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이트리아 첨가 붕규산염 유리로 제조한 알루미나-유리 복합체의 강도 평가
채민수,배태성,이주형,원대희,진영철 대한치과기재학회 1998 대한치과재료학회지 Vol.25 No.1
This study was performed to investigate the strength of dental alumina-glass composites. Four different brosilicacte glasses containing 1, 3, 6, 9 mol% Y₂O³ were prepared. Alumina compacts were prepared by pressing 150㎏/㎠ and sintering at 1100℃ for 2 hours. Dense composites were made by infiltrating partially sintered alumina with at 1200℃ for 6 hours. The obtained results were summarized as follows: 1. With increasing the amount of Y₂O₃ the peak of exothermic heat and softening point were shifted to the higher temperature. 2. Borosilicate glasses showed the coefficient of thermal expansion in the range of 6.36 to 6.56×10-6/℃. 3. The maximum biaxial strength of 385.7±34.4MPa was obtained with an addition of 6mol% Y₂O₃. 4. The observation of fracture surfaces showed the crack deflection and crack bridging and that appeared to be the principal strengthening mechanism in the alumina-glass composites.
GPS를 이용한 2차로 고속도로에서의 추월시거 산정방법에 관한 연구
임채문,김정민,박영환,이주호 大邱大學校 科學技術硏究所 2001 科學技術硏究 Vol.8 No.2
This study applied GPS(global positioning system) into the field of traffic and transportation, measured overtaking mechanism at two lane highway. After the analysis of the collected data from the measurement, it was constructed passing sight model which is based on AASHTO(american association of state highway and transportation officials) model and; as the result, passing sight distance was computed. To accomplish this goal, speed and position information for leading and following vehicles were recorded under actual highway conditions. Each vehicle's distance, speed, and acceleration characteristics were calcuated using the passing algorithm equations proposes. The computed value of acceleration was 1.37m/sec2. This value was twice as large as the value calculated earlier(0.6m/sec2). This study proposed 326m as passing sight distance at maximum speed(80km/hr) in 88 Olympic highway.
광중합형 수복용 복합레진의 인장강도에 미치는 thermal cycling과 시효 처리의 영향
백상현,채민수,이주형,김태조,배태성 대한치과기재학회 1998 대한치과재료학회지 Vol.25 No.1
The improvement in the mechanical properties of restorative composites has contributed to their increased use in recent years. In spite of their growing popularity, composites still have low resistance to fracture and wear in oral environments. This study was performed to examine whether the tensile strengths of light-cured restorative composites were affected by thermal cycling and aging in water. Five commerically available light-activated composites(Heliomolar : HM, Aelitefil : AF, Amelogen : AG, Clearfil AP-X : CF, Z100 : ZH) were used. Rectangular tension test specimens were fabricated in a teflon mold giving 5 mm in gauge length and 2mm in thickness. All samples were divided into 3 groups. Group 1 was stored in a desiccator for 10 days. Group 2 was immersed in a 37℃ distilled water for 10 days. Group 3 was subjected to 10,000 thermal cycles between 5℃ and 55℃, and the immersion time in each bath was 15 seconds per cycle. Tensile testing was carried out at a crosshead speed of 0.5 mm/min and fracture surfaces were observed with scanning electron microscope. The results obtained were summarized as follows; 1. The strength data fit to single-mode Weibull distribution(r²> 0.86) and Weibull parameters decreased after thermal cycling test. 2. The highest characteristics strength was observed in the CF group but the highest Weibull modulus was obtained in the AF group after thermal cycling test. 3. The highest tensile strength value of 83.92 MPa was obtained in the CF group and the lowest value of 13.91 MPa was obtained in the AG group. Tensile strengths showed no significant difference between HM and AG groups but other groups showed the significant differences in each group(p<0.05). 4. According to the microscopic observation of the fracture surfaces, fractures of large fillers were observed in the hybrid composites of the AF and CF groups.
이온교환법에 의한 탈질소공정개발의 기초연구 : 회분식 실험 Batch Experiment
이동환,채용곤,김장일,윤태경,주창식,이민규 동의대학교 기초과학연구소 1998 基礎科學硏究論文集 Vol.8 No.1
Ion exchange performance to remove nitrate in water was studied using commercially available strong base anion exchange resin of Cl^- type in the batch reactors. Anion exchange resin was more effective than activated carbon or zeolite. With large resin amount or high temperature or low initial concentration, nitrate removal characteristics for a typical gel-type resin was increased. The curves showed the generally accepted selectivity sequence as SO₄^2-$gt;NO₃^-$gt;NO₂^-$gt;HCO₃^-.
