Alkaloidal Metabolites from a Marine-Derived <i>Aspergillus</i> sp. Fungus

Liao, Lijuan,You, Minjung,Chung, Beom Koo,Oh, Dong-Chan,Oh, Ki-Bong,Shin, Jongheon American Chemical Society and American Society of 2015 Journal of natural products Vol.78 No.3

<P>Fumiquinazoline S (<B>1</B>), a new quinazoline-containing alkaloid, and the known fumiquinazolines F (<B>6</B>) and L (<B>7</B>) of the same structural class were isolated from the solid-substrate culture of an <I>Aspergillus</I> sp. fungus collected from marine-submerged wood. In addition, isochaetominines A–C (<B>2</B>–<B>4</B>) and 14-<I>epi</I>-isochaetominine C (<B>5</B>), new alkaloids possessing an unusual amino acid-based tetracyclic core framework related to the fumiquinazolines, were isolated from the same fungal strain. The structures of these compounds were determined by combined spectroscopic methods, and the absolute configurations were assigned by NOESY, ROESY, and advanced Marfey’s analyses along with biogenetic considerations. The new compounds exhibited weak inhibition against Na<SUP>+</SUP>/K<SUP>+</SUP>-ATPase.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2015/jnprdf.2015.78.issue-3/np500683u/production/images/medium/np-2014-00683u_0002.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np500683u'>ACS Electronic Supporting Info</A></P>

Asperphenins A and B, Lipopeptidyl Benzophenones from a Marine-Derived <i>Aspergillus</i> sp. Fungus

Liao, Lijuan,Bae, Song Yi,Won, Tae Hyung,You, Minjung,Kim, Seong-Hwan,Oh, Dong-Chan,Lee, Sang Kook,Oh, Ki-Bong,Shin, Jongheon THE AMERICAN CHEMICAL SOCIETY 2017 ORGANIC LETTERS Vol.19 No.8

<P>Asperphenins A (1) and B (2), novel diastereomeric lipopeptidyl benzophenone metabolites, were isolated from a marine-derived Aspergillus sp. fungus. On the basis of the results of combined spectroscopic analyses, the structures of these compounds were determined to be linear assemblies of three motifs: a hydroxy fatty acid, a tripeptide, and a trihydroxybenzophenone. The absolute configurations were assigned using chemical modifications and electronic circular dichroism (ECD) calculations. The novel compounds exhibited significant cytotoxicity on diverse cancer cells.</P>

Simultaneous analysis of bioactive metabolites from Ziziphus jujuba by HPLC–DAD–ELSD–MS/MS

Lijuan Liao,원태형,강삼식,신종헌 한국약제학회 2012 Journal of Pharmaceutical Investigation Vol.42 No.1

A high-performance liquid chromatography (HPLC) with diode array detector (DAD), evaporative light scattering detector (ELSD) and electrospray ionization mass spectrometry (ESI-MS) was established for the simultaneous determination of nine representative metabolites of the alkaloid, flavonoid and triterpenoid classes from Ziziphus jujuba var. spinosa. The optimal chromatographic conditions were obtained on an ODS column and the mobile phase was composed of water and methanol with 0.1% formic acid using a gradient elution system. Using the developed methods, all of the validation parameters were successfully obtained. In addition, effectiveness of diverse extraction methods was compared to each other for the development of standard analytic method. The verified method was successfully applied to the quantitative determination of representative metabolites in commercial samples of Z. jujuba and Z. mauritiana from different markets in Korea, China and Myanmar. The analytical results showed that the contents of the nine analytes vary significantly with sources and species, thus demonstrating its potential for the detection of this plant.

Penicillipyrones A and B, Meroterpenoids from a Marine-Derived <i>Penicillium</i> sp. Fungus

Liao, Lijuan,Lee, Jung-Ho,You, Minjung,Choi, Tae Joon,Park, Wanki,Lee, Sang Kook,Oh, Dong-Chan,Oh, Ki-Bong,Shin, Jongheon American Chemical Society and American Society of 2014 Journal of natural products Vol.77 No.2

<P>Penicillipyrones A (<B>1</B>) and B (<B>2</B>), two novel meroterpenoids, were isolated from the marine-derived fungus <I>Penicillium</I> sp. On the basis of the results of combined spectroscopic analyses, these compounds were structurally elucidated to be sesquiterpene γ-pyrones from a new skeletal class derived from a unique linkage pattern between the drimane sesquiterpene and pyrone moieties. Compound <B>2</B> elicited significant induction of quinone reductase.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jnprdf/2014/jnprdf.2014.77.issue-2/np400826p/production/images/medium/np-2013-00826p_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/np400826p'>ACS Electronic Supporting Info</A></P>

