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A 4th-Order Wideband Sigma Delta Modulator Using Linear System Theory Technique
Ming-yuan Ren,Yong-sheng Zhang,Wei-kun Wu,Zhen-xi Bao,Zi-wei Zhao,Chao Li,Hong-guo Zhang 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.1
A 4th-Order Wideband Sigma Delta modulator structure is proposed in this paper, which uses linear system theory technique. There are many implementation techniques to improve the performance of Sigma Delta ADCs, such as noise coupling, differential sampling and dynamic elements matching. An extra loop delay is needed to be added in the system. This paper explains how to make the modulator stable with the addition of feed-forward and feed-back branches which are used to compensate the extra loop delay. Next, we restore the signal and noise transfer functions. A 4th-Order Wideband delta-sigma modulator have been designed and simulated to verify the method.
( Yuan Qing Hu ),( Jin Lin Huang ),( Qiu Chun Li ),( Yu Wei Shang ),( Fang Zhe Ren ),( Yang Jiao ),( Zhi Cheng Liu ),( Zhi Ming Pan ),( Xin An Jiao ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.3
Campylobacter jejuni is a prevalent foodborne pathogen worldwide. Human infection by C. jejuni primarily arises from contaminated poultry meats. Genes expressed in vivo may play an important role in the pathogenicity of C. jejuni. We applied an immunoscreening method, in vivo-induced antigen technology (IVIAT), to identify in vivo-induced genes during human infection by C. jejuni. An inducible expression library of genomic proteins was constructed from sequenced C. jejuni NCTC 11168 and was then screened using adsorbed, pooled human sera obtained from clinical patients. We successfully identified 24 unique genes expressed in vivo. These genes were implicated in metabolism, molecular biosynthesis, genetic information processing, transport, and other processes. We selected six genes with different functions to compare their expression levels in vivo and in vitro using real-time RT-PCR. The results showed that the selected six genes were significantly upregulated in vivo but not in vitro. In short, these identified in vivo-induced genes may contribute to human infection of C. jejuni, some of which may be meaningful vaccine candidate antigens or diagnosis serologic markers for campylobacteriosis. IVIAT may present a significant and efficient method for understanding the pathogenicity mechanism of Campylobacter and for finding targets for its prevention and control.
Yi-Ming Ren,Xin Zhao,Tao Yang,Yuan-Hui Duan,Yun-Bo Sun,Wen-Jun Zhao,Meng-Qiang Tian 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.6
Purpose: To compare differentially expressed genes (DEGs) mediating osteoarthritis (OA) in knee cartilage and in normal kneecartilage in a rat model of OA and to identify their impact on molecular pathways associated with OA. Materials and Methods: A gene expression profile was downloaded from the Gene Expression Omnibus database. Analysis ofDEGs was carried out using GEO2R. Enrichment analyses were performed on the Gene Ontology (GO) and Kyoto Encyclopedia ofGenes and Genomes pathway using the Search Tool for the Retrieval of Interacting Genes database (http://www.string-db.org/). Subsequently, the regulatory interaction network of OA-associated genes was visualized using Cytoscape software (version 3.4.0;www.cytoscape.org). Results: In the gene expression profile GSE103416, a total of 99 DEGs were identified. Among them, 76 DEGs (76.77%) were overexpressed,and the remaining 23 DEGs (23.23%) were underexpressed. GO and pathway enrichment analyses of target geneswere performed. Using gene-gene interaction network analysis, relevant core genes, including MET, UBB, GNAI3, and GNA13,were shown to hold a potential relationship with the development of OA in cartilage. Using quantitative real-time PCR, the Gna13/cGMP-PKG signaling pathway was identified as a potential research target for therapy and for further understanding the developmentof OA. Conclusion: The results of the present study provide a comprehensive understanding of the roles of DEGs in knee cartilage in relationto the development of OA.
