A New Ferulic Acid Ester and Other Constituents from Dracocephalum peregrinum

Dai, Li-Min,Zhao, Chun-Chao,Jin, Hui-Zi,Tang, Jian,Shen, Yun-Heng,Li, Hui-Liang,Peng, Cai-Yon,Zhang, Wei-Dong 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.10

A new ferulic acid ester, 1'-methyl-2'-hydroxyethyl ferulate (1), together with methylcaffeate (2), 4-hydroxy cinnamic acid (3), ferulic acid (4), caffeic acid (5), diosmetin (6), luteolin (7), 5,3',4'-trihydroxy-3,7-dimethoxyflavone (8), eriodictyol (9), kaempferol (10), quercetin (11), acacetin-7-O-glcopyranoside (12), 4-($\beta$-glucopyranosyloxy) benzoic acid (13), luteolin-7-O-(6"-feruloyl) glucopyranoside (14), luteolin-7-O-glucopyranoside (15), kaempferide-3-O-rhamnopyranoside (16), quercitrin (17), kaempferol-3-O-glucopyranoside (18), prunasin (19), quercetin-7-O-glucopyranoside (20), quercetin-3-O-glucopyranoside (21), plantaginin (22), linarin (23), luteolin-7-O-rutinoside (24), and chlorogenic acid (25) were isolated from the aerial parts of Dacocephalum peregrinum. The structure of 1 was elucidated on the basis of spectroscopic and HR-ESI-MS analyses. In addition, compound 1 exhibited mild inhibitory effect on NO production in LPS-stimulated RAW264.7 cells.

A New Ferulic Acid Ester and Other Constituents from Dracocephalum peregrinum

Li-Min Dai,Chun-Chao Zhao,Hui-zi Jin,Yun-Heng Shen,Hui-Liang Li,Cai-Yun Peng,Jian Tang,Wei-Dong Zhang 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.10

A new ferulic acid ester, 1'-methyl-2'-hydroxyethyl ferulate (1), together with methylcaffeate (2), 4- hydroxy cinnamic acid (3), ferulic acid (4), caffeic acid (5), diosmetin (6), luteolin (7), 5,3',4'-trihydroxy- 3,7-dimethoxyflavone (8), eriodictyol (9), kaempferol (10), quercetin (11), acacetin-7-Oglcopyranoside (12), 4-(β-glucopyranosyloxy) benzoic acid (13), luteolin-7-O-(6''-feruloyl) glucopyranoside (14), luteolin-7-O-glucopyranoside (15), kaempferide-3-O-rhamnopyranoside (16), quercitrin (17), kaempferol-3-O-glucopyranoside (18), prunasin (19), quercetin-7-O-glucopyranoside (20), quercetin-3-O-glucopyranoside (21), plantaginin (22), linarin (23), luteolin-7-O-rutinoside (24), and chlorogenic acid (25) were isolated from the aerial parts of Dacocephalum peregrinum. The structure of 1 was elucidated on the basis of spectroscopic and HR-ESI-MS analyses. In addition, compound 1 exhibited mild inhibitory effect on NO production in LPS-stimulated RAW264.7 cells.

Two New Phenolic Compounds from the Fruiting Bodies of Ganoderma tropicum

Hu, Li-Li,Ma, Qing-Yun,Huang, Sheng-Zhuo,Guo, Zhi-Kai,Guo, Jian-Chun,Dai, Hao-Fu,Zhao, You-Xing Korean Chemical Society 2013 Bulletin of the Korean Chemical Society Vol.34 No.3

Chemical investigation of the fruiting bodies of Ganoderma tropicum led to the isolation of two new phenolic compounds, ganodermatropins A (1) and B (2). Their structures were elucidated by spectroscopic techniques (MS, 1D and 2D NMR). Ganodermatropin A exhibited antimicrobial activity against Staphylococcus aureus.

