Fault injection and failure analysis on Xilinx 16 nm FinFET Ultrascale+ MPSoC

Weitao Yang,Yonghong Li,Chaohui He 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.6

Energetic particle strikes the device and induces data corruption in the configuration memory (CRAM),causing errors and even malfunctions in a system on chip (SoC). Software-based fault injection is aconvenient way to assess device performance. In this paper, dynamic partial reconfiguration (DPR) isadopted to make fault injection on a Xilinx 16 nm FinFET Ultrascaleþ MPSoC. And the reconfigurationmodule implements the Sobel and Gaussian image filtering, respectively. Fault injections are executed onthe static and reconfiguration modules' bitstreams, respectively. Another contribution is that the failuremodes and effects analysis (FMEA) method is applied to evaluate the system reliability, according to theobtained injection results. This paper proposes a software-based solution to estimate programmabledevice vulnerability.

Analysis of correlation between electrical and infrared optical properties of anatase Nb doped TiO2 films

Weitao Su,Kaixin Song,Dexuan Huo,Bin Li 한국물리학회 2013 Current Applied Physics Vol.13 No.3

Optical and electrical analysis are required to clarify infrared reflection behavior of anatase Nb doped TiO2 (NTO) films, a novel transparent conductive oxide (TCO). In this paper, UVevis-near infrared transmission spectrum, Fourier transformed infrared (FTIR) reflection and ellipsometry analysis are conducted on anatase NTO films (Nb doping concentration: 6, 4 and 2 at%) deposited by pulse laser deposition (PLD). NTO samples show good transparency from 400 nm to 1000 nm, but no obvious plasmon induced high IR reflection even when wavelength >3000 nm. Assuming inhomogeneous resistivity (r) and mean scattering time (s) along film thickness, dielectric constants (εr, εi) and optical constants (n, k) are extracted by fitting spectroscopic ellipsometry using Code-Lorentz (CL) & Drude exponential model. It is shown that unique optical constants and small s (1.1e2.6 fs) intrinsically prevent NTO to be high infrared reflective TCO.

Food intake and its effect on the species and abundance of intestinal flora in colorectal cancer and healthy individuals

( Weitao Shen ),( Jiayu Sun ),( Zhiyang Li ),( Fen Yao ),( Kaihuang Lin ),( Xiaoyang Jiao ) 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.3

Background/Aim: It is known that an imbalance in the intestinal f lora plays a crucial role in colorectal cancer (CRC), but the effect of food consumption patterns on the types of intestinal flora remains to be clarified. We aimed to analyze the associations between food intake and intestinal flora in healthy and CRC individuals. Methods: Food intake data were recorded using the Food Frequency Questionnaire (FFQ). The composition and diversity of the intestinal flora detected by 16S rRNA gene sequencing, and the data were analyzed by R version 3.1.1 software. Results: Higher intake of red meat or pickled foods, and lower intake of white meat, fruits, vegetables, beans, nuts were found in the CRC group compared with the healthy group. Higher levels of Fusobacteria and Proteobacteria, and lower levels of Firmicutes were observed in the CRC group. Partial correlation analysis revealed that the intake of fruits, beans, and nuts was negatively correlated with Proteobacteria and Fusobacteria, but pickled food was positively correlated with Fusobacteria (p < 0.05). Fish, beans, and nuts intake was negatively correlated with Escherichia (p = 0.01). Multiple regression analysis revealed that vegetable oil (odds ratio [OR], 0.26; 95% confidence interval [CI], 0.13 to 0.82), vegetables (OR, 0.26; 95% CI, 0.10 to 0.64), eggs (OR, 0.26; 95% CI, 0.10 to 0.69), pickled foods (OR, 21.02; 95% CI, 6.02 to 73.45), and red meat (OR, 4.23; 95% CI, 1.68 to 10.60) had an impact on CRC risk. Conclusions: The species and abundance of intestinal flora varies between CRC and healthy individuals and may be affected by their food preference.

