Beliefs of and Attitudes toward Political Advertising

Jin, Hyun Seung(진현승),Ahn, Chasu(안차수) SBS 2007 미디어경제와 문화 Vol.5 No.3

소아 천식 환자 기도과민성에서 TNF-α-308G/A와 IL-13 +2044G/A의 유전자 상호작용

강미진 ( Mi Jin Kang ),김효빈 ( Hyo Bin Kim ),진현승 ( Hyun Seung Jin ),이소연 ( So Yeon Lee ),김자형 ( Ja Hyung Kim ),장성옥 ( Seong Ok Jang ),홍수종 ( Soo Jong Hong ) 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.2

Background: Asthma is the most common chronic disease in children. Tumor necrosis factor (TNF)-α is a pivotal pro-Inflammatory cytokine increased in the asthmatic airways. Also, interleukin (IL)-13 is a pivotal immunoregulatory cytokine in asthma pathogenesis. Objective: We assumed that there might be a synergistic effect between TNF-α and IL-13. We analyzed the genotypes of TNF-α and IL-13 polymorphisms in asthmatic patients and control groups, and investigated the association of asthma-related phenotypes with them. Method: We enrolled 719 asthmatic and 172 control children. Evaluated asthma phenotypes included pulmonary function test, and bronchial hyperresponsiveness (BHR) to methacholine and exercise. We analyzed the genotypes of TNF-α -308G/A and IL-13 +2044G/A polymorphism by using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Result: TNF-α polymorphism was associated with BHR to methacholine (P=0.026). Gene-gene interactions between TNF-α and IL-13 polymorphisms with heterozygote and homozygote of variant genotypes were associated with BHR to methacholine in asthma (P=0.008) and exercise-induced asthma (P=0.005) but were not associated with maximum % fall in FEV1 compared to those with homozygotes of common genotypes. Conclusion: TNF-α polymorphism was associated with BHR to methacholine. Gene-gene interactions between TNF-α and IL-13 polymorphisms were associated with BHR to methacholine. Therefore, TNF-α and IL-13 polymorphisms may show a synergistic effect in terms of BHR. (Korean J Asthma Allergy Clin Immunol 2007;27:98-104)

성인학습자의 지각된 유용성과 태도가 학습몰입과 학습실재감에 미치는 영향

유병민(Byeong Min Yu),박혜진(Hye Jin Park),진현승(Hyun Seung Jin) 한국농촌지도학회 2016 농촌지도와 개발 Vol.23 No.4

The purpose of this study are to examine the educational use of the Facebook and to examine the effects of the learners perceived usefulness, attitude and self-efficacy on learning flow and learning presence at university classes using social network service. The subjects of this study are 155 university students attending a class at a 4-year university in Seoul, and certain questions verified in the existing studies were modified, complemented, and used as a tool for measurement. The details of the purpose are as follows. First, it turned out that there were significant differences in learning flow and learning presence in accordance with the levels of the usefulness that learners perceived. It can be said that the higher the perceived level of usefulness, the higher the learning flow and learning presence. Second, it turned out that there were significant differences in learning flow and learning presence in accordance with the levels of learners’ perceived attitudes. We can interpret such a result as suggesting that the higher a learner’s perceived attitude, the higher the learning flow and learning presence.

증례보고 : 성문상 종양에 의한 성문 폐쇄 환자에서의 기관 내 삽관

이숙영 ( Suk Young Lee ),함태수 ( Tae Soo Hahm ),진현승 ( Hyun Seung Jin ) 대한마취과학회 2009 Korean Journal of Anesthesiology Vol.56 No.1

Intubation in patients with an obstruction of the glottis due to a large mass may present great challenge to most anesthesiologists. If tracheostomy is not available, flexible fiberscope guided endotracheal intubation is now the part of the standard management in these cases, but difficulty in advancing the tracheal tube over the fiberscope and into the trachea may be encountered. In this case, a 60-year-old male with a huge supraglottic mass was given general anesthesia for laryngomicroscopic surgery and debulking of the mass lesion. We planned an awake flexible fiberoptic intubation but failed to railroad the tube over the fiberscope even after successfully placing the scope inside the trachea. During various attempts to pass the tracheal entrance, the patient coughed and the tube slid into the trachea as mass moved aside and we could successfully secure the airway. (Korean J Anesthesiol 2009;56:87~91)

