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      • 그레이브스병에서 방사성 요오드 치료에 따른 갑상선 자극 호르몬 수용체 결합억제 면역글로불린(Thyrotropin Binding Inhibitory Immunoglobulin, TBII)의 변화

        조영석,권기현,이준철,나소영,이효진,홍우정,이유선,김군순,송민호,김영건,노흥규 충남대학교 의학연구소 2003 충남의대잡지 Vol.30 No.2

        Prediction of thrapeutic response to radioiodine in Graves' disease is poorly understood. Although thyrotropin binding inhibitor immunoglobulin(TBII) level is a strong index for relapse after antithyroid drug medication, conflicting results are reported regarding its prognostic significance in Graves' disease treated with RAI. This study is dengned to evaluate possible relationship between post-treatment hypothyroidism and TBII in Graves' disease treated with RAI. Fourty two patient with Graves' disease after radioiodine treatment were studied retrospectively. The subject were divided into hypothyroid group and euthyroid or hyperthyroid group. We evaluated the association of hypothyroidism and TBII with radioiodine treatment dose. The mean age of hypothyroid group was 48±11 years and euthyroid or hyperthyroid group was 47±12 years. There was no difference in two groups. And there was no significant difference in post- treatment TBII between two groups(49.9±28.5%, 29.9±14.3%, p-value >0.05). The treatment-dose had no influence on post-treatment thyroid state. Euthyroid or hyperthyroid group was done with 13.6±6.9mCi and hypothyroid group was 17.0±10.4mCi(p-value > 0.05). TBII had no prognostic significance on long-term hypothyrodism in Graves' disease treated with radioiodine. And, treatment-dose had no influence on post-treatment thyroid state.

      • 양성 갑상선 결절에서의 무수 알코올 치료 효과

        김도희,나소영,이효진,홍우정,김군순,조영석,구본정,송민호,김영건,노흥규 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

        목적 : 양성 갑상선 결절 환자에서의 PEI의 치료효과 및 부작용을 알아보고자 하였다. 방법 : 양성 갑상선 결절 환자 88명을 대상으로 초음파 소견에 따라 낭종성 결절, 복합성 결절, 고형성 결절 등 세 그룹으로 분류후 전체 및 각각에 대한 PEI의 치료효과 및 부작용을 조사하였다. 결과 : 양성 갑상선 결절 환자 88명을 PEI로 치료후 결절의 크기가 50%이상 감소한 경우는 전체 환자중 77.2%이었고 각 결절별로 살펴보면 고형성 결절에서 52.6%, 복합성 결절에서 72.4%, 낭종성 결절은 92.5%이었다. 부작용은 동통, 결절내 출혈, 감염, 결절의 누출등이 있었으나 대부분 무증상이었다. 결론 : PEI는 양성 갑상선 결절 환자증 적응증을 잘 살펴 고려해 볼 수 있는 치료법이라 생각되며 특히 낭종성 결절 환자에서 주사기에 의한 흡인후에 재발한 경우 일차적인 치료로 PEI를 고려해 볼 수 있겠다. Ultrasonography(US)-guided percutaneous ethanol injection (PEI) has been performed for the treatment of autonomous functioning thyroid nodules, thyroid cysts, & cold thyroid nodules. The author studied the efficacy of PEI in the treatment of benign cold thyroid nodules both solid and cystic (complex & pure). Eighty-eight euthyroid outpatients (age:44.2±13.9years, 75 women and 13 men) with benign cold thyroid nodules or simple thyroid cysts (69 with a single nodule and 19 with a prominent nodule within multinodular goiter) were includied in this study. After PEI, each subtype of thyroid nodules was divided into three groups in according to volume reduction complete response (90% or more of volume reduction), partial response (50% or more of reducton but below 90%), and failure (below 50% or increase in size) group. Overall response rates of PEI for benign thyroid nodules were complete 45(51.1%), partial 23(26.1%), failure 20(22.7%). In 20 cold solid nodules, complete response was observed in 6(30.0%), partial response in 5(25.0%), and failure in 9(45.0%). In 28 complex cysts, complete response was observed in 8(28.6%), partial response in 12 (42.9%), and failure in 8(28.6%). In 40 pure cysts, complete response was observed in 31(77.5%), partial response in 6 (15.0%), and failure in 3 (7.5%). Side effects comprised pain 8 (9.2%), intranodular bleeding 13 (14.6%), extracapsular leakage 1(1.1%), infection 1 (1.1%), increased size l(1.1%), and none 64(72.7%). PEI may prove a safe & effective tool for the therapy of cold thyroid nodules in selected cases and may be the treatment of choice of recurrent thyroid cysts. However, further investigation involving a larger number of patients and a longer follow-up is needed.

      • KCI등재후보

        사업장 소음 폭로에 의한 일과성 역치 상승과 회복

        조수헌,하미나,한상환,주영수,성주헌,강종원,윤덕로,송동빈,이명학,김선태 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.2

        To determine the recovery time from noise-induced temporary threshold shift(TTS), a prospective field study was conducted at three worksites where workers are known to be exposed high level of noise. Subjects were selected according to answers on a questionnaire which inquired about otological history and previous noise exposure, including avocational, military and occupational exposures. After excluding employee with past otologic problems, recent exposure to high level noise, and under medications, total 92 employees participated in the study. Among 92 participants, complete consecutive audiometric examinations were carried out at 0∼2 hours, 5∼7 hours, 14∼16 hours after worktime noise exposure on 26 participants wearing hearing protectors and 22 participants wearing no protective devices. The difference between the hearing level 0∼2 hours after noise exposure and 5∼7 hours is statistically significant by paired t-test(p<0.01). The median recovery times calculated from the data of 22 participants wearing no protective hearing devices are 15.6 hours at 4000Hz, and 7.7 hours, 10.3 hours, 8.4 hours at 1000Hz, 2000Hz and 8000Hz respectively. These data suggest that when measuring the pure tone audiometry for noise exposed workers, at least 16 hours noise-free interval is required.

