이중혈류유발 심폐소생술이 심정지를 유발한 개의 단기 생존율에 미치는 영향

황성오,조준휘,강구현,김성환,문중범,이강현,이승환,윤정한,최경훈,홍은석 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Background and Objectives: We previously reported that, compared with standard cardiopulmonary resuscitation(S-CPR), better hemodynamic effects could be achieved by simultaneous sterno-thoracic cardiopulmonary resuscitation(SST-CPR) in which we compressed the sternum and constricted the thorax circumferentially during the systolic period by using a device. This study was designed to assess whether SST-CPR, compared with S-CPR, improve the survival rate of dogs with cardiac arrest. Subjects and methods: Twenty-five mongrel dogs(19∼31㎏) were enrolled in this study. After four minutes of ventricular fibrillation induced by an AC current, animals were randomized to resuscitate with either S-CPR(n=13) or SST-CPR(n=12). Epinephrine(1 ㎎) was injected into the right atrium every three minutes after the beginning of CPR. Defibrillation was attempted after 6 minutes of CPR. Standard advanced cardiac life support was started if defibrillation was not successful. Results: SST-CPR resulted in significantly(p<0.001) higher systolic arterial pressure(91±47 vs 47±24 ㎜ Hg), diastolic pressure(43±24 vs 17±10 ㎜ Hg), coronary perfusion pressure(35±25 vs 13±9㎜ Hg), and end tidal CO2 tension(9±4 vs 3±2 ㎜ Hg). Two of 13 animals(15 %) resuscitated with S-CPR and six of 12 animals(50%) resuscitated with SST-CPR survived until 12 hours after cardiac arrest(p<0.05). Donclusion: SST-CPR, compared with S-CPR, improves the short-term survival rate in canine cardiac arrest.