IL-13 +2044G/A Polymorphism 과 소아천식의 관련성 및 그 기능 연구

김효빈 ( Hyo Bin Kim ),이소연 ( So Yeon Lee ),진현승 ( Hyun Seung Jin ),김자형 ( Ja Hyeong Kim ),김봉성 ( Bong Seong Kim ),강미진 ( Mi Jin Kang ),장성옥 ( Seong Ok Jang ),홍수종 ( Soo Jong Hong ) 대한천식알레르기학회 2006 천식 및 알레르기 Vol.26 No.4

Background: The IL-13 +2044G/A is known to be associated with increased serum total IgE levels and asthma development. Variant type of IL-13 was significantly more active than wild type in inducing CD23 expression in monocytes. Objective: We investigated the association of asthma susceptibility and asthma-related phenotypes with +2044G/A and the functional difference between wild (+2044G, R110) and variant types (+2044A, Q110). Method: We enrolled 358 atopic asthmatic, 81 non-atopic asthmatic, and 146 control children and evaluated total IgE and bronchial hyperresponsiveness. Genotypes were analyzed by PCR-RFLP method. We applied wild and variant types of IL-13 to B cells and evaluated CD23 expression by flow cytometry. Result: The group with more than one variant alleles of +2044G/A was associated with asthma development, but not with increased total IgE levels than those with wild homozygote in children with asthma. When Q110 was applied to peripheral blood B cells of normal subjects and EBV-transformed B cells from children with atopic asthma, CD23 expressions was higher than those when R110 applied. Conclusion: IL-13 +2044G/A was associated with asthma development in Korean children with asthma, but not with total IgE. In addition, Q110 enhanced CD23 expression on B cells. These findings suggest that IL-13 +2044A (Q110) polymorphism may play a role in asthma development or IgE production. (Korean J Asthma Allergy Clin Immunol 2006;26:271-276)

건강하였던 소아에서 전격성 감염의 경과를 보인 마이코플라즈마 폐렴 1례

김태희 ( Tae Hee Kim ),송영화 ( Young Hwa Song ),김명주 ( Myong Ju Kim ),유진호 ( Jin No Yu ),전종근 ( Chong Kun Cheon ),진현승 ( Hyun Seung Jin ),박성종 ( Sung Jong Park ),홍수종 ( Soo Jong Hong ) 대한소아알레르기호흡기학회 2009 소아알레르기 및 호흡기학회지 Vol.19 No.2

Mycoplasma pneumoniae is a common cause of community-acquired respiratory infection in children. Through uncertain pathologic mechanisms, which most probably involve immunologically cell-mediated tissue damage, it causes life-threatening disease on rare occasion. We herein report a case of M. pneumoniae pneumonia, with encephalopathy followed by multiple organ failure in a previously healthy boy. Despite of intensive therapies with intravenous antibiotics, corticosteroid, hemodiafiltration, and transfusion, his neurologic and pulmonary sequales have remained. In most cases M. pneumoniae pneumonia are usually self-limiting with benign outcome. Even in healthy individual, however, it can manifest itself with a fulminant course and multi organ failure. [Pediatr Allergy Respir Dis(Korea) 2009;19:191-198]

한국 3개 지역 고등학생에서 알레르기질환의 유병률에 대한 조사

김봉성 ( Bong Seong Kim ),김효빈 ( Hyo Bin Kim ),이소연 ( So Yeon Lee ),김자형 ( Ja Hyeung Kim ),진현승 ( Hyun Seung Jin ),김병주 ( Byung Ju Kim ),유진호 ( Jin Ho Yu ),유선미 ( Sun Mi Yoo ),홍수종 ( Soo Jong Hong ) 대한천식알레르기학회 2007 천식 및 알레르기 Vol.27 No.3

