IMPACTS OF SHELLFISH CULTURE ON THE ECOSYSTEM IN SEMI-ENCLOSED BAYS

Ming Yuan Zhu,Ru Bao Ji,Shang Chen,Xue Lei Zhang 한국해안해양공학회 1999 학술강연회 발표논문초록집 Vol.1 No.1

Stimulated by high economic profits, the industries of shellfish culture have grown rapidly during the last two decades. The expansion of mariculture adds pressure on the environment and associated ecosystem. The potential impacts of the cultivation include reduction of primary productivity due to the consumption of large quantities of phytoplankton, changes of water current movement resulted from the semi-permeation 'Island' effects of the suspended culture, and production of a large amount of faeces and pseudofaeces which may enhance the importance of benthic ecosystem in geo-biological cycling.

Reliability Evaluation of Key Hydraulic Components for Actuators of FAST Based on Small Sample Test

Ming Zhu,Jingyi Zhao,Qiming Wang 한국정밀공학회 2017 International Journal of Precision Engineering and Vol.18 No.11

The five-hundred meter aperture spherical radio telescope (FAST) is China’s major science and technology infrastructure project. Upon completion, this telescope will be considered the largest single-dish radio telescope in the world. As main active mechanism of FAST, 2225 hydraulic actuators are used for adjusting the reflectors. The reliability of hydraulic actuators is the most critical matter. This paper applies the reliability theory and reliability test method into large project for the first time. Firstly, a parallel energy-saving method and equipment to test the two components of the actuators for FAST are designed. Secondly, reliability model based on small sample test is used to perform the best linear unbiased estimation of the test data. Average impact lifetime of the sampled gear pump and the sampled relief valve in their working condition are calculated. Finally, the results show that the lifetime request of the sampled gear pump and the sampled relief valve for hydraulic actuator of FAST are satisfied. The research method has guiding significance to the reliability study of key hydraulic components for similar hydraulic systems.

HMGB1 regulates autophagy through increasing transcriptional activities of JNK and ERK in human myeloid Leukemia cells

( Ming Yi Zhao ),( Ming Hua Yang ),( Liang Chun Yang ),( Yan Yu ),( Min Xie ),( Shan Zhu ),( Rui Kang ),( Dao Lin Tang ),( Zhi Gang Jiang ),( Wu Zhou Yuan ),( Xiu Shan Wu ),( Li Zhi Cao ) 생화학분자생물학회(구 한국생화학분자생물학회) 2011 BMB Reports Vol.44 No.9

HMGB1 is associated with human cancers and is an activator of autophagy which mediates chemotherapy resistance. We here show that the mRNA levels of HMGB1 are high in leukemia cells and it is involved in the progression of childhood chronic myeloid leukemia (CML). HMGB1 decreases the sensitivity of human myeloid leukemia cells K562 to anti-cancer drug induced death through up-regulating the autophagy pathway, which is confirmed by the observation with an increase in fusion of autophagosomes and autophagolysosomes. When overexpressing HMGB1, both mRNA levels of Beclin-1, VSP34 and UVRAG which are key genes involved in mammalian autophagy and protein levels of p-Bcl-2 and LC3-II are increased. Luciferase assays document that over-expression of HMGB1 increases the transcriptional activity of JNK and ERK, which may be silenced by siRNA. The results suggest that HMGB1 regulates JNK and ERK required for autophagy, which provides a potential drug target for therapeutic interventions in childhood CML. [BMB reports 2011; 44(9): 601-606]

Effects of Lactobacillus salivarius Ren on cancer prevention and intestinal microbiota in 1, 2-dimethylhydrazine-induced rat model

Ming Zhang,Xing Fan,Bing Fang,Chengzhen Zhu,Jun Zhu,Fazheng Ren 한국미생물학회 2015 The journal of microbiology Vol.53 No.6

Probiotics have been suggested as a prophylactic measure in colon cancer. The aim of this study was to investigate the impact of Lactobacillus salivarius Ren (Ren) in modulating colonic microbiota structure and colon cancer incidence in a rat model after injection with 1,2-dimethyl hydrazine (DMH). The results indicated that oral administration of Ren could effectively suppress DMH-induced colonic carcinogenesis. A significant decrease in cancer incidence (87.5% to 25%) was detected in rats fed with a dose of 5 × 1010 CFU/kg bodyweight per day. Using denaturing gradient gel electrophoresis and Real-time PCR combined with multivariate statistical methods, we demonstrated that injection with DMH significantly altered the rat gut microbiota, while Ren counteracted these DMH-induced adverse effects and promoted reversion of the gut microbiota close to the healthy state. Tvalue biplots followed by band sequencing identified 21 bacterial strains as critical variables affected by DMH and Ren. Injection of DMH significantly increased the amount of Ruminococcus species (sp.) and Clostridiales bacteria, as well as decreasing the Prevotella sp. Administration of Ren reduced the amount of Ruminococcus sp., Clostridiales bacteria, and Bacteroides dorei, and increased the amount of Prevotella. Real-time PCR results were consistent with the results derived by t-value biplots. These findings suggested that Ren is a potential agent for colon cancer prevention. In conclusion, the results in the present study suggest a potential therapeutic approach based on the modulation of intestinal microflora by probiotics may be beneficial in the prevention of colorectal carcinogenesis.

