심전도의 디지털 기록화 모듈과 개인용컴퓨터 저장/분석시스템의 개발

조명찬,김기석,배장환,연태진,김동운,이태수,전은석,김유진 충북대학교 의학연구소 2001 忠北醫大學術誌 Vol.11 No.2

연구목적: 현재 우리나라의 의료분야에서는 정보기술의 발전으로 처방 전달 시스템과 전자차트의 활용이 상용화 되고 있으나 병원내에서 가장 많이 처방되고 검사되는 12-유도 심전도의 디지털화와 이에 연계된 심전도 결과의 개인용 컴퓨터로의 저장, 인터넷을 이용한 병원으로의 전송이나 타 기관에서의 심전도 결과의 동시 관찰 등에 관한 기술 등은 개발되지 못한 상태이다. 이에 본 연구에서는 심전도를 디지털화하며 저장이 가능한 PC 모듈을 개발하고 심전도 결과를 병원 전산 시스템에 포함시켜 병원내외에서 편리하게 조회, 검색할 수 있는 디지털 인터페이스를 개발하려 하였다. 재료 및 방법 : 낮은 전력에서 잡음특성이 우수한 대역여파기와 증폭기를 설계하였으며 각종기능이 내장된 고신뢰성 프로세서를 채택하였으며 전원 잡음이 고려된 필터와 전원 회로 설계로 하드웨어를 개발하였다. MSC 6.0과 Visual Basic 6.0을 바탕으로 하여 active X 모듈화를 유도하고 조회용 PC에서의 복원과 PACS로의 연동을 통해 순환기내과용 PACS 개발이 가능하도록 소프트웨어를 준비하였다. 결과: 심전도 검사자가 쉽게 장착, 검사가 가능한 소형화된 측정 모듈을 개발하였고 극저전류에서 동작이 가능하였으며 우수한 데이터의 압축 및 복원률을 구현하였다. 결론: 이번 심전도 디지털 모듈의 개발로 기존의 감광지에 의존하던 심전도 결과의 보존과 보관공간에 의한 경제적인 손실을 상당 부분 해결할 수 있으며 OCS에 연계된 결과로 인해 원내에서의 다면적 진료가 가능하다. 이번 연구에서 개발된 기술은 향후 디지털화된 심전도 기록장치와 같은 고부가 의료장치의 국산화와 광파일 의무기록 시스템이나 검사물의 무선 전송에 채용되어 의료 전달 체계나 응급체계의 발전에 기여하리라 사료된다. Purpose : The progressed communication technology commercialized the order communication system ( OCS) and the electric medical records( EMR) in the field of medicine in Korea. However, technologies of digitalization such as recording to personal computer, transfer to internet and simultaneous observation of electrocardiogram ( ECG) recorded at the different center were not realized yet. This study tried to invent personal computer module that can digitalize and record of the ECG and design the digital interface that can approach and search digitalized ECG in various part of hospital simultaneously. Materials and Methods : We had designed high-fidelity digital filter and amplifier which can work in very low voltage, had selected multifunctioned microprocessor. Activation X modulation was conducted by MSC 6.0 and Visual Basic 6.0. Softwares were prepared for the transfer of ECG informations from terminal PC to PACS and cardiologic PACS was designed for future application. Results : We have developed the small, portable, very low voltage managed ECG module and high quality digitalized information compression software in OCS and PACS. Conclusion : This invented ECG digital archive module can save hospital cost by substitution of ECG papers for digital storage or on-line storage, therefore ECG data can be handled in multisector of the hospital and through telemedicine. This technology can be applied to domestic ECG digitalizing device development and effective medical transfer system by adoption cordless medical information delivery.

