A Randomized Double-Blind Placebo-Control Study to Assess the Efficacy and Safety of OLNP-05 Versus Placebo for the Treatment of Subjects with Premature Ejaculation

Sanjib Kumar Panda,Somashekara Nirvanashetty,Vivek A. Parachur,Nilima Mohanty 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.9

Premature ejaculation (PE) is one of the foremost sex-related health problems among men. The global occurrence ranges from 20% to 30%, according to various studies. PE has a great impact on the men's quality of life, with deleterious effects such as embarrassment, frustration, and feeling of incompetence. Considering the necessity of treatment of PE, this study was planned to compare the efficacy and safety of OLNP-05 versus placebo for treating subjects suffering from PE. In this randomized clinical study, 60 men with PE were enrolled and randomly assigned to receive either OLNP-05 or placebo one capsule twice daily for a period of 8 weeks. Subjects were evaluated during visits on day 1, day 28, and day 56. Mean change from baseline in intravaginal ejaculatory latency time (IELT), improvement in premature ejaculation profile (PEP), and Clinical Global Impression-Improvement scale (CGI-I) were used to assess the efficacy of treatment. P-value <.05 was considered significant. At the end of the treatment, the improvement in IELT score in the OLNP-05 group was remarkably higher than the placebo. Subjects in the OLNP-05 treatment group also reported significantly greater improvement in PEP subscale score. Majority of OLNP-05-treated subjects were found to be in the “much improved” category as per CGI-I assessment. The result confirms the safety and efficacy of OLNP-05, therefore suggesting that OLNP-05 may be a safe and effective intervention for the management of PE.

Antenatal Diagnosis of Iniencephaly: Sonographic and MR Correlation: A Case Report

Sona A. Pungavkar,Nisha I. Sainani,Alka S. Karnik,Prita H. Mohanty,Malini A. Lawande,Deepak P. Patkar,Shweta Sinha 대한영상의학회 2007 Korean Journal of Radiology Vol.8 No.4

Iniencephaly is an uncommon and fatal neural tube defect involving the occiput and inion, this occurs together with rachischisis of the cervical and thoracic spine, and retroflexion of the head. We report the ultrasound (US) and magnetic resonance (MR) imaging findings of a case of iniencephaly with clubfeet and arthrogryposis. The diagnosis of iniencephaly is easy to make on ultrasound due to the typical star-gazing fetus. However, the details of the fetal brain and spinal cord may not be adequately delineated on US. We found MR imaging to be superior for depicting central nervous system abnormalities. MR imaging has evolved as an imaging modality and it is complementary to fetal US, yet US remains the screening modality of choice.

Effect of Needling at CV-12 (Zhongwan) on Blood Glucose Levels in Healthy Volunteers: A Pilot Randomized Placebo Controlled Trial

Sriloy Mohanty,A. Mooventhan,Nandi Krishnamurthy Manjunath 사단법인약침학회 2016 Journal of Acupuncture & Meridian Studies Vol.9 No.6

Introduction: Acupuncture, a key part of traditional Chinese medicine, is used to relieve symptoms of diabetes mellitus. The aim of this study was to evaluate the effect of needling CV-12 (Zhongwan) on blood glucose levels in healthy volunteers. Materials and methods: Thirty-six individuals were recruited and randomized into either the acupuncture group or the placebo control group. The participants in the acupuncture group were needled at CV-12 (4 cun above the center of the umbilicus), and those in the placebo control group were needled at a nonexisting “sham” point on the right side of the abdomen (1 cun beside the CV-12)da nonacupuncture point. For both groups, the needle was retained for 20 minutes without stimulation. Assessments were performed prior to and after the intervention. Statistical analysis was performed using the Statistical Package for the Social Sciences, version 16. Results: The result of this study showed a mild reduction in random blood glucose (RBG) levels in the acupuncture group and a mild increase in RBG levels in the placebo control group. However, these changes were not statistically significant both within and between groups.

Synchronization and Operation of Parallel Inverters using Droop Control

L. K. Sahoo,N. D. Thakur,K. Rai,P Sensarma,R. D. Jha,P. Mohanty,A Sharma 전력전자학회 2011 ICPE(ISPE)논문집 Vol.2011 No.5

To obtain a continuous power supply Distributed Generation (DG) with a Decentralized Power System (DPS), i.e. replacing a single UPS unit with multiple, smaller units in parallel, is emerging as new paradigm. The technically challenging aspect of DPS is the synchronization of inverters and load sharing among the parallel connected inverters. In this paper, a control method is proposed and implemented for synchronization and parallel operation of inverters. Droop control method has been used for equal power sharing, and design of power control loop. The design issues for voltage control loop are analyzed with the discussion of relative stability of the system. A current control loop is designed and analyzed to provide synchronization between the inverters.

