Comparative evaluation of gastroulcerogenic potential of nitrogen isoforms of salicyl alcohol and aspirin in rats: biochemical and histological study

Ali, Gowhar,Subhan, Fazal,Islam, Nazar Ul,Ullah, Nasir,Shahid, Muhammad,Ullah, Sami,Ullah, Ihsan,Shah, Rehmat,Khan, Ikhtiar,Sewell, Robert D. E.,Abbas, Ghulam 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.7

The aim of the current study was to explore in vivo any relative gastroulcerogenic prospective propensity of newly synthesized nitrogen containing derivatives of salicyl alcohol; compound (I) [1-(2-hydroxybenzyl) piperidinium chloride], compound (II) [4-carbamoyl-1-(2- hydroxybenzyl)piperidinium chloride] and aspirin in albino rats. The experimental groups received the following oral treatments daily for 6 days: group I saline control; group II, standard (aspirin) treatment group [150 mg/kg of body weight]; group III, test (compound I) treatment group [100, 150 mg/kg]; group IV, test (compound II) treatment group [100, 150 mg/kg]. The results showed that in the case of the aspirin treated group and compound (I) [150 mg/kg], there was a significant increase in gastric volume, free acidity, total acidity, ulcer score and a decrease in gastric pH. Furthermore, histopathological examination of gastric mucosa of these treated groups revealed detectable morphological changes. Utilizing the same protocol, synthetic compound (I) [100 mg/kg] and (II) [100, 150 mg/kg] exhibited no statistically significant ulcerogenic or cytotoxic properties. A cyclooxygenase (COX) selectivity test indicated the preferential inhibition of COX-I and COX-II enzymes by compounds (I) and (II). This study therefore indicates that these synthetic compounds may possess reduced ulcerogenic potential and could be a functional substitute to aspirin.

Comparative evaluation of gastroulcerogenic potential of nitrogen isoforms of salicyl alcohol and aspirin in rats: biochemical and histological study

Gowhar Ali,Fazal Subhan,Nazar Ul Islam,Nasir Ullah,Muhammad Shahid,Sami Ullah,Ihsan Ullah,Rehmat Shah,Ikhtiar Khan,Robert D. E. Sewell,Ghulam Abbas 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.7

The aim of the current study was to explorein vivo any relative gastroulcerogenic prospective propensityof newly synthesized nitrogen containing derivativesof salicyl alcohol; compound (I) [1-(2-hydroxybenzyl)piperidinium chloride], compound (II) [4-carbamoyl-1-(2-hydroxybenzyl)piperidinium chloride] and aspirin in albinorats. The experimental groups received the following oraltreatments daily for 6 days: group I saline control; group II,standard (aspirin) treatment group [150 mg/kg of bodyweight]; group III, test (compound I) treatment group [100,150 mg/kg]; group IV, test (compound II) treatment group[100, 150 mg/kg]. The results showed that in the case of theaspirin treated group and compound (I) [150 mg/kg], therewas a significant increase in gastric volume, free acidity,total acidity, ulcer score and a decrease in gastric pH. Furthermore, histopathological examination of gastricmucosa of these treated groups revealed detectable morphologicalchanges. Utilizing the same protocol, syntheticcompound (I) [100 mg/kg] and (II) [100, 150 mg/kg]exhibited no statistically significant ulcerogenic or cytotoxicproperties. A cyclooxygenase (COX) selectivity test indicatedthe preferential inhibition of COX-I and COX-IIenzymes by compounds (I) and (II). This study thereforeindicates that these synthetic compounds may possessreduced ulcerogenic potential and could be a functionalsubstitute to aspirin.

Behavior of Box Concrete-Filled Steel Tube Columns Considering Confinement Effect

Ammar Abbas Ali,Nazar Jabbar Abbas 한국강구조학회 2021 International Journal of Steel Structures Vol.21 No.3

In recent years considerable attention has been given to estimating the strength of box concrete-fi lled steel tube (CFST) stub columns. The eff ect of confi ning pressures is one of the complexities in determining the ultimate strength of the CFST columns. An experimental database of 188 tested columns has been used to produce two types of formulae: modifi ed and simplifi ed, that can help to predict the ultimate strength of box CFST columns with a wide range of geometrical and material properties. Diff erent code procedures and previous formulae given by other authors were used for verifi cation purposes and to show reliability. The axial load-shortening behaviors of composite columns were plotted using a proposed model of confi ned concrete adopted in a fi nite element analysis and compared with the experimental results. It has been found that the present formulae and concrete model have given results that agree quite well with the results of the experimental tests.