비ST분절상승 급성관동맥 증후군 환자에서 N-terminal Pro B-type Natriuretic Peptide(NT-proBNP)를 이용한 관동맥 협착의 중증도 및 초기 위험도 평가

김기석,한혜숙,황경국,연태진,김동운,조명찬 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.2

양자역학에서 반원자주의

김명석,최상돈,조상규,문장수 慶北大學校 師範大學 科學敎育硏究所 1999 科學敎育硏究誌 Vol.23 No.-

Atomism is physical and metaphysical doctrine that the world is made up of indivisible(a-tom) and imperceptible small material units. We review this doctrine and examine it physically in the light of quantum mechanics. From atomism, we elicit atomistical separability which says that properties of the whole system is determined by the properties of the parts. However, according to our argument, the atomistical separability cannot compatible with the formalism of quantum mechanics. In conclusion, atomism does not sustainable anymore, instead, holism of properties or things comes sound.

콰인의 예정조화

김명석 새한철학회 2001 哲學論叢 Vol.25 No.3

20세기 철학의 한 지류로 등장한 논리경험론은 언어의 본성을 탐구함으로써 인간의 인식과 존재를 해명하려는 시도라 할 수 있다. 논리경험론의 완성자라고 알려져 있는 과인은 특히 언어적 표현의 '의미'를 비 의미론적 용어에 의거하여 설명하는 데 주력했다. 이 설명에 있어서 가장 핵심적인 문제는 의미의 상호주관성을 해명하는 것이다. 그런데 콰인은 이 문제를 해결하기 위해 인식주체들이 선천적으로 가지고 있는 지각유사성표준들의 예정조화를 도입한다. 이 글의 목적은 그가 어떤 탐구과정을 통해 이 예정조화를 주장하게 되었는지를 추적하는 것이다. 과인은 비언어적 신경유입에서 어떻게 언어적 의미가 생성될 수 있었는지 해명하기 위해, 먼저 신경유입에서 언어로 가는 중간다리로서 관찰문장을 도입한다. 그런 다음 그는 이 관찰문장들이 공유하고 있는 경험적 의미를 명시적으로 정의한다 관찰문장의 의미는 그것의 자극의미이다. 그리고 한 주체에게 어떤 한 문장의 자극의미란 현재의 신경유입에 응답하여 그 문장에 동의하거나 이의하는 그 주체의 성향이다. 과인에 의하면, 한 주체가 두 신경유입에 대해 유사하게 반응하곤 하는 것은 그 주체의 선천적 지각유사성표준 때문인데, 콰인의 예정조화설은 두 주체가 가진 지각유사성표준이 잘 맞추어진 시계처럼 조화롭게 작동한다는 논제이다. Logical empiricism as one of trends of 20 century philosophy, can be thought as the attempt that, through inquiring logically and empirically into the nature of human language, tries to explicate the nature of his knowledge. W. V. Quine known as the last logical empiricist has concentrated on defining meanings of linguistic expressions in terms of nonsemantic one. In this definition, the most crucial problem is to establish the intersubjectivity of meanings. To solve this problem, Quine employes a preestablished harmony of standards of perceptual similarity. The aim of this paper is to trace the development of his inquires the terminal of which he has proposed this preestablished harmony. In order to explaining how linguistic meanings can be emerged from nonliguistic neural intakes, Quine at first introduces holophrastic observational sentences as intermediary bridges between neural intakes and natural language. Then he explicitly defines the empirical meanings being shared by these observational sentences: the meaning of an observational sentence is just its stimulus-meaning. Here the stimulus-meaning of a sentence for a subject amounts to his disposition to assent to or dissent from the sentence in response to present neural intake. According to Quine, it is by virtue of subject's standard of perceptual similarity that the subject finds the similarity of two neural intakes, where standards of perceptual similarity are given in part innately in part by experience to each subject. Quine's preestablished harmony is the thesis that two standards of perceptual similarity of two subjects cooperate harmoniously just as two well-adjusted clocks.

