인체혈장 중 에탐부톨의 HPLC 분석법의 검증 및 단일용량 투여에 의한 약물동태 연구

곽혜선,박경호,최준식,송진아,성민경,장정옥,이화정 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.2

An HPLC method was employed for the determination of ethambutol in human plasma. After addition of internal standard (IS, octylamine, 2 μg/mL) and alkalinization of the plasma with 5 M sodium hydroxide, the drug and IS were extracted into the mixture of chloroform and diethyl ether (40:60, v/v). Following a 15-min vortex-mixing and a 10-min centrifugation, the organic phase was spiked with 100 pL of phenylethylisocyanate (2000 μg/mL) for chemical derivatization, mixed for 5 min and evaporated to dryness under a stream of nitrogen. The residue was reconstituted with 100 μL of mobile phase and 20 pL was injected into Cl8 column with a mobile phase consisting of methanol:water (70:30, v/v). The samples were detected utilizing an ultraviolet detector at 200 nm. The method was specific and validated with a limit of 0.15 μg/mL. Infra- and inter-day precision and accuracy were acceptable for all quality control samples including the lower limit of quantification. The applicability of this method was demonstrated by analysis of human plasma after oral administration of a single 1200-mg dose to 20 healthy subjects. From the plasma ethambutol concentration vs. time curves, the mean AUC was 9.61 ± 1.64 μg hr/mL. and Cmax of 2.68 μg/mL reached 2.73 hr after administration. The mean biological half-life of ethambutol was 3.46 ± 1.21 hr. Based on the results, this simple and validated assay could readily be used in any pharmacokinetic studies using humans.

특수교육지원센터 치료지원서비스에 대한 견해 : - 작업치료 서비스를 받는 보호자를 중심으로 -

송민옥,이성자,김훈주 대한감각통합치료학회 2010 대한감각통합치료학회지 Vol.8 No.1

목적 : 본 연구에서는 특수교육지원센터에서 시행되는 치료지원서비스의 인식, 목적, 특징 및 개선방안을 살펴봄으 로써 치료지원서비스의 전반적 실태를 파악하고 이를 통해 최적의 치료지원서비스를 제공하기 위한 기초자료로 제시하고자 한다. 연구 방법 : 현재 특수교육지원센터에서 치료지원서비스를 받고 있는 치료지원대상 아동의 보호자를 대상으로 개별 인터뷰가 진행되었다. 인터뷰는 평균 40분이 소요되었으며, 모든 인터뷰는 녹취되었다. 결과 : 치료지원서비스에 대한 근본적인 인식이 부족하였고, 치료영역의 전문가가 치료를 담당함으로 인하여 치료사에 대한 신뢰도가 높은 것으로 조사되었다. 또한 치료실의 시설 및 교재교구의 다양성으로 인해 질적으로 높은 치료를 받는다고 생각하고 있었으며 모든 연구대상자는 무상교육을 치료지원서비스의 특징으로 꼽았다. 결론 : 작업치료사가 특수교육지원센터에서 치료지원서비스 전문가로 자리 매김하기 위해서 많은 노력과 연구 및 대외적인 홍보가 필요하다. Objective : The purpose of this study is to provide practical guidelines for the better performance of the Occupational therapy services(OT services) in the Supporting Center for Special Education. The study is based upon the quality and satisfaction of the OT services, measured by interviewing parents whose children have taken the services provided by Ulsan Kang-Nam Supporting Center for Special Education. Methods : Five parents for the children having OT services since March, 2010 in the Kang-Nam Supporting Center were interviewed individually. The interview per each person took thirty to fifty minutes and was all audio-recorded. Results : The satisfaction of the qualification for the OT therapists working at the Kang-Nam Supporting Center was high. The quality for treatment facilities and the variety for treatment materials met the expectation for OT to be well-performed. The free OT treatment system was the one of significant features for the OT services provided by the Kang-Nam Supporting Center. However, the perception of the interviewed parents for the OT was very low.

