랫드에서 l-muscone의 급성독성 및 아급성독성시험 연구

오승민,연제덕,남혜운,박대규,조명행,정규혁 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

l-Muscone is synthesized for use as substitutive material of musk which is the active ingredient of woohwangchungsimwon. The objective of this investigation was to evaluate the acute and subacute toxicity of l-muscone in rats. In oral acute toxicity test, SPF Sprague-Dawley male and female rats were gavaged with l-muscone of two doses(0, 5.0g/㎏). No dead animal and abnormal autopsy findings were found in control and treated group. Body weights were slightly decreased in both sexes of rats treated with 5.0g/㎏. Therefore, oral LD_50 of l-muscone was consider to be higher than 5.0g/㎏ in male and female rats. In intraperitoneal acute toxicity test, rats were injected intraperitoneally with dosages of 0, 1,000, 1,316, 1,732, 2,279 and 3,000 ㎎/㎏. Decreased body weights and motor activities were observed at high dose group. Intraperitoneal LD_50 of l-muscone were 1,920 ㎎/㎏ in male and female rats. In the subacute study. l-muscone was administrated orally to both sexes of rats for 4 weeks as several doses(0, 10, 100 and 1,000 ㎎/㎏). There were neither dead animals nor significant changes of body weights during the experimental period. In addition, no differences were found between control and treated groups in clinical signs, urinalysis, hematology, serum biochemical analysis, and other findings. Above data suggest that no observed adverse effect level of l-muscone in rats might be over 1,000 ㎎/㎏/day in this study.

랫드에서 신우황청심원의 급성 및 아급성독성시험

오승민,남혜윤,김준수,연제덕,신대희,이진영,박대규,조명행,정규혁 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

The acute and subacute toxicity of New Woohwangchungsimwon(NWCH) which was used l-muscone as substitutive material of musk were investigated in S.D. rats. In intraperitoneal acute toxicity test, rats(Sprague-Dawley, SPF) were injected intraperitoneally with dosages of 0, 540, 750, 1,070, 1,500 and 3,000 ㎎/㎏. Body weights were significantly decreased at 540 ㎎/㎏ dose group in both sexes and abnormal autopsy findings were founded in both sexes at all treated groups. Intraperitoneal LD_50 of NWCH was 812.3 ㎎/㎏ in male and 872.3 ㎎/㎏ in female rats. In the subacute toxicity study, NWCH was administrated orally to both sexes of rats for 4 weeks as several doses(0, 320, 800 and 2,000 ㎎/㎏). There were neither dead animals nor significant changes of body weights during the experimental period. In addition, no differences were found between control and treated groups in clinical signs, urinalysis, hematology, serum biochemical analysis, and other findings. Above data strongly suggest that no observed adverse effect level of NWCH might be over 2,000 ㎎/㎏/day in this study.

토마토 엽 절편으로부터 식물체 재분화

오명규,이영만,박문수 全南大學校 農業科學技術硏究所 1997 農業科學技術硏究 Vol.32 No.-

조직배양에 의한 토마토의 효율적인 재분화 체계를 밝히고저 토마토 엽절편을 재료로 하여 배지 조성 및 품종간의 차이가 재분화에 미치는 영향을 조사하였다. 토마토 엽절편으로 부터 유기된 shoot수는 Calypso에서 27∼79개로 PI 134417에서의 1∼30개에 비하여 현저히 높았으며, MS배지에 IAA 0.02 ㎎/ℓ와 zeatin 2.0㎎/ℓ가 첨가된 배지에서 Calypso가 79개, PI 134417이 30개로 가장 양호하였다. 토마토의 재분화식물체 shoot의 발근은 MS기본배지에 IAA 0.02 ㎎/ℓ+ GA₃ 0.05㎎/ℓ+ AgNO₃ 10㎎/ℓ를 첨가한 배지가 40%로 가장 양호하였다. Effects of culture medium on the plant regeneration of tomato (Lycopersicon esculentum L.) using leaf segments were investigated to establish the efficient in vitro regeneration systems. Numbers of shoot differentiated from leaf explants were remarkably higher cv. Calypso of 275079 compared to that observed in PI 134417 of 1 to 30. Among tested culture media, MS medium supplimented with 2.0 ㎎/ℓ zeatin and 0.02㎎/ℓ IAA was the best resulting in with 79 shoots for cv. Calypso and 30 shoots for PI 134417. Among rooting media tested, MS basal medium added with 0.02㎎/ℓIAA, 0.05㎎/ℓ GA₃, and 10.0㎎/ℓ AgNO₃ gave rise to the best rooting frequency in vitro tomato roots.

