Alginate-Coated Thiolated Chitosan Microspheres for an Oral Drug Delivery System In Vitro

Jiang, Hu Lin,Arote, Rohidas B.,Quan, Ji Shan,Yoo, Mi Kyong,Kim, You Kyoung,Kim, In Yong,Hong, Zhong Shan,Lee, Hong Gu,Jin, Xun,Choi, Yun Jaie,Cho, Chong Su Trans Tech Publications, Ltd. 2007 Key Engineering Materials Vol.342 No.-

<P>Thiolated polymers have been studied by many researchers because of the mucoadhesive properties of thiol group. Alginate is a natural and biocompatible polymer that has been widely used in drug delivery. In this study, thiolated chitosan microspheres (TCMs) were prepared by ionic gelation process with tripolyphosphate and then, the bovine growth hormone (BGH) was loaded as a model drug. Finally, the BGH-loaded TCMs (BTCMs) were coated with alginate to improve the stability in gastrointestinal (GI) track. The alginate-coated BTCMs (ABTCMs) were observed as spherical shapes. The average particle sizes of ABTCMs were 6.97±0.55 -m and the sizedistribution was shown uniformly. Release of BGH from ABTCMs was decreased by coating with alginate and increased rapidly with the change in medium pH from 1.2 to 7.4. Results indicate that the ABTCMs have a potential as a drug carrier for oral drug delivery.</P>

A Voronoi path planning extracted from improved skeleton for dynamic environments

Lin Jiang,Jun Li,Yuxin Hu,Feng Pan,Jianyang Zhu,Bin Lei,Rui Lin 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.4

Aiming at the problems that the robot being in the process of navigation cannot meet the requirements of real-time and accuracy at the same time, moreover is too close to obstacles and lacks the initiative to avoid obstacles, a Voronoi diagram algorithm for improved skeleton extraction suitable for dynamic environment is proposed. On the one hand, firstly the grid map is preprocessed by binarization, corrosion and expansion, so the reduced skeleton map suitable for navigation is obtained, then the reduced skeleton map is extracted for searching the global path, finally the improved cubic spline smoothing algorithm is used to optimize the global path each planned, thus overcoming the defects of bloated and tortuous in the path obtaining by original Voronoi diagram algorithm. On the other hand, the position information of all obstacles is obtained by a single scan lidar. Firstly, segmenting and linearly fitting all laser point clouds to remove the known obstacles in the map. Then to mark new possible dynamic obstacles with circles of appropriate size. Secondly detecting dynamic obstacles by the alteration of their center coordinates, moreover, solving their motion equations. Finally expanding the cost map along the speed direction of dynamic obstacles and combining DWA dynamic window method to realize dynamic obstacle avoidance. Compared with the original DWA algorithm, it can predict the motion state of dynamic obstacles in advance, which improves the safety of the robot in the dynamic environment. Moreover, the effectiveness of the algorithm is verified by many simulation experiments and real environment experiments.

LEVEL-m SCALED CIRCULANT FACTOR MATRICES OVER THE COMPLEX NUMBER FIELD AND THE QUATERNION DIVISION ALGEBRA

Jiang, Zhao-Lin,Liu, San-Yang 한국전산응용수학회 2004 Journal of applied mathematics & informatics Vol.14 No.1

The level-m scaled circulant factor matrix over the complex number field is introduced. Its diagonalization and spectral decomposition and representation are discussed. An explicit formula for the entries of the inverse of a level-m scaled circulant factor matrix is presented. Finally, an algorithm for finding the inverse of such matrices over the quaternion division algebra is given.

Impact of Dissection after Drug-Coated Balloon Treatment of De Novo Coronary Lesions: Angiographic and Clinical Outcomes

Lin Hui,신은석,전은정,백영준,Scot Garg,김태현,손창배,최병주,Liu Kun,Song Lin Yuan,Wang Zhi,Jiang Hao,Shi Zhentao,Tang Qiang 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.12