급성 충수염으로 진단된 예측 불가 염증성 맹장 종물에 대한 외과적 고찰

민경진,백무준,채만규,김성용,이문수,김창호,김재준,송옥평 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Purpose: An unexpected inflammatory cecal mass of uncertain etiology was encountered during surgery for presumed appendicitis. In this case, the surgeon couldn't exclude differential diagnosis which were severe appendicitis involving the cecal region, diverticular disease, other inflammatory bowel diseases, and neoplasm. Therefore, this finding leads to a therapeutic dilemma for the surgeon, when making surgical decisions during the operation. The aim of this study was to resolve this dilemma, a retrospective review was undertaken in this study. Methods: A retrospective study was performed to review the management of this problem at Soonchunhyang University Chunan Hospital for eight and half years from July 1991 to December 1999. A review of the emergency operation records identified 50 patients who had undergone ileocecal resection or right hemicolectomy for an inflammatory ileocecal mass of uncertain etiology when operated on for probable appendicitis. Results: Altogether, 39 patients underwent ileocecal resection, and 11 patients underwent right hemicolectomy. The final pathologic diagnosis was appendiceal abscess in 32 patients (63%), cecal diverticulitis in 7 patients (14%), neoplasm in 6 patients (12%), appendiceal phlegmon in 3 patients (6%), ileal tuberculosis in 1 patient (2%) and Anisakiasis in another patient (2%). The neoplasm of the 6 neoplasm patients was ascending colon cancer for 4 patients and cecal cancer for 2 patients. There was no mortality in this group. Conclusion: Although most inflammatory cecal masses are caused by benign disease, all cases in which the intraoperative diagnosis is unclear, any pathologic diagnosis including neoplasm cannot be ruled out. So this suggest ileocecal resection or right hemicolectomy to remove a possible underlying malignancy, and to decrease morbidity and mortality.

비수도권 대학생 임대주거 실태 및 요구

박경옥, 송민경, 이종현 충북대학교 생활과학연구소 2013 생활과학연구논총 Vol.17 No.2

The purpose of this study is to propose the renal housing policy direction for undergraduates based on their actual rental housing conditions and needs who reside in non capital area. For the study, questionnaires were answered by 315 undergraduates of 3 universities who reside in rental housings in Cheongju-city. Major findings were as follows: (1) Most of undergraduate rental housings had the size from 12㎡ to 29㎡ and from 29㎡ to 41㎡, were multi-household studio type with room+bath+kitchen, and were typically monthly rent payment. (2) The needs of rental housings were the same as present residence. The possible monthly rent were mostly 300 thousand won, and the most preferred distance was under 10 minute walk from university. The assistance policy that undergraduates need was firstly the central/local governments' refurbished housing supply near university with low rent, and then deposited housing supply for undergraduates by LH corporation.

洞報 廢鑛山 周邊地域 土壤 內 重金屬 移動 分布

문영옥,정송송이,최상민,김민철,박창웅,오광중 부산대학교 환경문제연구소 2003 環境硏究報 Vol.21 No.-

In this paper, we study heavy metal transport and distribution of soils around Dong-bo abandoned mine area. Inside the mine, concentration of Cd, Ca, Zn are exceeded soil management standards. Outside of mine, concentration of Pb, as is exceeded soil management standards. Especially, concentration of Pb is higher than soil protection standard of 300㎎/㎏ in S-6 point which is tailing accumulation area. Although heavy metal concentration of mine water was higher than Unsuchon, water contaminated level was lower than soil. 30cm-depth soil is serious in S-6 point, heavy metal transport had influence on Unsuchon. Further more, we used pollution index(PI) to evaluate soil contamination totally, it exceeded standard "1" in S-6 points of surface soil and 30cm-depth soil. So it decided that contamination of heavy metal is more seriously than other sampling points. In contaminated soil, pH and organic contents are lower than non-contaminated soil. Therefore heavy metal concentration has influence on adsorption and retardation of soil by pH and organic contents variation. Moisture contents also encouraged heavy metal transport velocity, but less than pH and organic contents.