Background: Whereas allergic disease has a high morbidity among adolescents, there have been few reports concerning asthma prevalence using objective parameters such as methacholine bronchial provocation tests in this age group. Objective: Thus we investigate the prevalence of asthma and other allergic diseases using questionnaires and measuring bronchial hyperresponsiveness (BHR) in high school students in Korea. Method: A questionnaire survey was conducted among 1499 high school students, from 3 regions in Korea between April and May, 2006. They responded to a modified International Study of Asthma and Allergies in Childhood (ISAAC) written (WQ) and video (AVQ) questionnaires. 709 subjects of them underwent methacholine bronchial challenge test. Result: The WQ showed that the lifetime and 12-month prevalences of wheeze were 16.0% and 8.9%. The lifetime prevalence of asthma diagnosis was 7.0% and 12-month prevalence of asthma treatment was 1.5%. By video questionnaire, the lifetime prevalence and 12-month prevalence of wheeze were 7.9% and 5.5%. The prevalence of current asthma based on the questionnaire and bronchial challenge tests was 3.2%. The prevalence of current asthma and BHR were higher in female than in male subjects. For 12-month prevalence of allergic rhinitis and atopic dermatitis were 37.7% and 11.4%, respectively. Conclusion: The prevalence of current asthma in high school students were 3.2%. Despite the fact that 12-month prevalence of wheeze and lifetime prevalence of asthma diagnosis were 8.9% was 7.0%, only 1.5% of answered subjects received asthma treatment. Its prevalence was still low compared to asthma prevalence. (Korean J Asthma Allergy Clin Immunol 2007;27:168-175)

농촌어메니티자원정보 구축과 활용 현황

박미정 ( Mee Jeong Park ),김상범 ( Sang Bum Kim ),김은자 ( Eun Ja Kim ),리신호 ( Shin Ho Rhee ),송이 ( Yi Song ),임창수 ( Chang Su Lim ),최진아 ( Jin Ah Choi ),진현승 ( Hyun Seung Chin ) 한국농촌계획학회 2014 농촌계획 Vol.20 No.4

The purpose of this study is to investigate the entire processes of rural amenity resources survey from the beginning to the end, to discuss the results of the survey and resources information establishment, and to comprehensively analyze the status of resources information application. Rural amenity resources survey, which is aimed at finding rural amenity resources to respond to the demands of the resources and support rural development, was first conducted by National Academy of Agricultural Science under Rural Development Administration in 2005. The first survey subjects were 149 eups and myeons in Korea, expanding to the nationwide rural villages. In 2012, the rural amenity resources survey was completed. Next year, the information establishment was completely made. It is expected that the rural amenity resources information established by the survey will be more applied and used, and that with the constant addition of new analyses in line with the changing environment demands, rural amenity resources will contribute to dynamic rural development.

기관지폐 이형성증의 임상 양상: 다기관 연구

성기혜 ( Ki Hye Sung ),김민희 ( Min Hee Kim ),김은령 ( Eun Ryoung Kim ),심재원 ( Jae Won Shim ),이정주 ( Jung Ju Lee ),임재우 ( Jae Woo Im ),진현승 ( Hyun Seung Jin ) 대한주산의학회 2009 Perinatology Vol.20 No.3

