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Kamiya, Mitsuru,Kamiya, Yuko,Tanaka, Masahito,Shioya, Shigeru Asian Australasian Association of Animal Productio 2006 Animal Bioscience Vol.19 No.8
This experiment was performed to examine the influences of high ambient temperature on milk production, nutrient digestibility, energy and protein sufficiency ratio, and plasma metabolites concentration in lactating cows. In a $2{\times}2$ crossover design, four multiparous lactating Holstein cows were maintained in a chamber under treatment of constant moderate ($18^{\circ}C$) ambient temperature (MT) or high ($28^{\circ}C$) ambient temperatures (HT). The DMI and milk protein yield were significantly lower in HT (p<0.05). The milk yield, milk lactose yield, and milk SNF yield tended to be lower in HT (p<0.10). No statistical differences for 4% fat-corrected milk and milk fat yield were observed. Rectal temperatures were significantly higher in HT than MT (p<0.05). The apparent DM, OM, ether extract, CF, and ash digestibility did not differ between treatments. On the other hand, the apparent CP digestibility was increased significantly (p<0.05) and nitrogen free extract tended to increase (p<0.10) in HT. The sufficiency ratio of ME and DCP intake for each requirement tended to be lower in HT than in MT (p<0.10). Concentrations of total protein (TP), albumin, and urea nitrogen in plasma did not differ between treatments. Plasma 3-methylhistidine (3MH) concentration as a marker of myofibrillar protein degradation tended to be higher in HT (p<0.15). In conclusion, high ambient temperature was associated with a lower energy and protein sufficiency ratio, and decreased milk protein production, even though the body protein mobilization tended to be higher.
Otokozawa, Seiko,Tanaka, Ryoichi,Akasaka, Hiroshi,Ito, Eiki,Asakura, Sumiyo,Ohnishi, Hirofumi,Saito, Shigeyuki,Miura, Tetsuji,Saito, Tsuyoshi,Mori, Mitsuru Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.12
Background: The aim of this study was to examine the association of serum isoflavones, adiponectin, and insulin levels with ovarian cancer risk. Materials and Methods: We gathered cases with histologically confirmed epithelial ovarian cancer at Sapporo Medical University Hospital from October 2010 to September 2012. Potential controls were recruited from female inpatients without any history of cancer or diabetes mellitus in different wards of the same hospital over the same period of time. Serum isoflavones, adiponectin, and insulin levels were measured in order to estimate associations with ovarian cancer risk in a case-control study. Data from 71 cases and 80 controls were analyzed with a logistic regression model adjusting for known risk factors. Results: A significant reduction in ovarian cancer risk was observed for the high tertile of serum daidzein level versus the low ($P_{trend}<0.001$). A significant reduction in ovarian cancer risk was also observed for the high tertile of serum glycitein level versus the low ($P_{trend}=0.005$). Furthermore, a significant reduction in ovarian cancer risk was observed for the high tertile of serum adiponectin level versus the low ($P_{trend}=0.004$). Conversely, serum insulin level showed significantly elevated risk for ovarian cancer with the high tertile versus the low $P_{trend}<0.001$). Conclusions: Decreased serum isoflavones levels, such as those for daidzein and glycitein, decreased serum adiponectin levels, and increased serum insulin levels could be shown to be associated with elevated risk of ovarian cancer.
Permeability imaging in granitic rocks based on surface resistivity profiling
Sudo Hiroshi,Tanaka Toshikazu,Kobayashi Tsuyoshi,Kondo Tatsutoshi,Takahashi Toru,Miyamoto Masaharu,Amagai Mitsuru Korean Society of Earth and Exploration Geophysici 2004 지구물리와 물리탐사 Vol.7 No.1
In order to image the distribution of permeability in granitic rocks, we carried out two-dimensional (2D) resistivity profiling, together with in-situ permeability tests, electrical logging of boreholes, and resistivity measurements of rock core samples in a laboratory. Based on the electrical logging and in-situ permeability data from boreholes, we obtained empirical equations which relate resistivity and permeability of the granitic rocks in the area studied. We then applied the empirical equation to a 2D resistivity section, to produce a 2D permeability section of the granitic rocks. In this paper, we present details of the field data and of the procedure for conversion from the resistivity section to a permeability section. The observed relationship between resistivity and permeability of the rocks is also discussed.