장중첩증을 동반한 맹장 지방종 1예

홍의실,나병규,김민옥,유일영,채지영,채희복,윤세진,이상전,송형근,박길선,정현용 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.2

대장 지방종은 주로 우측 결장에 호발하고 특히 회맹판 부위와 맹장 부위에 호발한다. 또한 50~60대에 빈도가 높고 증상이 있는 환자에서 장중첩증이 높게는 40~50%에서 보고되고 있어 성인 장중첩증의 원인으로 중요한 비중을 차지한다. 특히 성인 장중첩증 및 장폐쇄의 중요 원인인 악성 종양과 임상 양상이 유사하여 감별진단이 중요하다. 저자들은 반복적인 복통을 주소로 내원한 환자에서 맹장의 4×5㎝의 점막하 지방종이 말단 회장부위와 반복적인 장중첩중이 발생했던 1례를 부분 절제술로 치료하여 양호한 임상 경과를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Lipomas are one of the most common benign nonepithelial tumors of the colon which are often detected incidentally by radiologic investigation or on operation. These tumors are usually without specific symptoms. Colonic lipomas occur most often in the right colon, particularly in the ileocecal valve and the cecum. Most patients are asymptomatic. but tumors larger than 2 cm tend to produce a change in bowel habit. abdominal pain. rectorrhagia and complications including luminal obstruction or intestinal intussusception. Diagnosis can be made by colonoscopy abdominal CT. MRI, or barium enema. We report a case of lipoma of the cecum that originated in the submucosa and presented as a intussusception in a 50-year-old woman with a brief review of the literature.

