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김원(Won Kim),임철수(Cheol Su Lim),성미정(Mi Jung Sung),김성훈(Sung Hoon Kim),문상옥(Sang Ok Moon),이식(Sik Lee),나방주,박성광(Sung Kwang Park),강성귀(Sung Kyew Kang),김형진(Hyung Jin Kim),고규영(Gou Young Koh) 대한신장학회 2002 Kidney Research and Clinical Practice Vol.21 No.4
목 적 : Apoptosis를 억제하는 약물이나 성장인자는 세포생존효과가 있으므로 cisplatin 또는 adriamycin에 의해서 유도된 apoptosis에서 vascular endothelial growth factor(VEGF)와 angiopoietin-1(Ang1)의 세포생존효과를 보고자 하였다. 방 법: 항암제인 adriamycin 또는 cisplatin을 사구체 내피세포에 투여하여 apoptosis을 유발시키고, VEGF와 Ang1을 투여하여 apoptosis 억제 효과와 신호전달과정을 관찰하고자 하였다. 결 과 : 사구체 내피세포에서 adriamycin과 cisplatin은 농도에 의존적으로 apoptosis을 유발하였다. VEGF는 5 ng/mL 이상의 농도에서 adriamycin에 의해서 유도된 apoptosis에 억제 효과가 있었고, Ang1은 50 ng/mL 이상의 농도에서 adriamycin에 의해서 유도된 apoptosis 억제 효과가 있었다. 그리고 VEGF(20 ng/mL)와 Ang1(100 ng/mL)은 cisplatin 500, 1,000, 2,000 ng/mL 각각의 농도에서 apoptosis를 억제하였다. Ang1 또는 VEGF를 단독으로 투여하는 경우보다는 Ang1와 VEGF를 같이 투여하는 경우에 있어서 apoptosis 억제 효과가 더 높았다. 한편 Ang1와 VEGF의 apoptosis에 억제 효과는 phosphatidylinositol 3`-kinase/Akt를 통하여 신호전달이 이루어졌다. 결 론 : Adriamycin 또는 cisplatin을 투여할 때 VEGF와 Ang1을 전처치하거나 같이 투여하면 apoptosis를 줄임으로서 신손상을 예방하거나 치료할 수 있는 가능성을 제시할 수 있었다. Background : Because glomerular endothelium play a pivotal role in the renal diseases, damage of glomerular endothelial cells lead to progression of glomerular sclerosis and decrement of renal function. Apoptotic damage of cells is an important mechanism in renal disease. Therefore, several growth factors that have antiapoptotic effect may have a protective role in maintaining a renal function in apoptotic cell injury. Methods : The present study evaluated whether cisplatin or adriamycin induce apoptosis in glomerular endothelial cells. We also evaluated the antiapoptotic effect of angiopoietin-1 and VEGF in cisplatin or adriamycin- induced apoptosis. Results : Cisplatin or adriamycin induced apoptosis in glomerualr endothelial cell in dose dependent manner. Angiopoietin-1 and VEGF produced antiapoptotic effect in cisplatin or adriamycin-induced apoptosis in a dose dependent manner. The antiapoptotic effect of angiopoietin-1 was more potent than that of VEGF in glomerualr endothelial cells. Wortmannin, a phosphatidylinositol 3`-kinase inhibitor decrease the angiopoietin-1 or VEGF-induced antiapoptotic effect. Conclusion : These results suggest that angiopoietin-1 and VEGF may be a strong survival factor for the glomerular endothelial cells in the cisplatin or adriamycin-induced apoptosis through phosphatidylinositol 3`-kinase/Akt. Therefore, pretreatment of angiopoietin-1 and VEGF could play a beneficial role for maintaining normal glomerular endothelial cell integrity before and during systemic cisplatin or adriamycin therapy.