상피종양의 keratin 생성능에 대한 전자현미경적 연구
이길선,이명주,장정수,이민전,노광을,서재홍 朝鮮大學校 附設 醫學硏究所 1993 The Medical Journal of Chosun University Vol.18 No.1
Keratins are characteristically present in all keratinizing and nonkeratinizing epithelial cells and their neoplasms. They consist of at least 19 different polypeptides ranging from 40 to 69 kilodaltons, which are developmentally related to specific epithelial cell types. Keratins of high and intermediate molecular weights are readily demonstrated in squamous cell carcinomas, which are characteristically rich in tonofilaments and tonofilament-desmosome complexes. Keratins of low molecular weights are expressed in adenocarcinoma including renal cell carinoma, hepatocellular carcinoma, small cell carcinoma, and carcinoid tumor. These tumors do not reveal any tonofilaments and sacrcely show discrete filaments on electron microscopy. An immunoperoxidase technique employing antibody to keratin was used to study distribution and staining pattern of keratin filaments in benign and malignant epithelial tumors (20 squamous cell carcinomas, 20 gastric adenocarcinomas, 20 transitional cell carcinomas and 15 non-neoplastic epithelia). These immunohistochemical results were compared with ultrastructural features of neoplastic diagnosis of squamous cell carcinoma, adenocarcinoma and transitional cell carcinoma, and estimation of degree of differentiation. The results are as follows : 1. The squamous epithelium, glandular epithelium and transitional epithelium disclosed the positive reaction for keratin. 2. Squamous cell carcinoma and transitional cell carcinoma exhibited positive reaction for keratin. 3. Gastric adenocarcinoma showed uniformly negative or weakly positive reaction for keratin. 4. On electron microscopy, heavy bundles of tonofilaments and desmosomes were more frequently encountered in well differentiated squamous cell carcinoma, In poorly differentiated squamous cell carcinoma, a few tonofibrils and desmosome were noted. 5. In the adenocarcinomas, the intermediate filaments were arranged randomly as nonaggregated, short filaments spread throughout the cytoplasm, although occasionally they formed a perinuclear whorl. These filaments did not become aggregated to form tonofilaments. 6. On the immunogold labeling for keratin of low molecular weight areas in gastric adenocinoma, in tense labeling of intermediate filaments for keratin was noted. From the above result, ultrastructural and immunohistochemical study on malignant epithelial cell were useful in differential diagnosis of squamous cell carcinoma, adenocarcinoma and transitional cell carcinoma, and estimation of degree of differentiation. It was also proved that immunogold labeling technique was especially valuable for diagnosis of vague case which showed negative or weakly positive reaction in immunohistochemical stain.
Chemical inhibitors destabilize HuR binding to the AU-rich element of TNF-α mRNA
Min-Ju Chae,Hye Youn Sung,Eun-Hye Kim,Mira Lee,Hojoong Kwak,Chong Hak Chae,Sunwoo Kim,Woong-Yang Park 생화학분자생물학회 2009 Experimental and molecular medicine Vol.41 No.11
Hu protein R (HuR) binds to the AU-rich element (ARE) in the 3'UTR to stabilize TNF-α mRNA. Here, we identified chemical inhibitors of the interaction between HuR and the ARE of TNF-α mRNA using RNA electrophoretic mobility gel shift assay (EMSA) and filter binding assay. Of 179 chemicals screened, we identified three with a half-maximal inhibitory concentration (IC50) below 10 μM. The IC50 of quercetin, b-40, and b-41 were 1.4, 0.38, and 6.21 μM, respectively, for binding of HuR protein to TNF-α mRNA. Quercetin and b-40 did not inhibit binding of tristetraprolin to the ARE of TNF-α mRNA. When LPS-treated RAW264.7 cells were treated with quercetin and b-40, we observed decreased stability of TNF-α mRNA and decreased levels of secreted TNF-α. From these results, we could find inhibitors for the TNF-α mRNA stability, which might be used advantageously for both the study for post-transcriptional regulation and the discovery of new anti-inflammation drugs. Hu protein R (HuR) binds to the AU-rich element (ARE) in the 3'UTR to stabilize TNF-α mRNA. Here, we identified chemical inhibitors of the interaction between HuR and the ARE of TNF-α mRNA using RNA electrophoretic mobility gel shift assay (EMSA) and filter binding assay. Of 179 chemicals screened, we identified three with a half-maximal inhibitory concentration (IC50) below 10 μM. The IC50 of quercetin, b-40, and b-41 were 1.4, 0.38, and 6.21 μM, respectively, for binding of HuR protein to TNF-α mRNA. Quercetin and b-40 did not inhibit binding of tristetraprolin to the ARE of TNF-α mRNA. When LPS-treated RAW264.7 cells were treated with quercetin and b-40, we observed decreased stability of TNF-α mRNA and decreased levels of secreted TNF-α. From these results, we could find inhibitors for the TNF-α mRNA stability, which might be used advantageously for both the study for post-transcriptional regulation and the discovery of new anti-inflammation drugs.
