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한의진단명과 진단요건의 표준화 연구 III : 3차년도 연구결과 보고
최선미,양기상,최승훈,박경모,박종현,심범상,김성우,노석선,이인선,정진홍,이진용,김달래,임형호,김윤범,박성식,송태원,김종우,이승기,최윤정,신순식 한국한의학연구원 1997 한국한의학연구원논문집 Vol.3 No.1
The diagnostic requirements were suggested and explained regarding the systems of differentiation of symptoms and signs in the third year study of standardization and unification of the terms and conditions used for diagnosis in oriental medicine. The systems were as follows : - analyzing and differentiating of epidemic febrile disease - analyzing and differentiating in accordance with the Sasang constitution medicine based on four-type recognition - differentiation of disease according to pathological changes of Chong and Ren channels - standards for diagnosis of women's disease - standards for diagnosis of children's disease - standards for diagnosis of motor and sensor disturbance (-muscle. born, joint, etc.) - standards for diagnosis of neuropsychiatric disease - standards for diagnosis of five sense organ disease - standards for diagnosis of external disease The indivisual diagnosis pattern was arranged by the diagnostic requirements in the following order : another name, notion of diagnosis pattern, index of differentiation of symptoms and signs, the main point of diagnosis, analysis of diagnosis pattern, discrimination of diagnosis pattern, prognosis, a way of curing a disease, prescription, herbs in common use, disease appearing the diagnosis pattern, documents. The standards for diagnosis of each disease was arranged by the diagnostic requirements in the following order : another name, notion of disease, the main point of diagnosis, analyzing and differentiating of disease, analysis of disease, discrimination of disease, prognosis, a way of curing and prescription of disease, disease in western medicine appearing the disease in oriental medicine, documents.
종합 건강진단을 실시한 정상성인에서의 혈청지질 분포에 관한 연구
박일환,유선미,정유석 단국대학교 1997 論文集 Vol.31 No.-
Background: Hypercholesterolemia and dyslipidemia are regarded as the risk factors of atherosclerosis of the coronary arteries. The purpose of this study is to measure the serum lipid levels of the normal persons and to calculate the cut-off values of serum lipid levels to predict the occurence of coronary events. Methods: We investigated the serum lipid profiles of the normal adults who had visited the health promotion center of Dankook University Hospital. The mean values of serum lipids were evaluated according to the groups of age, we calculated the percentile values of serum total choleterol. Results: In normal adult persons, the means of total cholesterol increased according to age. The cut-off values of serum total cholesterol for the risk of atherosclerotic coronary events were 189 ㎎/dl for the moderate risk group(75∼90 percentile of normal persons) and 225 ㎎/dl for the high risk group(over 90 percentile of normal persons). Conclusions: This study shows that the mean and the cut-off values of serum lipid in the persons who are not obese and have normal blood pressure are significantly lower than those values of normal Korean adult persons.
국내 Fabry disease 환자의 a-Galatosidase A 유전자 돌연변이 검색
박기범,최지혜,강윤성,김선미,정향민,문영준,이광호 中央大學校 基礎科學硏究所 2001 基礎科學硏究所 論文集 Vol.15 No.-
Fabry disease(FD) is an X-linked recessive lysosomal disorder caused by a deficiency of a-galactosidase A(a-Gal A), localized at Xq22. Besides onset of pain and paresthesias in the extremities, FD was diagnosed by absence of a-Gal A activity. In this experiment the a-Gal A activity of Korean FD patients was spectrometrically analysed using an artificial substate, 4-Mrthylumbellifery1-a-D-galactoside. As expected, no a-Gal A activity was detected in lymphocytes and lymphoblastoid cells from FD patients. To screen the mutation in their a-Gal A genes, we performed single strand conformation polymorphism(SSCP) and PCR-direct sequencing form seven a-Gal A exons. The nonsense mutation was identified both in classically affected hemyzygotes and a heterozygote. They showed the C to T transition at nucleotide number 11,002, resulting in a arginine-to-stop(R342X). This result will be applicable for pre- and neonatal detection of FD and to define the genotype/phenotype correlation.