Preparation and photoluminescence properties of the Eu2+, Sm3+ co-doped Li2SrSiO4 phosphors

Lijuan Liu,Panli You,Guangfu Yin,Xiaoming Liao,Zhongbing Huang,Xianchun Chen,Yadong Yao 한국물리학회 2012 Current Applied Physics Vol.12 No.4

A series of Eu2+ and Sm3+ co-doped Li2SrSiO4 phosphors are prepared by the high temperature solidstate reaction. The morphology, structure and spectroscopic properties of the prepared samples are characterized by scanning electron microscopy, X-ray diffraction, diffuse reflection spectra, photoluminescence spectra and electron paramagnetic resonance spectra, respectively. The effect of Sm3þdoping concentration on the photoluminescence intensity of the prepared samples is also investigated. The results indicate that the crystal structure of Li2SrSiO4 is not changed with the Eu2+, Sm3+ co-doping. The spherical-like particle size of the obtained product is about 20-30 nm in diameter. When the Sm3+ concentration is 0.3 mol% and the Eu2+ concentration is 0.7 mol%, the phosphors show the maximum emission intensity, which is 50% higher than that of Eu2+ doped Li2SrSiO4. Excited at 420 nm, the phosphor presents a single broad emission band peaking at 558 nm, which is ascribed to the 4f65d1 / 4f7 transitions of Eu2+ and 4G5/2 / 6H5/2 and 4G5/2 / 6H7/2 transitions of Sm3+. The Commission International de I0Eclairage chromaticity coordinates of Li2SrSiO4:0.7 mol% Eu2+, 0.3 mol%Sm3+ are x = 0.28, y = 0.28. A series of Eu2+ and Sm3+ co-doped Li2SrSiO4 phosphors are prepared by the high temperature solidstate reaction. The morphology, structure and spectroscopic properties of the prepared samples are characterized by scanning electron microscopy, X-ray diffraction, diffuse reflection spectra, photoluminescence spectra and electron paramagnetic resonance spectra, respectively. The effect of Sm3þdoping concentration on the photoluminescence intensity of the prepared samples is also investigated. The results indicate that the crystal structure of Li2SrSiO4 is not changed with the Eu2+, Sm3+ co-doping. The spherical-like particle size of the obtained product is about 20-30 nm in diameter. When the Sm3+ concentration is 0.3 mol% and the Eu2+ concentration is 0.7 mol%, the phosphors show the maximum emission intensity, which is 50% higher than that of Eu2+ doped Li2SrSiO4. Excited at 420 nm, the phosphor presents a single broad emission band peaking at 558 nm, which is ascribed to the 4f65d1 / 4f7 transitions of Eu2+ and 4G5/2 / 6H5/2 and 4G5/2 / 6H7/2 transitions of Sm3+. The Commission International de I0Eclairage chromaticity coordinates of Li2SrSiO4:0.7 mol% Eu2+, 0.3 mol%Sm3+ are x = 0.28, y = 0.28.

Comparative Analyses of Bioactive Constituents from Forsythia suspensa and Forsythia viridissima by HPLC-DAD

원태형,Lijuan Liao,이승호,손종근,신종헌 한국생약학회 2011 Natural Product Sciences Vol.17 No.4

A high-performance liquid chromatography (HPLC) with diode array detector (DAD) method was established for the discrimination of a folk medicine Forsythia suspensa and Forsythia viridissima. Five and three representative metabolites of the lignan and phenolic glycoside classes were selected for the analysis from F. suspensa and F. viridissima, respectively. The optimal chromatographic conditions were obtained on an ODS column (5 mm, 4.6 ? 250 mm) with the column temperature at 40oC. The mobile phase was composed of methanol and 0.3% acetic acid using an isocratic elution with the flow rate 1 mL/min. Detection wavelength was set at 280 nm. All calibration curves showed good linear regression (r2 > 0.996) within test ranges. Limits of detection (LOD) and limits of quantitation (LOQ) values were lower than 0.096 and 0.291 mg/mL, respectively. The developed method provided satisfactory precision and accuracy with overall intra-day and inter-day variations of 0.07-0.63% and 0.14-0.62%, respectively, and the overall recoveries of 97.79-102.46% for all of the compounds analyzed. In addition, effectiveness of diverse extraction methods was compared to each other for the development of standard analytical method. The verified method was successfully applied to the quantitative determination of representative metabolites in fifty-three commercial F. suspensa samples and fifteen commercial F. viridissima samples from diverse sources. The overall analytical results showed the unequivocal differences in bioactive constituents between F. suspensa and F. viridissima.