SADEA-II:Ageneralizedmethodforefficient global optimization ofantennadesign

Bo Liu,Slawomir Koziel,Nazar Ali 한국CDE학회 2017 Journal of computational design and engineering Vol.4 No.2

Efficiency improvementisofgreatsignificance forsimulation-drivenantennadesignoptimizationmethodsbasedonevolutionaryalgorithms(EAs). Thetwomainefficiency enhancementmethodsexploitdata-drivensurrogatemodelsand/ormulti-fidelity simulationmodelstoassistEAs. However, optimizationmethodsbasedonthelattereitherneedadhoclow-fidelity modelsetuporhavedifficulties inhandlingproblemswithmore thanafewdesignvariables,whichisamainbarrierforindustrialapplications.Toaddressthisissue,ageneralizedthreestagemulti-fidelitysimulation-model assistedantennadesignoptimizationframeworkisproposedinthispaper.Themainideasincludeintroductionofanoveldatamining stagehandlingthediscrepancybetweensimulationmodelsofdifferent fidelities, andasurrogate-model-assistedcombinedglobalandlocal searchstageforefficient high-fidelity simulationmodel-basedoptimization.ThisframeworkisthenappliedtoSADEA,whichisastate-of-the-art surrogate-model-assistedantennadesignoptimizationmethod,constructingSADEA-II.ExperimentalresultsindicatethatSADEA-IIsuccessfully handlesvariousdiscrepancybetweensimulationmodelsandconsiderablyoutperformsSADEAintermsofcomputationalefficiencywhile ensuringimproveddesignquality.

Measurement and Explanation of DC/RF Power Loci of an Active Patch Antenna

Neil J. McEwan,Nazar T. Ali,Kahtan A. Mezher,Elmahdi A. El-Khazmi,Raed A. Abd-Alhameed 한국전자통신연구원 2011 ETRI Journal Vol.33 No.1

A case study of an active transmitting patch antenna revealed a characteristic loop locus of DC power versus RF output power as drive frequency was varied, with an operational bandwidth substantially smaller than the impedance bandwidth of the radiator. An approximate simulation technique, based on separation of the output capacitance of the power transistor, yielded easily visualized plots of power dependence on internal load impedance, and a simple interpretation of the experimental results in terms of a near-resonance condition between the output capacitance and output packaging inductance.

The role of risk perception, risk communication, and demographic factors in COVID-19 preventive behaviors: an online survey in Iran

Mansour Rezaei,Nader Rajabi Gilan,Ali Almasi,Mehdi Khezeli,Fatemeh Jamshidi Nazar,Zahra Jorjoran Shushtari,Yahya Salimi,Farid Najafi,Neda Sarabi,Shahram Saeidi,Saeid Saeidi 질병관리본부 2022 Osong Public Health and Research Persptectives Vol.13 No.4

Objectives: This study investigated preventive behaviors toward coronavirus disease 2019 (COVID-19) and related factors in a Kurdish Iranian sample.Methods: This online survey was conducted among the population aged 18 and above in Kermanshah Province, in western Iran, in April 2020. Samples were invited and recruited through social media. Data were collected using a questionnaire consisting of 4 sections (questions on demographic variables, risk perception, risk communication, and COVID-19 preventive behaviors) and analyzed using Stata ver. 8.Results: The Pearson correlation test showed that risk communication was significantly correlated with COVID-19 preventive behaviors (r=0.320, p<0.01). In the final model, where the explanatory power increased with the entry of the risk communication variable, the variables explained a total of 14% of variance in COVID-19 preventive behaviors. Sex (β=−0.482), risk perception (β=0.047), and risk communication (β=0.662) were significant determinants.Conclusion: Risk communication and risk perception related to COVID-19, as well as being a woman, were determinants of COVID-19 preventive behaviors.

Embedded Systems: Teaching and Design Challenges for Nonhomogeneous Classes

Intisar Ibrahim Ridwan,Izzeldin Ibrahim Mohamed,Rosmah Ali,Nazar ElFadil 보안공학연구지원센터 2016 International Journal of Multimedia and Ubiquitous Vol.11 No.10

The growth of technology leads the industry to move beyond and crosses the boundaries of its own disciplines. The changes from pure mechanical system, to electronics systems and the integration with control software brings new challenges to the engineers working in the industry and to the source shaped the engineers. As a result, institutes of higher education need to make the necessary changes to meet this continuing market demands. This work address the issue and describes a new systematic and an effective approach for teaching hardware based courses for large non-homogenous (Computer Science and Electronics students) class setting using existing e-learning system in the university to promote powerful, long-lasting learning outcomes. It is a blend of several approaches with an insightful goal to provoke deeper understanding in various topics in microprocessors and microcontrollers details, intended to teach the computer science students to learn low-level hardware interfacing, interrupt handling, and other microprocessors issues, as well as embedded systems through learning microcontrollers. Our methodology revolute around three steps: using visual simulators, incrementally weighted exercises, from easiest to hardest, and finally working on real hardware controllers. The proposed approaches developed for the course “Embedded Controller Technology”, but any other hardware based course can apply them. The approach comprises a 3-hour a week lecture and 2-hour a week laboratory, both taught in the 3rd semester. Imposing the approach leads to the overall improvement of the course quality: student satisfaction and interest, increased number of completed hardware projects and significant improvement in grade distribution and it has been observed that students feel better prepared to face the challenges to be found in their future professional activities.

