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      • KCI등재

        The Impact of Southern Song Buddhism on the Japanese Pure Land Movement in the Twelfth and Thirteenth Centuries: Shinran’s Thought in the Context of SinoJapanese Buddhist Exchange

        DAKE Mitsuya 동국대학교 불교학술원 2022 International Journal of Buddhist Thought & Cultur Vol.32 No.1

        This article discusses how Southern Song Buddhism, which flourished in the Taizhou 台州, Hangzhou 杭州 and Ningbo 寧波 area, positively impacted the transformational movement of Japanese Pure Land Buddhism in the late twelfth and thirteenth centuries. Recently, several excellent academic books were published in Japan that address the development of Buddhist thought during the Five Dynasties and Ten Kingdoms (907–960) and Song periods (960–1279) and Sino-Japanese Buddhist exchange from the perspective of cultural and textual relationships across East Asian during this era. These studies reveal the trans-sectarian and trans-national characteristics of Sino-Japanese Buddhist exchange during the twelfth and thirteenth centuries. These studies demonstrate not only cutting-edge methodological approaches by modern scholars, but also why comprehensive research of and knowledge about transformational Japanese Buddhist movements in the twelfth and thirteenth centuries is necessary for understanding the history of the development of Chinese and Japanese Buddhism. In this article, I overview the impact of Southern Song Buddhism on the development of Japanese Buddhism, especially the transformational movement of Japanese Pure Land Buddhism in the twelfth and thirteenth centuries focusing on Shinran 親鸞 (1173–1263), who is the founder of Jōdo Shinshū or Shin Buddhist sect. He was one of the main figures of the transform movement of Japanese Pure Land in the thirteenth century. Shinran is also recognized as a seminal, sophisticated religious thinker in Japanese Buddhism, and he is remembered in modern times for his provocative and insightful writings. Here, I examine his main work, the Ken Jōdoshinjitsu Kyōgyōshō monrui 顕浄土真実教行証文類 (Collected Passages Revealing the True Teaching, Practice, and Realization; hereafter The True Teaching, Practice, and Realization) and analyze how Song-dynasty Buddhist texts, especially written by masters in the Hangzhou area brought back to Japan during this time, greatly impacted Shinran’s innovative and transformational thought.

      • KCI등재

        Treatment strategies for patients with advanced ovarian cancer undergoing neoadjuvant chemotherapy: interval debulking surgery or additional chemotherapy?

        Yutaka Yoneoka,Mitsuya Ishikawa,Takashi Uehara,Hanako Shimizu,Masaya Uno,Takashi Murakami,Tomoyasu Kato 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.5

        Objective: To treat advanced ovarian cancer, interval debulking surgery (IDS) is performed after 3 cycles each of neoadjuvant chemotherapy (NAC) and postoperative chemotherapy (IDS group). If we expect that complete resection cannot be achieved by IDS, debulking surgery is performed after administering additional 3 cycles of chemotherapy without postoperative chemotherapy (Add-C group). We evaluated the survival outcomes of the Add-C group and determined their serum cancer antigen 125 (CA125) levels to predict complete surgery. Methods: A retrospective chart review of all stage III and IV ovarian, fallopian tube, and peritoneal cancer patients treated with NAC in 2007–2016 was conducted. Results: About 117 patients comprised the IDS group and 26 comprised the Add-C group. Univariate and multivariate analyses revealed that Add-C group had an equivalent effect on progression-free survival (PFS; p=0.09) and overall survival (OS; p=0.94) compared with the IDS group. Multivariate analysis revealed that patients who developed residual disease after surgery had worse PFS (hazard ratio [HR]=2.18; 95% confidence interval [CI]=1.45–3.28) and OS (HR=2.33; 95% CI=1.43–3.79), and those who received <6 cycles of chemotherapy had worse PFS (HR=5.30; 95% CI=2.56–10.99) and OS (HR=3.05; 95% CI=1.46–6.38). The preoperative serum CA125 cutoff level was 30 U/mL based on Youden index method. Conclusions: Administering 3 additional cycles of chemotherapy followed by debulking surgery exhibited equivalent effects on survival as IDS followed by 3 cycles of postoperative chemotherapy. Preoperative serum CA125 levels of ≤30 U/mL may be a useful predictor of achieving complete surgery.