System-on-Chip Single Event Effect hardening design and validation using proton irradiation

Yang Weitao,Li Yang,Guo Gang,He Chaohui,Wu Longsheng 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.3

A multi-layer design is applied to mitigate single event effect (SEE) in a 28 nm System-on-Chip (SoC). It depends on asymmetric multiprocessing (AMP), redundancy and system watchdog. Irradiation tests utilized 70 and 90 MeV proton beams to examine its performance through comparative analysis. Via examining SEEs in on-chip memory (OCM), compared with the trial without applying the multi-layer design, the test results demonstrate that the adopted multi-layer design can effectively mitigate SEEs in the SoC.

71% Common‑mode voltage suppression modulation strategy for indirect matrix converters

Shanhu Li,Zijing Lu,Sunpeng Cao,Xu Liu,Zhaoyang Jin,Weitao Deng 전력전자학회 2023 JOURNAL OF POWER ELECTRONICS Vol.23 No.2

Common-mode voltage (CMV) with a high amplitude and frequency is generated when an indirect matrix converter (IMC) is operating, which damages the motor winding insulation and accelerates motor aging. Existing IMC modulation methods can only suppress the CMV by 42.3%. However, this paper proposes a modulation strategy with a 71% reduction in the peak CMV. The proposed method selects active vectors based on the characteristics of the CMV amplitude under each of the active vectors. The rectifier stage selects two active vectors within each modulation sector. According to the sector where the input reference current vector is located, the inverter stage chooses active-voltage vectors whose corresponding peak CMV is 1/3 the minimum peak line voltage for modulation. Moreover, the CMV spikes caused by the dead zone effect are eliminated by reasonably arranging the switching sequence of the voltage vectors in the inverter stage. The proposed approach considerably lowers the peak CMV and has a good suppression effect on the amplitude of high-frequency CMV. Finally, experimental results illustrate the CMV reduction efficiency of the modulation strategy.

Tuning the Mechanical Properties of Silkworm Silk Fibres by Thermally Induced Modification of Crystalline Nanostructure

Shan Du,Weitao Zhou,Xing Jin,Yimin Zhang,Xiangxiang Chen,Jin Zhang,Jingliang Li,Xungai Wang 한국섬유공학회 2021 Fibers and polymers Vol.22 No.2

Antheraea pernyi and Bombyx mori silk fibres, the most important and the subjects of several studies, have attractedwidespread attention due to their exceptional mechanical properties and promising applications. However, the determinantsbehind the variations of mechanical property between these two fibres still remains unknown. In this paper, the nanocrystallinestructures of these two silk fibres were tuned by thermal treatment in order to understand how the structure affects themechanical properties of fibres. It has been found that, along with an increase in temperature for thermal treatment, theincrease in the intramolecular β-sheet leads to progressive increase in longitudinal modulus and radial hardness, whilst thereduction in crystallinity results in great reduction in breaking tensile strength. The yield strength is proportional to theaverage crystallite size which increases along with the annealing temperature. Compared to B. mori, A. pernyi silk fibres havemore obvious temperature-dependant structural changes. These findings explain how size effects can be exploited to createbioinspired materials with tuneable mechanical properties.

The Gut Microbiota of Pregnant Rats Alleviates Fetal Growth Restriction by Inhibiting the TLR9/MyD88 Pathway

Tang Hui,Li Hanmei,Li Dan,Peng Jing,Zhang Xian,Yang Weitao 한국미생물·생명공학회 2023 Journal of microbiology and biotechnology Vol.33 No.9

