서울·경기지역 병원직원의 혈액매개 감염노출에 대한 다기관 조사연구

박미라,김정은,박은숙,최정실,정선영,송영구,홍성관,김준명,허애정,양동규,조영주 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

중환자실 병원감염에 대한 다기관 공동 조사연구

박은숙,박미라,진혜영,김정은,최정실,송영구,최영화,이위교,홍성관,허애정,양동규,김준명 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

급성 췌장염의 합병이 추정되는 한국형 출혈열 1예

박영수,김창오,김영근,홍성관,장경희,허애정,염준섭,송영구,김준명 대한감염학회 2001 감염 Vol.33 No.5

The Korean hemorrhagic fever (KHF) is an acute febrile disease with characteristic of fever, bleeding tendency, and renal failure. There are many complications of Korean hemorrhagic fever such as infection, anemia, internal bleeding, hypopituitarism, respiratory, and neurologic complication. A few cases were reported on acute pancreatitis with hemorrhagic fever abroad, but there was no case about Korean hemorrhagic fever with acute pancreatitis in this country. We experienced a case of Korean hemorrhagic fever associated with suspected acute pancreatits. With review of articles, we report a case of 51 year-old woman with KHF, where acute pancreatitis developed during management, (Korean J Infect Dis 33:376∼379, 2001)

비개흉 심근 경색 동물모델을 이용한 심근 경색의 자기공명영상에 관한 연구

임명관,박재형,이활,정진욱,이동수,정준기,최영희 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.11

비호지킨 림프종환자에서 proMACE-cytaBOM 복합항암화학요법의 유효성에 대한 제 2상 임상시험

김성우,안명주,박석규,이영렬,정태준,최일영,김인순 한양대학교 의과대학 2000 한양의대 학술지 Vol.20 No.1

Aggressive non-Hodgkin's lymphoma by REAL classification is a heterogenous group of disease. With recent advances in combination chemotherapy, the long-term survival is improved to 40-65%. We investigated twenty-one aggressive non-Hodgkin's lymphoma patients treated with pro-MACE-cytaBOM (prednisone, adriamycin, cyclophosphamide, etoposide, cytosine arabinoside, bleomycin, vincristine and methotrexated) to determine the efficacy and toxicites. There were seven patients older than 60 years. Histologic types by REAL classification were as follows : diffuse large B cell (12/21), peripheral T cell (6/21), anaplastic large cell (2/21) and angiocentric T cell (1/21). Most of patients were classified in Stage Ⅱ-Ⅳ (20/21). According to IPI (international prognostic index) score, seven patients were included in low risk, five were low-intermediate risk, three were high-intermediated risk and six were high risk group. seventeen complete responses (85%) and two partial responses (10%) were achieved. The overall response rate was 95%. The mena disease free survival was 30 months, the mean overall survival was 29 months (range:21-36), and the median overall survival was not reached. WHO grade Ⅲ/Ⅳ neutropenia or thrombocytopenia was observed in 16.7% and 2.8%, respectively. There was no treatment-related death. These results suggest that proMACE-cytaBOM combination chemotherapy is very effective and has low toxicity in the treatment of aggressive non-Hodgkin's lymphoma even treated in elderly patients.