지진피해를 받은 R/C 기둥의 잔존내진성능 평가를 위한 비선형해석 모델 검증에 관한 연구
채주원 ( Chae Ju-won ),이상호 ( Lee Sang-ho ),김경민 ( Kim Kyung-min ),정주성 ( Jung Ju-seong ),이강석 ( Lee Kang-seok ) 한국구조물진단유지관리공학회 2021 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.25 No.1
2016 경주 및 2017 포항지진에서 발생한 철근콘크리트 (R/C) 학교 및 필로티 건축물의 지진피해 특성을 고려하여, 대상건축물 기둥의 잔존내진성능을 검토할 목적으로 기둥 실험체를 제작하여 반복가력 및 유사동적실험을 실시하였다. 실험결과를 기반으로 지진피해를 받은 R/C 기둥의 비선형해석을 위한 복원력모델을 구축하였으며, 실험결과와 해석결과의 비교를 통해 신뢰성을 검증하였다. 연구결과는 잔존내진성능을 해석적으로 평가하기 위한 대상 기둥을 확장할 수 있는 기반으로 활용가능하다고 사료된다.
지진피해를 받은 R/C 기둥의 잔존내진성능 평가를 위한 비선형해석 모델 검증에 관한 연구
채주원 ( Chae Ju-won ),이상호 ( Lee Sang-ho ),김경민 ( Kim Kyung-min ),정주성 ( Jung Ju-seong ),이강석 ( Lee Kang-seok ) 한국구조물진단유지관리공학회 2021 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.25 No.1
2016 경주 및 2017 포항지진에서 발생한 철근콘크리트 (R/C) 학교 및 필로티 건축물의 지진피해 특성을 고려하여, 대상건축물 기둥의 잔존내진성능을 검토할 목적으로 기둥 실험체를 제작하여 반복가력 및 유사동적실험을 실시하였다. 실험결과를 기반으로 지진피해를 받은 R/C 기둥의 비선형해석을 위한 복원력모델을 구축하였으며, 실험결과와 해석결과의 비교를 통해 신뢰성을 검증하였다. 연구결과는 잔존내진성능을 해석적으로 평가하기 위한 대상 기둥을 확장할 수 있는 기반으로 활용가능하다고 사료된다.
지진피해를 받은 R/C 기둥의 잔존내진성능 평가를 위한 비선형해석 모델 검증에 관한 연구
채주원 ( Chae Ju-won ),이상호 ( Lee Sang-ho ),김경민 ( Kim Kyung-min ),정주성 ( Jung Ju-seong ),이강석 ( Lee Kang-seok ) 한국구조물진단유지관리공학회 2021 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.25 No.1
2016 경주 및 2017 포항지진에서 발생한 철근콘크리트 (R/C) 학교 및 필로티 건축물의 지진피해 특성을 고려하여, 대상건축물 기둥의 잔존내진성능을 검토할 목적으로 기둥 실험체를 제작하여 반복가력 및 유사동적실험을 실시하였다. 실험결과를 기반으로 지진피해를 받은 R/C 기둥의 비선형해석을 위한 복원력모델을 구축하였으며, 실험결과와 해석결과의 비교를 통해 신뢰성을 검증하였다. 연구결과는 잔존내진성능을 해석적으로 평가하기 위한 대상 기둥을 확장할 수 있는 기반으로 활용가능하다고 사료된다.