Purpose: Dissection after plain balloon angioplasty is required to achieve adequate luminal area; however, it is associated with ahigh risk of vascular events. This study aimed to examine the relationship between non-flow limiting coronary dissections andsubsequent lumen loss and long-term clinical outcomes following successful drug-coated balloon (DCB) treatment of de novocoronary lesions. Materials and Methods: A total of 227 patients with good distal flow (Thrombolysis in Myocardial Infarction flow grade 3) followingDCB treatment were retrospectively enrolled and stratified according to the presence or absence of a non-flow limiting dissection. The primary endpoint was late lumen loss (LLL) at 6-month angiography, and the secondary endpoint was target vesselfailure (TVF, a composite of cardiac death, target vessel myocardial infarction, target vessel revascularization, and target vesselthrombosis). Results: The cohort consisted of 95 patients with and 132 patients without a dissection. There were no between-group differencesin LLL (90.8%) returning for angiography at 6 months (0.05±0.19 mm in non-dissection and 0.05±0.30 mm in dissection group, p=0.886) or in TVF (6.8% in non-dissection and 8.4% in dissection group, p=0.799) at a median follow-up of 3.4 years. In a multivariateanalysis, the presence of dissection and its severity were not associated with LLL or TVF. Almost dissections (93.9%) were completelyhealed, and there was no newly developed dissection at 6-month angiography. Conclusion: The presence of a dissection following successful DCB treatment of a de novo coronary lesion may not be associatedwith an increased risk of LLL or TVF (Impact of Drug-coated Balloon Treatment in de Novo Coronary Lesion; NCT04619277).

A Practical Stability Control Strategy for DC/DC Converters

Jiang, Lin,Li, Po The Korean Institute of Electrical Engineers 2018 Journal of Electrical Engineering & Technology Vol.13 No.3

This paper aims at designing an intelligent controller, based on control Lyapunov Function strategy integrated with fabricating discrete model of Buck and Boost converters and analyzing energy changes during the DC/DC progress to realize tracing reference current on Buck and Boost converters. In addition, practical stability phenomenon research and transient performance analysis has been proposed to give an insight to the influence of controller parameters in achieving an enhanced output performance and how the time of sample period affect the error of practical stability will be illustrated. The novelty of this controller in comparison to other schemes lies in the improved performance of practical stability.

Controlled Release of Bordetella Bronchiseptica Dermonecrotoxin(BBD) Vaccine from BBD-Loaded Chitosan Microspheres In Vitro

Jiang, Hu-Lin,Park, In-Kyu,Shin, Na-Ri,Yoo, Han-Sang,Akaike, Toshihiro,Cho, Chong-Su The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.3

Chitosan microspheres were prepared by ionic gelation process with sodium sulfate for nasal vaccine delivery. Bordetella Bronchiseptica Dermonecrotoxin (BBD) as a major virulence factor of a causative agent of atrophic rhinitis (AR) was loaded to the chitosan microspheres for vaccination. Morphology of BBD-loaded chitosan microspheres was observed as spherical shapes. The average particle sizes of the BBD-loaded chitosan microspheres were about $2.69$\mid${\;}\mu\textrm{m}$. More BBD was released with an increase of molecular weight of chitosan and with an increase of medium pH in vitro due to weaker intermolecular interaction between chitosan and BBD. Tumor necrosis $factor-{\alpha}{\;}(TNF{\alpha})$ and nitric oxide (NO) from RAW264.7 cells stimulated with BBD-loaded chitosan microspheres were gradually secreted, suggesting that released BBD from chitosan microspheres had immune stimulating activity of AR vaccine.

A Practical Stability Control Strategy for DC/DC Converters

Lin Jiang,Po Li 대한전기학회 2018 Journal of Electrical Engineering & Technology Vol.13 No.3

This paper aims at designing an intelligent controller, based on control Lyapunov Function strategy integrated with fabricating discrete model of Buck and Boost converters and analyzing energy changes during the DC/DC progress to realize tracing reference current on Buck and Boost converters. In addition, practical stability phenomenon research and transient performance analysis has been proposed to give an insight to the influence of controller parameters in achieving an enhanced output performance and how the time of sample period affect the error of practical stability will be illustrated. The novelty of this controller in comparison to other schemes lies in the improved performance of practical stability.

Implication of hydrolysis on vanadium precipitation with acidic ammonium salt from high concentration of alkaline vanadium solution

Jiang Lin,He Wenyi,Du Guangchao,Zheng Hao,Peng Yi 한국화학공학회 2023 Korean Journal of Chemical Engineering Vol.40 No.10