H₂^(15)O PET을 이용한 뇌혈류 파라메트릭 영상 구성을 위한 알고리즘 비교

이재성,이동수,박광석,정준기,이명철 대한핵의학회 2003 핵의학 분자영상 Vol.37 No.5

목적: H_(2)^(15)O PET의 정량화를 위하여 1-조직 구획모델이 쓰이며, 뇌혈류와 조직/혈액 분배계수를 구하기 위하여 nonlinear least squares (NLS) 방법이 사용되나 계산 시간이 긴 등의 문제로 파라미터를 각 화소마다 구해야 하는 파라메트릭 영상 구성에는 적합하지 않다. 이 연구에서는 이와 같은 NLS 문제점을 극복하여 파라메트릭 영상을 빠르게 구성하기 위하여 제안된 파라미터 추정 알고리즘들을 구현하고, 이 방법들의 통계적 신뢰도와 계산의 효율성을 비교하였다. 대상 및 방법: 이 연구에서 이용한 방법들은 linear least squares (LLS), linear weighted least squares(LWLS), linear generalized least squares (GLS), linear generalized weighted least squares (GWKS), weighted integration (WI), 그리고 model-based clustering method (CAKS)이다. 노이즈 정도에 따른 각 파라메트릭 영상법의 정확성 및 통계적 신뢰성을 알아보기 위하여 Zubal 뇌모형(brain phantom)으로부터 동적 PET 영상을 모사하고 포아송노이즈를 더한 후 각 파라메트릭 영상 구성 방법을 적용하였다. 또한 정상인 16명에 대하여 얻은 실제 자료에 대하여 이 방법들을 적용하고 결과를 비교하였다. 결과: 뇌혈류와 분배계수에 대한 평균 오차는 방법에 따라 크게 다르지 않았으며 모든 방법이 뇌혈류 및 분배계수 추정에 있어 무시할 만한 바이어스를 보였다. 파라메트릭 영상의 정성적 특성 또한 유사하였으나 CAKS 방법의 계산 속도가 월등하여 NLS 방법의 약 1/500, LLS 방법의 약 1/25의 계산시간을 보였다. 결론: 뇌혈류 파라메트릭 영상 구성을 위한 빠른 파라미터 추정 알고리즘들 중에 보다 개선되어 제아노딘 LWS, GLS, GLWS, CAKS 방법들이 단순하고 빠른 LLS, WI 방법들에 비하여 통계적 신뢰성을 크게 향상시키지는 못하나 CAKS 방법은 계산 시간을 유의하게 단축시키므로 가장 적합한 파라메트릭 영상 구성방법이라 할 수 있을 것이다. Purpose: To obtain regional blood flow and tissue-blood partition coefficient with time-activity curves from H_(2)^(15)O PET, fitting of some parameters in the Kety model is conventionally accomplished by nonlinear least squares (NLS) analysis. However, NLS requires considerable compuation time then is impractical for pixel-by-pixel analysis to generate parametric images of these parameters. In this study, we investigated several fast parameter estimation methods for the parametric image generation and compared their statistical reliability and computational efficiency. Materials and Methods: These methods included linear least squres(LSS), linear weighted least squares (LWLS), linear generalized least squares (GLS), linear generalized weighted least squares (GWLS), weighted integration (WI), and model-based clustering method (CAKS). H_(2)^(15)O dynamic brain PET with Poisson noise component was simulated using numerical Zubal brain phantom. Error and bias in the estimation of rCBF and partition coefficient, and computation time in various noise environments was estimated and compared, In addition, parametric images from H_(2)^(15)O dynamic brain PET data performed on 16 healthy volunteers under various physiological conditions was compared to examine the utility of these methods for real human data. Results: These fast algorithms produced parametric images with similar image quality and statistical reliability. When CAKS and LLS methods were used combinedly, computation tine was significantly reduced and less than 30 seconds for 128×128×46 images on Pentium III processor. Conclusion: Parametric images of rCBF and partition coefficient with good statistical properties can be generated with short computation time which is acceptable in clinical situation.

동아시아에서의 HIV/AIDS 역학

신소연,최준용,김영근,박윤선,김연아,김명수,송영구,Shuzo Matsshita,Taisheng Li,Hsi-Hsun Lin,Patrick Li,김준명,동아시아 HIV 네트워크(East-Asia Network on HIV; EAN-HIV) 대한감염학회 2007 감염과 화학요법 Vol.39 No.1