Associations Between Mammography and Ultrasound Imaging Features and Molecular Characteristics of Triple-negative Breast Cancer

Li, Bo,Zhao, Xin,Dai, Shao-Chun,Cheng, Wen Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.8

Background: The triple-negative breast cancer (TNBC) is an aggressive cancer characterized by the absence of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2). Preoperative mammography and ultrasound features of TNBC may potentially suggest characteristics of the disease and assist in treatment decisions. Materials and Methods: The study covered 153 patients with TNBC from May 2011 to May 2012 who were confirmed by postoperative pathology results in our hospital. We compared the radiological findings among the patients and sought to determine the significant iconographic features. The biomarkers p53 and Ki-67 are regarded as significant factors in TNBC. They were therefore used to divide the TNBC into four groups for assessment of relationships with TNBC imaging features. Results: On mammography, most TNBCs exhibit obscure (44.3%) masses. On ultrasound, the majority of masses (95.4%) were predominantly indistinct (50.7%), irregular (76.0%) or featuring posterior echo enhancement/shadowing. Color Doppler flow imaging (CDFI) emphasized hypervascular (32.9%) masses. Differences in CDFI by ultrasound among the four groups were statistically significant (p=0.009). There were obvious differences in the percentages of spiculated margin (p=0.049) and intensive posterior echo (p=0.006) with spotty flow imaging by ultrasound between the Ki-67 (+) p53 (+) and other groups. Conclusions: A combination of mammography and ultrasound revealed the imaging characteristics of TNBC included an obscure mass with less attenuated posterior echoes and some vascularity. A worse prognosis was associated with spiculated margin and intensive posterior echoes with spotty flow imaging.

Detection of structural damage via free vibration responses by extended Kalman filter with Tikhonov regularization scheme

Zhang, Chun,Huang, Jie-Zhong,Song, Gu-Quan,Dai, Lin,Li, Huo-Kun Techno-Press 2016 Structural monitoring and maintenance Vol.3 No.2

It is a challenging problem of assessing the location and extent of structural damages with vibration measurements. In this paper, an improved Extended Kalman filter (EKF) with Tikhonov regularization is proposed to identify structural damages. The state vector of EKF consists of the initial values of modal coordinates and damage parameters of structural elements, therefore the recursive formulas of EKF are simplified and modal truncation technique can be used to reduce the dimension of the state vector. Then Tikhonov regularization is introduced into EKF to restrain the effect of the measurement noise for improving the solution of ill-posed inverse problems. Numerical simulations of a seven-story shear-beam structure and a simply-supported beam show that the proposed method has good robustness and can identify the single or multiple damages accurately with the unknown initial structural state.