Testicular Cell Indices and Peripheral Blood Testosterone Concentrations in Relation to Age and Semen Quality in Crossbred (Holstein Friesian×Tharparkar) Bulls

Rajak, S.K.,Kumaresan, A.,Gaurav, M.K.,Layek, S.S.,Mohanty, T.K.,Aslam, M.K. Muhammad,Tripathi, U.K.,Prasad, Shiv,De, S. Asian Australasian Association of Animal Productio 2014 Animal Bioscience Vol.27 No.11

Present study analyzed the changes in peripheral blood testosterone concentrations and testicular cytogram in relation to age and semen quality in crossbred males. Three different age groups of crossbred males viz. bull calves (6 months, n = 5), young bulls (15 months, n = 5) and adult bulls (4 to 6 years, n = 8) were utilized for the study. Testicular fine needle aspiration cytology technique was used to quantify testicular cytology and their indices. Peripheral blood testosterone concentrations were measured using enzyme-linked immunosorbent assay method. Semen samples collected from adult bulls were microscopically evaluated for quality parameters. Mean peripheral blood testosterone concentrations in bull calves, young bulls and adult bulls were $2.28{\pm}0.09ng/mL$, $1.42{\pm}0.22ng/mL$ and $5.66{\pm}1.08ng/mL$ respectively, and that in adult bulls were significantly different (p<0.01) from young bulls and bull calves. There was no significant difference between the proportion of different testicular cells in bull calves and young bulls. Between young and adult bulls, significant differences (p<0.01) were observed in the proportion of spermatocytes, spermatozoa, and sperm: Sertoli cell ratio. The proportions of Sertoli cells showed a significant difference (p<0.01) between the three age groups. The number of primary spermatocytes had a positive correlation with peripheral blood testosterone concentrations in bull calves (r = 0.719, p<0.01). Number of Sertoli cells per 100 germ cells was negatively correlated with blood testosterone concentration in young bulls (r = -0.713, p<0.01). Among different semen parameters in adult bulls, ejaculate volume (r = 0.790, p<0.05) had positive relationship, and sperm motility had significant negative correlation (r = -0.711, p<0.05) with testosterone concentrations. The number of Sertoli cells and Sertoli cell index had a positive correlation with various semen quality parameters (p<0.001). Results of the present study conclude that number of Sertoli cells and Sertoli cell index are good indicators of semen quality, but peripheral blood testosterone concentrations may not have a direct relationship with various seminal attributes in crossbred bulls.

Microsystems for Whole Blood Purification and Electrophysiological Analysis

Han, Arum,Han, Ki-Ho,Mohanty Swomitra K.,Frazier A. Bruno The Institute of Electronics and Information Engin 2005 Journal of semiconductor technology and science Vol.5 No.1

This paper presents the development of a microsystem for whole blood purification and electrophysiological analysis of the purified cells. Magnetophoresis using continuous diamagnetic capture (DMC) was utilized for whole cell purification and electrical impedance spectroscopy (EIS) was utilized for electrophysiological analysis of the purified cells. The system was developed on silicon and plastic substrates utilizing conventional microfabrication technologies and plastic microfabrication technologies. Using the magnetophoretic microseparator, white blood cells were purified from a sample of whole blood. The experimental results of the DMC microseparator show that 89.7% of the red blood cells (RBCs) and 72.7% of the white blood cells (WBCs) could be continuously separated out from a whole blood using an external magnetic flux of 0.2 T. EIS was used as a downstream whole cell analysis tool to study the electrophysiological characteristics of purified cells. In this work, primary cultured bovine chromaffin cells and human red blood cells were characterized using EIS. Further analysis capabilities of the EIS were demonstrated by successfully obtaining unique impedance signatures for chromaffin cells based on the whole cell ion channel activity.