Research on Flame Retardant Formaldehyde-Free Plywood Glued by Aqueous Polymer Isocyanate Adhesive

( Ming-yu Wen ),( Jia-zhi Zhu ),( Meng Zhu ),( Yao-xing Sun ),( Hee-jun Park ),( Junyou Shi ) 한국목재공학회 2020 목재공학 Vol.48 No.5

Due to pronounced mechanical performance and being environmental friendly, aqueous polymer isocyanate adhesive (API) has been widely applied in the production of formaldehyde-free wood products. In this study, flame retardant formaldehyde-free plywood was prepared by incorporation of flame retardants into the API adhesive. Partially phosphorylated poly (vinyl alcohol) (PPVA) which was prepared by reacting poly (vinyl alcohol) with phosphoric acid was used to replace PVA in API formula. In addition, Mg-Al layered double hydroxides (LDH) was chosen as additive flame retardant, replacing traditional filler CaCO₃ in API adhesive formula. And then, the flame retardant API adhesive with main agent (PPVA replacing PVA70wt.%, SBR emulsion 30wt.%), curing agent 10wt.% (accounts for of the main agent), and 20wt.% LDHs (accounts of the main agent) was used to prepare flame retardant plywood. The effect of application of PPVA and Mg-Al LDH on bonding strength of plywood was investigated. The flammability characteristics of the plywood were determined by cone calorimeter test (CCT). The results revealed that compared with the plywood prepared with API adhesive, the use of PPVA and LDH enhanced the flame retardancy of plywood without negatively affecting bonding strength. The CCT tests indicated that the heat release and smoke production flame retardant API plywood were lower than those of the ordinary API glued plywood. Promising developments for flame retardant API adhesive were expected in future applications of flame retardant formaldehyde-free plywood.

Two Species of Spiders of the genus Trachelas (Araneae: Corinnidae) from China

Ming-Shing Zhu(주명생),Da-Xing Song(송대상),Joo-Pil Kim(김주필) 한국동물분류학회 1998 Animal Systematics, Evolution and Diversity Vol.14 No.4

Sex-related Differences in DNA Copy Number Alterations in Hepatitis B Virus-Associated Hepatocellular Carcinoma

Zhu, Zhong-Zheng,Wang, Dong,Cong, Wen-Ming,Jiang, Hongmei,Yu, Yue,Wen, Bing-Ji,Dong, Hui,Zhang, Xiao,Liu, Shu-Fang,Wang, Ai-Zhong,Zhu, Guanshan,Hou, Lifang Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1

Background: Males have a higher prevalence of hepatocellular carcinoma (HCC) than females in general, but the reasons for the sex disparity are still obscure. DNA copy number alteration (CNA) is a major feature of solid tumors including HCC, but whether CNA plays a role in sex-related differences in HCC development has never been evaluated. Methods: High-resolution array comparative genomic hybridization (CGH) was used to examine 17 female and 46 male HCC patients with chronic hepatitis B virus (HBV) infection in Shanghai, China. Two-tailed Fisher's exact or ${\chi}^2$ tests was used to compare CNAs between females and males. Results: The overall frequencies and patterns of CNAs in female and male cases were similar. However, female HCC tumors presented more copy number gains compared to those in males on 1q21.3-q22 (76.5% vs. 37.0%, P = 0.009), 11q11 (35.3% vs. 0.0%, P = 0.0002) and 19q13.31-q13.32 (23.5% vs. 0.0%, P = 0.004), and loss on 16p11.2 (35.3% vs. 6.5%, P = 0.009). Relative to females, male cases had greater copy number loss on 11q11 (63.0% vs. 17.6%, P = 0.002). Further analyses showed that 11q11 gain correlated with 19q13.31-q13.32 gain (P = 0.042), 11q11 loss (P = 0.011) and 16p11.2 loss (P = 0.033), while 1q21.3-q22 gain correlated with 19q13.31-q13.32 gain (P = 0.046). Conclusions: These findings suggest that CNAs may play a role in sex-related differences in HBVassociated HCC development.

MOLECULAR MODEL BUILDING USING KNOWLEDGE BASE

Ming, Ai Zhu,Yu, Wei 대한전자공학회 1992 HICEC:Harbin International Conference on Electroni Vol.1 No.1

The approach for building 3-D molecular models automatically using a knowledge base has been proposed in this paper. The approach predicts molecular fragmental structure using artificial intelligence, and it has no restriction as that in templet methods. The results are accurate enough to be used in computer-aided molecular design. The knowledge base can be set up either from crystal database or experimental data.

