江戶時代 小袖에 나타난 文樣 考察法

朴玉連,韓美卿 慶星大學校 1998 論文集 Vol.19 No.2

This study proposed that Japanese Kosode was appeared the kinds and technics of the pattern. The main results were as follows. 1. The pattern in Kosode expressed the human and the nature-animal, botanic, natural appearance, scenery. 2. The technics in Kosode were Embroidery, Tie-Dyeing, Especially, Yuzen-Dyeing advanced. 3. Kosode in Edo era influenced the brevity composition and splendour pattern in the current Kimono.

광중합방식이 콤포머의 변연폐쇄에 미치는 영향

조옥환,한진순,임미경,이수종 대한치과보존학회 2001 Restorative Dentistry & Endodontics Vol.26 No.1

The aim of this study was to evaluate the effect of various polymerization techniques on the microleakage of compomer restorations. Fifty extracted human premolar and molar were used and randomly divided into 5 groups. After cavity preparation, compomer (F2000) was filled according to the manufacturer's directions. All groups, except group 5, were filled using an incremental technique. Group 1was polymerized for 40 seconds at a continuous 485mW/㎠ with a VIP (Bisco, USA) light cure unit. Group 2 was polymerized for 20 seconds at a continuous 345mW/㎠ and then for 20 seconds at 645mW/㎠ with the VIP light cure unit. Group 3 was polymerized at 400mW/㎠, gradually increased to 50mW/㎠ per 10 seconds until 550mW/㎠ was reached; total 40 seconds with a Spectrum 800 (Dentsply Caulk, USA) light cure unit. Group 4 was polymerized for for 3 seconds using an incremental technique with a Flipo (LOKKi, France) light cure unit. Group 5 was polymerized for 3 seconds using a bulk fill technique with the Flipo light cure unit. The specimens were embedded with acrylic resin, and were sectioned with diamond saws in a mesiodistal direction along the longitudinal axis of the tooth so as to pass through the center of the restoration, and three surfaces (occlusal, pulpal, and gingival) were examined with SEM. The results were as follows; 1. Group 5 showed a significantly larger gaps compared to other groups on the gingival, occlusal, and pulpal walls. 2. All groups except group 5 had no statistically significant gap on the gingival, occlusal, and pulpal walls. 3. There was no significant correlation between the amount of enamel on the gingival and occlusal walls and polymerization shrinkage.

임신성 융모 종양의 Immunoperoxidase 방법에 의한 HCG, HPL 및 SP-1의 분포에 관한 면역조직화학적 연구

정미경,한운섭,김옥경 梨花女子大學校 醫科大學 醫科學硏究所 1987 EMJ (Ewha medical journal) Vol.10 No.3

Fourty-six cases of gestational trophoblastic neoplasms (32 cases of hydatidiform mole; 4 cases of invasive mole; 10 cases of choriocarcinoma) and five cases of normal pregnancy as control group were studied for the distribution and intensity of human chorionic gonadotropin(HCG), human placental lactogen(HPL) and regnancy specific beta-1 glycoprotein(SP-1) by immunoperoxidase method. The following results were obtained. 1) The HGC was seen in the syncytiotropholasts, but not cytotrophoblasts of normal placental tissue and hydatidiform mole in all 3 grades. However, in the invasive mole and choriocarcinoma, the HCG was also seen in the cytotrophoblasts. 2) The HPL and SP-1 were only seen in the syncytiotrophoblasts in all those trophoblastic neoplasms. 3) The more malignancy was progressed, the more intensity of the HCG in the syncytiotrophoblasts was increase. Especially, it was severe intensity of positivity in the choriocarcinoma. 4) Intensity of the HPL in the syncytiotrophoblast had the tendency of increase in the invasive mole. But, it was variable in the choriocarcinoma. 5) Intensity of the SP-1 in the syncytiotrophoblast had the tendency of increase in the grade Ⅱ of hydatidiform mole. But thereafter, it was decreased or variable in more aggressive trophoblastic neoplasms, In conclusion, the HCG, HPL and SP-1 were present in the syncytiotrophoblasts of normal placental tissue and various trophoblastic neoplasms. And, the more severe hyperplasia and undifferentiation of trophoblasts were seen, the more intensity of the HCG was increased, suggesting that the HCG can be a useful tumor marker of prognosis in gestational trophpblastic neoplasms.