직업적 연폭로에서 혈중 연량 수준에 따른 선별검사로서의 혈중 ZPP 검사의 타당도

한구석,안현철,김용배,리갑수,김화성,황규윤,장봉기,이성수,안규동,이병국 순천향대학교 산업의학연구소 1999 순천향산업의학 Vol.5 No.1

In order to evaluate the validity of current screening criteria of lead exposure and to provide effective information for the better health management of lead workers, author investigated the interrelationship between blood lead and blood zinc protoporphyrin(ZPP) and evaluate the validity of blood zinc protoporphyrin as the screening test and blood lead as gold standard of diagnostic test. The total of 2245 lead workers (male workers: 1982, female workers : 263) from 12 lead using industries were studied. Blood lead, ZPP, hemoglobin and hematocrit were selected as lead exposure variables. Personal information on sex, age and work duration were also checked. Blood lead was measured with flameless atomic absorption spectrometry (model: Hitachi 8100) using standard addition method. Blood ZPP was measured with portable hematoflurometer (model: Aviv 206). The results obtained were as follows: 1. The mean blood lead of all lead workers were 0.7±14.3㎍/㎗(Male: 31.0±14.4㎍/㎗, Female: 28.2±12.9㎍/㎗), whereas the mean blood ZPP of those were 68.1±47.5㎍/㎗(Male: 63.9±43.7㎍/㎗, Female: 100.1±61.0㎍/㎗). The mean value of hemoglobin and hematocrit of all lead workers were 14.5±1.5g/㎗(Male: 14.7±1.3g/㎗, Female: 12.3±1.2g/㎗) and 45.4±3.6(Male: 46.2±2.8, Female: 39.5±3.1) respectively. 2. Validity of test using blood zinc protoporphyrin as screening test for blood lead levels of 30㎍/㎗ as gold standard of diagnostic test revealed that the highest validity value for male and female lead workers were 50 and 90 ㎍/㎗ of ZPP respectively, showing 50 and 60 ㎍/㎗ of ZPP for all lead workers. While those test for blood lead levels of 40㎍/㎗ as gold standard of diagnostic test revealed that the highest validity value for male and female lead workers were 60 and 90 ㎍/㎗ of ZPP respectively, showing 60 ㎍/㎗ of ZPP for all lead workers, those test for blood lead levels of 50 and 60㎍/㎗ as gold standard of diagnostic test revealed that the highest validity value for male and female lead workers were 60 or 70 and 100 ㎍/㎗ ZPP respectively, showing 60and 70 or 80 ㎍/㎗ of ZPP for all lead workers. 3. Predictive value of test using blood zinc protoporphyrin as the screening test for different blood lead levels of 30, 40, 50 and 60㎍/㎗ as gold standard of diagnostic test revealed that positive predictive value of screening test were decreased by the increase of blood lead level regardless of csreening criteria value ZPP and negative predictive value of screening test were increased accordingly regardless of screening criteria value of ZPP. On the other hand, within same blood lead level as a gold standard positive predictive values were inceased by the increase of screening criteria value of ZPP, whereas the negative predictive value were decreased accordingly by the the increase of screening criteria value of ZPP. 4. The correlation analysis of all lead workers among study variables revealed that CPbB and natural log transformation ZPP(LZPP) were better correlated with other variables and found to be better estimate than PbB and ZPP themselves. The age was correlated with all other variables, but the work duration was not. The correlation analysis of male and female workers among study variables revealed the same results with all lead workers. 5. The slope of simple linear regression of CPbB (independent variable) with ZPP in female workers(3.223)was steeper than in male workers(2.144). That of lead workers with work duration of less than 1 year was steeper than that of lead workers whose work duration was more than 1 year. But there was no slope difference between two groups divided by their work duration of 2 years less and more. The slope of simple linear regression of CPbB lead (independent variable)with ZPP in lead workers whose blood lead were higher than 30㎍/㎗and 40㎍/㎗ were steeper than those whose blood lead were less than 30㎍/㎗ and 40㎍/㎗. 6. The slope of simple linear regression of CPbB (independent variable) with ZPP in lead industries with low mean blood lead were less steeper than those with high mean blood lead. 7. The slope of simple linear regression of CPbB (independent variable) with LZPP in female workers(0.0308was steeper than in male workers(0.0253). That of lead workers with work duration of less than 1 year was steeper than that of lead workers whose work duration was more than 1 year. But where was no slope difference between two groups divided by their work duration of 2 years less and more. While the slope of simple linear regression of CPbB lead (independent variable) with LZPP in lead workers whose blood lead were hogher than 30㎍/㎗ was not steeper than those whose blood lead were less than 30㎍/㎗, there was no slope difference between two groups whose blood lead were less than 40㎍/㎗ and more than 40㎍/㎗. 8. The slope of simple linear regression of CPbB (independent variable) with LZPP in lead industries with low mean blood lead were less steeper than those with high mean blood lead, but the difference was not significant then that of CPbB and ZPP. With above results, it is recommended that the screening criteria value of ZPP should be down to 60-70㎍/㎗ from 100㎍/㎗ for male lead workers and screening criteria of ZPP for female lead workers was all right with current value of 100㎍/㎗. So it is recommended to make different screening criteria of ZPP for male and female workers like the hemoglobin and hematocrit screening criteria. It is also preferable to use CPbB and LZPP rather than uncorrected PbB and ZPP in the evaluation of lead exposure for lead workers.

Spectral shaping of an OPCPA preamplifier for a sub-20-fs multi-PW laser

Lee, Hwang Woon,Kim, Yeong Gyu,Yoo, Je Yoon,Yoon, Jin Woo,Yang, Jung Moon,Lim, Hanbum,Nam, Chang Hee,Sung, Jae Hee,Lee, Seong Ku The Optical Society 2018 Optics express Vol.26 No.19

Biological Evaluation of Phellinsin A Analogues as Chitin Synthase II Inhibitors

Lee, Sang-Ku,Kim, Sung-Uk,Kim, Eung-Soo,Hwang, Eui-Il,Jung, Sang-Hun,Lee, Hyeong-Kyu Korean Chemical Society 2007 Bulletin of the Korean Chemical Society Vol.28 No.10

Distinct Features of Nonthyroidal Illness in Critically Ill Patients With Infectious Diseases