만화 과제를 이용한 정신분열병 환자의 사회인지 능력의 측정

오정은,나명현,하태현,신용욱,노규식,홍순범,이경진,신민섭,이영호,권준수 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.3

Objectives : This study is to investigate the hypothesis that schizophrenic patients have difficulty in inferring mental state of others. Methods : Twenty schizophrenic patients and twenty normal subjects were administered to the Cartoon Task required inferring the character's intention in a given context. Results : The schizophrenic patients showed a statistically significant impairment in the Cartoon Task. Both groups chose the card depicting a frequent everyday action significantly more rather than the similar card to the last picture in each story for wrong answers. Conclusion : These preliminary results suggest that schizophrenia is associated with a specific deficit of the cognitive ability referred to as social cognition, and this deficit can be detected not only in the acute phase as found in previous research studies, but also in remission. Also when subjects fail to appreciate what is going on in the minds of other people, they seem to rely on a socially familiar experience.

중·고등학교 아랍어 교재 집필 및 교재 내용에 관한 연구 보고서

오명근,송경숙,전완경,사희만,이규철,조희선,정규영,최진영 한국아랍어아랍문학회 1999 아랍어와 아랍문학 Vol.3 No.1

金屬薄膜導波管을 利用한 I/O Mode Filter

박한규,오한솔,김명수 연세대학교 산업기술연구소 1981 논문집 Vol.13 No.2

代表的인 3종류의 金屬薄膜導波管의 TEo-Mode와 TMo-Mode의 특성을 Computer Simulation에 의하여 비교 고찰하였다. 非對稱型平板薄膜導波管으로된 금속박막도파관은 TEo-Mode Filtering이 不可能하였다. 對稱型平板薄膜導波管으로된 금속박막도파관에서는 Film층과 그 외의 층과 굴절율 차이가 0.02 이하가 되면 TEo-Mode Filtering이 가능하며 TMo-Mode 의 損失이 10dB/cm이하가 되어 Mode Filter로서 使用可能함이 밝혀졌다. The typical three kinds of the Metal-Clad waveguides have been chosen, and the characteristics of TEo-Mode and TMo-Mode in them are investigated and compared with each other by computer simulation. TEo-Mode filtering has been impossible in the Metal-Clad waveguide made of the symmetric thin film slab waveguide. In the Metal-Clad waveguide made of the symmetric thin film slab waveguide, if the refraction index difference between the film layer and the other layers is below 0.02, it has made TEo-Mode filtering possible and has had TMo-Mode loss below 10dB/㎝. Therefore it has been improved that it can be used practically as a Mode Filter.

단일 섬유 근전도로 진단한 아세틸콜린수용체 항체 음성인 연소형 전신형 중증 근무력증 1례

이인규,오명호,김영창 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Myasthenia gravis is a well-recognized disorder of neuromuscular transmission that can by diagnosed by the presence of antibodies to the acetylcholine receptor(AChR). However, some patients with generalized myasthenia gravis do not have detectable AChR antibodies. Seronegative systemic myasthenia gravis is rare in childhood. We reported a case of juvenile seronegative systemic myasthenia gravis confirmed by single fiber electromyography.

最近 8年間의 精神神經科 入院 外來 및 患者에 對한 統計的 考察(1960年∼1967年)