중국 농촌 체험관광 요인이 농,특산물 구매 및 재방문의도에 미치는 영향

다이훼이 ( Hui Dai ),곽춘려 ( Guo Chun Li ) 한국관광산업학회 2014 Tourism Research Vol.39 No.3

최근 들어 많은 중국 관광객들이 여행목적지로 농촌을 선택하고 다양한 농촌관광활동이 일어나고 있다. 농어촌 마을의 전통문화·경관·어메니티 등을 관광객에게 휴식과 레크리에이션·체험·교육을 제공함과 동시에 농산물, 먹을거리 판매 및 숙박 제공 등을 통하여 농촌경제의 활성화에 기여한다. 따라서 농촌 특산물의 구매에 어떠한 체험요인들이 영향을 미치는 연구하는 것은 관광객이 다시 찾는 농촌, 지속적인 거래를 희망하는 농산물을 어떻게 구입하는지 그 행위에 관한 분석이 필요하다. 본 연구에서는 농촌체험관광을 통해 관광객들은 농촌의 자원요소와 농촌의 생활, 체험 등에 얼마나 만족하고, 체험과 농촌 특산물 안전성의 신뢰를 바탕으로 안심하고 먹을 수 있는 농촌 특산물 구매와 재방문 의도에 어떠한 영향을 미치는지를 실증적으로 분석하고자 한다. 실증 분석을 통해 본 연구에서 제시한 연구문제를 검증한 결과는 다음과 같다. 농촌체험관광은 ‘농·특산물의 특성``, ‘교육성과 프로그램’, ‘휴양·일탈성’, ‘시설편리성’, ‘문화·자연환경’ 등의 다섯 요인으로 도출되었다. 농촌 체험관광의 “농·특산물의 특성”과 “교육성과 프로그램”요인들이 농·특산물구매에 유의한 정(+)의 영향을 미치는 것으로 나타났다. 따라서 농산물의 안전성에 대한 소비자의 우려와 관심이 높아지고 있는 시점에서 농산물생산과정의 신뢰성, 우수한 맛 등에 대한 정보를 소비자에게 효과적으로 전달하는 것이 필요하다. 농촌관광객이 지역의 농·특산물을 경험할 수 있는 다양한 프로그램을 개발하고 홍보하여야 하며, 생산자가 소비자와의 관계를 구축할 수 있도록 하는 정책적 지원이 필요하다. 농촌 체험관광의 “농·특산물의 특성”, “교육성과 프로그램”과 “휴양·일탈성”요인들이 재방문의도에 유의한 정(+)의 영향을 미치는 것으로 나타났다. 이 결과를 바탕으로 볼 때 본 연구는 농촌체험 관광활동을 활성화시키기 위해 농촌의 생태자원, 생활 및 생업 자원을 활용한 차별화되고 고급화된 다양한 체험프로그램을 개발하고 방문객들의 특성을 고려한 마케팅 전략을 수행하여 안정적인 수익창출을 위한 기반을 조성하여야 할 것이다. Recently, rural tourism is booming in China since Chinese tourists have increasingly visited rural areas for vacation. Rural tourism provides various opportunities for urban residents to experience traditional culture, landscape, and environment of rural villages and to relax and learn. At the same time, rural tourism contributes to local economy by selling their special agricultural products and food and providing accomodations to tourists. Hence, it is important to identify the major factors of tourist experience that influence the purchase of special agricultural products of the village because it resulted in sustainable development of rural tourism. Therefore, this study aims to examine rural tourist experiences and how these experiences influence their intentions to purchase special agricultural products of the village and to revisit there. The results show that the rural tourist experience consists of the five main factors: "characteristics of special agricultural products", "education & program", "recreation & excape", "conveniences", and "cultural and natural environments". Among these factors, two factors, namely "characteristics of special agricultural products" and "education & program" positively influence responedents`` intention to purchase special agricultural products. This implies that it is necessary to inform consumers about the trustworthiness of the products as consumers have increasingly paid more attention to the safety of special agricultural products. Moreover, it is also needed to develop and promote various programs through which consumers can experience the special agricultural products and to support the relationship between manufactures and customers. Also, respondents`` intention to revisit the rurla village is positively influenced by three factors, namely "characteristics of special agricultural products", "education & program", and "recreation & excape". This indicates that rural villages should develop distinguished and advanced experiencce programs and perform effective marketing strategies considering characteristics of visitors in order to make stable profits.

The Methylenetetrahydrofolate Reductase C677T Polymorphism Influences Risk of Esophageal Cancer in Chinese

Qu, Hong-Hong,Cui, Li-Hong,Wang, Ke,Wang, Peng,Song, Chun-Hua,Wang, Kai-Juan,Zhang, Jian-Ying,Dai, Li-Ping Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

Methylenetetrahydrofolate reductase (MTHFR) plays a central role in folate metabolism. This study with 381 esophageal cancer patients and 432 healthy controls was conducted to examine the association of MTHFR C677T and A1298C polymorphisms with susceptibility to esophageal cancer (EC) in a Chinese population. Compared with the CC genotype of MTHFR C677T, subjects carrying homozygote TT and variant genotypes (CT+TT) demonstrated reduced risk of EC with adjusted ORs (95% CI) of 0.44 (0.28-0.71) and 0.57 (0.37-0.88), respectively. However, no association was found between the MTHFR A1298C polymorphism and the risk of EC. Comparing to haplotype CA, haplotypes TA and TC could reduce the susceptibility to EC with adjusted ORs (95% CI) of 0.61(0.47-0.79) and 0.06 (0.01-0.43), respectively. In conclusion, the present study suggested that the MTHFR C677T polymorphism can markedly influence the risk of EC in Chinese.

