산업단지 및 일반생활 지역의 공기 중 톨루엔에 대한 개인노출 및 생체시료의 상관성 분석

이병준(Byoungjun Lee),허 정(Jung Heo),정다영(Dayoung Jung),김순신(Sunshin Kim),류현수(Hyeon-Su Ryu),최민지(Min-Ji Choi),솨이지엔페이(Jian-Fei Shuai),임성국(Sung-Guk Im),양원호(Wonho Yang) 한국환경보건학회 2017 한국환경보건학회지 Vol.43 No.4

Objectives: The purpose of this study was to assess the correlation relationship between personal exposure and urinary hippuric acid in biological monitoring for airborne toluene in an industrial complex and in general environments. Methods: Personal exposure to toluene and its metabolite, hippuric acid, in urine were simultaneously measured in occupational environments area near an industrial complex and in general environments. The study subjects were divided into three types: 137 workers who use organic solvents in the workplace, 210 residents living near a dyeing industrial complex, and 379 residents living in general environments. The toluene exposures of workers and residents were measured by a passive sampler for four days. The urine of participants was sampled when the passive samplers of personal exposure were collected. Results: The toluene and hippuric acid concentrations of workers were the highest, followed by the concentrations of residents living near a dyeing industrial complex and residents living in general environments. The coefficient of correlation between the concentrations of toluene and hippuric acid among workers was 0.749 (p<0.01) in the workplace. On the contrary, correlations between the concentrations of toluene and hippuric acid among residents living near a dyeing industrial complex and residents living in general environments were all not significant. The relationship between the concentrations of hippuric acid and toluene in three types could be described by the exponential growth model. Conclusions: This study analyzed the relationships between toluene exposure and the concentrations of hippuric acid in urine in high, middle, and low exposure environments, and could be described by the exponential growth model.

기관지폐 이형성증의 임상 양상: 다기관 연구

성기혜 ( Ki Hye Sung ),김민희 ( Min Hee Kim ),김은령 ( Eun Ryoung Kim ),심재원 ( Jae Won Shim ),이정주 ( Jung Ju Lee ),임재우 ( Jae Woo Im ),진현승 ( Hyun Seung Jin ) 대한주산의학회 2009 Perinatology Vol.20 No.3

