후두 및 하인두 암종에서 p53단백 발현과 Espstein-Barr Virus 검출

최영환,도남용,나한조,이도용,노용훈,김완수,최종선 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2

Background and Objectives : When p53 cancer suppressor gene, occurs gene deletion or point mutation, malignancy develops by loss of p53 function with abnormal p53 protein. The Epstein-Barr virus (EBV) is the causative agent of certain type of lymphoma and undifferentiated nasopharyngeal carcinoma. However, the role of EBV as a causative factor in other head &eck tumors is not fully elucidated except nasopharyngeal carcinoma. This study, the author examined that p53 expression and detection rate of EBV correlate to development of laryngeal and hypopharyngeal squamous cell carcinoma(SCC) and play the possible role of prognostic indicators. Materials and Methods : Formalin-fixed, paraffin-embedded tissue specimen from 32 cases of larynx and hypopharyngeal squamous cell carcinomas were studied by immunohistochemical staining for p53 and EBV. The results of analysis were compared with clinicopathological parameters. Results : p53 expression was 56.3% (18 cases) and the detection rate of EBV was 43.6% (14 cases) of 32 cases in laryngeal and hypopharyngeal squamous cell carcinomas. p53 expression was correlate with histologic grade (p<05) only. Detection of EBV was not correlate with clinicopathological parmeters. Conclusion : These results suggest p53 expression and the detection of EBV may be related with development of laryngeal and hypopharyngeal squamous cell carcinoma. And, the expression of p53 protein can be used as a prognosticator in laryngeal and hypopharyngeal squamous cell carcinoma under certain limitation.

만성중이염의 골도청력변화

박선홍,노용훈,이도용,나한조,김용기,최봉남,도남용 朝鮮大學校 附設 醫學硏究所 1996 The Medical Journal of Chosun University Vol.21 No.1

We have usually experienced bone conduction impairment in chronic otitis media, but it is unclear that raised bone conduction threshold is due to the reflection of cochlear dam- age and / or Carhart effect ( an artificial elevation of bone conduction threshold due to conductive defect ) or both. The purpose of this study is to verify the influence of the artificial elevation of the bone conduction threshold in chronic otitis media and to estimate Carhart effect. A total of 336 cases of tympanoplasty with unilateral chronic otitis media without any other causes of sensorineural hearing loss was studied. The average threshold levels of the bone conduction in diseased ears ranged from 18.5dB at 4kHz to 12.1dB at 250Hz The longer duration of the disease, the larger perforation size, the more severe damage of the middle ear structure and the presence of the cholesteatoma made bone conduction threshold increased. The postoperative thresholds of bone conduction were Improved in 36 cases (40.4%) of the 89 cases that underwent operation with type I tympanoplasty technique without electrie drilling. The degree of the maximal improvement was 14.3dB at 2000Hz and the minimum was 8.8dB at 250Hz. but these result did differ from a statistically significant degree. The result suggest that the bone conduction threshold in chronic otitis media is elevated artificially by conductive defect and improved by successful reconstructive surgery.

보조기를 이용한 족관절 외과 골절의 비수술적 치료

최남홍,곽호윤,송백용,배상욱,이인묵,김도현 대한골절학회 2003 대한골절학회지 Vol.16 No.3

목적: 이번 연구의 목적은 보조기를 이용하여 최소 전위된 족관절 외과 골절의 보존적 치료 결과를 알아보는 것이다. 대상 및 방법: 11명 (11예)의 환자들이 수상 후 8주간 전 체중 부하 보행으로 보존적 치료를 받았다. 적응증으로는 3㎜ 이하의 골절 전위, 내과 부분의 동통과 부종이 없거나 있어도 미약한 경우, 거골의 외측 전위가 없는 경우로 삼았다. 환자들은 AOFAS (the American Orthopedic Foor and Ankle Society) Ankle-Hindfoot Scale에 의해 평가받았다. 결과: 평균 103주 (36~192주)의 추시 관찰을 하였으며, 전례에서 발목 관절의 운동 범위는 정상이었다. 평균 AOFAS Ankle-Hindfoot Scale 점수는 95점이었다. 결론: 보조기를 이용한 보존적 치료의 장점은 조기에 전 체중 부하 보행을 하며 일상생활 및 사회생활을 영위할 수 있다는 것, 환자의 편안함, 그리고 재활 치료 기간의 단축이었다. 그러므로 최소 전위된 족관절 외과 골절에 보조기를 이용한 보존적 치료는 권할만하다. Purpose: The purpose of this study was to evaluate the outcome of conservative treatment for minimal displaced lateral mallolar fracture using ankle brace. Materials and Methods: Eleven patients (eleven ankles) underwent conservative treatment with ankle brace for 8 weeks with full weight bearing ambulation. Inclusion criteria were minimal displacement (<3㎜) of fracture, no or mild tenderness or swelling on medial malleolar area and no lateral shift of talus. The patients were evaluated with AOFAS (the American Orthopedic Foot and Ankle society) Ankle-Hindfoot scale. Result: Average follow up was 103 weeks (36~192). All cases had normal range of motion of ankle. The average score of AOFAS Ankle-Hindfoot scale was 95 points. Conclusion: The advantages of conservative treatment with ankle brace were early return to daily activity and work, comfort to the patients and a short period of rehabilitation. Conservative treatment with ankle brace for minimal displaced lateral malleolar fracture is recommended.