목적: 최근 극소 저출생 체중아의 생존율의 개선으로 기관지폐 이형성증(bronchopulmonary dysplasia, BPD)이 늘고 있다. 다기관 연구에 의해 전국적인 BPD의 역학, 임상 양상과 각 병원 간의 차이를 조사하여 향후 우리나라의 BPD 감소와 중증도를 줄이는 것을 목적으로 본 연구를 시행하였다. 방법: 2005년 6월부터 2007년 5월까지 건국대학교병원, 영등포 성애병원, 강북삼성병원, 중앙대학교병원, 건양대학교병원, 강릉아산병원의 신생아 집중 치료실에 입원하였던 신생아 4,476명을 대상으로 하였다. BPD의 진단 기준은 비전형적인 BPD를 포함하여 병인적인 분류를 하고 있는 Ogawa 등의 분류법을 이용하여 신생아 호흡 곤란 증후군(respiratory distress syndrome, RDS)과 전형적 또는 미만성 혼탁의 방사선 소견, 산전 감염의 유무에 따라 6가지 type으로 분류하였다. 또한 전체 신생아의 출생체중 분포와 생존율, 각 출생체중 군별 BPD의 발생률, 병태 비율, 사망률 등을 조사하고, 이 후 재택 산소요법 시행 여부와 미숙아 망막증, 괴사성 장염 등의 합병증 여부를 조사하였다. 결과: 생후 28일째 산소 치료가 필요한 신생아는 89명이었고, 이 중 Ogawa 분류법에 의한 BPD 환아는 70명(1.6%)이었으며, 특히 1,500 g 미만의 환아 237명 중 60명(25.3%)이었다. 생후 28일 이상 생존율은 98.7%이고, 사망 예는 없었으며 평균 재원 기간은 97.8±51.2일(43~405일)이었다. BPD는 900~999 g, 1,000~1,249 g의 체중 군에서 발생률이 각각 15명(21.4%)으로 가장 높았으며, 교정 36주 이후에도 산소투여가 필요한 중증 BPD의 경우 900~999 g의 체중 군에서 7명(23.3%)로 가장 높았다. Ogawa 분류법으로 BPD의 각 병태 비율로는 RDS 이후에 나타나는 I, II형이 각각 전체의 17예(24.3%), 44예(62.9%)로 대다수를 차지하였다. 이외에도 III`형은 2예(2.9%), IV형은 2예(2.9%), V형은 5예(7.1%)이었고, III형, VI형은 없었다. 재택 산소요법은 8예에서 시행되어 전체의 11.4%였으며, 이 중 BPD I형이 7예로 87.5%를 차지하였다. 미숙아 망막증은 35명(50.0%)에서 발생하였으며, 700 g 이하 신생아에서 9예(26.5%)로 가장 많았다. 또한 괴사성 장염은 3명(4.3%)이었다. 결론: 본 연구는 국내에서 처음으로 진행된 BPD의 전국적인 다기관 역학 조사로, 대상 신생아의 Ogawa 분류에 의한 BPD 유병률은 1.6% 이었고 1,500 g 미만 신생아의 25.3%이었으며, 전체 신생아의 BPD 70명 중 Ogawa 분류의 I, II형이 각각 24.3%, 62.9%로 대다수를 차지하였다. Purpose: As the neonatal intensive care advanced, the incidence of neonatal bronchopulmonary dysplasia (BPD) has increased. We conducted a multi-center investigation of the prevalence of BPD in six hospitals to investigate the epidemiology of BPD in Korea. Methods: Retrospective reviews ware performed for survival rate, prevalence of BPD of total 4,476 newborn infants who were admitted to neonatal intensive care unit in Konkuk university hospital, Sung-Ae General hospital, Kangbuk Samsung hospital, Chung-Ang university hospital, Konyang university hospital, and Gangneung Asan hospital between June, 2005 and May, 2007. By Ogawa, BPD was defined as oxygen dependency at 28 days after birth, with respiratory distress symptoms and the change of chest x-ray finding, and classified as 6 subtypes. Classic BPD was defined as oxygen dependency at 36 weeks of postmenstrual age. Results: Survival rate at 28 day after birth was 98.7%. BPD infants by Ogawa classification were 70 (1.6% of overall newborn infants), classic BPD infants were 30 (0.7%). Especially, among 237 preterm infants with birth weight less than 1,500 gram who survived to 28 days of life, 60 (25.3%) had BPD by Ogawa classification and 23 (9.7%) had classic BPD. In Ogawa classification, infants with RDS as type I and II, were 17 infants (24.3%) and 44 infants (62.9%). Home oxygen therapy was performed 8 infants (11.4%). Prevalence of retinopathy of prematurity was 35 infants (50.0%), necrotizing enterocolitis was 3 infants (4.3%), and intraventricular hemorrhage was 6 infants (8.6%). Conclusion: Prevalence of BPD infants was 1.6% of overall newborn, 25.3% of preterm infants with birth weight less than 1,500 gram. Among 70 BPD infants, BPD by Ogawa classification with history of RDS as type I and II were 24.3%, 62.9% as the majority of BPD. This study would be the first report of epidemiology of Korean BPD infants by multi-center study.