      • KCI등재

        Development and characterization of 24 polymorphic microsatellite markers for bluegill sunfish, Lepomis macrochirus

        Kouichi Kawamura,Atushi Fujiwara,Mitsuya Yamada,Wataru Furukawa,Jun Kurita,Hiroyuki Okamoto 한국유전학회 2017 Genes & Genomics Vol.39 No.6

        The bluegill sunfish (Lepomis macrochirus) is a notorious exotic fish, which causes serious damages to freshwater ecosystems in the world. Therefore, it is a matter of urgency to control this species for the conservation of ecosystem. New microsatellite loci were developed for L. macrochirus using high throughput 454 GS-FLX+ pyrosequencing. We selected 24 primer pairs that were tested on 47 individuals from Lake Biwa, which encompasses the oldest and largest population of L. macrochirus in Japan. Allele per locus varied 2–17. Expected and observed heterozygosities ranged from 0.185 to 0.888 and 0.120 to 0.872, respectively. Applied to L. macrochirus in Lake Biwa, these markers could detect genetic differentiation among populations, which showed a pattern of isolation by distance. These markers are expected to be useful in the estimation of population structure and ecology of L. macrochirus.

      • KCI등재

        Prognostic factors of synchronous endometrial and ovarian endometrioid carcinoma

        Yutaka Yoneoka,Hiroshi Yoshida,Mitsuya Ishikawa,Hanako Shimizu,Takashi Uehara,Takashi Murakami,Tomoyasu Kato 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.1

        Objective: Gynecologists occasionally encounter synchronous endometrial and ovarian endometrioid carcinoma (SEO-EC) patients who show favorable prognosis than locally advanced or metastatic disease patients. This study aimed to elucidate prognostic factors of SEO-EC and identify patients who have a sufficiently low risk of recurrence without receiving adjuvant chemotherapy. Methods: We retrospectively reviewed 46 patients with pathologically confirmed SEO-EC who underwent surgery at the National Cancer Center Hospital between 1997 and 2016. Immunohistochemical evaluation of DNA mismatch repair (MMR) protein expression were performed for both endometrial and ovarian tumors. Patient outcomes were analyzed according to clinicopathologic factors. Results: From the multivariate analysis, cervical stromal invasion indicated a worse prognosis for progression-free survival (hazard ratio [HR]=6.85; 95% confidence interval [CI]=1.50–31.1) and overall survival (HR=6.95; 95% CI=1.15–41.8). Lymph node metastasis and peritoneal dissemination did not significantly affect survival. MMR deficiency was observed in 13 patients (28.3%), with both endometrial and ovarian tumors showing the same MMR expression status. MMR deficiency was not significantly associated with survival. Of 23 patients with lesions confined to only the uterine body and adnexa, only 2 had recurrence in the group receiving adjuvant therapy, while none of the 10 patients who did not receive adjuvant therapy had recurrence. Conclusion: SEO-EC patients with tumors localized to the uterine body and adnexa lesions had a low risk for recurrence and may not require adjuvant therapy. SEO-EC may have prognostic factors different from those of endometrial and ovarian cancer.

      • KCI등재

        Prognostic factors for patients with early-stage uterine serous carcinoma without adjuvant therapy

        Keisei Tate,Hiroshi Yoshida,Mitsuya Ishikawa,Takashi Uehara,Shunichi Ikeda,Nobuyoshi Hiraoka,Tomoyasu Kato,Keisei Tate 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.3

        Objective: Uterine serous carcinoma (USC) is an aggressive type 2 endometrial cancer. Data on prognostic factors for patients with early-stage USC without adjuvant therapy are limited. This study aims to assess the baseline recurrence risk of early-stage USC patients without adjuvant treatment and to identify prognostic factors and patients who need adjuvant therapy. Methods: Sixty-eight patients with International Federation of Gynecology and Obstetrics (FIGO) stage I–II USC between 1997 and 2016 were included. All the cases did not undergo adjuvant treatment as institutional practice. Clinicopathological features, recurrence patterns, and survival outcomes were analyzed to determine prognostic factors. Results: FIGO stages IA, IB, and II were observed in 42, 7, and 19 cases, respectively. Median follow-up time was 60 months. Five-year disease-free survival (DFS) and overall survival (OS) rates for all cases were 73.9% and 78.0%, respectively. On multivariate analysis, cervical stromal involvement and positive pelvic cytology were significant predictors of DFS and OS, and ≥1/2 myometrial invasion was also a significant predictor of OS. Of 68 patients, 38 patients had no cervical stromal invasion or positive pelvic cytology and showed 88.8% 5-year DFS and 93.6% 5-year OS. Conclusion: Cervical stromal invasion and positive pelvic cytology are prognostic factors for stage I–II USC. Patients with stage IA or IB USC showing negative pelvic cytology may have an extremely favorable prognosis and need not receive any adjuvant therapies.