기능평가를 통한 장애유아의 행동지원 실험연구 분석 : 1997~2006년 사이의 연구를 중심으로

이미애,한성희,이규옥 국립특수교육원 2007 특수교육연구 Vol.14 No.2

이 연구는 유아를 대상으로 기능평가를 통한 행동지원을 제공한 실험연구를 분석하여 현재의 전반적인 특징과 경향을 분석하고 문제행동 기능의 결과가 중재와 어떻게 연결되는지 살펴봄으로써 문제행동 중재를 위한 향후의 방향을 모색하고자 하였다. 이 연구의 분석 대상 논문은 주로 중다기초선 설계법을 사용하며 중재는 일반교실이나 가정 등의 자연스러운 환경에서 교사나 부모 등의 자연스러운 중재자에 의해서 이루어지고 있었으며 목표행동은 대상유아의 바람직한 행동보다는 부정적인 행동이 많았으며 중재자의 행동을 목표행동으로 본 연구도 5-6편이 있었다. 연구의 질적 수준에 대한 변인들 중 관찰자간 신뢰도를 제외하고는 중재충실도, 사회적 타당도, 유지, 일반화 등에 대한 파악이 부족한 것으로 나타났다. 기능평가는 주로 일반학급과 가정 등의 자연스러운 환경에서의 부모나 일반교사를 대상으로 한 인터뷰와 연구자나 가족, 교사 등에 의한 관칠 방법, 연구자에 의한 기능분석 방법이 많이 이용되었다. 기능평가 방법으로는 직접관찰과 인터뷰가 가장 많이 이용되었으며 평균 2~3가지 방법을 사용하고 있었으며 문제행동의 기능은 관심끌기가 가장 높았고 획득과 회피, 감각적 자극 순으로 나타났다. 행동의 기능에 따른 중재전략을 살펴보면 획득기능과 회피 기능을 가진 경우에는 선행사건 예방전략과 후속반응전략이 가장 많이 사용되었고 관심의 기능을 가진 경우에는 후속반응전략이, 감각적 자극을 목적으로 한 문제행동 중재에는 문제행동을 차단하는 전략이 사용되고 있었다. The purpose of this study was to analyze experimental studies that intervened young children's challenging behavior using functional assessment and to provide information and suggestions on future research. To accomplish this purpose, the elements of experimental study, the quality features of study(interobserver agreement, fidelity of intervention, social validity, maintenance and generalization of effect) and methods of functional assessment and intervention strategies were analyzed. The major findings of this study was followed. First, most of the analyzed articles used multi-baseline design, and the interventions were implemented were natural settings like classroom and home, and the interventionists were natural people like teachers and parents. Target behaviors were focused on problematic behaviors of subjects than desirable behaviors. Second, among the 5 quality features of study I chose, fidelity of intervention, social validity, maintenance and generalization of effect were identified poorly except interobserver agreement. Third, functional assessment was implemented by natural people like teachers and family members, and at the natural settings like classrooms and home routine. Interview to teachers and family members and direct observation by researchers, teachers and family members were used. The most common functional assessment methods were direct observation and interview. And 2 or 3 methods were used one study. The order of the function of problematic behavior was attention, obtain tangible, escape, and sensory stimulation. As an interventions strategies, antecedents events, alternative skills and consequent responding were applied comparatively the same rate. Based on this results, some recommendations are suggested.

Azoloquinoxaline類의 간편한 合成에 관한 硏究 : 第1報

郭美玉,南順花,金恩慶,金眞姬,韓盛旭,李萬佶,朴義煥,金浩植 고신대학교 자연과학연구소 1993 고신대학교 자연과학연구소 논문집 Vol.3 No.-

The reaction of 2, 6-dichoroquinoxaline with m-chloroperbenzoic acid gave 2, 6-dichloroquinoxaline 4-oxide, whose reaction with sodium azide provided 7-chlorotetrazolo[1, 5-a]quinoxaline 5-oxide and not the isomeric azide. The structures of the synthesized compounds were confirmed on the basis of IR, ¹H-NMR, elemental analysis and mass spectral data.

