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Lee, Sung Won,Lee, Hae Lim,Han, Nam Ik,Kwon, Jung Hyun,Nam, Soon Woo,Jang, Jeong Won,Bae, Si Hyun,Choi, Jong Young,Yoon, Seung Kew SAGE Publications 2017 Therapeutic advances in medical oncology Vol.9 No.10
<P><B>Background:</B></P><P>More than one-third of hepatocellular carcinoma (HCC) patients are diagnosed at advanced stage with portal vein tumor thrombosis (PVTT) or extrahepatic metastasis. However, the outcomes of current therapeutic approaches are unsatisfactory. As a novel therapeutic strategy for unresectable HCC with PVTT, we analyzed the outcomes of transarterial infusion of epirubicin and cisplatin combined with systemic infusion of 5-fluorouracil (TAC-ECF) and compared its therapeutic effects and toxicity with transarterial chemoembolization (TACE) using doxorubicin (DOX).</P><P><B>Methods:</B></P><P>A total of 540 consecutive HCC patients who received TACE at the Catholic Medical Center between January 2007 and November 2013 were enrolled. Of these patients, we retrospectively analyzed 129 Barcelona clinic liver cancer stage C HCC patients with PVTT who received either TAC-ECF or TACE using DOX.</P><P><B>Results:</B></P><P>The objective tumor response rate was higher in the TAC-ECF group, with 31.3% objective response rate after TAC-ECF compared to 10% after DOX treatment (<I>p =</I> 0.004). Median follow-up period was 7 months (range, 1–57 months). The overall survival rate was also significantly higher in the TAC-ECF group compared to the DOX group (median 9.3 <I>versus</I> 4.6 months, <I>p</I> < 0.0001). Multivariate analysis revealed that TAC-ECF and extrahepatic metastasis were independent predictive factors for overall survival (<I>p</I> < 0.0001 and <I>p</I> = 0.002 respectively). No serious adverse effects developed in both groups.</P><P><B>Conclusions:</B></P><P>TAC-ECF therapy was tolerable and showed higher overall survival rate and tumor response compared to the conventional TACE DOX in advanced stage HCC patients with PVTT. Therefore, TAC-ECF may be considered as an effective treatment option for patients with unresectable HCC.</P>
Lee, Jang Eun,Yoon, Na Ri,Kim, Jin Dong,Song, Myeong Jun,Kwon, Jung Hyun,Bae, Si Hyun,Choi, Jong Young,Jeong, Sung Won,Yoon, Seung Kew The Korean Society of Gastroenterology 2011 대한소화기학회지 Vol.57 No.3
<P>Background/Aims: Pegylated interferon plus ribavirin combination therapy has been the standard of therapy for patients with chronic hepatitis C. Although previous studies have reported long term durability after the sustained virologic response (SVR) with standard therapy for chronic hepatitis C, it is still unclear in Korea. The aim of this study was to evaluate the relapse rate and related factors after SVR to pegylated interferon therapy in Korean patients with chronic hepatitis C. Methods: A total of 119 chronic hepatitis C patients were treated with pegylated interferon plus ribavirin, and 73 patients achieved SVR (61.3%). Among 73 patients who achieved SVR, 68 patients (genotype 1, n=40; genotype non-1, n=28) were evaluated for virological response after SVR. Results: SVR rate in genotype 1 and genotype non-1 were 52.5%, and 65.1%, respectively. Relapse after SVR occurred in 5 patients (7.4%) with genotype 1, and the median time to relapse from SVR was 10 months. Univariate analysis revealed that the dose reduction of pegylated interferon (p=0.005) and cirrhosis (p=0.03) were significantly associated with relapse. Conclusions: These results suggested that the relapse could occur even after SVR achievement in Korean patients with chronic hepatitis C, and the dose reduction of pegylated interferon during treatment or having cirrhosis may increased the risk for relapse.</P>
Modification of Polysulfone Membranes and Their Application to Gas Separations
Lee, Kew Ho,Park, You In,Kim, Jung Ran,Rhim, Ji Won 한국공업화학회 2001 Journal of Industrial and Engineering Chemistry Vol.7 No.5
The surface of polysulfone membranes has been modified using the fluorine chemicals, PFPA (pentafluoropropionic anhydride F.W.=310.05) and TFI (Trideca-fluoro-8-idoctane, F.W.=474.0), based on Friedel-Crafts reaction mechanism with varying reaction temperatures, reaction time, and catalysis types. The resulting membranes were characterized through the analysis of ESCA, contact angle measurement and pure water permeability. And the modified PS membranes were exposed to gases of O₂, N₂, and CO₂ to measure the permeation rates and ideal separation factors. In addition, the diffusivities and solubilities of individual gases were measured.