목적: 최근 극소 저출생 체중아의 생존율의 개선으로 기관지폐 이형성증(bronchopulmonary dysplasia, BPD)이 늘고 있다. 다기관 연구에 의해 전국적인 BPD의 역학, 임상 양상과 각 병원 간의 차이를 조사하여 향후 우리나라의 BPD 감소와 중증도를 줄이는 것을 목적으로 본 연구를 시행하였다. 방법: 2005년 6월부터 2007년 5월까지 건국대학교병원, 영등포 성애병원, 강북삼성병원, 중앙대학교병원, 건양대학교병원, 강릉아산병원의 신생아 집중 치료실에 입원하였던 신생아 4,476명을 대상으로 하였다. BPD의 진단 기준은 비전형적인 BPD를 포함하여 병인적인 분류를 하고 있는 Ogawa 등의 분류법을 이용하여 신생아 호흡 곤란 증후군(respiratory distress syndrome, RDS)과 전형적 또는 미만성 혼탁의 방사선 소견, 산전 감염의 유무에 따라 6가지 type으로 분류하였다. 또한 전체 신생아의 출생체중 분포와 생존율, 각 출생체중 군별 BPD의 발생률, 병태 비율, 사망률 등을 조사하고, 이 후 재택 산소요법 시행 여부와 미숙아 망막증, 괴사성 장염 등의 합병증 여부를 조사하였다. 결과: 생후 28일째 산소 치료가 필요한 신생아는 89명이었고, 이 중 Ogawa 분류법에 의한 BPD 환아는 70명(1.6%)이었으며, 특히 1,500 g 미만의 환아 237명 중 60명(25.3%)이었다. 생후 28일 이상 생존율은 98.7%이고, 사망 예는 없었으며 평균 재원 기간은 97.8±51.2일(43~405일)이었다. BPD는 900~999 g, 1,000~1,249 g의 체중 군에서 발생률이 각각 15명(21.4%)으로 가장 높았으며, 교정 36주 이후에도 산소투여가 필요한 중증 BPD의 경우 900~999 g의 체중 군에서 7명(23.3%)로 가장 높았다. Ogawa 분류법으로 BPD의 각 병태 비율로는 RDS 이후에 나타나는 I, II형이 각각 전체의 17예(24.3%), 44예(62.9%)로 대다수를 차지하였다. 이외에도 III`형은 2예(2.9%), IV형은 2예(2.9%), V형은 5예(7.1%)이었고, III형, VI형은 없었다. 재택 산소요법은 8예에서 시행되어 전체의 11.4%였으며, 이 중 BPD I형이 7예로 87.5%를 차지하였다. 미숙아 망막증은 35명(50.0%)에서 발생하였으며, 700 g 이하 신생아에서 9예(26.5%)로 가장 많았다. 또한 괴사성 장염은 3명(4.3%)이었다. 결론: 본 연구는 국내에서 처음으로 진행된 BPD의 전국적인 다기관 역학 조사로, 대상 신생아의 Ogawa 분류에 의한 BPD 유병률은 1.6% 이었고 1,500 g 미만 신생아의 25.3%이었으며, 전체 신생아의 BPD 70명 중 Ogawa 분류의 I, II형이 각각 24.3%, 62.9%로 대다수를 차지하였다. Purpose: As the neonatal intensive care advanced, the incidence of neonatal bronchopulmonary dysplasia (BPD) has increased. We conducted a multi-center investigation of the prevalence of BPD in six hospitals to investigate the epidemiology of BPD in Korea. Methods: Retrospective reviews ware performed for survival rate, prevalence of BPD of total 4,476 newborn infants who were admitted to neonatal intensive care unit in Konkuk university hospital, Sung-Ae General hospital, Kangbuk Samsung hospital, Chung-Ang university hospital, Konyang university hospital, and Gangneung Asan hospital between June, 2005 and May, 2007. By Ogawa, BPD was defined as oxygen dependency at 28 days after birth, with respiratory distress symptoms and the change of chest x-ray finding, and classified as 6 subtypes. Classic BPD was defined as oxygen dependency at 36 weeks of postmenstrual age. Results: Survival rate at 28 day after birth was 98.7%. BPD infants by Ogawa classification were 70 (1.6% of overall newborn infants), classic BPD infants were 30 (0.7%). Especially, among 237 preterm infants with birth weight less than 1,500 gram who survived to 28 days of life, 60 (25.3%) had BPD by Ogawa classification and 23 (9.7%) had classic BPD. In Ogawa classification, infants with RDS as type I and II, were 17 infants (24.3%) and 44 infants (62.9%). Home oxygen therapy was performed 8 infants (11.4%). Prevalence of retinopathy of prematurity was 35 infants (50.0%), necrotizing enterocolitis was 3 infants (4.3%), and intraventricular hemorrhage was 6 infants (8.6%). Conclusion: Prevalence of BPD infants was 1.6% of overall newborn, 25.3% of preterm infants with birth weight less than 1,500 gram. Among 70 BPD infants, BPD by Ogawa classification with history of RDS as type I and II were 24.3%, 62.9% as the majority of BPD. This study would be the first report of epidemiology of Korean BPD infants by multi-center study.

Usefulness of the Cytomegalovirus Antigenemia Assay in Patients With Ulcerative Colitis

( Jaeyoung Chun ),( Changhyun Lee ),( Ji Eun Kwon ),( Sung Wook Hwang ),( Sang Gyun Kim ),( Joo Sung Kim ),( Hyun Chae Jung ),( Jong Pil Im ) 대한장연구학회 2015 Intestinal Research Vol.13 No.1

Background/Aims: Patients with ulcerative colitis (UC) are at high risk for cytomegalovirus (CMV) reactivation. The useful-ness of the CMV antigenemia assay in active UC patients has rarely been studied. We assessed whether the assay detects CMV colitis and predicts clinical outcomes in patients with UC. Methods: We retrospectively reviewed the medical records of pa-tients hospitalized for moderate-to-severe UC from 2003 to 2012. Positive CMV antigenemia was defined as ≥1 pp65-positive cell per 2×105 polymorphonuclear neutrophils. CMV colitis was defined as the presence of inclusion bodies and/or positive im-munohistochemistry in the colonic mucosa. The primary outcome was steroid refractoriness, defined as the absence of clinical improvement after intravenous high-dose steroid administration. Results: A total of 43 patients were enrolled. CMV antigen-emia was detected in 12 (27.9%) patients. Positive CMV antigenemia was significantly associated with CMV colitis (P=0.001). The sensitivity and specificity of positive CMV antigenemia for diagnosing CMV colitis were 66.7% and 87.1%, respectively. Steroid refractoriness was found in 11 of 12 (91.7%) and 12 of 31 (38.7%) patients with positive and negative CMV antigenemia, respectively (P=0.002). The independent predictors for steroid refractoriness were positive CMV antigenemia (adjusted odds ratio [OR], 7.73; 95% confidence interval [CI], 1.22-49.19; P=0.030) and a shorter duration from the diagnosis of UC (adjusted OR, 0.99; 95% CI, 0.98-0.99; P=0.025). Conclusions: The CMV antigenemia assay shows low sensitivity but high specificity for detecting CMV colitis and may predict steroid-refractory UC. Early rescue therapy might be considered in UC patients positive for CMV antigenemia. (Intest Res 2015;13:50-59)

