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Kim, Sungchul,Lee, Sanghyun,Shin, Jinwook,Kim, Youngkyun,Evnouchidou, Irini,Kim, Donghyun,Kim, Young-Kook,Kim, Young-Eui,Ahn, Jin-Hyun,Riddell, Stanley R,Stratikos, Efstratios,Kim, V Narry,Ahn, Kwangs Nature Publishing Group, a division of Macmillan P 2011 NATURE IMMUNOLOGY Vol.12 No.10
Major histocompatibility complex (MHC) class I molecules present peptides on the cell surface to CD8<SUP>+</SUP> T cells, which is critical for the killing of virus-infected or transformed cells. Precursors of MHC class I??presented peptides are trimmed to mature epitopes by the aminopeptidase ERAP1. The US2??US11 genomic region of human cytomegalovirus (HCMV) is dispensable for viral replication and encodes three microRNAs (miRNAs). We show here that HCMV miR-US4-1 specifically downregulated ERAP1 expression during viral infection. Accordingly, the trimming of HCMV-derived peptides was inhibited, which led to less susceptibility of infected cells to HCMV-specific cytotoxic T lymphocytes (CTLs). Our findings identify a previously unknown viral miRNA??based CTL-evasion mechanism that targets a key step in the MHC class I antigen-processing pathway.
Smart Sensor-based Interface Controlin the Mobile CloudEnvironment
Sanghyun Park,Ilmin Kim,Jinsul kim 보안공학연구지원센터 2014 International Journal of Control and Automation Vol.7 No.10
In this paper we propose the use of cloud services to delivery next-generation dynamic mobile interface. The improvement is focused on existing soft keyboard application. Through a simple sign-in process, the customized keyboard interfaced defined by user own can by synced, stored on the cloud and ready to be apply on other compatible devices of the same user in anytime. With cloud based interface, through specific username and password, various smart mobile devices are able to receive their custom interface. Also, we use Gyro Sensor and Wi-Fi direct to help the users freely share their layout through the internet.
Evaluation of wheat type I and II resistance to Fusarium head blight in the greenhouse and field
Sanghyun Shin,Kyeong-Hoon Kim,Hag-Sin Kim,In-Duck Choi,Jong-Chul Park,Jong-Nae Hyun,Kee-Jong Kim,Chul Soo Park,Chon-Sik Kang 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
Fusarium head blight (FHB), caused by Fusarium graminearum is a major disease problem on wheat and barley in Korea and around the world. We screened for Type II resistance in the greenhouse using single floret inoculation and for Type I resistance in the field using spray inoculation. Sumai 3 was used the FHB resistant check. Three hundred and seventy lines were evaluated for resistance to spread of symptoms within spike (type II). The 2012 field screening with 300 wheat lines was located in Kimjae-si Joeonbuk Korea. All plots were inoculated twice. The first inoculation was applied at anthesis for wheat. The second inoculation was applied three days after the initial inoculation (dai) for each plot. The inoculum was F. graminearum (GZ3639) prepared at a concentration of 100,000 macroconidai/ml with Tween 20 added as a wetting agent. Mist-irrigation was applied from the first inoculation on May 7 till June 7 to facilitate FHB development. FHB severity was assessed visually 21 days after inoculation on 20 arbitrarily selected spikes per plot. FHB severity was determined as the percentage of symptomatic spikelets from the total of all spikelets observed in these 20 spikes. Based on the field test, we could observe four categories of FHB severity: resistant (R: 0-20%), moderately resistant (MR: 21-40%), moderately susceptible (MS: 41-60%), and susceptible (S: 61-100%). The results showed that forty four lines showed the resistant category on FHB severity between 2.7% and 19.8%. In addition, ten lines showed similar FHB severity compared to Sumai 3 (9.9%).
Kim, Youngjo,Kim, Hyung-Jun,Cha, Sun Joo,Choi, Hyun-Jun,Kim, Hayoung,Lee, Sanghyun,Jeon, Yu-Mi,Lee, Mihye,Lee, Seongsoo,Kim, Kiyoung Elsevier 2019 NEUROBIOLOGY OF AGING Vol.73 No.-
<P><B>Abstract</B></P> <P>Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder that is characterized pathologically by the loss of motor neurons. Mutations in the <I>TAF15</I> gene have been implicated in the pathogenesis of ALS. TATA-binding protein associated factor 15 (TAF15) accumulates as cytoplasmic aggregates in neuronal cells, the clearance of which may be a therapeutic strategy for ALS. However, the identification of a novel regulator for protection against a TAF15-induced proteinopathy and the exact pathogenic mechanism of TAF15-induced neurodegeneration remain to be elucidated. Here, we show that parkin directly binds to TAF15 and that parkin overexpression can suppress the defective phenotypes, including the life span and locomotive activity of a TAF15-induced proteinopathy. We also found that overexpression of parkin in neuronal cells leads to a reduction in TAF15 levels, because of the E3 ubiquitin ligase activity of parkin. Our study provides in vivo evidence supporting the use of parkin for neuroprotection in a TAF15-induced proteinopathy and offers new insights into the pathogenic mechanisms underlying TAF15-induced ALS.</P>
Kim, Sang-Hyun,Kim, Sung Hyun,Kang, Kyung Hun,Lee, Sanghyun,Kim, Seoung Ju,Kim, Jeong Gyun,Chung, Mi Ja Elsevier 2017 FOOD SCIENCE AND TECHNOLOGY -ZURICH- Vol.84 No.-
<P>The role of kimchi probiotic bacteria in reducing the amounts of N-nitrosodimethylamine (NDMA) and its precursors occurring in the kimchi-making process and digestion was assessed using Leuconostoc carnosum (LEC), Leuconostoc mesenteroides (LEM), Lactobacillus plantarum (LP), and Lactobacillus sakei (LS) grown in MRS broth containing NDMA or its precursors. The results showed that the four bacteria could directly deplete NDMA and nitrite levels in the MRS broth, and this effect was more pronounced in the presence of LP and LS than in LEC and LEM. The concentration of NDMA and its precursors (nitrite, dimethylamine, and biogenic amine) were significantly reduced in bacteria-fortified kimchi compared with the control kimchi, the extent of which depended on the respective bacterial load. Endogenous formation of NDMA by precursors in bacteria-fortified kimchi was demonstrated under simulated gastric digestion. Following digestion, the bacteria-fortified kimchi inhibited NDMA formation. These results suggest that probiotic bacteria may cause a significant decrease in NDMA occurring in kimchi, possibly by direct degradation and inhibition of NDMA formation. Therefore, such lactic acid bacteria could be used in the kimchi-making process to reduce NDMA levels, with an emphasis on LP as it exerted a greater reduction in NDMA concentration in the bacteria-fortified kimchi. (C) 2017 Elsevier Ltd. All rights reserved.</P>