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Byeon Mi-kyeong,Park Sun-jung,Choi Eun-young J-INSTITUTE 2019 International Journal of Crisis & Safety Vol.4 No.1
The purpose of this study was to examine the wellbeing behaviors, life satisfaction and subjective quality of life of community elderly people and to verify the effectiveness and usefulness of a wonderful life program provided for successful life in old age. This study made an attempt to examine the wellbeing behaviors, life satisfaction and subjective quality of life of community elderly people and to verify the effectiveness and usefulness of the wonderful life program so that community elderly people could lead a successful life in old age. This study is a quasi-experimental research that adopted nonequivalent control group pretest-posttest design to determine the effects of the wonderful life program on wellbeing behaviors, life satisfaction and the subjective quality of life after offering it to the selected community elderly people. We selected 30 people who were given permission from elderly people over 65 years of age at the social welfare center in W city. In the homogeneity test, there was no statistically significant difference in well-being behavior, life satisfaction, and subjective quality of life, indicating that the experimental group and the control group before the experiment were the same level. The findings of the study were as follows: The program was found to have effects on the wellbeing behaviors(z=-3.408, p=.001), life satisfaction(z=-3.225, p=.001) and subjective quality of life(z=-3.419, p=.001) of the experimental group. In contrast, there were no changes in the wellbeing behaviors(z=-.253, p=.800), life satisfaction(z=-1.418, p=.156) and subjective quality of life(z=-.000, p=1.000) of the control group. Therefore intensive efforts should be directed into the development and supply of various educational programs that could encourage elderly people to keep boosting their wellbeing behaviors, life satisfaction and subjective quality of life. In the future, this program will be indispensable to senior citizens who are increasingly larger in number due to the advancement of the times and the growing elderly population, and the program is expected to make a great contribution to fast- developing aging society.
만학도 간호대학생의 대학생활 적응경험 : 내용분석기법을 적용하여
변미경(Mi Kyeong, Byeon),박선정(Sun Jung, Park),최은영(Eun Young, Choi) 한국간호연구학회 2020 한국간호연구학회지 Vol.4 No.4
Purpose : This study was attempted in order to offer basic data to the development in a program for confirming a requisite demand in late-starting nursing students and for increasing college life adjustment through grasping and analyzing the contents on the experience of college life adjustment that the late-starting nursing students go through. Methods : This study is a descriptive qualitative research that analyzed the consultation diary contents, which were recorded after counseling the experience of college life targeting the late-starting nursing students of 3 universities where are located in Gyeonggi-do Province and Gangwon-do Province. Results : According to the procedure of the content analysis method, the interview materials on the experience of college life adjustment that the late-starting nursing students experience were elicited 82 significant statements and 16 categories. Through this study, the advice and counseling system is demanded that is available for supporting the college life adjustment as it is important for late-starting nursing students to be adjusted to college life. Conclusion : A multilateral effort is needed for arranging a college life adjustment system and offering education in order to be helpful for the late-starting nursing students’ adjustment not only in the dimension of academic department but also in the dimension of university.
통계적 경향 분석을 통한 남한강 상류 수계 수질 변동 해석
변상돈 ( Byeon Sang-don ),노연정 ( Noh Yeon-jung ),임경재 ( Lim Kyeong-jae ),김종건 ( Kim Jong-gun ),김동진 ( Kim Dong-jin ),홍은미 ( Hong Eun-mi ) 한국농공학회 2020 한국농공학회논문집 Vol.62 No.5
There are fifteen non-point pollution management areas in Korea and three of them (Doam lake, Daegi district and Golji-cheon) are located in the upstream of the Namhan river watershed. Many efforts to reduce non-point sources (NPS) pollution have been conducted, however, water quality pollution in the watershed is still serious. To solve these problems, it is a priority to grasp water quality using statistical techniques. In this study, a trend analysis was conducted to evaluate the effect of NPS management in the watershed. The long-term trends from 1996 to 2018 of water quality properties were analyzed using data collected from the water environment information system. Seventeen monitoring stations were selected along the main stream in Namhan river basin. Monthly water quality properties (BOD, COD, TN, TP, TN/TP ratio, Conductivity, SS and Chlorophyll-a) were collected and analyzed by Mann-Kendall test and LOWESS. The results showed that the Conductivity tended to increase in all regions and was the highest level in Jijangcheon. Organic pollution such as BOD and COD tended to increase in the Jungseon area. SS did not show a large tendency, but it showed high concentration in the Doam watershed. In all regions, 40% of water quality properties showed a tendency to ‘UP’, 15% of water quality properties tended to ‘DOWN’, and 46% indicated no tendency. In order to determine the cause of this, additional research and measures for improvement are necessary. This study will be used for the establishment of water quality policy in the future.
