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문기내,남철현,김귀희,위광복,박경옥,이미경,심규범,장영진 慶山大學校 保健福祉硏究所 2003 保健福祉硏究 Vol.8 No.-
This study was conducted to examine middleㆍhigh school 720 students in seven regions of middleㆍsmall city and town, Myon for 2 months from March 2 through April 30, 2002 in order to realize a side of school health education in middleㆍhigh school and health education need as well as health education specialist in school in the future. The results of this study can be summarized as follows. 1. Health condition is now 'normal' is 51.0%, 'good' is 45.0%, 'not good' is 4.1% and health condition of children is good as much as education level of mother is higher. 2. Experience to learn health education in school for one year recently is 'no' is 39.6%, 'don't know' is 32.6%, 'yes' is 27.8% and it represents health education in school doesn't work well and experience to learn health education is lower and lower in town and Myon. 3. Health education ways to work in school now are 'Movie, Video, Slide' is 40.7%, 'education as groups of nurse-teacher' is 38.6%, 'to distribute health education material and book' is 7.7%, 'education by setting an example' is 3.4%, 'the others' is 9.7%. 4. Time of appropriate health education for one time is 'about a hour' is 56.7%, 'about 30 minute' is 33.8%, 'about two hour' is 7.6%, it represents this situation is because of what students' time is lack and burden about a curriculum in an education administratin and school classed of a focused school score. 5. The average score of satisfaction of health education in school is 16.99±0.58, 'men' is 1.79±0.60, 'women' is 1.61±0.55 as the distinction of sex, satisfaction level of men is higher than women. 6. Learning route about health information is 'through mass media' is 59.9%. 'through family, friend' is 15.0% 'health education lecture' is 7.2%, 'printing media' is 6.1%, 'medical institution' is 5.6%, 'the others' is 5.1%, 'public health center' is 1.0%, 'through mass media' is the highest percent as each 59.1% and 60.6% in all of men and women. 7. The most efficient education way of health education is 'movie, video, slide' is 32.6%, 'health education specialist who works school' is 21.9%, 'school health education by nurse-teacher' is 16.0%, 'way through mass communication' is 11.6%. 8. The appropriate health education specialist in the future is 'health education specialist who has qualifications' is the highest as 64.5%, 'nurse-teacher' is 12.4%, 'medical personnel(doctor, a physician of oriental medicine etc.,)' is 11.0%, 'staff in public health center' is 7.2%, people in other regions(health and medical professor etc.,) is 7.0%, it represents school health education is not actual and is formal now in second hand. 9. The most necessary health education program is 'program of stress solution' is the highest as 24.9%, 'program of no smoking' is 22.7%, 'sexual education program' is 19.8%, 'school violence program' is 8.8%, 'isolate from their friends prevention program' is 8.0%, solution program of stress which gives student by school score was very necessary. Therefore, school health education is formal and inefficient because school education focuses on an entrance exam, so middleㆍhigh school students decrease concern and interest about health education. Furthermore, reliance is gotten down about nurse-teacher who takes charge of school health, a charged person of school health education wants more chargeable health education staff. And a solution program of stress that gives students by school score was very necessary. According to active concern and planned, systematic school health education is necessary to give right health knowledge, health maintenanceㆍpromotion and setting of appropriate health education specialist is very urgent.
Potential involvement of glycogen synthase kinase (GSK)-3β in a rat model of multiple sclerosis:
Mee jung Ahn,Jeong tae Kim,Chang nam Park,Jin hee Cho,Young heun Jee,Kyung sook Jung,Chang jong Moon,Tae kyun Shin 대한해부학회 2017 Anatomy & Cell Biology Vol.50 No.1
Glycogen synthase kinase (GSK)-3β has been known as a pro-inflammatory molecule in neuroinflammation. The involvement of GSK-3β remains unsolved in acute monophasic rat experimental autoimmune encephalomyelitis (EAE). The aim of this study was to evaluate a potential role of GSK-3β in central nervous system (CNS) autoimmunity through its inhibition by lithium. Lithium treatment significantly delayed the onset of EAE paralysis and ameliorated its severity. Lithium treatment reduced the serum level of pro-inflammatory tumor necrosis factor a but not that of interleukin 10. Western blot analysis showed that the phosphorylation of GSK-3β (p-GSK-3β) and its upstream factor Akt was significantly increased in the lithium-treated group. Immunohistochemical examination revealed that lithium treatment also suppressed the activation of ionized calcium binding protein-1–positive microglial cells and vascular cell adhesion molecule-1 expression in the spinal cords of lithium-treated EAE rats. These results demonstrate that lithium ameliorates clinical symptom of acute monophasic rat EAE, and GSK-3 is a target for the suppression of acute neuroinflammation as far as rat model of human CNS disease is involved.
홍미 ( Mee Hong ),남승우 ( Seung Woo Nam ),이연경 ( Yeon Kyung Lee ),고선영 ( Sun Young Ko ),신손문 ( Son Moon Shin ) 대한주산의학회 2014 Perinatology Vol.25 No.1
Pai syndrome is a rare disorder, first described in 1987. Diagnostic criteria are the presence of the nasal polyp and one of the following: midline cleft lip, congenital polyp of mid-anterior alveolar process, and pericallosal lipoma. Thirty-six cases of Pai syndrome have been described so far. We report 1 case of Pai syndrome accompanied by congenital nasal polyp and callosal lipoma with partial agenesis of corpus callosum, the first time in Korea.