Vanadium precipitation with acidic ammonium salt is widely applied in industrial practice of vanadium pentoxide production. However, the ammonia wastewater produced in the precipitation process and resultant environmental issues have been paid increasing attention. With the intention of reducing wastewater and extra cost, an enhancement in the vanadium content of basic qualified solution is the most directly effective method. Unfortunately, high vanadium concentration brings about a low precipitation rate and a high Na content in ammonium polyvanadate, as a result of hydrolysis existence in the precipitation process. The effect of hydrolytic vanadium reaction on acidic ammonium salt precipitation has rarely been reported. Therefore, the whole precipitation process, including the effect of pH value, reaction temperature and vanadium concentration on precipitation result were clarified by analyzing the thermodynamic form of vanadate radicals in this work. Simultaneously, a study on technological parameters was inquired based on the theoretical analysis. The phase composition and crystal morphology of precipitates were also inspected using XRD and SEM-EDS. The results show the negative reaction of vanadium hydrolysis cannot be eliminated in the process of vanadium precipitation with acidic ammonia salt. When vanadium content is higher than 35g/L, Na in APV is easy to exceed 0.6%. Na mainly precipitates in V2O5·H2O in the formation of amorphous body or chemical absorption. The results in this work provide a fundamental guide for the application of high concentration vanadium precipitation technology.

Effects of Soy Isoflavone on Performance, Meat Quality and Antioxidative Property of Male Broilers Fed Oxidized Fish Oil

Jiang, S.Q.,Jiang, Z.Y.,Lin, Y.C.,Xi, P.B.,Ma, X.Y. Asian Australasian Association of Animal Productio 2007 Animal Bioscience Vol.20 No.8

This study was conducted to determine the effect of dietary soy isoflavone (ISF, 0 and 20 mg/kg) on performance, meat quality and antioxidative property in male broilers. Six replicates of 45 birds (42 d old) were used for each treatment. The birds were fed soybean meal-free diets containing 3% oxidized fish oil (acid value, 6.76 mg potassium hydroxide/g; and peroxide value, 6.18 meq/kg) for 3 wk. The results showed that average daily gain, feed intake, feed conversion and carcass traits were not affected by soy ISF. Compared with the control group, breast muscle color redness value and water holding capacity were increased (p<0.05) by ISF supplementation. The activity of plasma catalase was increased by supplementing with 20 mg ISF/kg diet. In breast muscle, Broilers fed 20 mg ISF/kg had decreased production of malondialdehyde and lactic acid. The ISF supplementation elevated total antioxidative capacity and activities of total superoxide dismutase and glutathione peroxidase. The results indicated that dietary ISF could increase redness and water holding capacity of meat, and antioxidative property of meat in male broilers fed oxidized fish oil diet.

In situ directional formation of Co@CoO_x-embedded 1D carbon nanotubes as an efficient oxygen electrocatalyst for ultra-high rate Zn–air batteries

Lin, Chao,Shinde, Sambhaji S.,Jiang, Zheng,Song, Xiaokai,Sun, Yu,Guo, Linli,Zhang, Hao,Jung, Jin-Young,Li, Xiaopeng,Lee, Jung-Ho The Royal Society of Chemistry 2017 Journal of materials chemistry. A, Materials for e Vol.5 No.27

<▼1><P>A “three birds one stone” strategy for preparing 1D N-doped porous carbon nanotubes embedded with Co@CoOx nanoparticles results in the unprecedentedly high-rate Zn–air batteries.</P></▼1><▼2><P>In this work, we demonstrate a “three birds one stone” strategy for preparing 1D N-doped porous carbon nanotubes embedded with core–shell Co@CoOx nanoparticles (Co@CoOx/NCNTs) from bimetallic ZnO@Zn/Co-ZIF nanowires. The ZnO nanowires played three roles: (i) ZnO acted as a template for 1D metal–organic framework (MOF) growth, (ii) <I>in situ</I> evaporation of Zn during pyrolysis prevented the aggregation of the carbon framework and benefited the formation of hierarchical pores, and (iii) the excess oxygen species released from ZnO <I>in situ</I> reacted with metallic cobalt nanoparticles during pyrolysis, leading to the configuration of a Co@CoOx core–shell structure. The as-prepared 1D Co@CoOx/NCNTs exhibited excellent oxygen reduction reaction performance, including a high kinetic current (4.6 times better compared to 20 wt% Pt/C at 0.7 V), a low Tafel slope of 80 mV dec<SUP>−1</SUP>, outstanding stability, and strong tolerance to CH3OH crossover. The assembled Zn–air batteries with Co@CoOx/NCNTs yielded high open-circuit voltage (1.52 V), superior stability (over 100 h of operation), and unprecedented rate performance that ranged from 1 to 500 mA cm<SUP>−2</SUP>, while existing batteries have never achieved a galvanostatic discharge current density larger than 300 mA cm<SUP>−2</SUP>. Such exceptional rate capability was ascribed to the formation of a uniform interconnected nanotube network, facilitated electron transport, and an enlarged electrochemically accessible surface area in the unique 1D porous tubular structure.</P></▼2>