목적 : 최근 동아시아에서의 HIV 감염자 수의 급속한 증가는 여러 가지 심각한 문제를 야기하고 있다. 따라서 이지역에서의 HIV/AIDS 역학에 대해서 정확한 조명 및 분석이 무엇보다 필요하다. 이에 저자들은 동아시아 HIV 네트워크(East Asia Network on HIV; EAN-HIV)를 통하여 동아시아 HIV/AIDS 유행의 시작, 변천 및 현황에 관하여 알아보고자 한다. 재료 및 방법 : 동아시아에 HIV/AIDS가 처음 유입된 1984년부터 2005년까지 한국, 일본, 중국, 대만, 홍콩의 HIV/AIDS 관련 역학 자료를 동아시아 HIV 네트워크(East Asia Network on HIV; EAN-HIV)를 통하여 수집하고 분석하였다. 결과 : 동아시아에서의 HIV/AIDS 유행은 1980년대 중반에 시작되었다. 2005년 말까지 한국에서는 3,829명, 일본에서는 7,078명(혈우병 환자 제외), 대만에서는 10,423명,홍콩에서는 2,825명의 HIV 감염자가 보고되 었으며, 중국에서는 141,241명이 보고되었으나 실제로는 84만명 이상의 감염자가 존재할 것으로 추정하고 있다. 주사마약사용, 혈장매매, 성접촉에 의한 감염이 주를 이루고 있으며, 감염자중 남자가 많고 20-30대가 다수를 차지하였다. 중국이나 대만의 경우에는 최근 감염자 수가 급증하고 있으며 주사마약사용에 의한 감염이 주로 문제가 되고 있는 반면, 한국, 일본, 홍콩의 경우에는 남성동성애자에 의한 전파가 주가 되고 있다. 동아시아에서 유행하는 HIV의 주 아형은 B, C, CRFO1_AE 형이며, 최근에는 CRF07_BC형이 확산되고 있다. 결론 : 동아시아의 HIV 감염률은 빠르게 증가하며, 또한 HIV/AIDS 역학도 빠르게 변화하고 있다. 이 지역의 유행은 중국이 부분적으로 커다란 영향을 미치고 있다. Background : Recent predictions of catastrophic epidemic surge of HIV infection in East Asia concern experts and governmental organizations. As in many other areas, countries in East Asia show diversities in their HIV epidemics, both geographically and temporally. However, they have similar regional, cultural and racial characteristics which allow them to have certain common factors. Having a clear picture of the current extent and feature of HIV/AIDS in this region is a very difficult task largely due to the fast pacing of expending epidemic and difficulty in data-sharing among countries in the region. Hence, we decided to study the epidemiologic feature of HIV/AIDS in East Asia through East Asia Network on HIV (EAN-HIV). Materials and Methods : The epidemiological patterns of HIV/AIDS in East Asian countries were investigated by collecting data through EAN-HIV. Results : The HIV/AIDS epidemic in East Asia started relatively late at mid 1980s. Since then, the number of newly infected HIV/AIDS cases has been steadily increasing with stiffer escalation in recent years. In China and Taiwan, IDU plays an important part in the swiftly growing HIV epidemics; however, in other regions like Korea, Japan, and Hong Kong, MSM (men who have sex with men) seems to be more of a problem. The major subtypes of HIV in East Asia are subtype B, C, and CRF01_AE, and rapidly evolving circulating recombinant forms (CRF) between subtypes such as CRF07_BC give dynamic change to the current status. Conclusion : The incidence of HIV/AIDS is rapidly increasing in East Asia. The epidemic pattern has undergone dynamic changes over time. China seems to be the leading source of HIV/AIDS epidemic in East Asia due to its large population and rapidly growing epidemics.

Nonlinear Model Order Reduction and Control of Particle Size Distribution in a Semibatch Vinyl Acetate/Butyl Acrylate Emulsion Copolymerization Reactor

Park, Myung-June,Doyle Ⅲ, Francis J. 한국화학공학회 2004 Korean Journal of Chemical Engineering Vol.21 No.1

This paper addresses the control of the full particle size distribution (PSD) in a semibatch emulsion copolymerization reactor. The numerical approximation of a fundamental population balance model results in a high order system to accurately describe the distribution of particle size ; therefore, model order reduction is required. Pseudo random input signals are input to the mechanistic model to generate a data set which covers the reachable region of the system, on the basis of which the transformation matrices are calculated by principal component analysis (PCA). A linear time varying model with the reduced order obtained from the transformation matrices is augmented in the prediction equation of linear model predictive control. The performance of the controller is evaluated to drive the particle size distribution at the final time of the batch to the desired distribution in the presence of disturbances.