Kawasaki, Yasuhiro,Saito, Mitsuru,Won, Jonghwa,Bae, Jin Young,Sato, Hajime,Toyoda, Hiroki,Kuramoto, Eriko,Kogo, Mikihiko,Tanaka, Takuma,Kaneko, Takeshi,Oh, Seog Bae,Bae, Yong Chul,Kang, Youngnam Frontiers Media S.A. 2018 Frontiers in cellular neuroscience Vol.12 No.-
<P>Glutamatergic dendritic EPSPs evoked in cortical pyramidal neurons are depressed by activation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels expressed in dendritic spines. This depression has been attributed to shunting effects of HCN current (<I>I</I><SUB>h</SUB>) on input resistance or <I>I</I><SUB>h</SUB> deactivation. Primary sensory neurons in the rat mesencephalic trigeminal nucleus (MTN) have the somata covered by spine-like microvilli that express HCN channels. In rat MTN neurons, we demonstrated that <I>I</I><SUB>h</SUB> enhancement apparently diminished the glutamate receptor (GluR) current (<I>I</I><SUB>GluR</SUB>) evoked by puff application of glutamate/AMPA and enhanced a transient outward current following <I>I</I><SUB>GluR</SUB> (OT-<I>I</I><SUB>GluR</SUB>). This suggests that some outward current opposes inward <I>I</I><SUB>GluR</SUB>. The <I>I</I><SUB>GluR</SUB> inhibition displayed a U-shaped voltage-dependence with a minimal inhibition around the resting membrane potential, suggesting that simple shunting effects or deactivation of <I>I</I><SUB>h</SUB> cannot explain the U-shaped voltage-dependence. Confocal imaging of Na<SUP>+</SUP> revealed that GluR activation caused an accumulation of Na<SUP>+</SUP> in the microvilli, which can cause a negative shift of the reversal potential for <I>I</I><SUB>h</SUB> (<I>E</I><SUB>h</SUB>). Taken together, it was suggested that <I>I</I><SUB>GluR</SUB> evoked in MTN neurons is opposed by a transient decrease or increase in standing inward or outward <I>I</I><SUB>h</SUB>, respectively, both of which can be caused by negative shifts of <I>E</I><SUB>h</SUB>, as consistent with the U-shaped voltage-dependence of the <I>I</I><SUB>GluR</SUB> inhibition and the OT-<I>I</I><SUB>GluR</SUB> generation. An electron-microscopic immunohistochemical study revealed the colocalization of HCN channels and glutamatergic synapses in microvilli of MTN neurons, which would provide a morphological basis for the functional interaction between HCN and GluR channels. Mathematical modeling eliminated the possibilities of the involvements of <I>I</I><SUB>h</SUB> deactivation and/or shunting effect and supported the negative shift of <I>E</I><SUB>h</SUB> which causes the U-shaped voltage-dependent inhibition of <I>I</I><SUB>GluR</SUB>.</P>
Usuda, Katsuo,Sagawa, Motoyasu,Motono, Nozomu,Ueno, Masakatsu,Tanaka, Makoto,Machida, Yuichiro,Matoba, Munetaka,Taniguchi, Mitsuru,Tonami, Hisao,Ueda, Yoshimichi,Sakuma, Tsutomu Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2
Background: The epidermal growth factor receptor (EGFR) mutation status of lung cancer is important because it means that EGFR-tyrosine kinase inhibitor treatment is indicated. The purpose of this prospective study is to determine whether EGFR mutation status could be identified with reference to preoperative factors. Materials and Methods: One hundred-forty eight patients with lung cancer (111 adenocarcinomas, 25 squamous cell carcinomas and 12 other cell types) were enrolled in this study. The EGFR mutation status of each lung cancer was analyzed postoperatively. Results: There were 58 patients with mutant EGFR lung cancers (mutant LC) and 90 patients with wild-type EGFR lung