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- 저자 : Manna Chen (검색결과 3 건)
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Propagation Dynamics of a Finite-energy Airy Beam with Sinusoidal Phase in Optical Lattice
Xiaoyuan Huang,Manna Chen,Geng Zhang,Ye Liu,Hongcheng Wang 한국광학회 2020 Current Optics and Photonics Vol.4 No.4
The propagation of a truncated Airy beam with spatial phase modulation (SPM) is investigated in Kerr nonlinearity with an optical lattice. Before the truncated Airy beam enters the optical lattice, a sinusoidal phase is introduced on the wave-front of the beam. The effect of the spatial phase modulation and optical lattice on propagation behavior is analyzed by direct numerical simulation. It is found that the propagation direction of a truncated Airy beam can be effectively controlled by adjusting the values of phase shift. The effects of optical amplitude, truncation factor, spatial modulation frequency, lattice period and lattice depth on the propagation are discussed in detail. By choosing a high modulation depth, the finite-energy Airy beam can be deflected with a large deflection angle in an optical lattice.
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Huang Peng,Qin Xiaofei,Fan Chuiqin,Wang Manna,Chen Fuyi,Liao Maochuan,Zhong Huifeng,Wang Hongwu,Ma Lian 한국조직공학과 재생의학회 2023 조직공학과 재생의학 Vol.20 No.5
BACKGROUND: Despite the progress in perinatal-neonatal medicine, complications of extremely preterm infants continue to constitute the major adverse outcomes in neonatal intensive care unit. Human umbilical cord Wharton’s Jellyderived mesenchymal stem cells (HUMSCs) may offer new hope for the treatment of intractable neonatal disorders. This study will explore the functional differences of HUMSCs between extremely preterm and term infants. METHODS: UMSCs from 5 extremely preterm infants(weeks of gestation: 22?5 w,24?4 w,25?3 w,26 w,28 w) and 2 term infants(39 w,39?2 w) were isolated, and mesenchymal markers, pluripotent genes, proliferation rate were analyzed. HUVECs were injured by treated with LPS and repaired by co-cultured with HUMSCs of different gestational ages. RESULTS: All HUMSCs showed fibroblast-like adherence to plastic and positively expressed surface marker of CD105,CD73 and CD90, but did not expressed CD45,CD34,CD14,CD79a and HLA-DR; HUMSCs in extremely preterm exhibited significant increase in proliferation as evidenced by CCK8, pluripotency markers OCT-4 tested by RT-PCR also showed increase. Above all, in LPS induced co-cultured inflame systerm, HUMSCs in extremely preterm were more capable to promote wound healing and tube formation in HUVEC cultures, they promoted TGFb1 expression and inhibited IL6 expression. CONCLUSIONS: Our results suggest that HUMSCs from extremely preterm infants may be more suitable as candidates in cell therapy for the preterm infants.
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IL28B Is Associated with Outcomes of Chronic HBV Infection
Xiaodong Shi,Junqi Niu,Xiumei Chi,Yu Pan,Yanhang Gao,Wanyu Li,Chen Yang,Jin Zhong,Damo Xu,Manna Zhang,Gerald Minuk,Jing Jiang 연세대학교의과대학 2015 Yonsei medical journal Vol.56 No.3
Purpose: The role of IL28B gene variants and expression in hepatitis B virus (HBV) infections are not well understood. Here, we evaluated whether IL28B gene expression and rs12979860 variations are associated with HBV outcomes. Materialsand Methods: IL28B genetic variations (rs12979860) were genotyped by pyrosequencingof DNA samples from 137 individuals with chronic HBV infection [50 inactive carriers (IC), 34 chronic hepatitis B (CHB), 27 cirrhosis, 26 hepatocellular carcinoma (HCC)], and 19 healthy controls. IL28A/B mRNA expression in peripheralblood mononuclear cells was determined by qRT-PCR, and serum IL28B proteinwas measured by ELISA. Results: Patients with IL28B C/C genotype had greater IL28A/B mRNA expression and higher IL28B protein levels than C/T patients. Within the various disease stages, compared to IC and healthy controls, IL28B expression was reduced in the CHB, cirrhosis, and HCC cohorts (CHB vs. IC, p=0.02; cirrhosis vs. IC, p=0.01; HCC vs. IC, p=0.001; CHB vs. controls, p<0.01; cirrhosis vs. controls, p<0.01; HCC vs. controls, p<0.01). When stratified with respect to serum HBV markers in the IC and CHB cohorts, IL28B mRNA and protein levels were higher in HBeAg-positive than negative individuals (p=0.01). Logistic regression analysis revealed that factors associated with high IL28B proteinlevels were C/C versus C/T genotype [p=0.016, odds ratio (OR)=0.25, 95% confidence interval (CI)=0.08‒0.78], high alanine aminotransferase values (p<0.001, OR=8.02, 95% CI=2.64‒24.4), and the IC stage of HBV infection (p<0.001). Conclusion: Our data suggest that IL28B genetic variations may play an important role in long-term development of disease in chronic HBV infections.
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