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Antiapoptotic Effect of Paricalcitol in Gentamicin-induced Kidney Injury
Sang Heon Suh,Ko Eun Lee,Jeong Woo Park,In Jin Kim,Ok Kim,Chang Seong Kim,Joon Seok Choi,Eun Hui Bae,Seong Kwon Ma,Jong Un Lee,Soo Wan Kim 대한생리학회-대한약리학회 2013 The Korean Journal of Physiology & Pharmacology Vol.17 No.5
While the anti-apoptotic effect of paricalcitol has been demonstrated in various animal models, it is not yet clear whether paricalcitol attenuates the apoptosis in gentamicin (GM)-induced kidney injury. We investigated the effect of paricalcitol on apoptotic pathways in rat kidneys damaged by GM. Rats were randomly divided into three groups: 1) Control group (n=8), where only vehicle was delivered, 2) GM group (n=10), where rats were treated with GM (150 mg/kg/day) for 7 days, 3) PARI group (n=10), where rats were co-treated with paricalcitol (0.2 Ռg/kg/day) and GM for 7 days. Paricalcitol attenuated renal dysfunction by GM administration in biochemical profiles. In terminal deoxynu-cleotidyl transferase dUTP nick end labeling staining, increased apoptosis was observed in GM group, which was reversed by paricalcitol co-treatment. Immunoblotting using protein samples from rat cortex/outer stripe of outer medulla showed increased Bax/Bcl-2 ratio and cleaved form of caspase-3 in GM group, both of which were reversed by paricalcitol. The phosphorylated Jun-N-terminal kinase (JNK) expression was increase in GM, which was counteracted by paricalcitol. The protein expression of p-Akt and nitro-tyrosine was also enhanced in GM-treated rats compared with control rats, which was reversed by paricalcitol co-treatment. Paricalcitol protects GM-induced renal injury by antiapoptotic mechanisms, including inhibition of intrinsic apoptosis pathway and JNK.
Overview of Conductor Production for ITER Toroidal Field Magnet in Korea
Soo-Hyeon Park,Soun Pil Kwon,Won Woo Park,Heekyung Choi,Young Jae Ma,Young Ho Seo,Ki Hong Sim,Pyeong Yeol Park,Jun-Seg Lee,Il-Young Han,Sung Chan Kang,Dong Hee Lee,Turtu, S.,Di Zenobio, A.,Quagliata, IEEE 2014 IEEE transactions on applied superconductivity Vol.24 No.3
<P>The ITER toroidal field (TF) conductor is made up of superconducting Nb<SUB>3</SUB>Sn and copper strands assembled into a multistage, rope-type cable inserted into a conduit of butt-welded stainless steel jacket sections. For the ITER Project, the Korean Domestic Agency (KODA) took the responsibility of the procurement of 27 superconducting conductors for the ITER TF magnets. After concluding the Procurement Arrangement (PA) with the ITER International Organization in May 2008, KODA has been implementing the PA through four major industrial contracts: (1) Nb<SUB>3</SUB>Sn strand, (2) cable, (3) stainless steel jacket sections, and (4) jacketing. Prior to the production of conductors required for the TF coils, one 760-m-long copper dummy conductor and one 100-m-long superconducting conductor were fabricated for manufacturing process qualification. As of June 2013, 16 TF conductors were successfully manufactured. The full-size conductor performance tests in the SULTAN facility yielded very high performance. This article describes the technical requirements of the TF conductor and how KODA has been manufacturing the conductors with a high-level quality assurance/quality control system. It also presents the results of acceptance tests, including those of the SULTAN test.</P>
Optimal design using genetic algorithm with nonlinear inelastic analysis
Sang-Soo Ma,김승억 국제구조공학회 2007 Steel and Composite Structures, An International J Vol.7 No.6
An optimal design method in cooperated with nonlinear inelastic analysis is presented. The proposed nonlinear inelastic method overcomes the difficulties due to incompatibility between the elastic global analysis and the limit state member design in the conventional LRFD method. The genetic algorithm used is a procedure based on Darwinian notions of survival of the fittest, where selection, crossover, and mutation operators are used to look for high performance ones among sections in the database. They are satisfied with the constraint functions and give the lightest weight to the structure. The objective function taken is the total weight of the steel structure and the constraint functions are load-carrying capacity, serviceability, and ductility requirement. Case studies of a planar portal frame, a space two-story frame, and a three-dimensional steel arch bridge are presented.