Phenylephrine, a small molecule, inhibits pectin methylesterases
Cheong, Mi Sun,Lee, Deuk Yeong,Seo, Kyung Hye,Choi, Geun-Hyoung,Song, Yeong Hun,Park, Ki Hun,Kim, Jin-Hyo Elsevier 2019 Biochemical and biophysical research communication Vol.508 No.1
<P><B>Abstract</B></P> <P>Pectin methylesterases (PMEs) catalyze pectin demethylation and facilitate the determination of the degree of methyl esterification of cell wall in higher plants. The regulation of PME activity through endogenous proteinaceous PME inhibitors (PMEIs) alters the status of pectin methylation and influences plant growth and development. In this study, we performed a PMEI screening assay using a chemical library and identified a strong inhibitor, phenylephrine (PE). PE, a small molecule, competitively inhibited plant PMEs, including orange PME and <I>Arabidopsis</I> PME. Physiologically, cultivation of <I>Brassica campestris</I> seedlings in the presence of PE showed root growth inhibition. Microscopic observation revealed that PE inhibits elongation and development of root hairs. Molecular studies demonstrated that <U>R</U>oot <U>H</U>air <U>S</U>pecific 12 (RHS12) encoding a PME, which plays a role in root hair development, was inhibited by PE with a Ki value of 44.1 μM. The biochemical mechanism of PE-mediated PME inhibition as well as a molecular docking model between PE and RHS12 revealed that PE interacts within the catalytic cleft of RHS12 and interferes with PME catalytic activity. Taken together, these findings suggest that PE is a novel and non-proteinaceous PME inhibitor. Furthermore, PE could be a lead compound for developing a potent plant growth regulator in agriculture.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Phenylephrine (PE) inhibits Pectin methylesterases (PMEs). </LI> <LI> Phenylephrine (PE) serves as a competitive inhibitor of active PMEs. </LI> <LI> Phenylephrine (PE) is a non-proteinaceous PME inhibitor. </LI> <LI> Phenylephrine (PE) inhibits the growth of <I>Brassica campestris</I> seedlings. </LI> <LI> Phenylephrine (PE) inhibits RHS12 (<U>R</U>oot <U>H</U>air <U>S</U>pecific 12), which PME plays a role in root hair development. </LI> </UL> </P>
Shin, Sun Mi,Cho, Kyu Suk,Choi, Min Sik,Lee, Sung Hoon,Han, Seol-Heui,Kang, Young-Sun,Kim, Hee Jin,Cheong, Jae Hoon,Shin, Chan Young,Ko, Kwang Ho Kluwer Academic/Plenum Publishers 2010 Neurochem Res Vol.35 No.7
<P>In response to brain injury, microglia migrate and accumulate in the affected sites, which is an important step in the regulation of inflammation and neuronal degeneration/regeneration. In this study, we investigated the effect of urokinase-type plasminogen activator (uPA) on the BV-2 microglial cell migration. At resting state, BV-2 microglial cells secreted uPA and the release of uPA was increased by ATP, a chemoattractant released from injured neuron. The migration of BV-2 cell was significantly induced by uPA and inhibited by uPA inhibitors. In this condition, uPA increased the activity of matrix metalloproteinase (MMP-9) and the inhibition of MMP activity with pharmacological inhibitors against either uPA (amiloride) or MMP (phenanthrolene and SB-3CT) effectively prevented BV2 cell migration. Interestingly, the level of MMP-9 protein and mRNA in the cell were not changed by uPA. These results suggest that the increase of MMP-9 activity by uPA is regulated at the post-translational level, possibly via increased activation of the enzyme. Unlike the uPA inhibitor, plasmin inhibitor PAI-1 only partially inhibited uPA-induced cell migration and MMP-9 activation. The incubation of recombinant MMP-9 with uPA resulted in the activation of MMP-9. These results suggest that uPA plays a critical role in BV-2 microglial cell migration by activating pro-MMP-9, in part by its direct action on MMP-9 and also in part by the activation of plasminogen/plasmin cascade.</P>
당뇨병 환자의 임상영양치료를 위한 임상영양사의 직무표준 개발
권수진 ( Su Jin Gwon ),우미혜 ( Mi Hye Woo ),주달래 ( Dal Lae Ju ),김은미 ( Eun Mi Kim ),박미선 ( Mi Sun Park ),손정민 ( Cheong Min Sohn ),위경애 ( Gyung Ah Wie ),이송미 ( Song Mi Lee ),차진아 ( Jin A Cha ),서정숙 ( Jung Sook Seo 대한영양사협회 2015 대한영양사협회 학술지 Vol.21 No.1
This study was conducted to develop job standards for clinical dietitian administering clinical nutrition therapy to diabetic patients in hospitals. Based on DACUM (Developing A Curriculum) analysis of 17 members including clinical dietitians, professors majoring in clinical nutrition and researchers, information on duties, tasks and task elements of clinical dietitians for diabetes care were derived and applied to diabetes mellitus- specific clinical nutrition care in hospitals for evaluation. The final developed job standards for clinical dietitians for diabetes care included four duties, 19 tasks and 56 task elements. The duties consisted of nutrition assessment, nutrition diagnosis, nutrition intervention, and nutrition monitoringㆍevaluation. For application of diabetes mellitus-specific job standards in clinical nutrition care, 108 work activities were developed and classified into 90 basic and 18 recommended types. Performance rates of standardized jobs were 80.2% at nutrition assessment, 99.6% at nutrition diagnosis, 78.5% at nutrition intervention, and 32.9% at nutrition monitoringㆍevaluation. These results can be applied as guidelines to implement jobs for diabetes mellitus-specific clinical nutrition services in clinical settings. In addition, they would be useful for education standards in educational institutions for education and training of clinical dietitian.
Development of Job Standards for Clinical Nutrition Therapy for Dyslipidemia Patients
( Min-jae Kang ),( Jung-sook Seo ),( Eun-mi Kim ),( Mi-sun Park ),( Mi-hye Woo ),( Dal-lae Ju ),( Gyung-ah Wie ),( Song-mi Lee ),( Jin-a Cha ),( Cheong-min Sohn ) 한국임상영양학회 2015 Clinical Nutrition Research Vol.4 No.2
Dyslipidemia has significantly contributed to the increase of death and morbidity rates related to cardiovascular diseases. Clinical nutrition service provided by dietitians has been reported to have a positive effect on relief of medical symptoms or reducing the further medical costs. However, there is a lack of researches to identify key competencies and job standard for clinical dietitians to care patients with dyslipidemia. Therefore, the purpose of this study was to analyze the job components of clinical dietitian and develop the standard for professional practice to provide effective nutrition management for dyslipidemia patients. The current status of clinical nutrition therapy for dyslipidemia patients in hospitals with 300 or more beds was studied. After duty tasks and task elements of nutrition care process for dyslipidemia clinical dietitians were developed by developing a curriculum (DACUM) analysis method. The developed job standards were pretested in order to evaluate job performance, difficulty, and job standards. As a result, the job standard included four jobs, 18 tasks, and 53 task elements, and specific job description includes 73 basic services and 26 recommended services. When clinical dietitians managing dyslipidemia patients performed their practice according to this job standard for 30 patients the job performance rate was 68.3%. Therefore, the job standards of clinical dietitians for clinical nutrition service for dyslipidemia patients proposed in this study can be effectively used by hospitals.