      • 思考技能 訓練프로그램의 開發 및 適用에 關한 硏究 : 衝動性 減少를 中心으로

        朴鎭玹,朴敬玉,申東魯,羅東晉,李永植 全北大學校 學生生活硏究所 1994 學生生活硏究 Vol.21 No.-

        Many of college students have the cognitive deficits, one of which is the impulsiveness, in the process through which they solve their problems in the daily life. This study attemted to develop the program for the purpose of improving college students' thinking skills. Also, the program was intended to encourage the college students to reduce their impulsiveness, and to help them maintain the rational reasoning solving the complex of problems. For this purpose, researchers examined the difficulties which college students had in the process of their thinking, focussed on their impulsiveness in particular, based on the findings of preceding works related to the thinking skills, including some of programs for improving the thinking skills and intelligence. As a result, a program was developed to improve the thinking skills of college students in order to reduce their impulsiveness. This program was composed of two parts, each of which included five units. Part One, titled "Human Life and the Limited Rationality", was focused on training college students with metacognition or cognitive style. In this part, the trainees explored those phases passed on the human problem solving and the sources of impulsiveness. This part included five units: (1) Introduction; (2) Journey in the universe of learning; (3) Uncertainty and impulsiveness; (4) Human problem solving; and (5) Human information processing and limited rationality. Part Two, titled "Resolution of the Limited Rationality and Intellectual Limitations of Human Being", was focused on training college students with cognitive strategies. In this part, the trainees searched for the general cognitive strategies with which they would learn each unit, and used it to resolve the limited rationality of human being and thus to solve the problems more efficiently. This part included five units: (1) Search for strategies to resolve the intellectual limitations of human being; (2) Utility of the external representations; (3) Application of strategic knowledge of inferences; (4) Resolution of the inferential baises; and (5) Evaluation and termination. A pilot study attempted to verify the effectiveness of the training program. Subjects were 118 sophomores of a national university in Chon-buk. They were assigned to an experimental group(N=56) and a control group(N=62) to test the effectiveness of the training program. The experimantal group received 12 sessions of training instruction for 50 to 60 minutes each week. The control group was given no intervention. After training sessions, they were given a cognitive style (impulsiveness) scale as well as a reasoning test, and also checked a questionnaire which asked the participants to express their opinions of the training program. The findings of the study might be summarized as follows: 1. The program seemed to contribute posively to change participants' cognitive style, particularly to reduce their dysfunctional impulsiveness. 2. The program seemed to contribute substantially to improve participants' performance of reasoning tasks. 3. Many of participants (about tow-third) of the participants reported to have a novel feel- ing on the program, to perceive the program different from the existing curriculum, and also to take some benefits from the program. However, this study suggested several recommandations as follow: 1. It is necessary to verify the effectiveness of the program on the basis of a valid design of experiment. 2. It is necessary to take a effort to extend the breadth and depth of the program, including a discussion of the functional impulsiveness. 3. It is necessary to establish the reinforcement schedule in order to encourage the participant to engage in the program actively.

      • KCI등재
      • SCIESCOPUSKCI등재

        Foreign Body Granuloma Following Hwangryunhaedok-tang Pharmacopuncture for Postherpetic Neuralgia

        ( Na Young Kim ),( Hae Chang Joh ),( Jeong Eun Kim ),( Young Suck Ro ),( Joo Yeon Ko ) 대한피부과학회 2023 Annals of Dermatology Vol.35 No.7

        Foreign body granuloma can be caused by endogenous compounds as well as various injectable materials. In oriental medicine, pharmacopuncture combining herbal medicine administration and injection is one of the commonly used procedures. Hwangryunhaedoktang (HHT, a.k.a., Huang-Lian-Jie-Du-Tang in China), an oriental medicinal herb known to produce anti-inflammatory effects, has been recently made in pharmacopuncture products and commonly used for various disorders. An 88-year-old female presented with multiple tender nodules on the left parietal scalp and forehead. The diagnosis of foreign body granuloma caused by HHT pharmacopuncture was revealed by more detailed previous treatment history of postherpetic neuralgia and histopathologic examination. Herein, we report a foreign body granuloma as a delayed adverse reaction caused by non-standard administration of herbal extracts, considered biologically inert.

      • SCIESCOPUSKCI등재

        Pilomatricoma on the Sole Following Wart Treatment

        ( Na Young Kim ),( You Jin Jung ),( Ki Yeon Kim ),( Joo Yeon Ko ),( Young Suck Ro ),( Jeong Eun Kim ) 대한피부과학회 2023 Annals of Dermatology Vol.35 No.7

        Pilomatricoma is a benign skin tumor that arises from hair follicle stem cells. It typically presents in the facial region and rarely involves the palms and soles. A 15-year-old boy presented with a solitary tender nodule on the left sole. He had a history of plantar warts on the same site and had received multiple treatments including cryotherapy and intralesional bleomycin injection for nine months. Excisional biopsy was performed, and the specimen showed a well-demarcated mass in the deep dermis with basaloid cells undergoing abrupt keratinization. Ghost cells were seen with calcification. Based on these findings, he was diagnosed with pilomatricoma on the sole. We report a case of pilomatricoma, which developed on a site without hair follicles.

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