폐 내 병변으로 인한 소아 급성 호흡부전의 원인 질환과 예후

이혜영,박지숙,최희라,서지현,김점수,임재영,최명범,박찬후,우향옥,윤희상 대한소아과학회 2004 小兒科 Vol.47 No.5

가치명료화 이론을 적용한 가정과 오차림 단원 교수-학습 과정안 개발 및 효과 : 상업계고등학교를 중심으로 Centering The Business High School

김소라,이혜자 한국 가정과 교육 학회 2002 한국가정과교육학회지 Vol.14 No.2

The purposes of this study are first to develop the teaching and learning plan for the dress part in high school's Home Economics by the application of the values clarification theory, then to apply it to the classroom activities, and lastly to analyze its effects. We developed the master plan for teaching and learning, and developed the 12 hours sub plans including 7 activities and learning materials. The effects of the teaching are as followings: First, When the self-esteem was compared with the whole classes, there was no difference between the twos, but a boy and a girl who were observed as not making a value-oriented life marked higher score in answering the self-esteem. Second, It was found that values clarification theory made student's degree of participation and interest higher and helped them to choose their dresses in the real life.

국내의 치매관련 간호연구논문 분석

김혜영,홍춘실,오경옥,이선영,정현숙,이지혜,남미라 충남대학교 간호과학연구소 2002 충남대 간호학술지 Vol.5 No.1

The purpose of this study was to analyze the trends of korean nursing research on dementia and to suggest the direction of future research. A total of 52 nursing research articles published from 1992 to 2001 were selected for this study. These articles were analyzed in a systematic way including time and source of publication, design of research, type of subjects, variable and tool of measurement, intervention outcome of experimental research, and theme of qualitative research. The results were as follows : 1. The nursing research about dementia has appeared since 1992 and increased rapidly since 1998. 2. Eighteen of 52 studies were composed of dissertation of graduate school, and the research designs were mostly quantitative. There were 36 nonexperimental research, 11 experimental research, and 5 qualitative research designs. 3. The subjects of studies were mostly the caregivers of dementia patients as 33 of 52 studies. 4. Most measurement instruments used for research were developed by researcher him/herself, or redesigned and translated into korean as the original foreign version was used. 5. In correlational research, the trend was to study physical conditions in relation to activities of daily living and functional status in dementia patients and psychological conditions in relation to burden, quality of life, depression, and stress in their families. 6. 2 methodological research were development of assessment tool of dementia patients in community, and assessment of burden of caregiver. 7. In experimental research, subjects were all dementia patients, and interventions were music therapy(5), light therapy(2), education program, cognitive stimulation training, validation therapy, hand massage, reminiscence, horticultural therapy, and art therapy. 8. Theme of qualitative research was all caring experience of family. There were 3 phenomenologic methodology, l ethnography and l case study. Based on these findings, the following recommendations were made: 1. It' s necessary to develop a reliable and valid instrument to measure the characteristics of dementia patients and family caregivers of dementia patients. 2. Experimental study should be repeated to prove the effect of intervention for dementia patients and their family.

