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SERS-based genetic assay for amplification-free detection of prostate cancer specific PCA3 mimic DNA
Yu, Jimin,Jeon, Jinhyeok,Choi, Namhyun,Lee, Jin Oh,Kim, Young-Pil,Choo, Jaebum Elsevier 2017 Sensors and actuators. B, Chemical Vol.251 No.-
<P><B>Abstract</B></P> <P>We report the development of amplification-free surface-enhanced Raman scattering (SERS)-based DNA assays for the rapid and highly sensitive detection of prostate cancer antigen 3 (PCA3) mimic DNA. This technique does not require any DNA amplification process using thermo-cycles in conventional polymerase chain reaction (PCR) due to its highly sensitive detection capability. Herein, the PCA3 mimic DNA, composed of 45 nucleotide sequences, was sandwiched between two probe DNA-immobilized particles (ASO<SUB>735</SUB>-conjugated detection HGNs and ASO<SUB>683</SUB>-immobilized capture magnetic beads) by hybridization reactions. Its quantitative analysis was performed by monitoring the characteristic Raman peak intensity of sandwich DNA complexes. The limit of detection (LOD) is estimated to be 2.7fM, which is about four orders of magnitude more sensitive than that of conventional PCR. This SERS-based DNA assay technique is expected to be a potentially useful tool for early disease diagnosis.</P> <P><B>Highlights</B></P> <P> <UL> <LI> We developed a SERS-based biosensor for the highly sensitive detection of PCA3 mimic DNA. </LI> <LI> DNA amplification process is not required for this SERS-based assay platform. </LI> <LI> This method has strong potential to be a tool for early genetic disease diagnosis. </LI> </UL> </P>
Image Denoising Based on Adaptive Fractional Order Anisotropic Diffusion
( Jimin Yu ),( Lijian Tan ),( Shangbo Zhou ),( Liping Wang ),( Chaomei Wang ) 한국인터넷정보학회 2017 KSII Transactions on Internet and Information Syst Vol.11 No.1
Recently, the method based on fractional order partial differential equation has been used in image processing. Usually, the optional order of fractional differentiation is determined by a lot of experiments. In this paper, a denoising model is proposed based on adaptive fractional order anisotropic diffusion. In the proposed model, the complexity of the local image texture is reflected by the local variance, and the order of the fractional differentiation is determined adaptively. In the process of the adaptive fractional order model, the discrete Fourier transform is applied to compute the fractional order difference as well as the dynamic evolution process. Experimental results show that the peak signal-to-noise ratio (PSNR) and structural similarity index measurement (SSIM) of the proposed image denoising algorithm is better than that of other some algorithms. The proposed algorithm not only can keep the detailed image information and edge information, but also obtain a good visual effect.
Yu, Subeen,Cho, Eunjeong,Kim, Jimin,Lee, Sunwoo American Chemical Society etc. 2017 Journal of organic chemistry Vol.82 No.20
<P>A palladium-catalyzed decarboxylative coupling reaction was developed for the synthesis of 3-(1-alkynyl)-2-cyclohexen-1-ones. A variety of alkynyl carboxylic acids were coupled with 3-oxocyclohexenyl tosylates to afford the corresponding enynones in good to excellent yields. The developed catalytic system is phosphine free and showed good tolerance toward various functionalities such as chloride, cyano, nitro, ester, aldehyde, and alcohol groups. In addition, phenylpropiolic acid exhibited higher reactivity in the reaction with alkenyl toslyate than phenyl acetylene.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/joceah/2017/joceah.2017.82.issue-20/acs.joc.7b02175/production/images/medium/jo-2017-02175d_0009.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jo7b02175'>ACS Electronic Supporting Info</A></P>
조유경,김미연,강지민,전영준,박철종 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.11
Dermatofibrosarcoma protuberans(DFSP) is an unusual, locally aggressive, cutaneous neoplasm of low grade malignancy. Several histologic variants have been described. Among them, fibrosar-comatous dermatofibrosarcorna protuberans is associated with a higher rate of local recurrence and distal metastases as well as a shorter latency period of time until recurrence than does ordinary DFSP. As a result, it needs more intense treatments and more vigorous follow up. A 37-year-old man presented with an asymptomatic erythematous hard nodule and several reddish papules on the chest for 2 years. Histopathologic examination revealed fibrosarcomatous dermatofibrosarcoma protuberans. We, herein, report an unusual case of fibrosarcomatous dermatofibrosarcoma protuberans. (Korean J Derrnatol 2003;41(11) : 1560-1563)