초기 톨루엔 농도가 톨루엔-NO_(x)-공기 혼합물의 광산화 반응에 미치는 영향 : II. 입자상 물질의 생성 및 성장 II. Aerosol Formation and Growth
이영미,배귀남,이승복,김민철,문길주 한국대기환경학회 2005 한국대기환경학회지 Vol.21 No.1
An experimental investigation of the gas-phase photooxidation of toluene-NOx-air mixtures at sub-ppm concentrations has been carried out in a 6.9 ㎡, indoor smog chamber irradiated by blacklights. Measured parameters in the toluene-NO_(x) experiments included aerosol, O₃, NO, NO₂, NO_(x), CO, SO₂, toluene, and air temperature. The initial toluene concentration ranged from 225 ppb to 991 ppb and the initial concentration ratio of toluene/NOx in ppbC/ppb was in the range of 5~20. It was found that the variation of aerosol number concentration with irradiation time caused by the photooxidation of toluene-NOx-air mixtures depended on the initial toluene concentration for similar concentration ratio of toluene/NO_(x). The dependency of initial toluene concentration on the photooxidation of toluene-NO_(x)-air mixtures for toluene/NOx=5~6 seemed to be opposite to that for toluene/NO_(x)= 10~11. The maximum number concentration of aerosols formed by photooxidation and the aerosol yield depended on both initial toluene concentration and initial concentration ratio of toluene/NO_(x). In this study, the aerosol yield, defined as aerosol formed per unit toluene consumed, was found to be 0.01~0.16.
초기 톨루엔 농도가 톨루엔-NOx-공기 혼합물의 광산화 반응에 미치는 영향 : I. 가스상 물질의 변화 I. Change of Gaseous Species
이영미,배귀남,이승복,김민철,문길주 한국대기환경학회 2005 한국대기환경학회지 Vol.21 No.1
An experimental investigation of the gas-phase photooxidation of toluene-NO_(x)-air mixtures at sub-ppm concentrations has been carried out in a 6.9 ㎥, indoor smog chamber irradiated by blacklights. Measured parameters in the toluene-NOx experiments included O₃, NO, NO₂, NO_(x), CO, SO₂, toluene, and air temperature. The initial toluene concentration ranged from 225 ppb to 991 ppb and the initial concentration ratio of toluene/NOx in ppbC/ppb was in the range of 5~20. It was found that the variation of gaseous species with irradiation time caused by the photooxidation of toluene-NOx-air mixtures depended on the initial toluene concentration for similar concentration ratio of toluene/NOx. The dependency of initial toluene concentration on the photooxidation of toluene-NO_(x)-air mixtures for toluene/NOx =5~6 seemed to be opposite to that for toluene/NOx=10~11. The arriving time at maximum ozone concentration depended on both initial toluene concentration and initial concentration ratio of toluene/NOx. However, the maximum concentration of ozone formed by photooxidation depended only on the initial toluene concentration.
Proposal of Evidence-based Korean Guidelines for the Prevention of Venous Thromboembolism (VTE) (초)
( Soo Mee Bang ),( Moon Ju Jang ),( Kyoung Ha Kim ),( Ho Young Yhim ),( Yeo Kyeoung Kim ),( Seung Hyun Nam ),( Sung Hwa Bae ),( Sung Hyun Kim ),( Yeung Chul Mun ),( In Ho Kim ),( Chul Won Jung ),( Nan 대한내과학회 2012 대한내과학회 추계학술대회 Vol.2012 No.1
BRAF and KRAS mutations in prostatic adenocarcinoma
Cho, Nam-Yun,Choi, Minhee,Kim, Baek-Hee,Cho, Yong-Mee,Moon, Kyung Chul,Kang, Gyeong Hoon Wiley Subscription Services, Inc., A Wiley Company 2006 International journal of cancer: Journal internati Vol.119 No.8
<P>Constitutive activation of the kinase cascade involving RAS, RAF, MEK and ERK is common to human cancers, and mutations of KRAS and BRAF are mutually exclusive and serve as alternatives to activate the RAS/RAF/ERK signaling pathway. RAS mutations are known to occur in prostate adenocarcinomas, but little is known about BRAF mutations in these tumors. In the present study, BRAF and KRAS mutations were characterized in 206 prostate adenocarcinomas by enhanced PCR-RFLP and direct sequencing. The identified KRAS and BRAF mutations were then analyzed with respect to preoperative serum PSA levels, Gleason scores and tumor stages. Mutations in codon 600 of BRAF were identified in 21 (10.2%) of 206 prostate adenocarcinomas. KRAS mutations in codons 12 or 13 were found in 15 (7.3%) of 206 prostate adenocarcinomas. However, no tumor specimen contained both BRAF and KRAS mutations. Prostate adenocarcinomas with a BRAF mutation tended to show higher preoperative serum PSA levels, Gleason scores and tumor stages than prostate adenocarcinomas with a KRAS mutation. The results obtained show that BRAF mutations are as uncommon as KRAS mutations in prostate adenocarcinoma. Although BRAF and KRAS are members of the same RAS/ERK signaling pathway, prostate adenocarcinomas with a BRAF mutation showed clinicopathologic features that differed from those of prostate adenocarcinoma with a KRAS mutation. © 2006 Wiley-Liss, Inc.</P>