천연 생약재 열수 및 알코올 추출물의 어병 세균에 대한 항균력

최혜승,김이청,이주석,조미라,서창호,박수일 한국어병학회 2004 한국어병학회지 Vol.17 No.1

감초 외 48종의 천연 생약제로부터 열수 및 알콜 추출액을 제작하여 19 균주 어병 세균을 대상으로 항균력을 조사한 결과, 알콜 추출액은 22종, 열수 추출액은 16종이 어병 세균에 대하여 항균력을 나타내며 이 중 13종의 생약재는 알콜 및 열수 추출액 모두 8㎜ 이상의 저지대를 나타내어 항균력이 있는 것으로 나타났다. 열수 추출물에서 항균력을 나타내는 약재 중 그람 음성균에 감수성이 양호한 약재는 저지대 8 ㎜ 이상을 나타내는 애엽, 개옻나무, 연교, 지유, 파엽, 대황 및 황금이었으며, 그람 양성균에 항균력이 양호한 약재는 삼지구엽초, 육계 및 보골지 등 이었다. 그리고 오매, 황련, 계혈등, 상백피, 오배자 및 오미자는 저지대가 8㎜ 이상으로 그람 음성,양성균 모두에 항균력이 있었다. 알콜 추출물중에서 그람 음성균에 항균력을 나타내는 것은 백작약, 오매, 선모 및 황금 등으로 저지대가 8㎜ 이상으로 측정되었으며, 그람 양성균에 항균력을 나타내는 것은 감초, 계혈등, 단삼, 상백피, 육계 및 보골지 등으로 저지대가 8㎜ 이상이었다. 또한 그람 음성, 양성균에 모두 8㎜ 이상의 저지대를 나타내는 것은 애엽, 개옻나무, 황련, 지유, 오배자 및 오미자 등이었다. 그러나 이 중에서 오배자 열수 추출물의 어병 세균에 대한 발육 저지대가 32㎜로 그람 음성, 양성균 모두에 가장 뛰어난 항균력을 나타내어 다른 생약재와 다른 광범위 생약재인 것으로 나타났다. 애엽, 황금, 지유, 오매, 황련 및 오배자 열수 ·알콜 추출물은 tetracycline에 내성을 나타내는 균주에 감수성을 나타내었다. Hundreds of medicinal herbs have been using for the purpose of diseases treatment and immune enhancement for human being and other animals including fishes. Among them, 49 species of medicinal herbs were selected and tested for antibacterial activities against 19 strains of fish pathogenic bacteria in different 4 species. The 49 medicinal herbs were extracted by water and ethyl alcohol. The extracts were freeze dried and some paper discs from the extracts were prepared for the evaluation of antibacterial activity. The tested pathogenic bacteria were 5 strains of Edwardsiellu tarda, 5 strains of Vibrio sp., 4 strains of Lactococcus gawieae, 1 strain of Lactococcus raffinose. 1 strain of Streptococcus parauberius, and 3 strains of Streptococcus iniue. The Galla rhois (Obaeja), Gaeonnamu and Hwangleyon showed antibacterial activities on both gram negative and gram positive fish pathogenic bacteria. The Youkgae, Sangbaekpi, Bogolji and Gamcho showed very effective antibacterial activities on gram positive pathogens while Jiyu, Aeyoeb and Yeonkyo showed very effective on gram negative pathogens.

한국여성에서 자궁내막증의 발생위험도와 Estrogen Receptor-α 유전자 다형성과의 관련성에 관한 연구

이사라,허성은,문혜성,김형래,정혜원 이화여자대학교 의과대학 2003 EMJ (Ewha medical journal) Vol.26 No.2

Objectives: To investigate whether polymorphism of gene encoding estrogen receptor-a is asso-ciated with the risk of endometriosis in Korean women. Material and Methods :We investigated 136 patients with histopathologically confirmed endo-metriosis rAFS stage III/IV and 251 control group women who were surgically proven to have no endometriosis. Polymerase chain reaction(PCR) and restriction fragment length polymorphism (RFLP) of PCR products were done to determine each participant's estrogen receptor-a genotype. Results : The distridution according to PvuII genetic polymorphism of estrogen receptor-a were as follows. PP, Pp and pp were 14.7%(20 women), 39.0%(53 women) and 46.3%(63 women) in the study group and 13.9%(35 women), 38.6%(98 women) and 47.4%(119 women) in the con-trol group, respectively. There was no significant difference between the study group and the control group. Conclusion : The results suggest that estrogen receptor-a genetic polymorphism may not be associated with the development of endometriosis in Korean women. 목적: 자궁내막증은 에스트로겐에 의존적인 질환이므로 에스트로겐의 합성, 대사 및 작용에 관여하는 유전자의 다형성이 자궁내막증의 발생기전에 중요한 역할을 할 수 있다. 이에 본 연구에서는 한국인 여성에서 에스트로겐 수용체-a의 유전자 다형성이 자궁내막증의 발생 위험도를 증가시키는 지에 대해 연구하고자 하였다. 방법: 1996년 9월부터 2003년 8월가지 본원 산부인과에서 수술을 통해 병리조직학적으로 자궁내막증 III기와 IV기를 확인한 한국인 여성 136명을 대상으로 하였다. 대조군은 자궁내막증 환자군과 연령이 비슷한 만삭 산모에서 제왕절개술을 시행하거나 양성 난소낭종으로 수술을 시행 하였을 때, 자궁내막증이 없음을 확인한 여성 251명 으로 하였다. 결과: ER-a 유전자의 PvuII 다형성의 분포는 자궁내막증 환자군에서 PP군이 20명(14.7%), Pp군이 53명(39.0%), pp군이 63명(46.3%) 이었고 대조군에서의 분포는 각각 35명(13.9%), 97명(38.7%), 119명(47.4%)으로 나타났으며 자궁내막증 환자군과 대조군 사이의 유의한 차이는 없었다. Pp, pp형을 가지는 경우가 자궁 내막증 환자의 85.3%(116명), 대조군의 86.1%(216명)로 나타났으며, 이 경우 자궁내막증이 발생할 odds ratio가 0.904(95% CI, 0.519~1.702)로 통계적으로 유의한 차이가 없었다. 결론: 이상의 결과로 볼 때, 한국인 여성에서 자궁내막증의 발생위험과 에스트로겐 수용체 a 유전자 다형성간에 연관성은 없는 것으로 나타났다.