대학생의 봉사활동 의식 수준별 성격 특성 연구

최진승,한미옥,김경원 동아대학교 교육대학원 2002 동아교육논총 Vol.28 No.-

This study research on service cognitions of college's students and their personality traits. The subjects are 1,417 college students (504 male students and 913 female students). The used tools are college student's personality test and questionnaires of college student's service activities. The sub-factors of personality traits are 12 traits as responsibility, leadership, diligent, independent, planning, tolerance, self-esteem, legality, generosity, anxiety, impulse, and masculinity. The categories of service activities on college students are 11 items as the importance of service activity to college students, the desire of service activity to college students, the beginning times of service activity to college students, the expense of service activity of college students, the times in one year of service activity to college students, the satisfactions of service activity to college students, the obstacles of service activity to college students, the obstacles of service activity to college students, the advantages of service activity to college students, the credit permissions of service activity to college students, the areas of service activity to collee students, the perspectives in future time of service activity to college students. From the results and discussions, conclusions as follows: 1.The college students on higher level traits as level traits as responsibility, leadership, diligent, planning, tolerance, self-esteem, legality, generosity, impulse, and masculinity recognize the importance of service activity. 2.The college students on higher level traits as responsibility, leadership, diligent, planning, tolerance, self-esteem, legality, and generosity recognize the importance of service activity. But the college students on higher level traits as independent recognize the unimportance of service activity. 3.The college students on higher level traits as leadership tolerance, self-esteem, and legality rrecognize the desire of service activity. 4.The college students on higher level traits as tolerance, legality, and generosity recognize the importance of self-expenses. 5.The college students on higher level traits as planning, tolerance, self-esteem, legality, generosity, and masculinity recognize the more than five times in a year as college students' service activity. 6.The college students on higher level traits as responsibility, leadership, diligent, independents planning, tolerance, self-esteem, legality, generosity, impulse, and masculinity recognize the satisfaction of service activity. 7.The college students on higher level traits as responsibility, leadership, planning, tolerance, and self-esteem recognize the obstacle as misunderstanding of college students, but the college students on higher level traits as independents recognize the obstacle as lake of systems and support from college and govemment. 8.There are no differences among the college student's traits and college student's advantages as spirits of sacrifice, professional knowledge, and a lot of times in college courses. 9.The college students on higher level traits as leadership, diligent, planning, tolerance, self-esteem, generosity, impulse, and masculinity recognize the importance of the credit permissions of service activity to college students. 10.The college students on higher level traits as responsibility and masculinity recognize the importance of visiting home for orphans, the college students on higher level traits as leadership recognize the importance of helping farm country, and the college students on higher level traits as independence recognize the importance of helping homelessness parents. 11.The college students on higher level traits as leadership, planning, tolerance, self-esteem, legality, and generosity recognize the positive perspectives in future time of service activity to college students.

개선된 사람 혈장중 세파클러 농도 정량법을 이용한 세파클러 캡슐의 생체이용률 측정

김태완,송옥경,한선영,Cao, Qing-Ri,박미진,강성화,신관석,Cui, Jing-Hao,이범진 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.2

After establishing improved HPLC analytical method ofcefaclor in human plasma samples, a bioavailability study of cefaclor capsules was conducted according to the guidelines of Korea Food and Drug Administration (KFDA). The standard calibration curve using an HPLC with UV detector was constructed in a range of 0.0324--16 μg/m1. The 6% perchloric acid instead of 6% trichloroacetic acid was used to precipitate plasma protein. The HPLC chromatograms were precisely and accurately resolved when spiked with human plasma spiked with cefaclor and cephalexin (internal standard). Twenty healthy male Korean volunteers received two commercial cefaclor capsules, Neocef ' capsule (Jinyang Pharm. Co., Ltd) or Ceclor" capsule {Lilly Korea. Co., Ltd.) at the 250 mg cefaclor in a 2 x 2 crossover study. There was a one-week washout period between the doses. Plasma concentrations of cefaclor were monitored for 8 hours after oral drug administration. AUC, the area under the plasma concentration-time curve from time zero to 8 hr (13 points), was calculated by the linear trapezoidal rule method. C,,,a" (maximum plasma drug concentration) and Tmax (time to reach Cma,) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed AUC, and Cmax. No significant sequence effect was found for all of the bioavailability parameters indicating that the cross-over design was properly performed. The 90% confidence intervals of the AUC, ratio and the Cmax ratio for Neocer/Ceclor" were 0.9049 S S < 1.0304 and 0.9776 5 S 1.226, respectively. These values were within the acceptable bioequivalence intervals of 0.80-1.25. Thus, our study demonstrated the bioequivalence of Neocef"/Ceclor" with respect to the extent of absorption.

벗나무속 수종간의 핵 리보솜 DNA의 ITS Ⅰ 염기서열 비교

오유성,김기옥,정용환,오문유,한상현,고미희 제주대학교 생명과학연구소 1998 제주생명과학연구 Vol.1 No.-

Comparison of four species (Prunus yedoensis, P. sargentii, P. pendula for. ascendens, P. serrulata var. quelpaertensis) and one cultivar of P. yedoensis were carried out by comparing their nucleotide sequences from the internal transcribed spacers (ITS) I of nuclear ribosomal DNA (rDNA). The length of the ITS I region was ranged from 229 to 236 base pairs (bp). The G+C contents of ITS I ranged from 58.5 to 60.2%. The value of nucleotide divergence across for four Prunus species and one cultivar ranged from 0.4 to 6%. The pairwise distance between P. pendula for. ascendens and P. yedoensis was 0.004 showing the lowest value among any other pairs. On the other hand, the pairwise distance betwen P. yedoensis and cultivated P. yedoensis was 0.026. The nucleotide analysis based on ITS I sequence was considerably similar to previous studies on the basis of random amplified polymorphic DNA (RAPD).