효율적인 유전자 전달을 위한 Transferrin과 PEI가 도입된 O-carboxymethyl Chitosan의 합성
박순정 ( Sun Jeong Park ),변지예 ( Ji Ye Byeon ),박소영 ( Soyoung Park ),김영민 ( Young Min Kim ),남정표 ( Joung Pyo Nam ),박성철 ( Seong Cheol Park ),박영훈 ( Yung Hoon Park ),나재운 ( Jae Woon Nah ),장미경 ( Mi Kyeong Jang ) 한국키틴키토산학회 2014 한국키틴키토산학회지 Vol.19 No.2
본 연구에서는 키토산의 유전자 전달 효율과 암세포 표적효율을 향상시키기 위하여 OCMCh의 amine group과 carboxyl group에 각각 표적물질인 TF와 양이온고분자인 PEI를 도입하여, 유전자 전달체인 POPT를 제조하였다. 제조된 POPT는 1 H-NMR 을 통해 성공적으로 합성되었음을 확인하였고, DLS를 통해 입자크기를 측정한 결과 POPT의 비율이 증가함에 따라 입자크기가 작아지며, POPT가 나노 크기의 입자를 형성함을 확인하였다. 또한 전기영동 실험을 통해 POPT가 pEGFP-N1와 복합체를 잘 형성하며, heparin 실험결과 혈액 내에서 pEGFP-N1를 잘 방출할 수 있으며, DNase로부터 pE GFP-N1를 보호할 수 있음을 확인하였다. POPT의 유전자 전달효율은 정상세포와 암세포를 사용하여 확인한 결과 POPT 가 증가할수록 유전자 전달 효율이 향상되며, TF의 표적능력으로 인해 암세포에서만 유전자가 전달됨을 확인할 수 있었다. 이 같은 실험 결과들을 통해 POPT는 암세포만을 표적해 유전자를 전달할 수 있는 전달체로써 사용 가능성이 있는 우수한 물질로 사료된다. 추후에 수행할 실험에서는, 이러한 시스템의 가능성을 보다 더 정확히 확인하기 위하여 동물실험을 진행할 예정이며, 질병을 치료할 수 있는 유전자를 전달체를 통하여 전달하는 실험을 통하여 유전자 치료를 수행할 수 있는지 여부를 확인하는 연구를 진행할 것이다. The polyethyleneimine / O-carboxymethyl chitosan / polyethyleneglycol / transferrin (POPT) copolymer was evaluated as nonviral gene delivery carrier. The structural analysis of POPT copolymer was confirmed by 1-proton nuclear magnetic resonance ( 1 H-NMR). The particle size of - pEGFP-N1/POPT polyplexes was confirmed by dynamic light scattering (DLS). The results of DLS showed that the particle sizes of pEGFP-N1/POPT polyplexes has small size of 130~260 nm. The binding ability with pEGFP-N1, pEGFP-N1 protecting assay against DNase, and pEGFP-N1 release assay through heparin of POPT were evaluated by gel retardation assay. In addition, gene transfection effect of pEGFP-N1/POPT polyplexes was evaluated in fibroblast cell line (L929, without transferrin receptor) and cervical cancer cell line (HeLa-S3, with transferrin receptor) cells. The results of transfection were shown that green fluorescence was cancer cell more expression than normal cell due to receptor mediated endocytosis between transferrin of POPT and transferrin receptor on the cancer surface. Therefore, pEGFP-N1/POPT polyplexes could be a promising gene delivery system.