인산용액의 농도 및 적용시간 차이에 따른 상아질 표면의 형태적 변화

김명수,온영석,이광원,손호현 大韓齒科保存學會 1998 Restorative Dentistry & Endodontics Vol.23 No.1

The depth and patterns of demineralization according to the difference in concentration and application time of phosphoric acid were observed through the transmission electron microscope, and shear bond strengths to the acid-conditioned dentin were then measured and compared with the TEM results. To investigate the influence of polymer addition into the phosphoric acid and the effect of difference in concentration and application time of the acid, the specimens were randomly divided into 9 groups. Among the specimens, the exposed dentin surfaces were acid-conditioned with 10% polymer-thickened phosphoric acid(All Bond 2, Bisco, U.S.A.) and aqueous 10%, 20%, 30%, 40% phosphoric acid for 20 seconds, The rest of the specimens were acid-conditioned with 10% phosphoric acid for 15s, 30s, 60s, 120s respectively. The specimens were immersed in 4% glutaraldehyde in 0.1M sodium cacodylate buffer and postfixed with 1% osmium tetroxide without decalcification and then observed under a JEOL Transmission Electron Microscope(JEM 1200 EXⅡ,Japan). After the specimens were acid-conditioned as the above, primer and adhesive resin were applied to blot-dried dentin and shear bond strengths were then measured and analysed. The results were as follows : 1. The intertubular demineralization depth of 4.0-5.0㎛ in 10% polymer-thickened phosphoric acid gels was similar or slightly deeper than that of 4.0-4.5㎛ in aqueous 10% phosphoric acid solution. 2. The intertubular demineralization depth of aqueous 20%, 30% and 40% phosphoric acid solution was 6.5-7.0㎛, 6.5-7.5㎛ and 9.0-15.0㎛ respectively. It showed that the depth of dentin demineralization is partly related to the concentration of phosphoric acid solution. 3. The intertubular demineralization depth of aqueous 10% phosphoric acid solution in application time for 15s, 30s, 60s and 120s was 2.5-3.0㎛, 4.0-6.0㎛, 6.5-7.0㎛ and 8.5-14.0㎛ respectively. It showed that the depth of dentin demineralization is directly related tothe application time of phosphoric acid solution. 4. The partially demineralized dentin layer between demineralized collagen layer and unaffected dentin was showed to a width of 0.5-1.0㎛ in lower concentration groups treated with aqueous 10% phosphoric acid for 20s, 60s, 120s and 20% phosphoric acid for 20s. 5. The demineralization effect at the border of intertubular-peritubular junction was less evident than that in the peritubular and intertubular dentin. The collagen fibers in the intertubular dentin had a random orientation, whereas those that lined the tubules were circumferentially aligned. The cross-linkage of dentinal collagen in demineralized collagen layer was clearly seen. 6. A statistically significant difference of bond strengths according to the difference in phosphoric acid concentration did not exist among the groups treated with 10%, 20%, 30% and 40% acid solution (P>0.05). However, bond strengths to the treated dentin with 10% phosphoric acid solution for 30s were significantly higher than that for 120s (P<0.05).

데이타베이스 시스템을 이용한 웹 자원 관리 엔진의 설계 및 구현

이명석,김진호,김상욱,유한양 강원대학교 정보통신연구소 1999 정보통신논문지 Vol.3 No.-

In this paper, we propose a web resource management engine based on general DBMSs. The web resources management engine manages the meta information describing the characteristics of resourves in a target web site. The engine extracts the meta information from HTML documents in the site and stores it into a predefined database called virtual schema. We use a general-purpose DBMS for maintaining the virtual schema. For design of the virtual schema, we model each element of HTML documents as a DBMS relation, and each attribute of an element as an attribute of its corresponding DBMS relation. We also model the link information among HTML documents as another relation. In order to merge the web and database having the virtual schema, we employ some additional tags in HTML documents, which were originally proposed in the INFORMIX WebDataBlade. Our web resource management engine has the following good features: (1) it supports dynamic changes of the web resources in a site by issuing update queries on the virtual schema, (2) it provides such searches that are based on structural characteristics of HTML documents since the virtual schema keeps the necessary information, (3) it provides the standard SQL interface for users to simply search and update the web resources, and finally, (4) it is portable to any DBMSs by just extending the gateway between the web and database since it only uses the common facilities supported by general-purpose DBMSs.