李哲奎,盧英一,張煥一,金明源,任允明,韓東洙,吳承煥,金光日 大韓神經精神醫學會 1969 신경정신의학 Vol.8 No.1

1) The number of the out-and in-patients had increased year after year (Table Ⅰ & Ⅲ). 2) Schizophrenia was the greatest number of the in-patients and its rate to whole was 49.1 percent, and neurosis was the greatest number of the out-patients and its rate to whole was 41.66 per cent (Table Ⅰ & Ⅶ). 3) In in-patients, hysteria revealed relatively large in percentage as 11.8% than the other groups (Table Ⅰ). 4) The rate of the male hysteria patients to all male patients was 3.5 per cent and the rate of female hysteria was 20.5 per cent (Table Ⅱ). 5) In in-patients, all the patients of general paresis and alcoholism were only males in sex(Table Ⅱ). 6) In in-patients of schizophrenia, the ratio of the male patients to the female patients was 57.0 : 43.0, but the each rate of each total numbers of the all diseases of the both sexes was almost same (Table Ⅲ). 7) The largest age group of the all patients was between 21∼30 years old, and the next was between 31∼40 years in in-patients (Table Ⅲ). 8) The largest age group of schizophrenia patients was between 21∼30 years and that of M.D.R patients was between 31∼40 years in in-patients (Table Ⅲ). 9) In in-patients of hysteria, the largest age group was between 31∼40 years, and the next was between 21∼30 years (Table Ⅲ). 10) The results of treatment in in-patients were as followings; Recovered; 27.6% Much improved; 43.1% Slightly improved and no changed; 28.2% (Table Ⅳ) 11) The results of treatment in schizophrenia of the in-patients were as followings; Recovered; 19.1% Much improved; 48.3% Slightly improved and no changed; 32.1% (Table Ⅴ) 12) The mode of treatment had been somewhat changed during last 8 years from 1960 to 1967 in treatment of the in-patients (Table Ⅵ). (1) The combined therapy of tranquilizers and EST had been increased, but the therapy of tranquilizer alone or EST alone had been decreased, compared to 1960. (2) The therapy of ICT in the treatment of in-patients had been much decreased.

안정 기포 검사(stable microbubble test)를 이용한 전혈이 폐표면활성제에 미치는 영향에 관한 연구

이인규,김선영,오명호 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.2

배경 : 신생아에서의 폐출혈은 매우 치명율이 높으며 그러한 원인 중 하나는 호흡곤란 증후군이 병발하여 진행되는 것으로 잘 알려져 있다. 기전으로 혈액내의 단백성분들이 2형 폐포에서 생성되는 표면활성제에 대한 억제 효과를 일으켜 호흡곤란증후군을 일으킬 것이라는 증거들이 밝혀지고 있으나 출혈된 혈액 자체가 계면활성제의 효과를 농도에 비례하여 감소시킨다는 연구결과는 현재까지 거의 발표된 바가 없었다. 목적 : 저자들은 호흡곤란 증후군 치료에 점차로 증가되는 농도의 혈액이 섞였을 때 폐 표면활성제의 표면장력에 영향을 미치는지에 대해 알아보고자 이 연구를 시행하였다. 재료 및 방법 : 흔히 사용되는 250 ug/ml 농도의 계면 활성제 용액에 대해 전혈을 5ul~65ul까지 혈액양을 변화시키면서 각 농도에 SM test를 3회씩 측정하여 평균값을 구하였다. 표면장력에 대한 측정은 임상에서 흔히 사용되고 DPPC(dipalmitoyl-phosphatidyl choline) 농도와 비례하는 Stable microbubble (SM) test를 시행하였다. 결과 : 혈액과 표면활성제가 혼합된 농도가 증가되면서 SM 결과상 비례하여 표면장력이 떨어지는 결과와 회귀방정식을 구했다. (y=122.78Ln(x)+610.92. r2=0.8683) 결론 : 폐출혈로 인한 전혈이 표면 활성제의 기능을 감소시키므로 호흡곤란증이 진행되는 폐출혈이 있는 환자에서 SM 검사의 유용성이 있으며, 고농도의 표면활성제 투여지침 결정에 도움이 될 것으로 사료된다.

쌀밥 통조림의 製造工程에 따른 營養成分의 變動에 關한 硏究

朴性五,李明煥,李相圭 서울여자대학교 1980 서울여자대학논문집 Vol.- No.9

The average losses of nutrients during washing of three pure strains of rice prior to cooking on the process for production of canned rice have been found to be about thiamine 5%, riboflavin 17%, niacin 10%, calcium 9%, phosphorus 5%, phytin phosphorus 3%, iron 22%, available iron 29%, and nitrogen 2%. The average losses(over the loss during washing) of these nutrients in gruel of rice cooked with six volumes of water are thiamine 25%, riboflavin 28%, calcium 20%, phosphorus 13%, phytin phosphorus 11%, iron 24%, available iron 24%, and nitrogen 4%. These losses increase when the rice is cooked with 8 volumes of water and are 35%, 37%, 35%, 27%, 15%, 15%, 32%, 29% and 6% respectively. The retention of the nutrients in rice corresponds well with the values as calculated from loss of nutrients in the gruel. The loss of nutrients in rice cooked with just sufficient water is negligible.