( Soon Man Yoon ),( Do Hoon Kim ),( Mi Young Do ),( Byong Duk Ye ),( Jeong Sik Byeon ),( Suk Kyun Yang ),( Jin Ho Kim ),( Seung Jae Myung ),( Hyun Mi Kim ),( Kyeong Soon Park ),( Kwang Meyung Kim ),( 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Early detection of small primary tumors remains the mainstay of successful cancer therapy and improves survival rates. Matrix metalloproteinases (MMPs) revealed to participate in the early stages of tumorigenesis and primary tumor growth. The aim of the current study was to develop an efficient animal model for early and small colon tumors and assess the feusibility of protease activatable probes to detect early and small tumors. Methods: We used a mouse model for colon tumor by a combined treatment with azoxymethane (AOM) and dextran sodium sulfate (DSS). Male BALB/c mice (n=8, age 5 weeks) were given a single intraperitoneal administration (10 mg/kg body weight) of a colon carcinogen, AOM, followed by 2% DSS in drinking water for 7 days, and there-after they received no further treatment for up to 14 weeks. At week 16, all mice were injected via tail vein with MMP reporter probe (MMPSenseTM680, VisEn, Medical, Inc., MA, USA) followed by surgical exposure of the colon. Excised colons were evaluated with fluorescence imaging, histologic examination, and immunohistochemistry. Results: All mice treated with AOM and DSS developed colon tumors in distal colon with a multiplicity (no. of tumors/mouse) of 7.9±2.1. Fluorescence imaging demonstrated that all tumors were visible with the protease activatable probe. A target-to-background ratio (TBR) of 5.61 for tumor to adjacent normal mucosa was achieved. Histopathologically, all colon tumors revealed adenocarcinoma with or without adenoma. Results of immunohistochermistry confirmed MMP overexpression in the tumor compared with adjacent mucosa. Conclusions: The current experimental study shows that the expression of MMP is up-regulated in the mouse colon tumors induced by AOM and DSS, and highly matched with fluorescence imaging by a protease activatable probe. This strategy can be used to detect early stage tumors and may be used for early diagnosis of early and small tumors.
슬리브 구조를 갖는 모노폴 안테나의 활용분야에 따른 설계와 동향분석
강상원,변미경,이신희,최광제,Kang, Sang-Won,Byeon, Mi-Kyeong,Lee, Shin-Hee,Choe, Gwang-Je 한국인터넷방송통신학회 2020 한국인터넷방송통신학회 논문지 Vol.20 No.5
This paper summarizes the data of a monopole antenna with a sleeve structure that can be applied in various ways. Sleeve monopole antennas have broadband characteristics and are used for multi-frequency applications. The sleeve monopole antenna is composed of a vertical conductor, which is a radiator, and a sleeve having the same structure as a coaxial cable. The sleeve acts as a radiator and an open stub. The length of the sleeve should be 1/3~2/3 of the total length of the antenna. A monopole antenna having a sleeve structure is applicable to a vehicle wiper antenna. In addition, the case of applying this antenna to a broadband sleeve antenna using a loading coil, a broadband printed sleeve monopole antenna for an ISM band, a gap sleeve and a double sleeve, and a UWB planar monopole antenna using half cutting was summarized and analyzed in terms of structure and broadband. 본 논문은 다양하게 적용 가능한 슬리브 구조를 갖는 모노폴 안테나 자료를 정리한 것이다. 슬리브 모노폴 안테나는 광대역 특성을 갖고 다주파수용으로 사용된다. 슬리브 모노폴 안테나는 복사기(radiator)인 수직 도체부분과 동축 케이블과 같은 구조를 갖는 슬리브(sleeve)로 구성되어져 있다. 슬리브는 복사기와 개방 스터브 동작을 한다. 슬리브 길이는 안테나 전체 길이의 1/3~2/3로 되어야 한다. 슬리브 구조를 갖는 모노폴 안테나는 차량용 와이퍼 안테나에 적용 가능하다. 더불어, 로딩 코일을 이용한 광대역 슬리브 안테나, ISM 밴드용 광대역 프린티드 슬리브 모노폴 안테나, 갭 슬리브와 이중 슬리브, 하프 커팅을 이용한 UWB 평면형 모노폴 안테나에 적용한 사례를 구조와 광대역 측면에서 정리 분석하였다.