중환자실 병원감염에 대한 다기관 공동 조사연구

박은숙,박미라,진혜영,김정은,최정실,송영구,최영화,이위교,홍성관,허애정,양동규,김준명 대한병원감염관리학회 2003 의료관련감염관리 Vol.8 No.1

일부 고등학교 여학생의 여드름 유형 실태와 관련요인

심화정,윤혜은,강수경,이재란,송미라,김기순,류소연 조선대학교 2003 The Medical Journal of Chosun University Vol.28 No.1

Background and Objectives : This study was conducted to investigate the actual conditions and the relevant factors of acnes, the most common skin troubles of the adolescent period. Materials and Method : This study was carried out through a survey on 382 female students in a high school from October 24, 2002 to October 31. The survey was formed with questions on the general characteristics of the subject; questions relevant to the actual conditions of acnes; questions of the bio-rhythm; questions on washing and hair shape, the condition of the skin, eating habits; and questions on stress and sicknesses Chi-square test, t-test and multiple logistic regression were used as the method of statistical analysis, to investigate the associated factors with acnes that occur on the face. Results : 1. There were 65.4% of the female students who had acnes, and the most common site were on the forehead and nose, then the cheeks and the whole of the face respectively. On the type of the acnes, 39.1% non-inflammatory acnes, 29.7% were inflammatory and 12.3% were the combination of both 2 As a result of bivariate analysis, there was statistically significant relevance of sleeping time, number of time of washing face, type of cleansing product, type of skin, condition of skin, sensitiveness of skin, preference of meat, menstrual irregularity and stress with acnes 3 Multiple logistic regression analysis showed that the odds ratio(OR) of acnes in case of use of soap instead of cleansing products was 3.00 (95% confidence interval(CI): 1.03 - 8.79), in case of the use of special pimple soap was 27.32 (95% CI 2.68 - 278.51), in case of oily face, 9.40 (95% CI 3.45 - 25.61); in case of combination face was 3.95 (95% CI. 1.64 - 9.50); in case of moist face without shine when compared to seriously lightened skin was 0.22 (95% CI. 0.07 - 0.72); in case of non-preference of meat when compared to preference of meat was 2.00 (95% CI : 1.11 - 3.61) Apart from this, there was no significant relevance with sleeping time, menstrual irregularity and stress Conclusion : It was concluded that there was relevance in the skin condition, skin type and face-wash with the acnes on the face of adolescent female students. There is a necessity of conducting studies about the occurrence of acnes and its relevant factors, in the future.

Thymoquinone-Induced Tristetraprolin Inhibits Tumor Growth and Metastasis through Destabilization of MUC4 mRNA

Lee, Se-Ra,Mun, Jeong-Yeon,Jeong, Mi-So,Lee, Hyun-Hee,Roh, Yun-Gil,Kim, Won-Tae,Kim, Min-Hye,Heo, Jeonghoon,Choi, Yung Hyun,Kim, Su Jin,Cha, Hee-Jae,Jun, Mira,Leem, Sun-Hee MDPI AG 2019 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.20 No.11

