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Original Article : Ultrawide-field Fluorescein Angiography for Evaluation of Diabetic Retinopathy
( Min Gui Kong ),( Mee Yon Lee ),( Don Il Ham ) 대한안과학회 2012 Korean Journal of Ophthalmology Vol.26 No.6
Purpose: To investigate the advantages of ultrawide-field fluorescein angiography (FA) over the standard fundus examination in the evaluation of diabetic retinopathy (DR). Methods: Ultrawide-field FAs were obtained in 118 eyes of 59 diabetic patients; 11 eyes with no DR, 71 eyes with nonproliferative diabetic retinopathy (NPDR), and 36 eyes with proliferative diabetic retinopathy (PDR), diagnosed by the standard method. The presence of peripheral abnormal lesions beyond the standard seven fields was examined. Results: Ultrawide-field FA images demonstrated peripheral microaneurysms in six (54.5%) of 11 eyes with no DR and all eyes with moderate to severe NPDR and PDR. Peripheral retinal neovascularizations were detected in three (4.2%) of 71 eyes with NPDR and in 13 (36.1%) of 36 eyes with PDR. Peripheral vascular nonperfusion and vascular leakage were found in two-thirds of eyes with severe NPDR and PDR. Conclusions: Ultrawide-field FA demonstrates peripheral lesions beyond standard fields, which can allow early detection and a close evaluation of DR.
Optimizing Mass Culture for Sphingomonas sp.C8-2 to Degrade Triazole Fungicide Defenoconazole
Jun-Kyung PARK,Gui Hwan HAN,Ho-Dong LIM,Kong-Min KIM,Jung-Hwan JI,So-Jung RHYU,Yeon-Woong CHOI,Yul-A CHOI,In-Cheol PARK,Jae-Hyung AHN 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
In the agricultural environment, chemical control, chemicals and fertilizers were used as methods for pest control to improve the quality of crop cultivation. It has problems that cause environmental pollution, such as nondecomposing residual problems and the resulting ecological destruction, and environmentally friendly policies are being implemented around the world. The most commonly used triazole-based disinfectant is reported to have a relatively long residual period in the soil, and are likely to remain in soil and crops for long time, damaging the environment. Preliminary research by Rural Development Administration (RDA) has isolated microorganisms that biodegrading the triazole-based disinfectant difenoconazole, and we want to develop the formulation and industrialization technology of this strain. So, the aim of this research, we have optimized to culture conditions of microorganism such as, Sphingomonas sp.C8-2 that have an efficiency of degrading defenoconazole fungicide. This effective microorganism Sphingomonas sp., was kindly provided by Rural Development Administration (RDA) and Republic of Korea. First, optimization of parameters for Sphingomonas sp. growth, for instance, carbon source, nitrogen source, mineral source, temperature, pH and agitation speed were determined in small scale. As a results, the optimal media were developed carbon and nitrogen sources were determined as glucose and peptone, respectively, then resulted in 1.4~3.4 x 10⁹ CFU/ml by flask cultivations. And then, growth optimization of Sphingomonas sp.C8-2 in 5L jar-fermenter with the optimized defined medium were carried out and OD600㎚, pH, viable cell count (CFU/ml) was determined. Initial incubation pH was measured from 7.28 to 7.81 and for OD600㎚ it was 1.100 for 39 hours. The final viable cell count by optimized conditions was measured at 1.8 x 10⁹ CFU/mL. Now, at the lab scale level, the storage stability of Sphingomonas sp.C8-2 in liquid type and three different types of powder formulation type with different ingredients form was developed and optimized for their effect on fungicide at different temperature for more than 6 months continuously. For the cultivation of the pilot scale, researches using this microorganism agent are in progress. Furthermore, the degradation of defenoconazole by liquid or powder formulation types of Sphingomonas sp.C8-2 will be used as base line data that can be utilized directly on the field for development and industrialization.