Lee, Woo Kyung,Hwang, Sena,Kim, Daham,Lee, Seul Gi,Jeong, Seonhyang,Seol, Mi-Youn,Kim, Hyunji,Ku, Cheol Ryong,Shin, Dong Yeop,Chung, Woong Youn,Lee, Eun Jig,Lee, Jandee,Jo, Young Suk Wolters Kluwer Health 2016 Medicine Vol.95 No.14

<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>Nonthyroidal illness (NTI), often observed in critically ill patients, arises through diverse alterations in the hypothalamus-pituitary-thyroid (HPT) axis. However, the causal relationship between underlying disease and NTI diversity in critically ill patients is poorly understood.</P><P>The aim of this study was to examine NTI severity and adverse outcomes in critically ill patients with respect to their underlying disease(s).</P><P>The medical records of 616 patients admitted to the intensive care unit (ICU) between January 2009 and October 2014 were retrospectively reviewed. Patients with known diseases or taking medications that affect thyroid function were excluded. All-cause mortality (ACM) and length of stay (LOS) in the ICU were assessed as adverse outcomes.</P><P>The enrolled patients (n = 213) were divided into the following 4 groups according to the severity of NTI at the nadir of their thyroid function test (TFT): normal (n = 11, 5.2%), mild NTI (n = 113, 53.1%), moderate NTI (n = 78, 36.6%), and severe NTI (n = 11, 5.2%). There was no significant difference between the groups in terms of age and gender. NTI severity showed a significantly strong association with ACM (<I>P</I> < 0.0001) and a significant positive association with LOS in the ICU (<I>P</I> = 0.031). After adjusting for age, gender, and current medications affecting TFT, increasing NTI severity led to increased ACM (odds ratio = 3.101; 95% confidence interval = 1.711–5.618; <I>P</I> < 0.0001). Notably, the prevalence of moderate-to-severe NTI was markedly higher in patients with infectious disease than in those with noninfectious disease (<I>P</I> = 0.012). Consistent with this, serum C-reactive protein levels were higher in patients with moderate-to-severe NTI (<I>P</I> = 0.016).</P><P>NTI severity is associated with increased ACM, LOS, and underlying infectious disease. Future studies will focus on the biological and clinical implications of infectious disease on the HPT axis.</P></▼2>

Influences of Extended Selenization on Cu₂ZnSnSe₄ Solar Cells Prepared from Quaternary Nanocrystal Ink

Hwang, Yoonjung,Park, Bo-In,Lee, Byung-Seok,Kim, Jin Young,Jeong, Jeung-Hyun,Kim, Honggon,Ko, Min Jae,Kim, BongSoo,Son, Hae Jung,Lee, Seung Yong,Lee, Jae-Seung,Park, Jong-Ku,Cho, So-Hye,Lee, Doh-Kwon American Chemical Society 2014 The Journal of Physical Chemistry Part C Vol.118 No.48

<P>Kesterite Cu<SUB>2</SUB>ZnSnSe<SUB>4</SUB> (CZTSe) thin films prepared by the selenization of mechanochemically synthesized Cu<SUB>2</SUB>ZnSnS<SUB>4</SUB> (CZTS) nanocrystal films are systematically investigated as a function of the annealing time in terms of the phase purity, microstructure, composition, and device characteristics. It is shown that selenization for an extended time does not cause a noticeable amount of Sn loss or segregation of Zn-rich layers. Thus, the prolonged annealing leads to improvements (reduction) in the shunt conductance, reverse saturation current, and diode ideality factor. However, it also leads to a deterioration of the series resistance, of which influence turned out to overwhelm all of the aforementioned positive effects on the device performance. As a consequence, the CZTSe solar cell exhibits its highest efficiency (5.43%) at the shortest annealing time (10 min). Impedance spectroscopy is demonstrated to be of good use in detecting the change in the back contact of CZTSe solar cells during annealing. The impedance spectra of the CZTSe solar cells are analyzed in association with the microstructures of the back-contact electrodes, demonstrating that the increase in the series resistance is attributed to the formation of the resistive MoSe<SUB>2</SUB> layer.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jpccck/2014/jpccck.2014.118.issue-48/jp508028t/production/images/medium/jp-2014-08028t_0007.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/jp508028t'>ACS Electronic Supporting Info</A></P>

