransferases (UGTs) of X. quadripes is unavailable. Here, we characterized 30 UGT genes identified from an antennal transcriptome of X. quadripes. Among them, 16 UGT genes encoding 508–527 amino acids shared the full-length sequences and signal peptides in N-terminus. Multiple sequence alignment revealed that X. quadripes UGTs had a variable N-terminus and a conserved C-terminus. Phylogenetic analysis showed that X. quadripes UGTs were classified into ten sub-families with the largest UGT one of UGT352 (nine genes) and a strict single copy of UGT50 within coleopteran species. Gene structural analysis indicated that coleopteran UGT50s underwent intron gains or losses. Expression profile revealed that all studied X. quadripes UGTs were transcribed in the antennae of both sexes, some of which exhibited sex-biased expression including UGT2, UGT6, UGT20 and UGT27 in females as well as UGT3, UGT11 and UGT12 in males. In addition, most of UGTs were widely expressed in other tissues, indicating their functional diversities in this beetle. Together, these findings provide valuable information for further functional studies of UGTs in X. quadripes, especially their roles in olfaction.
Antioxidant and Anti-anemia Activity of Heme Iron Obtained from Bovine Hemoglobin
Ning Tang,Yuanyuan Zhu,Hong Zhuang 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.2
The industrial by-product bovine blood was used to prepare heme iron. Obtained heme iron exhibited strong in vitro antioxidant activities. Heme iron exhibited a significantly (p<0.05) higher DPPH radical scavenging activity than ascorbic acid at low concentrations. The effects of heme iron in iron deficient anemic rats were evaluated. Heme iron exhibited an effective restorative action by returning hemoglobin, red blood cell, hematocrit, mean corpuscular hemoglobin concentrations, and serum iron levels in iron-deficient animals to normal or better values. Rats in the medium dosage group (2 mg of Fe/kg of body weight) experienced better iron bioavailability than rats in other treatment groups. The activities of antioxidant enzymes were enhanced while malondialdehyde levels were reduced in iron deficient anemic rats. Heme iron obtained from bovine blood can be used as a safe and efficient new iron supplement.
Ning Dai,Yuan Zou,Lei Zhu,Hui-Fang Wang,Mu-Gen Dai 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.6
Liver steatosis is characterized by lipid dysregulation and fat accumulation in the liver and can lead tooxidative stress in liver. Since proanthocyanidins are present in plant-based foods and have powerful antioxidant properties,we investigated whether proanthocyanidins can prevent oxidative stress and subsequent liver injury. Carbon tetrachloride(CCl4) treatment can cause steatosis in rats that models both alcoholic and non-alcoholic fatty liver disease in humans. Wepre-treated rats by oral administration of proanthocyanidins extracted from grape seeds 7 days prior to intragastricallyadministering CCl4. Proanthocyanidin treatment continued for an additional 2 weeks, after which time liver and serum were harvested, and mediators of liver injury, oxidative stress, and histological features were evaluated. CCl4-treated rats exhibited significant increases in the following parameters as compared to non-treated rats: fat droplets in the liver, liver injury (ALT, AST), and DNA damage (8-OHdG). Additionally, CCl4 treatment decreased antioxidant enzymes SOD, GSH, GPX, and CAT in the liver due to their rapid depletion after battling against oxidative stress. Compared to CCl4-treated rats, treatment with proanthocyanidins effectively suppressed lipid accumulation, liver injury, DNA damage, as well as restored antioxidant enzyme levels. Further investigation revealed that proanthocyanidins treatment also inhibited expression of CYP2E1 in liver, which prevented the initial step of generating free radicals from CCl4. The data presented here show that treatment with orally administered proanthocyanidins prevented liver injury in the CCl4-induced steatosis model, likely through exerting antioxidant actions to suppress oxidative stress and inhibiting the free radical–generating CYP2E1 enzyme.
Zhu, Xue-Mei,Hu, Jiang-Ning,Shin, Jung-Ah,Lee, Jeung-Hee,Hong, Soon-Teak,Lee, Ki-Teak The Korean Society of Food Science and Nutrition 2010 Preventive Nutrition and Food Science Vol.15 No.4
The chemical characteristics of seed oils of Asian ginseng (Panax ginseng C.A. Meyer) at different ages grown in Korea (3, 4 and 5-year old) and China (5-year old), and American ginseng (Panax quinquefoliu L., 5-year old) grown in China were compared. Total fatty acid composition showed a significantly higher oleic acid content in American (87.50%) than in Korean (68.02~69.14%) and Chinese ginseng seed oils (61.19%). At the sn-2 position, the highest oleic acid (81.09%) and lowest linoleic acid (15.77%) were found in American ginseng seed oil. The main triacylglycerol species in ginseng seed oils were triolein (OOO) and 1,2-dioleoyl-3-linoleoyl-glycerol (LOO)/1,3-dioleoyl-2-linoleoyl-glycerol (OLO). In addition, the seed oils possessed an ideal oxidative stability showing 16.55~23.12 hr of induction time by Rancimat test. The results revealed that ginseng seed oil could be developed as a new healthy edible oil, and that the oil's chemical characteristics were strongly associated with the ginseng species and habitats.