Measurements and Analysis of Fingerprinting Structures for WLAN Localization Systems

Nuha Al Khanbash,Nayef Al Sindi,Nazar Ali,Saleh Al-Araji 한국전자통신연구원 2016 ETRI Journal Vol.38 No.4

Channel-based radio-frequency fingerprinting such as a channel impulse response (CIR), channel transfer function (CTF), and frequency coherence function (FCF) have been recently proposed to improve the accuracy at the physical layer; however, their empirical performance, advantages, and limitations have not been well reported. This paper provides a comprehensive empirical performance evaluation of RF location fingerprinting, focusing on a comparison of received-signal strength, CIR-, CTF-, and FCF-based fingerprinting using the weighted k-nearest neighbor pattern recognition technique. Frequency domain channel measurements in the IEEE 802.11 band taken on a university campus were used to evaluate the accuracy of the fingerprinting types and their robustness to human-induced motion perturbations of the channel. The localization performance was analyzed, and the results are described using the spatial and temporal radio propagation characteristics. In particular, we introduce the coherence region to explain the spatial properties and investigate the impact of the Doppler spread in time-varying channels on the time coherence of RF fingerprint structures.

Antioxidant Activities and Inhibitory Effects of Dietary Plants against Sodium Nitroprusside Induced Lipid Peroxidation in the Mouse Brain and Liver

Asmatullah Khan,Syed Mubashar Sabir,Halima Nazar,Abdul Hamid,Khan Usmanghani,Hussain Ali 한국식품과학회 2014 Food Science and Biotechnology Vol.23 No.4

The antioxidant properties of aqueous extractsof 6 medicinal plants, Phyllanthus emblica, Terminalia chebula(black and yellow), Terminalia arjuna, BalsamodendronMukul, and Alium sativum against lipid peroxidation inmouse tissues were investigated. Extracts showed inhibitionagainst thiobarbituric acid reactive species (TBARS)induced by pro-oxidant (5 μM sodium nitroprusside) in themouse brain and liver. Extracts displayed high free radicalscavenging activities against DPPH (IC50, 23.23±1.2 μg/mL, P. emblica), 20.24±0.9 μg/mL (T. chebula yellow),17.33±1.1 μg/mL (T. chebula black), 19.44±0.45 μg/mL (T. arjuna), 56.59±2.1 μg/mL (Balsamo-dendron Mukul), andhigher than 200 μg/mL (A. sativum). Higher antioxidantand inhibitory effects of T. chebula black are attributed toa higher phenolic content, Fe(II) chelating ability, reducingability, nitric oxide radical scavenging, and free radicalscavenging activity. Oxidative stress in the brain and livercould potentially be managed/prevented by dietary intakeof these plants.

Assessment of Rheological and Piezoresistive Properties of Graphene based Cement Composites

Sardar Kashif Ur Rehman,Zainah Ibrahim,Mohammad Jameel,Shazim Ali Memon,Muhammad Faisal Javed,Muhammad Aslam,Kashif Mehmood,Sohaib Nazar 한국콘크리트학회 2018 International Journal of Concrete Structures and M Vol.12 No.6

The concrete production processes including materials mixing, pumping, transportation, injection, pouring, moulding and compaction, are dependent on the rheological properties. Hence, in this research, the rheological properties of fresh cement paste with different content of graphene (0.03, 0.05 and 0.10% by weight of cement) were investigated. The parameters considered were test geometries (concentric cylinders and parallel plates), shear rate range (300–0.6, 200–0.6 and 100–0.6 s<SUP>−1</SUP>), resting time (0, 30 and 60 min) and superplasticizer dosage (0 and 0.1% by weight of cement). Four rheological prediction models such as Modified Bingham, Herschel–Bulkley, Bingham model and Casson model were chosen for the estimation of the yield stress, plastic viscosity and trend of the flow curves. The effectiveness of these rheological models in predicting the flow properties of cement paste was verified by considering the standard error method. Test results showed that the yield stress and the plastic viscosity increased with the increase in graphene content and resting time while the yield stress and the plastic viscosity decreased with the increase in the dosage of superplasticizer. At higher shear rate range, the yield stress increased while the plastic viscosities decreased. The Herschel–Bulkley model with the lowest average standard error and standard deviation value was found to best fit the experimental data, whereas, Casson model was found to be the most unfitted model. Graphene reduces the flow diameter and electrical resistivity up to 9.3 and 67.8% and enhances load carrying capacity and strain up to 16.7 and 70.1% of the composite specimen as compared with plain cement specimen. Moreover, it opened a new dimension for graphene-cement composite as smart sensing building construction material.