위화(胃火) 1호(號)로 호전(好轉)된 만성위염(慢性胃炎) 환자(患者) 치험(治驗) 2례(例)

이경민,이세연,임성철,서정철,한상원,Lee, Kyung-min,Lee, Se-yun,Im, Sung-chul,Seo, Jung-chul,Han, Sang-won 대한침구의학회 2003 대한침구의학회지 Vol.20 No.6

Objective: This study was designed to investigate the effect of Wihwa herbal-acupuncture on chronic gastritis. Methods: Wihwa herbal-acupuncture was administered two times a week. The following points were selected: CV12(中脘), CV13(上脘), S36(足三里), Liv3(太衝). We checked pain rating score(P.R.S.), visual analogue scale (V.A.S.) and Gastroscopy. Results: After 6 weeks of treatment, the patient showed that clinical symtoms was disappeared, Lee's P.R.S. changed from 77 to 8 and Park's P.R.S. from 55 to 0 and gastric erosion disappeared on gastroscopy. Conclusions: These results suggest that and Wihwa herbal-acupuncture has good effect on chronic gastritis. But further studies are required to concretely prove the effectiveness of Wihwa herbal-acupuncture for treating chronic gastritis.

Comparison of the Long-Term Effects of Tenofovir and Entecavir Therapy in Nucleos(t)ide-Naive Chronic Hepatitis B Patients with High Baseline Viral Load: Propensity Score Analysis

( Sang Yu Oh ),( Bo Ryung Park ),( Byung Uk Lee ),( Jae Ho Park ),( Byung Gyu Kim ),( Seok Won Jung ),( In Du Jeong ),( Sung-jo Bang ),( Jung Woo Shin ),( Neung Hwa Park ),( Yun Im Lee ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: Rare data are available on the comparison of tenofovir (TDF) and entecavir (ETV) therapy in chronic hepatitis B patients with baseline high viral load (HVL) in clinical practice, defined as having hepatitis B virus (HBV) DNA >8 log10 copies/mL (7.3 log10 IU/mL). Methods: We performed a retrospective analysis of the efficacy of TDF therapy, as compared to that of ETV therapy, in patients with HVL. A matched study population was constructed to compare the antiviral efficacy of TDF therapy and ETV therapy by a propensity score analysis. Results: Three hundreds two patients were selected after matching propensity score with 1:1 ratio. Virologic response (VR) was observed in 63.6% (96/151) of patients in the TDF group and in 64.2% (97/151) of the patients in the ETV group. The VR rates were not different between the TDF and ETV groups (51.5 vs. 51.4% at month 12, and 72.1 vs. 69.2% at month 24; log rank P = 0.432). During therapy, 70.2% of patients in the TDF group, and 74.8% of patients in the ETV group had partial VR, respectively (P=0.367). ALT normalization rates also did not differ between both the treatment groups (94.3% and 92.1% in the TDF and ETV therapy groups, respectively; P = 0.838). Nineteen patients experienced a virological breakthrough. Among them, 7 patients (4.6 %) was in the TDF group and 12 patients (7.9 %) were in the ETV group (P = 0.236). During therapy, 21.2% (28 of 132) of patients in the TDF group, and 19.1% (25 of 131) of patients in the ETV group achieved HBeAg seroconversion, respectively (P = 0.667). In multivariate analysis, absolute HBV DNA level at baseline (P<0.001), HBeAg-positive status (P< 0.001) and ALT levels at baseline (P =0.044) were significantly associated with VR. Conclusions: In patients with HVL >8 log10 copies/mL (7.3 log10 IU/mL), virological and biochemical responses were similar between ETV and TDF therapy groups in CHB patients. Therefore, either ETV or TDF are recommended to use as the first-line nucleoside analogues in patients with HVL..

Application of volume-retarded osmosis and low-pressure membrane hybrid process for water reclamation

Im, Sung-Ju,Choi, Jungwon,Lee, Jung-Gil,Jeong, Sanghyun,Jang, Am Elsevier 2018 CHEMOSPHERE - Vol.194 No.-