요로결석 환자의 체외충격파쇄석술 치료경과와 결석 특성과의 관련성

김성길,김기순,류소연,한미아,이선옥,노준 朝鮮大學校 附設 醫學硏究所 2009 The Medical Journal of Chosun University Vol.33 No.S

요로 결석에 대한 비 침습적 치료 방법인 체외충격파쇄석술에 의한 치료경과와 결석 특성과의 관련성을 파악키 위해 2002년 12월부터 2008년 3월까지 G시 H병원에서 요로 결석으로 진단되어 체외충격파쇄석술을 받은 33l례를 대상으로 의무기록 자료를 이용하여 분석한 결과는 다음과 같다. 1. 조사 대상자 331례중 남자는 68.6%, 여자는 31.4%이었으며 평균연령(표준편차)은 44.2 (13.9)세 이었고 84%가 G시내 거주자였다. 2. 조사 대상자에게 시행된 체외충격파쇄석술의 평균 시술횟수(표준편차)는 1.9(1.5)회 이었으며 평균 통증제거기간(표준편차)은 3.2(2.1)일 이었고 요로결석 진단 시로부터 치료가 완료되었다고 의사가 판정했을 때까지의 치료기간의 평균(표준편차)은 10.3(8.4)일 이었다. 3. 시술횟수에 통계적으로 유의하게(P<0.01) 관련된 요인은 결석크기, 결석의 방사선 투과성, 요관 폐색여부 이었으며 모형의 설명력은 13.5%이었다. 4. 통증제거기간에 통계적으로 유의하게(P<0.01) 관련된 요인은 결석의 방사선 투과성 이었으며 모형의 설명력은 7.4%이었다. 5. 치료기간에 통계적으로 유의하게(P<0.01) 관련된 요인은 결석크기와 결석의 방사선 투과성 이었으며 모형의 설명력은 13.5%이었다. 따라서 결석의 크기가 크거나 결석이 방사선에 비 투과성일 때, 요관이 폐색되어 있을 때 치료경과가 늦게 됨으로 이러한 사실을 참고 하여 추후 진료지침을 작성 시 보다 효과적이고 효율적인 치료법을 적용할 필요가 있다고 판단되며 보다 체계적인 평가와 연구가 필요할 것이다. Objectives & Methods: To find the treatment process by extracorporeal shock wave lithotripsy (ESWL) and its related stone characteristics in urinary tract stone patients, an analysis was done from medical records of 331 cases who were treated by ESWL from December 2002 to March 2008 at H hospital in G city. Results: Among 331 study subjects 68.6% were male and 31.4% were female. Their mean age (standard deviation, SD) was 44.2 (13.9) years old and 84.0% lived in G city. Average frequency of ESWL done toward study cases were 1.9±1.5 times. Mean duration of disappearance from pain was 3.2±2.1 days and total treatment period for a stone was 10.3±8.4 days. Statistically significant (p<0.01) stone and urinary tract characteristics related with frequency of ESWL were stone size, radio-opacity of the stone, and obstruction of urinary tract. The model composed of these 3 independent variables explained 13.5% of frequency of ESWL. Statistically significant (p<0.01) variable related with disappearance from pain was radio-opacity of the stone, and this model explained 7.4%. Statistically significant (p<0.01) variables related with treatment duration due to stone were stone size and radio-opacity of the stone. These two variables explained 13.5%. Conclusion: The bigger the size of stone are, the slower the treatment process will be. And when the stone is radio-opaque and urinary tract is obstructed, the treatment process will be slower than stone is radio-luscent and urinary tract is not obstructed. So to make effective and efficient treatment manual for ESWL, above fact must be considered and continuous systematic evaluation and research toward ESWL are necessary.

랫드에서 인체 재조합 적혈구 조혈인자, rHuEPO의 13주 정맥투여 아만성독성에 관한 연구

김형식,곽승준,천선아,박현선,한하수,임소영,안미영,김원배,김병문,안병옥,홍성렬,이병무 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

A recombinant human erythropoietin (rHuEPO) was administered intravenously at dosage levels of 0, 100, 500, and 2500 IU/㎏/day for a period of 13 weeks. There were no observed clinical signs and deaths related to treatment in all groups tested. Decreases in body weight gain and food consumption were observed only in males of 2,500 IU/㎏ group after 2 weeks. In hematological parameters, erythrocyte content, hematocrit values and hemoglobin concentration were dose-dependently increased in rHuEPO treated groups. The ratio between kidney weight and whole body weight was significantly increased in females of 500 and 2,500 IU/㎏ groups. The spleen weight was also increased in both sexes of 500 and 2,500 IU/㎏ groups. However, the absolute weight change of other organs was not observed. In histopathological examinations, the renal tubular basophilia was observed only in males and females of 2,500 IU/㎏ groups. From these results, it is concluded that the no-observed adverse effect level(NOAEL) of rHuEPO is 100 IU/㎏ in rats in the present study.