공민귀,이민규,김정훈,이정혜,우경인,김윤덕,Min Gui Kong,Min Gyu Lee,Jung Hoon Kim,Jung Hye Lee,Kyung In Woo,Yoon Duck Kim 대한안과학회 2013 대한안과학회지 Vol.54 No.4
Purpose: To report a case of ankyloblepharon filiforme adnatum in a newborn male. Case summary: A 4-day-old male was referred for fused right eyelids with unremarkable other pediatric examinations. Ocular examination under general anesthesia revealed partial fusion of his right upper and lower eyelids by a 4 mm-wide band of tissue which arose from the skin of the upper and lower eyelids. The adhesion was separated by sharp scissors and no other ocular abnormalities were revealed. Conclusions: Ankyloblepharon filiforme adnatum is a rare congenital malformation. In this case, the band of tissue connecting the upper and lower eyelids arose not from the eyelid margin but from the eyelid skin, which is even rarer, thus supporting the theory that this condition is due to the fusion of eyelids at abnormal positions, and not due to problems during the separation of eyelids.
안구 철 침착증으로 발생한 백내장 및 지연성 이차성 녹내장 1예
한겨레(Gyu Le Han),공민귀(Min Gui Kong),한종철(Jong Chul Han),기창원(Chang Won Kee) 대한안과학회 2015 대한안과학회지 Vol.56 No.11
목적: 저자들은 철 이물에 의한 백내장 제거 후 10년 뒤 지연성 녹내장이 발생한 안구 철 침착증의 드문 증례를 경험하였기에 이를 보고하고자 한다. 증례요약: 47세 환자가 3년 전 좌안을 철 조각에 수상한 뒤 본원에서 수정체 철 침착증으로 백내장 수술을 시행 받았다. 백내장 수술 10년 뒤 좌안의 안압 상승이 발생하였으며 철 침착증에 의한 이차성 녹내장으로 진단되었다. 섬유주 절제술을 시행 받았으며, 절제된 섬유주에서 철 성분은 관찰되지 않았으나 섬유 조직의 퇴행성 변화가 관찰되었다. 결론: 외상성 수정체 철 침착증이 있는 환자에서 이를 치료한 후에도 지연성 이차성 녹내장이 발생할 수 있다. Purpose: We report a rare case of ocular siderosis with delayed-onset secondary glaucoma occurring 10 years after cataract and iron foreign body removal. Case summary: A 47-year-old male who suffered an ocular injury with an iron material to his left eye 3 years prior to his initial visit was treated in our clinic for a cataract with siderosis lentis. Ten years after he underwent cataract surgery he developed secon-dary open-angle glaucoma. Trabecular block taken during trabeculectomy showed no iron material, however, a fibrosclerotic change was observed. Conclusions: In patients with a history of traumatic siderosis lentis, a potential risk of siderosis remains for a long period.
Ho-Dong LIM,Jun-Kyung PARK,Kong-Min KIM,Jung-Hwan JI,So-Jung RHYU,Gui Hwan HAN 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
Potato and sweet potato is an important food crop in the world. Crop consumption is gradually increasing, but production yields are declining due to injury of continuous cultivation or infection of soil-borne fungal pathogens such as Phytophthora infestans, Alternaria solani, Rhizoctonia solani and Fusarium spp. In order to find promising biocontrol agents, we have isolated 47 soil bacteria from potato cultivated soil and tested their antifungal activities. Among them, 3 strains were selected and identified as Bacillus velezensis RS15-1, B. velezensis RSS4-1, and B. velezensis PL1-1 using phylogenetic analysis based on 16S rRNA gene sequences. Subsequently we have optimized the medium formula using control of carbon, nitrogen mineral source for mass fermentation of B. velezensis RS15-1. In addition, in order to induce sporulation of the B. velezensis RS15-1, we adjusted temperature, pH and agitation speed in flask level. Initial incubation pH was measured from 6.83 to 7.81 and for OD600nm it was 4.8 for 39 hours. The final viable cell count by optimized conditions was measured at 2.37 × 10<SUP>9</SUP> CFU/mL.