Adjusted interactions of nickel nanoparticles with cobalt-modified MgAl₂O₄-SiC for an enhanced catalytic stability during steam reforming of propane

Park, Kyung Soo,Son, Minji,Park, Myung-June,Kim, Dae Hyun,Kim, Jeong Hwa,Park, So Hyun,Choi, Joon-Hwan,Bae, Jong Wook Elsevier 2018 Applied catalysis. A, General Vol.549 No.-

<P><B>Abstract</B></P> <P>Steam reforming of propane (SRP) for the stable production of hydrogen-rich reformates was investigated using the Ni-supported on the cobalt-modified SiC-embedded MgAl<SUB>2</SUB>O<SUB>4</SUB> support (denoted as NCMAS). The adjusted interactions of the Ni nanoparticles with the cobalt-modified SiC-embedded MgAl<SUB>2</SUB>O<SUB>4</SUB> (MgAl<SUB>2</SUB>O<SUB>4</SUB>-SiC) and its crystallite size distributions largely altered the catalytic activity and stability of NCMAS. The introductions of SiC on the NCMAS, where SiC has a higher thermal conductivity, also increased the dispersion of smaller MgAl<SUB>2</SUB>O<SUB>4</SUB> grains with the less formations of inactive NiAl<SUB>2</SUB>O<SUB>4</SUB> species, which resulted in the higher catalytic activity with smaller formations of unreformed light hydrocarbons. The positive roles of cobalt promoter on the MgAl<SUB>2</SUB>O<SUB>4</SUB>-SiC matrices were mainly attributed to the suppressed aggregation of nickel nanoparticles by their strong and intimate interactions with the cobalt-modified MgAl<SUB>2</SUB>O<SUB>4</SUB>. The effects of cobalt promoter at an optimal 5wt%Co in the MgAl<SUB>2</SUB>O<SUB>4</SUB>-SiC (NCMAS(5)) enhanced the oxidation-resistance of the nickel nanoparticles with less formations of inactive metal aluminates by being reversibly re-reduced under the SRP reaction conditions. These phenomena further lessen coke depositions by intimately interacting with highly dispersed oxophilic cobalt or cobalt aluminate species. The optimal NCMAS(5) was applied to derive kinetic parameters using Langmuir-Hinshelwood-Hougen-Watson (LHHW) mechanisms, and the reasonable activation energy of 73 kJ/mol and optimal operating parameters to maximize hydrogen production by SRP reaction was estimated in terms of the reaction conditions such as space velocity, feed ratio and reaction temperature.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Steam reforming of propane (SRP) was studied over the Ni-supported on Co-modified MgAl<SUB>2</SUB>O<SUB>4</SUB>@SiC (NCMAS). </LI> <LI> Adjusted interactions of Ni nanoparticles largely altered the activity and stability. </LI> <LI> Cobalt promoter showed the suppressed Ni aggregation with intimate interactions with CMAS support. </LI> <LI> Kinetic parameters using LHHW model were properly derived for SRP reaction. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Optimization of methanol synthesis reaction on Cu/ZnO/Al2O3/ZrO2 catalyst using genetic algorithm: Maximization of the synergetic effect by the optimal CO2 fraction

Myung-June Park,Hye-Won Lim,Hye Jin Jun,Hyo-Sik Kim,Jong Wook Bae,하경수,Ho-Jeong Chae,전기원 한국화학공학회 2010 Korean Journal of Chemical Engineering Vol.27 No.6

A kinetics model that takes the synergetic effect of carbon dioxide fraction on the methanol production rate into account is applied to the development of a mathematical model for the bench-scale reactor. A comparison between the simulation results and the experimental data corroborates the validity of the model. Several optimization strategies are suggested to maximize the methanol yield, among which the utilization of piecewise trajectories for wall temperature along the reactor axis as well as the optimal CO2 fraction at the inlet of the reactor is found to be the best strategy in the sense of methanol production per unit amount of the feed, in such a way that the optimization strategy considers the variation of the reaction temperature in the reactor and maximizes the synergetic effect on the production rate by the addition of carbon dioxide.