Fetal growth restriction (FGR) is a prevalent obstetric condition. This study aimed to investigate the role of Toll-like receptor 9 (TLR9) in regulating the inflammatory response and gut microbiota structure in FGR. An FGR animal model was established in rats, and ODN1668 and hydroxychloroquine (HCQ) were administered. Changes in gut microbiota structure were assessed using 16S rRNA sequencing, and fecal microbiota transplantation (FMT) was conducted. HTR-8/Svneo cells were treated with ODN1668 and HCQ to evaluate cell growth. Histopathological analysis was performed, and relative factor levels were measured. The results showed that FGR rats exhibited elevated levels of TLR9 and myeloid differentiating primary response gene 88 (MyD88). In vitro experiments demonstrated that TLR9 inhibited trophoblast cell proliferation and invasion. TLR9 upregulated lipopolysaccharide (LPS), LPS-binding protein (LBP), interleukin (IL)-1β and tumor necrosis factor (TNF)-α while downregulating IL-10. TLR9 activated the TARF3-TBK1-IRF3 signaling pathway. In vivo experiments showed HCQ reduced inflammation in FGR rats, and the relative cytokine expression followed a similar trend to that observed in vitro. TLR9 stimulated neutrophil activation. HCQ in FGR rats resulted in changes in the abundance of Eubacterium_coprostanoligenes_group at the family level and the abundance of Eubacterium_coprostanoligenes_group and Bacteroides at the genus level. TLR9 and associated inflammatory factors were correlated with Bacteroides, Prevotella, Streptococcus, and Prevotellaceae_Ga6A1_group. FMT from FGR rats interfered with the therapeutic effects of HCQ. In conclusion, our findings suggest that TLR9 regulates the inflammatory response and gut microbiota structure in FGR, providing new insights into the pathogenesis of FGR and suggesting potential therapeutic interventions.

Guanine nucleotide-binding protein 2, GNBP2, accelerates the progression of clear cell renal cell carcinoma via regulation of STAT3 signaling transduction pathway

Cao Qingfei,Ma Jiaji,Li Weitao,Hong Peng,Shen Tong,Tong Ming 한국유전학회 2023 Genes & Genomics Vol.45 No.1

Background Guanine nucleotide-binding protein 2 (GNBP2) is a GTPase that has critical roles in host immunity and some types of cancer, but its function in clear cell renal cell carcinoma (ccRCC) is not fully understood. Objective This work explored the role of GNBP2 in ccRCC progression and the underlying molecular mechanism. Methods Two public human cancer databases TNMplot and TISIDB were employed to analyze the expression pattern of GNBP2 during ccRCC progression and the correlation between GNBP2 expression and clinical features of ccRCC patients. GNBP2 functions in ccRCC cells were determined by EdU staining, flow cytometry, scratch wound assay, transwell assay, and xenograft model. Gene expression was evaluated using qPCR, Western blot, immunofluorescence staining, and immunohistochemical staining. Results GNBP2 expression was significantly elevated in ccRCC tissues and increased gradually with the increasing tumor grades. Patients with higher GNBP2 expression had shorter overall survival times. Knockdown of GNBP2 suppressed tumor cell proliferation and cell cycle progression and reduced the capability of migration and invasion, while GNBP2 overexpression exhibited protumor effects. GNBP2 silencing by RNA interference significantly inhibited the tumor growth of tumor-bearing nude mice and decreased the proliferation marker Ki67. Mechanistically, GNBP2 downregulation suppressed the STAT3 signaling transduction, as it reduced the phosphorylation of STAT3 and modulated the expression of the target genes, including c-Myc, MMP2, N-cadherin, and E-cadherin. Conclusion These findings reveal that GNBP2 promotes ccRCC progression by regulating STAT3 signaling transduction, indicating that GNBP2 might be a promising molecular target for ccRCC therapy.

ULTRAFINE AU NANODOTS ON GRAPHENE OXIDE FOR CATALYTIC REDUCTION OF 4-NITROPHENOL

JIANLI CHEN,GANG CHENG,ZHUANGNAN LI,FUJUN MIAO,XIAOQIANG CUI,WEITAO ZHENG 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2013 NANO Vol.8 No.3

Graphene oxide nanosheet is an ideal platform to capture nanoparticles for highly efficient catalysis, electrochemical sensing and biosensing. In this work, we have described a simple synthesis method for preparation graphene oxide–Au nanohybrid. Au nanodots with an average size of 1.6 nm uniformly dispersed on the surface of graphene oxide. The well-defined nanostructure has been characterized by transmission electron microscopy (TEM) and atomic force microscopy (AFM). The nanohybrid also exhibits enhanced catalytic activity toward the reduction of 4-nitrophenol by NaBH4. Comparing with pure Au nanodots and graphene oxide, graphene oxide–Au nanohybrid shows the highest catalytic activity. This approach not only suggests a wide potential application of graphene oxide nanosheet as a host material for supporting a variety of nanoparticles, but also provides a new approach for the fabrication of graphene-based nanohybrids with multiple physical and chemical properties.