      • KCI등재

        Baseline risk of recurrence in stage I–II endometrial carcinoma

        Shinsuke Sasada,Mayu Yunokawa,Yae Takehara,Mitsuya Ishikawa,Shunichi Ikeda,Tomoyasu Kato,Kenji Tamura 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.1

        Objective: Though there are no evidences that postoperative therapy improves overall survival (OS) in stage I–II endometrial carcinoma, many women receive postoperative radiation or chemotherapy. This study aimed to investigate the baseline risk of recurrence after complete resection without any adjuvant therapies and to suppose the validity of postoperative therapy for stage I–II endometrial carcinoma. Methods: Charts for patients with stage I–II endometrial carcinoma who underwent operation without postoperative therapy between January 2005 and December 2011 were retrospectively reviewed and the baseline risk of recurrence and prognosis were assessed. Risk classifications were performed according to European Society for Medical Oncology (ESMO) clinical practice guidelines and Japanese guideline written by Japan Society of Gynecologic Oncology Group. Results: Among 374 patients who underwent complete resection, 311 were evaluable. Five-year recurrence rates by ESMO and Japanese were 2.6% and 3.1% in low-risk, 9.2% and 6.6% in intermediate-risk and 13.5% and 13.8% in high-risk group (p=0.003 and 0.015, respectively). High-risk group had worse OS compared with low- and intermediate-risk groups (5-year OS, low: 97.9% and 97.6%, intermediate: 97.9% and 98.8%, and high: 89.5% and 87.5%; p=0.003 and 0.008, respectively). Independent predictive factors of recurrence were age over 60 years, type 2 (estrogen-independent) and peritoneal cytology. Conclusion: ESMO and Japanese risk classification similarly stratify the baseline risk of recurrence. Patients with stage I–II endometrial carcinoma, especially low- and intermediate-risk diseases, have low recurrence rate and favorable OS, and the benefit of postoperative therapy might be small.

      • Cognitive Characteristics of Directional Judgment Through Binocular Disparity on a Virtual Tilted Screen

        ( Sanghyun Kim ),( Harumi Itaoka ),( Hiroyuki Morikawa ),( Reiko Mitsuya ),( Takashi Kawai ),( Katsumi Watanabe ) 한국감성과학회 2014 춘계학술대회 Vol.2014 No.-

        Cognitive activities in recognition directional judgment, such as short-term memory, were examined on a virtual tilted screen by using stereoscopic three-dimensional (3D) images. The virtual tilted screen was composed of 3D images; 2D images without perspective views were converted into tilted 3D images by using a simple gradient depth map. In the experiments, a cognitive bias in directional judgment was induced as participants were allowed to perceive the tilted direction through binocular disparity with positive parallax. In Experiment 1, a subjective evaluation in which tilted simple stimuli were presented on a 3D screen was performed, and participants were able to make a right or left turn on a driving simulator. The participants made a directional judgment at the intersection after viewing tilted 3D images. Experiment 2 was carried out to evaluate the rate of correct answers and searching times in four conditions: with 2D, 3D, or tilted 3D images, and tilted 3D distractors. In the tilted 3D condition, tilted 3D images were presented in the same direction as instructed via headphones (Left or Right). Images were presented in the opposite direction from that indicated via headphones in the tilted 3D distractor condition. The results suggested that the tilted 3D condition was able to easily support participants` directional judgment as well as remain in short-term memory.

      • Cognitive characteristics of directional judgment through binocular disparity on a virtual tilted screen

        Sanghyun Kim,Harumi Itaoka,Hiroyuki Morikawa,Reiko Mitsuya,Takashi Kawai,Katsumi Watanabe 대한인간공학회 2014 대한인간공학회 학술대회논문집 Vol.2014 No.5

        Cognitive activities in recognition directional judgment, such as short-term memory, were examined on a virtual tilted screen by using stereoscopic three-dimensional (3D) images. The virtual tilted screen was composed of 3D images; 2D images without perspective views were converted into tilted 3D images by using a simple gradient depth map. In the experiments, a cognitive bias in directional judgment was induced as participants were allowed to perceive the tilted direction through binocular disparity with positive parallax. In Experiment 1, a subjective evaluation in which tilted simple stimuli were presented on a 3D screen was performed, and participants were able to make a right or left turn on a driving simulator. The participants made a directional judgment at the intersection after viewing tilted 3D images. Experiment 2 was carried out to evaluate the rate of correct answers and searching times in four conditions: with 2D, 3D, or tilted 3D images, and tilted 3D distractors. In the tilted 3D condition, tilted 3D images were presented in the same direction as instructed via headphones (“Left” or “Right”). Images were presented in the opposite direction from that indicated via headphones in the tilted 3D distractor condition. The results suggested that the tilted 3D condition was able to easily support participants’ directional judgment as well as remain in short-term memory.

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