제2형 당뇨병 환자에게 적용한 표준진료지침이 혈당, 당화혈색소, 당뇨지식 및 재원일수에 미치는 효과

김희승,윤건호,유양숙,오정아,송민선,신미옥,김경희,송복례 대한당뇨병학회 2002 임상당뇨병 Vol.3 No.1

연구배경 : 당뇨병 환자의 평균 재원기간을 단축시키고, 제한된 입원기간 내에서 질적인 면과 비용효과성을 고려한 총체적인 건강관리체계의 필요성이 요구됨으로써 생겨난 것이 당뇨병 표준진료지침(Critical Pathway: CP)이다. 현재 개발된 당뇨병 CP를 통한 진료가 환자의 당뇨병에 관한 지식을 개선시키고 이에 따라 장기적으로 당뇨병 환자의 혈당조절이 개선되었다는 과학적인 검증은 당뇨병 CP를 여러 병원에 정착시키기이전에 반드시 선행되어야 할 과제이다. 이에 본 연구는 2000년 3월부터 1년간 강남성모병원에 입원하는 당뇨병 환자를 대상으로 현재 개발된 1주일 CP를 적용한 실험군의 혈당, 당뇨병 관련 지식 및 재원일수가 대조군에 비하여 차이가 있는지를 조사하였다. 방법 : 1주일 CP를 적용한 실험군은 내과병동에 입원한 당뇨병 환자 89명이었고, 대조군은 기타병동에 입원한 당뇨병 환자 22명이었으며 CP를 적용하지 않았다. CP를 적용하기 전인 입원시에 실험군과 대조군의 공복혈당, 식후 2시간혈당, 당화혈색소 및 당뇨관련 지식을 측정하였고, 퇴원 시에 실험군과 대조군에게 공복혈당과 당뇨관련 지식을 재측정하고 재원일수를 파악하였다. 그리고 두 군에게 퇴원 3개월 후의 공복혈당, 식후 2시간 혈당 및 당화혈색소를 조사하였다. 결과 : 1) 실험군의 공복혈당은 입원 시 238.7: 1) 실험군의 공복혈당은 입원 시 238.7mg/dL에서 퇴원 시 139.4mg/dL로 감소하는 경향이었으나 퇴원 3개월 후에는 150.6mg/dL로 약간상승하는 경향을 보였다. 대조군은 입원 시 251.5mg/dL에서 퇴원 시 136.2mg/dL로 감소하는 경향이었으나, 퇴원 3개월 후에는 219.3mg/dL로 현저히 증가하는 경향이었다. 2) 실험군의 입원 시 식후 2시간 혈당은 312.5mg/dL에서 퇴원 3개월 후 248.5mg/dL로 감소하는 경향이었다. 대조군도 입원 시 식후 2시간 혈당이 300.1mg/dL에서 퇴원 3개월 후 262.5mg/dL로 감소하는 경향이었으나 실험군보다 감소의 폭이 적은 경향이었다. 3) 실험군과 대조군의 입원 시 당화혈색소는 각각 10.3%와 9.7%로 유의한 차이가 없었으나,퇴원 3개월 후 실험군은 7.5%로 대조군의 9.1% 보다 유의하게 감소하였다. 4) 실험군의 입원 시 당뇨지식 점수는 실험군이 12.1점 대조군은 12.0점으로 유의한 차이가 없었으나 퇴원 시는 실험군이 15.5점으로 대조군의 14.6점 보다 높은 경향이었다. 5) 재원일수는 실험군이 8.4일로 대조군의11.0일 보다 유의하게 적었다. 결론 : 따라서 당뇨병 환자를 위한 CP는 재원일수의 감소뿐만 아니라 환자의 자가관리에 대한 체계적인 교육과 개선의 기회를 가짐으로써 장기적인 혈당 조절의 향상을 도모할 수 있는 효과적인 방법이라고 생각한다. Background: The aim of this study was to examine the effects of the critical pathway for the admitted patients with type 2 dia betes me llitus on glycemic control, the knowledge on the disease, and the length of hospital stay. Methods: 89 diabetic in-patients were applied with the 1 week critical pathwa which was consisted of intensive education program for self-management of diabetes me llitus such as glucose monitoring, excercise prescription, diet control, self-a djustment of the drugs and so on. The results were compared with 22 diabetic inpatients who were treated with conventional way. We assessed the effects of critical pathway on the degree of glycemic control, the knowledge on the disease, and the length of hospital stay. Results: Although fasting and postprandial 2 hours blood g lucose levels did not showed sta tistically significantd ifference between critical pathway group and conventional group on discharge , HbA1c was significantly decreased in critical pathwa group compared with the conventional group (7.5±1.8% vs 9.1±2.6%) on 3 months after discharge . Knowledge on the disease tended to increase in critical pathway group compared with the conventional group on discharge. The Length of hospital stay was significantly decreased in critical pathway group compared with the conventional group (8.4±2.8day vs 11.0±3.9da ) Conclusion: These results showed that critical pathway for the patients with diabetes mellitus might be a usefulway for improving the long term glycemic control through motivation, enhancing the knowledge on the disase as well as reducing the length of hospital stay.

Eight new records of monogonont and bdelloid rotifers from Korea

Song, Min Ok The National Institute of Biological Resources 2014 Journal of species research Vol.3 No.1

The rotifers collected from a brackish water zone as well as various terrestrial habitats such as mosses, ichens, and leaf litter at seven different locations in Korea were investigated. Eight species/subspecies belonging to five genera in five families of monogonont and bdelloid rotifers new to Korea were identified: Encentrum incisum, Encentrum uncinatum, Cephalodella innesi, Adineta gracilis, Macrotrachella timida timida, Macrotrachella timida inquies, Habrotrocha pavida and Habrotrocha scabropyga. Five bdelloids are new to Asia as well. Notably, these eight Korean new records included three rare species. H. scabropyga is recorded outside its type locality for the first time. For M. timida timida, this study is the third record after its description. In addition, E. incisum has been reported only from Austria, Germany and Russia before the present study.

<b>A new species and ten new records of bdelloid rotifers from Korea</b>

SONG, MIN OK,MIN, GI-SIK Magnolia Press 2015 Zootaxa Vol.3964 No.2

Three Brackish Water Rotifers from Korea

Song, Min Ok(송민옥),Kim, Won(김원) 한국동물분류학회 1992 Animal Systematics, Evolution and Diversity Vol.8 No.2