Microsystems for Whole Blood Purification and Electrophysiological Analysis

Arum Han,Ki-Ho Han,Swomitra K. Mohanty,A. Bruno Frazier 대한전자공학회 2005 Journal of semiconductor technology and science Vol.5 No.1

This paper presents the development of a microsystem for whole blood purification and electrophysiological analysis of the purified cells. Magnetophoresis using continuous diamagnetic capture (DMC) was utilized for whole cell purification and electrical impedance spectroscopy (EIS) was utilized for electrophysiological analysis of the purified cells. The system was developed on silicon and plastic substrates utilizing conventional microfabrication technologies and plastic microfabrication technologies. Using the magnetophoretic microseparator, white blood cells were purified from a sample of whole blood. The experimental results of the DMC microseparator show that 89.7% of the red blood cells (RBCs) and 72.7% of the white blood cells (WBCs) could be continuously separated out from a whole blood using an external magnetic flux of 0.2 T. EIS was used as a downstream whole cell analysis tool to study the electrophysiological characteristics of purified cells. In this work, primary cultured bovine chromaffin cells and human red blood cells were characterized using EIS. Further analysis capabilities of the EIS were demonstrated by successfully obtaining unique impedance signatures for chromaffin cells based on the whole cell ion channel activity.

Trihalomethanes in the Cooling Discharge of a Power Plant on Chlorination of Intake Seawater

R. K. Padhi,S. Subramanian,A. K. Mohanty,S. N. Bramha,M. V. R. Prasad,K. K. Satpathy 대한환경공학회 2012 Environmental Engineering Research Vol.17 No.-

Trihalomethanes (THMs) formation and species distribution in the discharged chlorinated cooling seawater of a nuclear power plant was assessed during Aug 2010 to July 2011. The monthly variation of chlorine demand of the source seawater under laboratory chlorination conditions was studied for the same period. The entire period can be divided into two separate zones; viz. Feb, Mar, Apr, Sep, Oct (low chlorine demand), and May, Jun, Jul, Aug, Nov, Dec, Jan (high chlorine demand) months. Bromoform was found to be the single dominant THMs species in the chlorinated cooling seawater discharge. The THMs concentration was observed to be highest for the month of Nov 2010 (41 μg/L), and lowest for Feb 2011(12 μg/L). Under laboratory chlorination of intake seawater with 1 ppm Cl2, the concentration of THMs that was formed within 5–15 min is in agreement with the actual concentration in the discharge water. A simplified predictive approach is proposed for the total THMs concentration at the cooling discharge outlet of a power plant, based on the actual chlorine demand of source water.

Genetic Variability and Association of Yield Attributing Characters with Grain Yield in Deepwater Rice

L. K. Bose,S. K. Pradhan,A. Mohanty,M. Nagaraju 韓國作物學會 2005 Korean journal of crop science Vol.50 No.4

A study on genetic variability and association of yield attributing characters with grain yield was carried out using 35 deepwater rice genotypes. High genotypic co-efficient of variation (GCV) was observed for plot yield, EBT/m2 , plant height and days to 50~% flowering (DFF). For all the traits, estimates of the phenotypic co-efficient of variation (PCV) were higher than GCV, indicating presence of environmental influence. High heritability and genetic advance was observed for plot yield, EBT/m2 and plant height. Plot yield had significant positive association with test weight, EBT/m2 and DFF. However, test weight had the maximum direct effect on grain yield

Identification of candidate network hubs involved in metabolic adjustments of rice under drought stress by integrating transcriptome data and genome-scale metabolic network

Mohanty, B.,Kitazumi, A.,Cheung, C.Y.M.,Lakshmanan, M.,de los Reyes, B.G.,Jang, I.C.,Lee, D.Y. Elsevier Scientific Publishers Ireland Ltd 2016 Plant science Vol.242 No.-

In this study, we have integrated a rice genome-scale metabolic network and the transcriptome of a drought-tolerant rice line, DK151, to identify the major transcriptional regulators involved in metabolic adjustments necessary for adaptation to drought. This was achieved by examining the differential expressions of transcription factors and metabolic genes in leaf, root and young panicle of rice plants subjected to drought stress during tillering, booting and panicle elongation stages. Critical transcription factors such as AP2/ERF, bZIP, MYB and NAC that control the important nodes in the gene regulatory pathway were identified through correlative analysis of the patterns of spatio-temporal expression and cis-element enrichment. We showed that many of the candidate transcription factors involved in metabolic adjustments were previously linked to phenotypic variation for drought tolerance. This approach represents the first attempt to integrate models of transcriptional regulation and metabolic pathways for the identification of candidate regulatory genes for targeted selection in rice breeding.