서울 지역 대학생의 식습관 및 식생활태도에 관한 조사

최순남,정남용,윤미은 한국식생활문화학회 2002 韓國食生活文化學會誌 Vol.17 No.1

This study was to investigate the food habits and the dietary behaviors of university students. Questionnaires were completed by 492 students in five different departments. The data were analyzed by SAS program. The results are summarized as follows: Fifty(10.2%) of respondents were vegetarians, 81(16.4%) were heavy meat eaters and all the others were light meat eaters. All students had their biggest meal at supper. Three hundred and ninety-three(79,9%) of the respondents usually had rice for breakfast. Three hundred -sixteen(64.2%} ate 3 meals a day, 155(31.5%) ate 2 meals and all the others ate 1 meal or more than 3 meals. The length of mealtime was 30 minutes in 268(54.5%), 10 minutes in 209(42.5%) and more than 1 hour in all the others. Respondents considered taste the most important meal factor with nutrition, hygiene, and amount ranked accordingly. A majority(63.0%) of respondents ate occasionally ate between meals, while 28.1% snacked frequently, and 8.9% ate no snacks. Although nutrition dept. students had studied nutrition subject, some results of nutrition dept. students were desirable and others were undesirable in dietary behaviors. Therefore they should have a nutritional education program to improve their food habits and the dietary behaviors for students' health. And nutritional education program should be organized practically and systematically.

시차주사열량계를 이용한 치과용 광중합형 복합레진의 분석

최용석,김경남 大韓齒科器材學會 1995 대한치과재료학회지 Vol.22 No.1

The purpose of this study was to investigate the thermal behavior of three dental composite resins (Aelitefil, Hipolite, Photo Clearfil Posterior) currently used in dental clinics as well as to find out a correlation between diametral tensile strengths and thermal behaviors according to the light curing time. After making specimens 15, 30, 45 and 60 seconds light cured respectively, those were measured in diametral tensile strengths and analyzed by Differential Scanning Calorimetry, and by measuring the weight of specimens before and after thermal analysis and calculating the proportion of filler in composite resin, following results were obtained. 1. Diametral tensile strengths of Photo Clearfil Posterior showed no significant difference with respect to curing time, but Aelitefil at 60 sec was different from other curing time(p<0.05). 2. Filler content of each products was of range of 72-85% and there was no difference between the cured and the uncured. 3. Light-cured Photo Clearfil Posterior showed two sharp endothermic peaks at 450℃ and 575℃ but Hipolite and Aelitefil showed one sharp endothermic peak at 450℃ respectively. 4. As for Aelitefil and Hipolite, melting temperatures and decomposition temperatures of light-cured group were significantly higher than those of uncured group and heats of decomposition of light-cured group were significantly lower than those of uncured group(p<0.05), but Photo Clearfil Posterior showed no significant difference in decomposition temperatures and heats of decomposition between light-cured group and uncured group. As mentioned above, there was significant difference between Differential Scanning Calorimetric analysis results of light-cured group and those of uncured group. It is suggested that Differential Scanning Calorimetry has the potential in analysis and understanding of thermal behavior of dental light-cured composite resin.