초기 성문암 환자에서 소분할조사법의 방사선 치료 결과와 예후 인자
이미조(Mi Jo Lee),김헌정(Hun Jung Kim),김우철(Woo Chul Kim),노준규(Jun Gou Loh) 대한두경부종양학회 2005 대한두경부 종양학회지 Vol.21 No.2
Purpose: The purpose of this study was to establish general guidelines for the treatment of patients with early glottic cancer(T1-2N0M0), by assessing the role of primary radiation therapy and by analyzing the tumor-related and treatment-related factors that influence treatment results. We also studied the results of hypofractionated radiation therapy for early glottic cancer. Material and Methods: This retrospective study comprised 48 patients who suffered from early glottic cancer and were treated by primary radiotherapy at Inha University Hospital, between May 1997 and October 2004. T-stage distribution showed 38 patients as T1 and 10 patients as stage T2. Thirty-eight patients underwent hypofractionated radiotherapy using a 6 MY photon beam, a total tumor dose of 63Gy, in 5 weekly fractions of 2.25Gy, with an overall radiation treatment time of 38 days. Ten patients in the T2 stage tolerated a total dose of 63-72 Gy(median 68.4Gy) in 5 weekly fractions of 1.8-2.0Gy, with an overall radiation treatment time of 40-87 days(median 51 days). All patients were followed up for at least 3 years. Univariate and multivariate analyses were performed to identify the prognostic factors affecting the treatment results. Result: The 5-year survival rate was 92% for all patients, 94% for T1 patients and 91% for T2 patients. The local control rate was 93.5% for all patients, 95% for T1 and 92.2% for T2 patients. Three patients suffered a relapse following radiotherapy, and underwent subsequent salvage surgery. We included T-stage, tumor location, total radiation dose, field size and overall radiation treatment time as potential prognostic factors. Only T-stage was found to be statistically significant in the univariate analysis, but in the multivariate analysis, it was not found to be significant. Conclusion: High curative and voice preservation rates were obtained with hypofractionated radiotherapy. Further study with a larger number of patients is needed to determine the prognostic factors affecting treatment results.
Geun-Ha Suh,Mi-Gou Kim,Chang-Soo Suh 한국유통과학회 2015 유통과학연구 Vol.13 No.12
Purpose – The purpose of this research paper is twofold. First, this paper attempts to grasp the damage caused to small and medium-size retail traders from online wholesalers in the field. Second, this paper engages in a psychological characterization of the enterprise spirit and the management of small and medium-size entrepreneurs in the retail trade business that are harmed by online wholesalers. Research design, data, and methodology – Data on three large Korean wholesalers engaged in ongoing litigation during the first half of 2014, including E-Mart Traders E-Club, and regarding applications for business adjustments from three large wholesalers were used. Results – The results show that small and medium-size distribution merchants seek political support for facility modernization, policy-specific funds, development of the distribution of PB products, advanced distribution techniques, joint logistics systems, establishment of distribution and logistics centers, sharing of parking facilities, and joint ordering systems. Conclusions – This study examined the damage to, and the government’s support of policy demands from, small retail traders.