Soo-Hyeon Park,Jun Young Kim,Won Woo Park,Heekyung Choi,Young Jae Ma,Soun Pil Kwon,Keeman Kim,Sung Chan Kang,Dong Hee Lee Institute of Electrical and Electronics Engineers 2012 IEEE transactions on applied superconductivity Vol.22 No.3
<P>While the manufacturing of superconducting CICC (cable in conduit conductor) and winding conductors into winding packs for ITER TF magnets, cold work is unavoidably applied on the jacketing tube. This article investigates the effect of plastic deformation on low temperature mechanical and magnetic properties of austenite 316LN stainless steel tube for ITER TF conductor. To simulate the manufacturing process of TF magnet, tubes were compacted, extended to 2.5% in longitudinal direction and heat treated. After each step, specimens were sectioned using wire cutting EDM, and tensile tests at 4 K, magnetic susceptibility measurements, and hardness tests have been carried out on those specimens. Remarkable reductions of elongation at failure have been observed as the amount of cold work is increased through compaction and extension. Further, correlations among results of tensile tests, magnetic susceptibility measurements and hardness tests are presented.</P>
( Sang Heon Suh ),( Tae Ryom Oh ),( Hong Sang Choi ),( Chang Seong Kim ),( Eun Hui Bae ),( Seong Kwon Ma ),( Kook-hwan Oh ),( Tae-hyun Yoo ),( Dong-wan Chae ),( Soo Wan Kim ) 대한신장학회 2023 Kidney Research and Clinical Practice Vol.42 No.2
Background: Urine chloride has recently been suggested as a biomarker of renal tubule function in patients with nondialysis chronic kidney disease (CKD), as low urinary chloride concentration is associated with an increased risk of CKD progression. We investigate the association between urinary chloride excretion and the progression of coronary artery calcification (CAC). Methods: A total of 1,065 patients with nondialysis CKD were divided into tertiles by spot urine chloride-to-creatinine ratios. The 1st, 2nd, and 3rd tertiles were defined as low, moderate, and high urinary chloride excretion, respectively. The study outcome was CAC progression, which was defined as an increase in coronary artery calcium score of more than 200 Agatston units during the 4-year follow-up period. Results: Compared to moderate urinary chloride excretion, high urinary chloride excretion was associated with decreased risk of CAC progression (adjusted odds ratio, 0.379; 95% confidence interval, 0.190-0.757), whereas low urinary chloride excretion was not associated with risk of CAC progression. Restricted cubic spine depicted an inverted J-shaped curve, with a significant reduction in the risk of CAC progression in subjects with high spot urine chloride-to-creatinine ratios. Conclusion: High urinary chloride excretion is associated with decreased risk of CAC progression in patients with nondialysis CKD.
Marsupial Development and Molt Cycle of Archaeomysis kokuboi : Crustacea:Mysidacea
Ma, Chae Woo,Hong, Sung Yun,Jo, Soo Gun 한국수산학회 2002 Fisheries and Aquatic Sciences Vol.5 No.4
Ovarian cycle, marsupial development and molt cycle of Archaeomysis kokuboi were studied to understand these processes as a whole event. Based on morphological characters the marsupial development is divided into 3 stages, Embryonic stage (duration time of 4 days), Nauplioid stage (5 days) and Postnauplioid stage (4 days). Morphological description was made for the 3 stages, and each stage was examined in relation to the corresponding stages of ovarian cycle and molt cycle.
Ma, Hong,Kim, Chung-Soo,Ma, Yuan,Nam, Sang-Yoon,Kim, Dong-Seon,Woo, Sung-Sick,Hong, Jin-Tae,Oh, Ki-Wan John Wiley Sons, Ltd. 2009 Phytotherapy research Vol.23 No.9
<P>This study was performed to investigate whether magnolol enhances pentobarbital-induced sleeping behaviors through the GABAergic systems. Magnolol prolonged the sleeping time induced by pentobarbital. In addition, magnolol increased chloride influx in primary cultured cerebellar granule cells. The expression of the GABA<SUB>A</SUB> receptor &agr;-subunit was increased selectively by magnolol, but magnolol had no effect on the abundance of &bgr;- or &ggr;-subunits. The expression of glutamic acid decarboxylase (GAD) was not influenced by magnolol. It is suggested that magnolol may enhance pentobarbital-induced sleeping behaviors through the activation of GABAergic systems. Copyright © 2009 John Wiley & Sons, Ltd.</P>