비수용매에서 전이금속 Ni(II) 착물의 전기화학적 연구

최용국,채희남 全南大學校 觸媒硏究所 1997 觸媒硏究 論文集 Vol.19 No.-

Tridentate schiff base ligand salicylidene-2-iminophenol(SIPH₂) was prepared by the reaction of salicylaldehyde with 2-aminophenol, a its Ni(II) complex was synthesized. The structure and properties of the ligand and its complex were studied by elemental analysis, ¹H-NMR, IR, UV-visible spectroscopy, and thermogravimetric analysis. The mole ratio of Schiff base to the metal of complex was found to be 1:1. Ni(II) complex was contemplated to have hexa-coordinated octahedral configuration containing three water molecules. The redox process of ligand and complex in DMSO solution containing 0.1 M TBAP as supporting electrolyte was investigated by cyclic voltammetry and differential pulse voltammetry with glassy carbon electrode. The redox process of the tridentate Schiff base ligand was totally irreversible. The redox process of Ni(II) complex was quasi-reversible and diffusion-controlled as one electron by one step process Ni(II)/Ni(I). Therefore we conclued that the redox process of complex are as follows : ??

Semiclassical Analysis for O + Pb Elastic Scattering at E=216.6 and 312.6 Mev

최치규,현남규,김용주,홍성락 제주대학교 1992 논문집 Vol.34 No.-

실험실계에서의 입사핵?? 에너지가 216.6과 312.6 MeV이고 표적핵?? 인 탄성산란에 대한 실험데이타를 수정된 Glauber모델을 사용하여 분석하였다. 계산된 결과들은 실험데이타와 좋은 일치를 보여주었다. .

응급실 방문 정신과 환자의 지역특성에 따른 질병행동 비교 : 서울과 구리의 경우

최주연,정운섭,박용천,남정현 漢陽大學校 精神健康硏究 1999 精神健康硏究 Vol.18 No.-

ZnS_(1-x)Te_x 단결정 박막의 격자진동

최용대,남성운,유영문 목원대학교 자연과학연구소 2000 自然科學 硏究論文集 Vol.9 No.1

Hot-wall epitaxy에 의하여 GaAs (100) 기판 위에 성장된 ZnS_1-xTe_x(0<x<1) 단결정 박막의 특성이 Raman 산란을 이용하여 조사되었다. Raman 산란으로부터 측정된 장파장의 ZnTe-like의 longitudinal 광학 포논의 주파수는 성분비 x와 함께 선형으로 변하였다. ZnS_1-xTe_x 단결정 박막의 x의 함수로서 zone-center 광학 포논의 주파수는 two-mode이었고, 이 결과는 MERI 모델의 이론치와 잘 일치하였다. ZnS_1-xTe_x(0<x<1) alloys grown on (100) GaAs substrates by hot-wall epitaxy are investigated using Raman scattering. The frequencies of long wavelength ZnTe-like and ZnTe-like longitudinal optical phonons determined from Raman scattering show linear variation with the composition x. The frequency of the zone-center optical phonons as a function of x of the ZnS_1-xTe_x mixed crystal shows a typical two-mode behavior. which is in good agreement with the theoretical results from a modified random-element isodisplacement model.

食用 고사리의 Thiaminase에 관한 硏究

崔瑢鎭,南昌祐 同德女子大學校 1977 同大論叢 Vol.7 No.1

In the course of studies on a thiaminase from wild bracken, Korean's common foodstuff, and its effects on the human nutrition, some properties of the enzyme were investigated. The obtained results were as follows; 1. From 10 g of the powdered bracken, thiaminase was extracted about 2,924 units of specific activity 10.99. 2. The bracken thiaminase exhibited the sharp optimum pH at a range of 7.5 to 8.0 for its activity. And the maximum reaction rate was achieved at the temperature of 60℃. 3. The Km value for the enzyme was calculated to be 1.54 x 10-³mole with respect to thiamine hydrochloride and 3.57 x 10-³mole with respect to pyridine. 4. Of the metal ions tested, only manganese ion was recognized to have a slight effect in activating the enzyme while heavy metal ions especially cupric salt showed a remarkable inhibitory effect. 5. The enzyme activity was strongly inhibited by p-chloromercuric benzoate, a typical "SH-reagent". But the whole activity was recovered by thereafter incubating with cysteine solution. Therefore the bracken thiaminase was considered to be an enzyme which possesses essential SH group in order to retain its normal active conformation. 6. On storage at low temperature below 5℃, the enzyme was greatly inactivated but it showed considerable stability at the temperature around 20℃. 7. The enzyme was best protected from thermal denaturation at pH 7.0 with phosphate buffer, but it lost almost all the activity by 10 minute's heating at 80℃.