Yang, Hannah,Lee, Mi-Hee,Park, Intae,Jeon, Hanwool,Choi, Junyoung,Seo, Seyoung,Kim, Sang-We,Koh, Gou Young,Park, Kang-Seo,Lee, Dae Ho Elsevier 2017 Cancer letters Vol.411 No.-
<P><B>Abstract</B></P> <P>Small cell lung cancer (SCLC) cannot be efficiently controlled using existing chemotherapy and radiotherapy approaches, indicating the need for new therapeutic strategies. Although ABT-737, a B-cell lymphoma-2 (BCL-2) inhibitor, exerts anticancer effects against BCL-2-expressing SCLC, monotherapy with ABT-737 is associated with limited clinical activity because of the development of resistance and toxicity. Here, we examined whether combination therapy with ABT-737 and heat shock protein 90 (HSP90) inhibitor NVP-AUY922 exerted synergistic anticancer effects on SCLC. We found that the combination of ABT-737 and NVP-AUY922 synergistically induced the apoptosis of BCL-2-expressing SCLC cells. NVP-AUY922 downregulated the expression of AKT and ERK, which activate MCL-1 to induce resistance against ABT-737. The synergistic effect was also partly due to blocking NF-κB activation, which induces anti-apoptosis protein expressions. However, interestingly, targeting BCL-2 and MCL-1 or BCL2 and NF-κB did not induce the cytotoxicity. In conclusion, our study showed that combination of BCL2 inhibitor with HSP90 inhibitor increased activity in in vitro and in vivo study in only BCL-2 expressing SCLC compared to either single BCL2 inhibitor or HSP inhibitor. The enhanced activity might be led by blocking several apoptotic pathways simultaneously rather than a specific pathway.</P>
류마티스관절염 환자에서 TNF-α 억제제 사용 후 발생한 백반증 1예
송란 ( Ran Song ),김소미 ( So Mi Kim ),이상훈 ( Sang Hoon Lee ),이연아 ( Yeon Ah Lee ),홍승재 ( Seung Jae Hong ),조희령 ( Hee Ryung Cho ),김교영 ( Gou Young Kim ),양형인 ( Hyung In Yang ) 대한류마티스학회 2012 대한류마티스학회지 Vol.19 No.4
As the usage of biologics for rheumatic diseases increases, such as rheumatoid arthritis and ankylosing spondylitis, various cutaneous adverse events are also being increasingly reported. We experienced a case of development of vitiligo during a TNF-α antagonist therapy in a 22-year-old woman with rheumatoid arthritis. The patient was presented with vitiligo lesions on the dorsum of both hands after 1 month of treatment with etanercept. Vitiligo improved with topical tacrolimus ointment and excimer laser treatment without the discontinuation of etanercept. No clearly defined mechanism for vitiligo induced by TNF-α antagonist exits. However, considering that vitiligo is an autoimmune disorder, the development of this skin lesion in association with the TNF-α antagonist could be explained by a paradoxical induction of the autoimmune process.
효율적인 의약품 평가를 위한 약물계량학 분석법 도입의 전략 방안
( Sang Min Lee ),( Boyoon Choi ),( Hwi Yeol Yun ),( Da Hae Jun ),( Myung Gou Kim ),( Ji Hye Ha ),( Young Hoon Kim ),( Eun Hee Ji ),( Won Ku Kang ),( Na Young Han ),( Wan Gyoon Shin ),( Jung Mi Oh ) 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0
Over the past few decades, drug regulatory agencies in advanced countries have been emphasizing pharmacomctrics as a tool for an effective and efficient drug evaluation. Despite this international movement, the value of pharmacometrics is still poorly recognized by the Korean drug evaluation system. This study aimed to analyze the current state of utiliza-tion of pharmacometrics by foreign drug regulatory agencies and develop a road map to guide the implementation phar- macometrics into the Krean drug evaluation system. MEDLINE and foreign drug regulatory agency database were extensively searched to obtain scientific research articles, guidance, regulations and pharmacometric review reports on foreign pharmacometric drug evaluation system. A systematic roadmap comprised of 3 stages to implement pharmaco-metrics in Lorean drug evaluation system was formulated after analyzing the collected data in tune with the current evaluation system. Pharmacometrics is an urgently required tool to achieve an efficient drug evaluation and review in Korea. The road map developed by this study is expected to aid in setting up a policy to implement and utilize phar-macometrics in Korea.
Ryu, Ji-Kan,Tumurbaatar, Munkhbayar,Jin, Hai-Rong,Kim, Woo Jean,Kwon, Mi-Hye,Piao, Shuguang,Choi, Min Ji,Yin, Guo Nan,Song, Kang-Moon,Kang, Yong-Jin,Koh, Young Jun,Koh, Gou Young,Suh, Jun-Kyu Blackwell Pub 2012 JOURNAL OF SEXUAL MEDICINE Vol.9 No.12
<P>Men with diabetic erectile dysfunction (ED) often have severe endothelial dysfunction and respond poorly to oral phosphodiesterase-5 inhibitors.</P>