cancers (wild-type LC). There were significant differences in gender, smoking status, maximum tumor diameter in chest CT, type of tumor shadow, clinical stage between mutant LC and wild-type LC. EGFR mutations were detected only in adenocarcinomas. Maximum standardized uptake value (SUVmax:$3.66{\pm}4.53$) in positron emission tomography-computed tomography of mutant LC was significantly lower than that ($8.26{\pm}6.11$) of wild-type LC (p<0.0001). Concerning type of tumor shadow, the percentage of mutant LC was 85.7% (6/7) in lung cancers with pure ground glass opacity (GGO), 65.3%(32/49) in lung cancers with mixed GGO and 21.7%(20/92) in lung cancers with solid shadow (p<0.0001). For the results of discriminant analysis, type of tumor shadow (p=0.00036) was most significantly associated with mutant EGFR. Tumor histology (p=0.0028), smoking status (p=0.0051) and maximum diameter of tumor shadow in chest CT (p=0.047) were also significantly associated with mutant EGFR. The accuracy for evaluating EGFR mutation status by discriminant analysis was 77.0% (114/148). Conclusions: Mutant EGFR is significantly associated with lung cancer with pure or mixed GGO, adenocarcinoma, never-smoker, smaller tumor diameter in chest CT. Preoperatively, EGFR mutation status can be identified correctly in about 77 % of lung cancers.
Usuda, Katsuo,Sagawa, Motoyasu,Motono, Nozomu,Ueno, Masakatsu,Tanaka, Makoto,Machida, Yuichiro,Maeda, Sumiko,Matoba, Munetaka,Kuginuki, Yasuaki,Taniguchi, Mitsuru,Tonami, Hisao,Ueda, Yoshimichi,Sakuma Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.11
Background: Diffusion-weighted imaging (DWI) makes it possible to detect malignant tumors based on the diffusion of water molecules. However, it is uncertain whether DWI has advantages over FDG-PET for distinguishing malignant from benign pulmonary nodules and masses. Materials and Methods: One hundred-forty-three lung cancers, 17 metastatic lung tumors, and 29 benign pulmonary nodules and masses were assessed in this study. DWI and FDG-PET were performed. Results: The apparent diffusion coefficient (ADC) value ($1.27{\pm}0.35{\times}10^{-3}mm^2/sec$) of malignant pulmonary nodules and masses was significantly lower than that ($1.66{\pm}0.58{\times}10^{-3}mm^2/sec$) of benign pulmonary nodules and masses. The maximum standardized uptake value (SUVmax: $7.47{\pm}6.10$) of malignant pulmonary nodules and masses were also significantly higher than that ($3.89{\pm}4.04$) of benign nodules and masses. By using optimal cutoff values for ADC ($1.44{\times}10^{-3}mm^2/sec$) and for SUVmax (3.43), which were determined with receiver operating characteristics curves (ROC curves), the sensitivity (80.0%) of DWI was significantly higher than that (70.0%) of FDG-PET. The specificity (65.5%) of DWI was equal to that (65.5%) of FDG-PET. The accuracy (77.8%) of DWI was not significantly higher than that (69.3%) of FDG-PET for pulmonary nodules and masses. As the percentage of bronchioloalveolar carcinoma (BAC) component in adenocarcinoma increased, the sensitivity of FDG-PET decreased. DWI could not help in the diagnosis of mucinous adenocarcinomas as malignant, and FDG-PET could help in the correct diagnosis of 5 out of 6 mucinous adenocarcinomas as malignant. Conclusions: DWI has higher potential than PET in assessing pulmonary nodules and masses. Both diagnostic approaches have their specific strengths and weaknesses which are determined by the underlying pathology of pulmonary nodules and masses.