<P><B>Abstract</B></P> <P>A new concept of volume-retarded osmosis and low-pressure membrane (VRO-LPM) hybrid process was developed and evaluated for the first time in this study. Commercially available forward osmosis (FO) and ultrafiltration (UF) membranes were employed in a VRO-LPM hybrid process to overcome energy limitations of draw solution (DS) regeneration and production of permeate in the FO process. To evaluate its feasibility as a water reclamation process, and to optimize the operational conditions, cross-flow FO and dead-end mode UF processes were individually evaluated. For the FO process, a DS concentration of 0.15 g mL<SUP>−1</SUP> of polysulfonate styrene (PSS) was determined to be optimal, having a high flux with a low reverse salt flux. The UF membrane with a molecular weight cut-off of 1 kDa was chosen for its high PSS rejection in the LPM process. As a single process, UF (LPM) exhibited a higher flux than FO, but this could be controlled by adjusting the effective membrane area of the FO and UF membranes in the VRO-LPM system. The VRO-LPM hybrid process only required a circulation pump for the FO process. This led to a decrease in the specific energy consumption of the VRO-LPM process for potable water production, that was similar to the single FO process. Therefore, the newly developed VRO-LPM hybrid process, with an appropriate DS selection, can be used as an energy efficient water production method, and can outperform conventional water reclamation processes.</P> <P><B>Highlights</B></P> <P> <UL> <LI> New energy saving forward osmosis-low pressure membrane hybrid process was tested. </LI> <LI> The system could produce final product with an increase in inner pressure of tank. </LI> <LI> A polymeric draw solute was effective in the operation of this hybrid system. </LI> <LI> A mass balance modeling was used for optimization. </LI> <LI> An applicability of this hybrid process in wastewater treatment was confirmed. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Therapeutic potential of heat-processed American ginseng against diabetic renal damage in vitro and in vivo

LEE Ji Hwan,HAN Im-Ho,LEE Seung Young,KANG Ki Sung 大韓藥學會 2012 大韓藥學會 總會 및 學術大會 Vol.2012 No.1

A follow-up study on extracorporeal fixation of condylar fractures using vertical ramus osteotomy

Sung Yong Park,Jae Hyoung Im,Seong Hoe Yoon,Dong Kun Lee 대한구강악안면외과학회 2014 대한구강악안면외과학회지 Vol.40 No.2

Objectives: The aim of this study is to report the results of extracorporeal fixation in patients with mandibular condylar fractures and compare them with the clinical results of conservative treatment. Materials and Methods: The medical records of 92 patients (73 male [M] : 19 female [F], age 13-69 years, mean 33.1 years) treated for condylar fractures at the Department of Oral and Maxillofacial Surgery in Sun Dental Hospital (Daejeon, Korea) from 2007 to 2012 were reviewed. Patients were divided into three groups: group A (23 patients; M : F=18 : 5, age 21-69 years, mean 32.6 years), treated with extracorporeal fixation; group B (30 patients; M : F=24 : 6, age 16-57 years, mean 21.1 years), treated by conventional open reduction; and group C (39 patients; M : F=31 : 8, age 16-63 years, mean 34.4 years), treated with the conservative method (‘closed’ reduction). Clinical and radiographic findings were evaluated and analyzed statistically. Results: Occurrence of postoperative condylar resorption correlated with certain locations and types of fracture. In this study, patients in group A (treated with extracorporeal fixation) did not demonstrate significant postoperative complications such as malocclusion, mandibular hypomobility, temporomandibular disorder, or complete resorption of condyle fragments. Conclusion: In superiorly located mandibular condyle fractures, exact reconstruction of condylar structure with the conventional open reduction technique can be difficult due to the limited surgical and visual fields. In such cases, extracorporeal fixation of the condyle using vertical ramus osteotomy may be a better choice of treatment because it results in anatomically accurate reconstruction and low risk of complications.

A Low-Temperature Thin-Film Encapsulation for Enhanced Stability of a Highly Efficient Perovskite Solar Cell

Lee, Young Il,Jeon, Nam Joong,Kim, Bong Jun,Shim, Hyunjeong,Yang, Tae-Youl,Seok, Sang Il,Seo, Jangwon,Im, Sung Gap Wiley (John WileySons) 2018 Advanced energy materials Vol.8 No.9

INFLUENCE OF CHOLERA ON THE WATER CONTENT IN BLOOD

Lee, K.Y.,Im, J.S.,Sung, N.U. 서울대학교 1957 서울대학교 論文集 Vol.6 No.-

1946年 9月에 南韓에서 發生한 虎列剌患者 7名에 對하여 그 臨床經過와 아울러 血液水分量의 變動을 調査하여 다음과 같은 結果를 얻어 여기 發表하는 바이다. (1) 虎列剌患者에 있어서는 血水量이 우리가 調査한 各種疾患中에서 最低値를 보여 주고 있다. (70.1%-75.3%) 이것은 標準正常穴深水分量보다 各各 8.7%-5.1%나 적은 것을 意味한다. (2) 臨床增勢가 良好하여짐에 따라 血水量은 迅速히 增加되며 大槪 4-5日間 內에 正常値에 지 到達한다. (3) 死亡한 例에 있어서는 血水量은 72%에 不過하고 入院後 곧 死亡한 故로 그後 調査는 不能하였다. (4) 一般으로 血水量이 적은 患者일수록 脫水狀態는 甚하다.