Experimental and Clinical Study of Korea Red Ginseng Treatment on Hypertension
(En Yuan Jin),(Ming Jin),(Yu Lin Wei),(Lin Hun Huang),(Xiao Ping Yan),(Zai Xiang Shi),(Li Huang),(De Chu Shen),(Ren Jie Fu),(Tian Yu Zhao),(Ki Yeul Kam),(Akira Kumagai) 고려인삼학회 1998 Advances in Ginseng Research - Proceedings of the Vol.- No.-
Test Method for Determination of Optimum Moisture Content of Soil and Maximum Dry Density
Xiao-Chuan Ren,Yuan-Ming Lai,Fan-Yu Zhang,Kai Hu 대한토목학회 2015 KSCE Journal of Civil Engineering Vol.19 No.7
A method for accurately determining the optimum water content of soil and the corresponding maximum dry density has been developed using a small number of soil samples, based on the physical parameters of the confined compression modulus of soil. The peak value of the compression modulus on the force-compression modulus curve is used to determine the optimum moisture content and maximum dry density. The proposed method is validated using four different types of soils: Qinghai-Tibet clay, SiO2-clay, Lanzhou loess, and Qinghai-Tibet sand soil. The results show that as opposed to conventional compaction methods, the new method allows for accurate determination of the optimum water content and the maximum dry density for various types of soil. Additionally, for certain moisture contents, when the compaction of soil is the greatest, clay and SiO2-clay attain the theoretical saturation status, whereas sand soil and loess do not.
Correspondence analysis for studying association between geography and cancer
송준진,Pingjian Yu,Yuan Ren,Ming-Hua Chung 한국데이터정보과학회 2009 한국데이터정보과학회지 Vol.20 No.5
Geographical location carries information such as demography, local economy, environment, and life styles, which could be the sources of cancer occurrence. Analyzing geographical location associated with cancer occurrence can be instructive to physicians, patients, and health administrators regarding resource allocation, expenditures, prophylaxis and treatments. In this paper, we explored the correspondence relationship between geographical locations and mortality rates of the cancers using correspondence analysis and illustrated the approach with the mortality rates of the top 10 cancers in the 75 counties in Arkansas from 2001 to 2005. Geographical variations with respect to the mortality rates of cancers are evaluated across Arkansas counties. Based on the contingency table, correspondence analysis model is developed and the simple indices which indicate the degree to which the regions and the cancers affect each other are calculated. Quantitative results are visualized and mapped in two-dimensional graphs.
Endophytic Fungal strains Specifically Modified the Biochemical Status of Grape Cells
Li-Hua Huang,Ming-Zhi Yang,Xiu-Jin Ao,An-Yun Ren,Ming-Quan Yuan,Han-Bo Zhang 한국식물학회 2018 Journal of Plant Biology Vol.61 No.4
Previously, specific interactions in morphologywere observed between grape cells and endophytic fungalstrains during a dual culture experiment. However, thebiochemical impacts of these fungal endophytes on grapecells is also expected due to their potential application in grapequality management. After assessed multiple physiochemicaltraits to those grape cells which have co-cultured with differentendophytic fungal strains in this study, and found the presenceof fungal endophytes obviously triggered ROS stress responsesin grape cells, and the biochemical status in grape cells weredifferentially modified by different fungal strains. In thosetested endophytic fungal strains, RH37 (Epicoccum sp.),RH6 (Alternaria sp.), RH32 (Alternaria sp.) and RH34(Trichothecium sp.) conferred greater metabolic impacts ongrape cells. And soluble protein (SPr), total flavonoids (TF),total phenols (TPh) and malondialdehyde (MDA) on the otherhand, were sensitive biochemical parameters which can beinfluenced in greater ranges than other detected parameters. Most interestedly, fungal endophytes shaped metabolitespatterns in grape cells during the dual culture appeared fungalgenus/species/strain-specificity. The work confirmed thesignificance of fungal endophytes in grape metabolic regulationand elucidated the possibility to purposely manage grapequality using tool of fungal endophytes.
Song, Hai-Yan,Deng, Xiao-Hui,Yuan, Guo-Yan,Hou, Xin-Fang,Zhu, Zhen-Dong,Zhou, Li,Ren, Ming-Xin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3
Aim: To investigate the mechanisms of induction of apoptosis of esophageal cancer cells by esophageal cancer-related gene 2 (ECRG2) in combination with cisplatin (DDP). Methods: Hoechest staining was performed to analyze the effects of single ECRG2 and ECRG2 in combination with DDP on apoptosis of EC9706 cells. The expression levels of p53 and bcl-2 mRNA and protein were determined by RT-PCR and Western blotting, respectively. Results: The number of apoptotic cells after the treatment with ECRG2 in combination with DDP for 24 hours was more than that after the treatment with single ECRG2. RT-PCR and Western blotting showed that the expression levels of bcl-2 mRNA and protein were both down-regulated, while p53 mRNA and protein were both up-regulated in the cells treated with ECRG2 in combination with DDP compared with those given ECRG2 alone. Conclusion: ECRG2 in combination with DDP can enhance the apoptosis of EC9706 cells, possibly by down-regulating bcl-2 expression and up-regulating p53.