Insight into the anti-corrosion performance of Acanthopanax senticosus leaf extract as eco-friendly corrosion inhibitor for carbon steel in acidic medium

Bokai Liao,Zhigang Luo,Shan Wan,Lijuan Chen 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.117 No.-

In this work, the extract of acanthopanax senticosus leaf (ASLE), prepared using one-step pure waterextraction method, is firstly utilized as a sustainable eco-friendly corrosion inhibitor for carbon steel inacidic solutions. The corrosion inhibition efficiency is evaluated by weight loss method and electrochemicaltests, including electrochemical impedance spectroscopy and potentiodynamic polarization curve. The compositions of ASLE are analyzed using Fourier transform infrared spectroscopy, components andmicrostructures of corrosion products are characterized by scanning electron microscopy and X-ray photoelectronspectroscopy. Results indicate that ASLE is successfully prepared using the clean productionprocess, and it can act as an efficient mixed-type corrosion inhibitor for Q235 carbon steel in 1 mol/LHCl. The maximum corrosion inhibition efficiency can reach 98.79 % after 144 h immersion with the additionof 150 mg/L. ASLE also displays the superior long-term corrosion inhibition performance. The protectivehydrophobic adsorption film can effectively retard the invasion of aggressive ions and inhibit thecorrosion of carbon steel in acidic service occasions.

Micro drilling quality of the multi-layer IC substrate

Shan Li,Lijuan Zheng,Chengyong Wang,Bingmiao Liao,Lianyu Fu 한국생산제조학회 2014 한국생산제조시스템학회 학술발표대회 논문집 Vol.2014 No.9(2)

Application of model reduction technique and structural subsection technique on optimal sensor placement of truss structures

Chenguang Huang,Lingling Lu,Lijuan Liao,Yanpeng Wei,Yanchi Liu,Xi Wang 국제구조공학회 2015 Smart Structures and Systems, An International Jou Vol.15 No.2

An optimal sensor placement (OSP) method based on structural subsection technique (SST) and model reduction technique was proposed for modal identification of truss structures, which was conducted using genetic algorithm (GA). The constraints of GA variables were determined by SST in advance. Subsequently, according to model reduction technique, the optimal group of master degrees of freedom and the optimal objective function value were obtained using GA in a case of the given number of sensors. Correspondingly, the optimal number of sensors was determined according to optimal objective function values in cases of the different number of sensors. The proposed method was applied on a scaled jacket offshore platform to get its optimal number of sensors and the corresponding optimal sensor layout. Then modal kinetic energy and modal assurance criterion were adopted to evaluate vibration energy and mode independence property. The experiment was also conducted to verify the effectiveness of the selected optimal sensor layout. The results showed that experimental modes agreed reasonably well with numerical results. Moreover the influence of the proposed method using different optimal algorithms and model reduction technique on optimal results was also compared. The results showed that the influence was very little.

Hydrogen Peroxide is Involved in Salicylic Acid-Induced Adventitious Rooting in Cucumber Under Cadmium Stress

Gong Wenting,Niu Lijuan,Wang Chunlei,Wei Lijuan,Pan Ying,Liao Weibiao 한국식물학회 2022 Journal of Plant Biology Vol.65 No.1

Cadmium (Cd) stress can cause system disorders in plants, affect the absorption of some nutrients. The roles and their relationship of salicylic acid (SA) and hydrogen peroxide (H2O2) in adventitious root formation (ARF) of cucumber (Cucumis sativus L.) under Cd stress were studied. The results showed that the exogenous SA and H2O2 in enhancing ARF in cucumber explants under Cd stress was concentration-dependent, with an optimal biological effect at 0.1 µM SA or 50 µM H2O2. Under Cd stress, SA-induced ARF was significantly reversed by H2O2 scavenger and inhibitor, indicating that endogenous H2O2 may be involved in SA-induced ARF under Cd stress. In addition, endogenous H2O2 levels were also promoted by SA in cucumber explants. The application of SA promoted pectin content and decreased pectin methylesterification degree under Cd stress. Moreover, we founded that SA and SA + H2O2 up-regulated the expression level of CsQUA and CsPME under Cd stress, respectively. However, the application of H2O2 scavenger and inhibitor could significantly reverse the effects of SA on the expression of the above genes. These results suggested that SA might play an important role in ARF in cucumber under Cd stress via enhancing endogenous H2O2 levels.