Obesity and the risk of primary liver cancer: A systematic review and meta-analysis
( Won Sohn ),( Hyun Woong Lee ),( Sangheun Lee ),( Jin Hong Lim ),( Min Woo Lee ),( Chan Hyuk Park ),( Seung Kew Yoon ) 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.1
Background/Aims: In this systematic review and meta-analysis, we aimed to clarify the effect of obesity on the occurrence of and mortality from primary liver cancer. Methods: This study was conducted using a systematic literature search of MEDLINE, EMBASE, and the Cochrane Library until November 2018 using the primary keywords “obesity,” “overweight,” “body mass index (BMI),” “body weight,” “liver,” “cancer,” “hepatocellular carcinoma,” “liver cancer,” “risk,” and “mortality.” Studies assessing the relationship between BMI and occurrence of or mortality from primary liver cancer in prospective cohorts and those reporting hazard ratios (HRs) or data that allow HR estimation were included. Results: A total of 28 prospective cohort studies with 8,135,906 subjects were included in the final analysis. These included 22 studies with 6,059,561 subjects for cancer occurrence and seven studies with 2,077,425 subjects for cancer-related mortality. In the meta-analysis, an increase in BMI was associated with the occurrence of primary liver cancer (HR, 1.69; 95% confidence interval, 1.50-1.90, I<sup>2</sup>=56%). A BMI-dependent increase in the risk of occurrence of primary liver cancer was reported. HRs were 1.36 (95% CI, 1.02-1.81), 1.77 (95% CI, 1.56-2.01), and 3.08 (95% CI, 1.21-7.86) for BMI >25 kg/㎡, >30 kg/㎡, and >35 kg/㎡, respectively. Furthermore, increased BMI resulted in enhanced liver cancer-related mortality (HR, 1.61; 95% CI, 1.14-2.27, I<sup>2</sup>=80%). Conclusions: High BMI increases liver cancer mortality and occurrence of primary liver cancer. Obesity is an independent risk factor for the occurrence of and mortality from primary liver cancer. (Clin Mol Hepatol 2021;27:157-174)
Lee, Young Ki,Hur, Wonhee,Lee, Sung Won,Hong, Sung Woo,Kim, Sung Woo,Choi, Jung Eun,Yoon, Seung Kew Nature Publishing Group 2014 Experimental and molecular medicine Vol.46 No.2
<P>14-3-3ζ is related to many cancer survival cellular processes. In a previous study, we showed that silencing 14-3-3ζ decreases the resistance of hepatocellular carcinoma (HCC) to chemotherapy. In this study, we investigated whether silencing 14-3-3ζ affects the radioresistance of cancer stem-like cells (CSCs) in HCC. Knockdown of 14-3-3ζ decreased cell viability and the number of spheres by reducing radioresistance in CSCs after γ-irradiation (IR). Furthermore, the levels of pro-apoptotic proteins were upregulated in CSCs via silencing 14-3-3ζ after IR. These results suggest that 14-3-3ζ knockdown enhances radio-induced apoptosis by reducing radioresistance in liver CSCs.</P>
( Won Hee Hur ),( Sung Woo Kim ),( Young Ki Lee ),( Jung Eun Choi ),( Sung Woo Hong ),( Seung Kew Yoon ) 대한간학회 2012 춘·추계 학술대회 (KASL) Vol.2012 No.1
Background: Non-alcoholic fatty liver disease (NAFLD) is one of the most common hepatic disorders in developed countries and a predominant risk factor for cirrhosis. NAFLD progresses through steatohepatitis as an intermediate stage of increased liver cell death and hepatic inflammation. Free fatty acid (FFA)-induced lipotoxicity plays a pivotal role in the pathogenesis of NAFLD. Accordingly, the inhibition of FFAassociated hepatic toxicity represents a potential therapeutic strategy. Oleuropein, a bitter glucoside in green olive leaves, and its metabolite hydroxytyrosol display powerful antioxidant activity, both in vivo and in vitro. However, the mechanism underlying the anti-lipogenic effect of oleuropein is poorly understood. Methods: In the present study, we investigated the potential anti-hepatosteatotic effect of oleuropein in vitro in hepatic steatosis model systems. To assess the anti-lipogenic effect of oleuropein in a NAFLD model, HepG2 and FL83B cells were incubated with 0.5 mM FFAs (oleate:palmitate, 2:1) together with oleuropein. Intracellular lipid levels were quantitatively measured by Nile Red staining. The sizes and distributions of lipid droplets were visualized by transmission electron microscopy. Cellular apoptosis was determined by annexin V/propidium iodide staining, and the activities of lipogenic signaling proteins were evaluated by immunoblotting. Results: Oleuropein significantly decreased the number and size of lipid droplets in FFA-treated cells and reduced intracellular triglyceride accumulation. The level of phosphorylated ERK decreased in FFA-treated cells in the presence of oleuropein. Conclusions: The protective effects of oleuropein against FFAinduced hepatocellular steatosis suggest a promising therapeutic intervention strategy for NAFLD. Supported by grants of the Korean Health Technology R&D Project, Ministry of Health &Welfare (A090282).