Association of mir-499 and mir-149 Polymorphisms with Cancer Risk in the Chinese Population: Evidence from Published Studies

Zhang, You-Gai,Shi, Jian-Xiang,Song, Chun-Hua,Wang, Peng,Dai, Li-Ping,Zhang, Jian-Ying,Shi, Jia-Chen Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4

Meta-analyses have shown that microRNA polymorphisms have variable effects in different population. Yet, no meta-analysis investigated the association of two common polymorphisms of miRNA, mir-499 rs3746444 polymorphism and mir-149 rs2292832 polymorphism, with cancer risk in the Chinese population. We searched the PubMed, Web of Knowledge, MEDLINE, CNKI databases, as well as Cochrane library, updated on December 31, 2012 for assays regarding cancer risk association with these two common polymorphisms in the present meta-analysis. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were used to explore the strength of associations. The results showed that rs3746444 polymorphism was associated with increased cancer risk (dominant model: GG/AG vs. AA: OR = 1.43, 95% CI: 1.14-1.80; recessive model: GG vs. AG/AA: OR = 1.54, 95% CI: 1.04-2.30; homozygote model: GG vs. AA: OR = 1.69, 95% CI: 1.10-2.60; heterozygote model: AG vs. AA: OR = 1. 35, 95% CI: 1.09-1.67), and rs3746444 was associated with liver cancer in the subgroup of cancer types. For the rs2292832 polymorphism, the results showed no significant risk association in both overall pooled analysis and subgroup of cancer types, smoking status, gender and tea drinking status in the Chinese population. This meta-analysis suggested that the rs3746444 GG genotype is associated with increased cancer risk, especially liver cancer, while the rs2292832 polymorphism showed no association with cancer risk in Chinese.

Bioinformatic Prediction of SNPs within miRNA Binding Sites of Inflammatory Genes Associated with Gastric Cancer

Song, Chuan-Qing,Zhang, Jun-Hui,Shi, Jia-Chen,Cao, Xiao-Qin,Song, Chun-Hua,Hassan, Adil,Wang, Peng,Dai, Li-Ping,Zhang, Jian-Ying,Wang, Kai-Juan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2

Polymorphisms in miRNA binding sites have been shown to affect miRNA binding to target genes, resulting in differential mRNA and protein expression and susceptibility to common diseases. Our purpose was to predict SNPs (single nucleotide polymorphisms) within miRNA binding sites of inflammatory genes in relation to gastric cancer. A complete list of SNPs in the 3'UTR regions of all inflammatory genes associated with gastric cancer was obtained from Pubmed. miRNA target prediction databases (MirSNP, Targetscan Human 6.2, PolymiRTS 3.0, miRNASNP 2.0, and Patrocles) were used to predict miRNA target sites. There were 99 SNPs with MAF>0.05 within the miRNA binding sites of 41 genes among 72 inflammation-related genes associated with gastric cancer. NF-${\kappa}B$ and JAK-STAT are the two most important signaling pathways. 47 SNPs of 25 genes with 95 miRNAs were predicted. CCL2 and IL1F5 were found to be the shared target genes of hsa-miRNA-624-3p. Bioinformatic methods could identify a set of SNPs within miRNA binding sites of inflammatory genes, and provide data and direction for subsequent functional verification research.

A Swimming Hydroponic System for Leafy Vegetable Production (ZAAS-SwimHydro)

Zhi-hao Xu,Wei-shon Shou,Cheng-hao Zhang,Wen-qi Dong,Jue-li Lei,Jian Cheng,Sheng-jun Zhou,Yu-qian Zhu,Dang-li Dai,Li-ping Cheng,Jian Xu,Jin-chun Fang,Sang Gyu Lee,Myeong-Cheoul Cho 한국원예학회 2008 한국원예학회 기타간행물 Vol.- No.-