In vitro Study of the Carotenoid-cleavage Enzyme from Staphylococcus pasteuri TS-82 Revealed Substrate Specificities and Generation of Norisoprenoid Flavors

Ming-Ming Zhu,Shu-Lin Wang,Ming-Tao Fan,Jing Li 한국식품과학회 2016 Food Science and Biotechnology Vol.25 No.1

Reactions of a crude enzyme extracted from S. pasteuri TS-82 to cleave carbon-carbon bonds in bicyclic and monocyclic carotenoid substrates were investigated. Dependencies of enzyme activities on processing temperature and pH were investigated and non-volatile and volatile breakdown products were characterized. The crude enzyme showed a maximum activity with zeaxanthin, followed in decreasing order by β-carotene, canthaxanthin, astaxanthin, and β-apo-8'- carotenal. The optimum pH value of the enzyme was 3.0 for both bicyclic and monocyclic substrates, whereas the optimum temperature of the enzyme was substrate specific at 60oC for C40 carotenoids and 50oC for β-apo-8'-carotenal. Liquid Chromatography-Mass Spectra (LC-MS) and Gas Chromatography- Mass Spectra (GC-MS) indicated that the crude enzyme was able to catalyze substrates with cleavage at 9-10 and 9'-10' double bonds with C13 norisoprenoids being the main volatile reaction products in each case. Astaxanthin is a major source for α,β-dihydro-β-ionone.

20, 30대 중국 소비자의 생명보험 가입 의도 -국가에 대한 인식 및 집단주의 성향에 따른 유형별 특성과 코로나19 불안의 조절 효과-

Ming-Yi Zhu,천혜정 한중사회과학학회 2023 한중사회과학연구 Vol.21 No.2

The purpose of this study is to categorize Chinese consumers in their 20s and 30s according to their perception of the state and their collectivism tendency, and to empirically analyze how perception of the state, collectivism tendency, attitudes toward insurance, and preparation for old age affect insurance purchasing intention. In addition, it also analyzes the moderating effect of anxiety caused by covid-19. To this end, an online survey was conducted on Chinese consumers in their 20s and 30s living in Shanghai, China, and a total of 500 questionnaires were used for analysis. The main findings are as follows. First, according to the perception of the state and the tendency of collectivism, Chinese consumers in their 20s and 30s were categorized into three groups. Specifically, the three groups are “individualist critics” who are negative and critical of the state and have the lowest collectivism tendency, “moderate neutrals” who have a moderate attitude toward the state and collectivitism, and “collectivist optimists” who are positive and optimistic about the state and have the highest collectivism tendency. Second, there were no significant demographic differences among the three groups, but significant differences were found in the attitude toward insurance, the degree of preparation for old age, and the level of anxiety about covid-19. Third, attitude toward insurance, perception of the state, and collectivism tendency were found to affect the insurance purchasing intention among 3 groups, respectively, and covid-19 anxiety has a moderating effect to attitude toward insurance, perception of the state, and collectivism tendency for each group. Based on these results, the relationship between covid-19 anxiety and insurance purchasing intention was discussed in various ways along with diversity within the Chinese consumers in their 20s and 30s. 본 연구의 목적은 국가에 대한 인식 및 집단주의 성향에 따라 20, 30대 중국 소비자를 유형화하고 집단별 보험 가입 의도에 영향을 미치는 요인을 실증적으로 살펴보고, 이 과정에서 코로나19로 인한 불안이 어떠한 조절 효과를 가지는지 분석하는 것이다. 이를 위해 중국 상하이시에 거주하는 20, 30대 중국 소비자를 대상으로 온라인 설문조사를 실시했으며 총 500부의 자료를 분석에 활용했다. 주요 연구 결과는 다음과 같다. 첫째, 국가에 대한 인식 및 집단주의 성향에 따라 20, 30대 중국 소비자를 유형화한결과 3개의 집단으로 분류되었다. 구체적으로 이 세 집단은 국가에 대해 부정적이고비판적인 태도를 가지면서 집단주의 성향도 가장 낮은 “개인주의적 비판론자”, 국가에대해 중도적인 온건한 태도를 가지면서 집단주의 성향도 중간 정도 수준을 보이는 “온건한 중립자”, 그리고 국가에 대해 긍정적이고 낙관적인 태도를 가지면서 집단주의 성향도 가장 높은 “집단주의적 낙관론자”이다. 둘째, 세 집단간 유의미한 인구통계학적차이는 나타나지 않았지만, 보험에 대한 태도, 노후 준비 정도, 그리고 코로나19 불안수준에서는 유의미한 차이가 나타났다. 셋째, 집단별 보험 가입 의도에 영향을 미치는요인과 이 과정에서 코로나19 불안의 조절 효과를 분석한 결과, 개인주의적 회의론자집단은 보험에 대한 태도, 온건한 중립자 집단은 국가에 대한 인식, 그리고 집단주의적 낙관론자는 집단주의 성향이 유의미한 요인으로 확인되었으며 각각의 독립변수와코로나19 불안과의 상호작용 또한 유의미한 것으로 나타났다. 이러한 결과를 바탕으로20, 30대 중국 소비자 집단 내부의 다양성과 함께 코로나19 불안과 보험 가입 의도와의 관계를 다각적으로 논의하였다.