鬱血性心不全症에 對한 臨床的 觀察

徐明洙,金吉洙,金佑泰,張錫源,金承源,宋昌燮 대한적십자사 1983 적십자병원지 Vol.10 No.2

소의 시상하부내에서 Vasopressin과 Oxytion분비세포의 분포에 관한 면역조직화학적 연구

유명철,김종중,장인엽,문정석,정주현,김흥중,조사선 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1

This study was done to observe the distributions of Oxytocinergic and Vasopressinergic neurons in the hypothalamus of the cow. For the immunohistochemical staining, sections were reacted with the following sequence of solutions: monoclonal anti-vasopressin and anti-oxytocin, biotinylated anti-mouse IgG, avidin-biotin peroxidase complex, and Ni-DAB. The results observed under light microscope were summarized as follows. Our immunohistochemical investigations reveal both vasopressinergic and oxytocinergic neurons in the supraoptic nucleus(SON), paraventricular nucleus(PVN), accessory supraoptic nucleus (ASN), periventricular nucleus(PN), suprachiasmatic nucleus(SCN), and arcuate nucleus(AN), but these two types of neurons were mainly distributed in the PVN and SON and the ratio of the number of vasopressinergic neurons to that of oxytocinergic neurons was 1:1.30 in the PVN, and 1:1.00 in the SON. These two types of neurons were round, oval and spindle-shaped and cell size was 30-55um.

韓牛 末梢血液 淋巴球의 在來山羊 赤血球 Rosette形成

宋憙鍾,金鍾冕,姜明大,蔡孝錫 全北大學校 附設 畜産開發硏究所 1988 畜産開發硏究報告 Vol.2 No.-

In order to enumerate the T lymphocytes in bovine peripheral blood lymphocytes(PBL) by E rosette assay, KGRBC were treated with various concentration of 2-aminoethylisothiouronium bromide hydrobromide(AET) and dextran(Dex), singte or combination. The PBL from 10 clinically normal Korean native cattle were formed as low percentage of spontaneous E rosette(6.7±2.4%) in control group, whereas KGRBC treated with 0.1M AET for 20 minutes and 8%Dex were formed as 37.3±2.7% and 45.1±2.1%, respectively. And the synergistic effects were noted no less than 66.5±5.6% when the KGRBC treated with 0.1M AET and 8% Dex subsequently. These results suggest that the KGRBC would be a useful agent for the enumeration of T tymphocytes by E rosette assay in bovine PBI.

전자정부 서비스의 이용에 관한 인식 연구

정병걸,김석주,명승환 한국정보사회진흥원 2005 정보화정책 Vol.12 No.2

정보통신 기술에 기반한 전자적 수단을 통한 행정 서비스의 제공은 정부의 대응성 향상을 위한 좋은 대안으로 인식되고 있다. 2002년부터 전자정부 민원서비스가 본격적으로 제공되기 시작했지만 뚜렷한 이용의 증가가 이루어지지는 못하고 있다. 전자정부 서비스는 서비스 제공의 초기 단계에 머물고 있으며, 서비스의 다양성이나 질적 측면 등에서 해결해야할 많은 문제를 가지고 있기 때문이다. 본 연구에서는 전자정부 서비스의 이용자들을 대상으로 한 인터넷 설문 조사 결과를 바탕으로 전자정부 서비스 이용의 현황, 특성과 문제점을 파악하였다. 분석 결과 전통적인 서비스를 일부 대체하고 있는데 그치고 있지만 충분한 개선이 이루어진다면 향후의 이용 가능성은 매우 높은 것으로 나타났다. 이와 관련하여 전자정부 서비스의 이용을 활성화하기 위한 함의를 제시하였다.