Polychlorinated biphenyls (PCBs) in agricultural waters in Kangwon and Gyeonggi provinces

Hwang-Ju Jeon,Bonhwa Ku,Tae-Hun Nam,Yong chan Kim,Ji hyoung Lee,Seong woo Lee,Sung-Eun Lee 한국농약과학회 2015 한국농약과학회 학술발표대회 논문집 Vol.2015 No.10

Effect of Oral Administration of Intact Casein on Gastrointestinal Hormone Secretion and Pancreatic α-Amylase Activity in Korean Native Steer

Lee, S.B.,Choi, C.W.,Jin, Y.C.,Wang, T.,Lee, K.H.,Ku, M.B.,Hwang, J.H.,Kim, K.H.,Vega, R.S.A.,Lee, H.G. Asian Australasian Association of Animal Productio 2013 Animal Bioscience Vol.26 No.5

Three Korean native steers ($779{\pm}24$ kg) fitted with duodenal cannulas were used in a $3{\times}3$ Latin square design to investigate the influence of oral administration of soluble proteins, intact casein (IC) and acid hydrolyzed casein (AHC), on gastro-intestinal hormone (GIH) secretion in the blood and pancreatic ${\alpha}$-amylase activity in the duodenum. Oral treatment consisted of a basic diet (control), IC (C+100% protein), or AHC (C+80% amino acid, 20% peptide) for 21 d. Blood and duodenum samples were collected for measurement of serum GI hormones, and pancreatic ${\alpha}$-amylase activity was determined at 900, 1030, 1330, 1630, and 1930 h after feeding on d 21 of treatment. The levels of serum cholecystokinin (CCK) and secretin in the IC treatment group were higher compared to the other treatment groups (p<0.05). In addition to the changes in CCK and secretin levels upon IC treatment, the pancreatic ${\alpha}$-amylase activity in the duodenum was higher in the IC group compared to the control diet group (p<0.05). The response of serum ghrelin to IC and AHC treatment was in accordance with the response of serum secretin. The level of peptide fragments flowing in the duodenum was higher in the IC treatment group than the other treatment groups (p<0.05). In conclusion, this study demonstrated that an increase in duodenal CCK and secretin upon IC oral administration increased pancreatic ${\alpha}$-amylase secretion. In addition, ghrelin may be associated with GI hormone secretion in Korean native steers.

고장력 선재를 적용한 고성능 낙석방지망

이종구(Lee Jong Ku),이용주(Lee Yong Ju),나승민(La Seung Min),유병옥(Yoo Byung Ok),황영철(Hwang Young Chul) 대한토목학회 2008 대한토목학회 학술대회 Vol.2008 No.10

북미 6속 자동변속기 공장 EOL NVH 개발에 대한 연구

이현구(Lee, Hyun-Ku),김무석(Kim, Moo-Suk),황선양(Hwang, Seon-Yang),유동규(Yoo, Dong-Kyu),강구태(Kang, Koo-Tae),이태휘(Lee, Tae-Hwi) 한국소음진동공학회 2011 한국소음진동공학회 논문집 Vol.21 No.7

This paper shows a whole noise quality checking system for the new developed 6th speed automatic transmission manufactured in USA. Due to demand for manufacturing of the high NVH quality transmissions in the mass product line, some special checking system called EOL NVH is adapted. This EOL system is using vibration sensor and analysis technologies. Through adapting vibration analysis technologies and functions likewise RMS, crest factor, harmonics, peak, band and order tracking, various noise problems caused by wear, nick and deformations could be successfully detected and predicted. Therefore, automatic transmissions manufactured in the USA could get high NVH quality. The developing process described in this paper and results on EOL system will offer good guides to the engineers who built the next transmission factory.