( Won Hee Hur ),( Young Ki Lee ),( Joon Ho Lee ),( Sung Woo Hong ),( Tian Zhu Li ),( Jung Hee Kim ),( Jung Eun Choi ),( Sung Woo Kim ),( Sung Min Kim,),( Eun Byul Lee ),( Seung Kew Yoon ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: MicroRNAs (miRNAs) play critical roles in diverse biological cellular processes including non-alcoholic fatty liver disease (NAFLD). In the present study, we investigated the role of miR-451, which was identified as a target gene for NAFLD, on the molecular mechanisms underlying inflammatory events during high fat diet (HFD)-induced NAFLD. Methods: Microarray and stem-loop RT-PCR were performed to detect dysregulated miRNAs in mouse models of high fat diet (HFD)-induced NAFLD. After then, we searched the direct miRNA targets through performing pair-wise correlation coeffi cient analysis on expression levels of mRNAs, and compared the results with predicted miRNA targets from TargetScan5.1. Here, the role of miR-451 in FFA-induced inflammation was investigated in hepatocytes. The following factors were examined: (1) miR-451 expression levels in HepG2 cells treated with palmitate, (2) the palmitate-induced protein synthesis of interleukin-8 in miR-451 mimic or miR-NC-transfected steatotic HepG2 cells, and (3) the expression of nuclear factor-κB (NF-κB) in miR-451 mimic-transfected steatotic HepG2 cells by real time RT-PCR, luciferase reporter assays and Western blotting Results: We identified 7 new miRNAs-target gene pairs by bioinformatics analysis and further confirmed their expression by stem-loop RT-PCR in murine models of HFD-induced NAFLD. Among those genes, we found that miR-451 expression was downregulated in HFD-induced mice. We also found that Cab39 is the direct target of miRNA-451 in steatotic HepG2 cells. Mechanistically, we demonstrated that AMPK activation through Cab39 as a direct target of miRNA-451 inhibits NF-κB transactivation induced by fatty acid palmitate in HepG2 cells. Consequently, overexpression of miRNA-451 in steatotic HepG2 cells suppressed palmitate-induced proinflammatory cytokine IL-8 expression. Conclusions: These results demonstrated the miRNA/mRNA profiles dysregulated in HFD-induced NAFLD mice model, and suggest that miRNA-451 may play an important role in the pathogenesis of NAFLD.
Two-port access versus four-port access laparoscopic ovarian cystectomy
( Won Kyu Choi ),( Jang Kew Kim ),( Jung Bo Yang ),( Young Bok Ko ),( Sang Lyun Nam ),( Ki Hwan Lee ) 대한산부인과학회 2014 Obstetrics & Gynecology Science Vol.57 No.5
Objective This study was conducted to compare the surgical outcomes between two-port access and four-port access laparoscopic ovarian cystectomy. Methods Four hundred and eighty nine patients who had received two-port access laparoscopic ovarian cystectomy (n=175) and four-port access laparoscopic ovarian cystectomy (n=314) in Chungnam National University Hospital from January 2009 to August 2012 were analyzed retrospectively. The data were compared between the bilaterality of the cysts and cyst diameter of less than 6 cm and 6 cm or more. Results There were no significant differences in patient`s age, parity, body weight, body mass index and history of previous surgery between the two-port and four-port access laparoscopy group. Bilaterality of ovarian cysts was more in fourport access laparoscopy group (13.7% vs. 32.5%, P=0.000). There were no significant differences in operation time, hemoglobin change, hospital stay, adhesiolysis, transfusion, and insertion of hemo-vac between the two-port and four-port access laparoscopy group for size matched compare. However additional analgesics were more in four-port access laparoscopy group for unilateral ovarian cystectomy. Conclusion Two-port access laparoscopic surgery was feasible and safe for unilateral and bilateral ovarian cystectomy compare with four-port access laparoscopic surgery.