<P>Tristetraprolin (TTP), a well-characterized AU-rich element (ARE) binding protein, functions as a tumor suppressor gene. The purpose of this study was to investigate whether a bioactive substance derived from a natural medicinal plant affects the induction of TTP and to elucidate its mechanism. We examined the effects of natural bioactive materials including Resveratrol (RSV), thymoquinone (TQ) and curcumin on the expression of TTP in cancer cell. TQ derived from a natural plant Nigella sativa increased the expression levels of TTP mRNA and proteins in a dose-dependent manner in gastric and breast cancer cells. TQ-induced TTP increased the instability of MUC4 mRNA by direct binding of TTP to ARE in the 3′UTR of MUC4 mRNA. The induction of TTP by TQ also reduced the proliferation, migration and invasion of cancer cells. The expression of the epithelial-mesenchymal (EMT)-related genes, which were target genes of TTP, was also decreased by the TQ treatment. In the in vivo experiments using mouse melanoma cells, TQ-induced TTP inhibited metastasis of tumor cells. We have found that TQ-induced TTP might inhibit metastasis by reducing tumor cell migration and invasion through destabilization of MUC4 mRNA, which suggest the MUC4 as a novel target to TTP.</P>

A role for Leu247 residue within transmembrane domain 2 in ginsenoside-mediated α7 nicotinic acetylcholine receptor regulation

Lee, Byung-Hwan,Choi, Sun-Hye,Pyo, Mi Kyung,Shin, Tae-Joon,Hwang, Sung-Hee,Kim, Bo-Ra,Lee, Sang-MoK,Lee, Jun-Ho,Lee, Joon-Hee,Lee, Hui Sun,Choe, Han,Han, Kyou-Hoon,Kim, Hyoung-Chun,Rhim, Hyewhon,Yong, Springer-Verlag 2009 Molecules and cells Vol.27 No.5

<P>Nicotinic acetylcholine receptors (nAChRs) play important roles in nervous system functions and are involved in a variety of diseases. We previously demonstrated that ginsenosides, the active ingredients of Panax ginseng, inhibit subsets of nAChR channel currents, but not alpha7, expressed in Xenopus laevis oocytes. Mutation of the highly conserved Leu247 to Thr247 in the transmembrane domain 2 (TM2) channel pore region of alpha7 nAChR induces alterations in channel gating properties and converts alpha7 nAChR antagonists into agonists. In the present study, we assessed how point mutations in the Leu247 residue leading to various amino acids affect 20(S)-ginsenoside Rg(3) (Rg(3)) activity against the alpha7 nAChR. Mutation of L247 to L247A, L247D, L247E, L247I, L247S, and L247T, but not L247K, rendered mutant receptors sensitive to Rg(3). We further characterized Rg(3) regulation of L247T receptors. We found that Rg(3) inhibition of mutant alpha7 nAChR channel currents was reversible and concentration-dependent. Rg(3) inhibition was strongly voltage-dependent and noncompetitive manner. These results indicate that the interaction between Rg(3) and mutant receptors might differ from its interaction with the wild-type receptor. To identify differences in Rg(3) interactions between wild-type and L247T receptors, we utilized docked modeling. This modeling revealed that Rg(3) forms hydrogen bonds with amino acids, such as Ser240 of subunit I and Thr244 of subunit II and V at the channel pore, whereas Rg(3) localizes at the interface of the two wild-type receptor subunits. These results indicate that mutation of Leu247 to Thr247 induces conformational changes in the wild-type receptor and provides a binding pocket for Rg(3) at the channel pore.</P>

Which Environmental Factors Caused Lammas Shoot Growth of Korean Red Pine?

Lee, Chang-Seok,Song, Hye-Gyung,Kim, Hye-Soo,Lee, Bit-Na-Ra,Pi, Jeong-Hoon,Cho, Yong-Chan,Seol, Eun-Sil,Oh, Woo-Seok,Park, Sung-Ae,Lee, Seon-Mi The Ecological Society of Korea 2007 Journal of Ecology and Environment Vol.30 No.1

Lammas growth, a rare phenomenon for Korean red pine (Pinus densiflora), occurred in 2006. Lammas shoots showed higher frequency and longer length in Seoul's hotter urban center than in urban boundary or suburban forest sites. Frequency and length showed a close correlation with urbanization density and vegetation cover expressed in NDVI. Air temperature in the late summer of 2006 was more than $1^{\circ}C$ higher than an average year. Of the predominant environmental signals that modulate bud flush, only temperature changed significantly during the year. Differences in temperature between the urban centers, urban boundaries and suburban forests correlated with varying land-use density. The rise in temperature likely spurred lammas growth of the Korean red pine. Symptoms of climate change are being detected throughout the world, and its consequences will be clearer in the future. Considerate interest in the responses of ecological systems to the variable changes is required to prepare for unforeseeable crises. Monitoring of diverse ecological phenomena at Long Term Ecological Research sites could offer harbingers of change.