상악골 비구개관 낭종의 치험예

이상철,김여갑,류동목,송우식 경희대학교 1989 慶熙醫學 Vol.5 No.2

최근 5년간 악교정수술 증례에 관한 임상적 연구

이백수,류동목,김여갑,이상철,최유성 大韓顎顔面成形再建外科學會 1995 Maxillofacial Plastic Reconstructive Surgery Vol.17 No.1

As a society develops and a standard of living raises, the orthoganthic operation, the purpose of which is the harmony of oral and surrounding tissue, the improvement of the basal bony relations for stable tooth-support, and the improvement of facial appearance, generalized in our society. This is a clinical study on 135 patients who underwent orthognathic operation at the Dept. of Oral and Maxillofacial surgery, College of Dentistry, Kyung-Hee University during the last 5 years. The results were as follows. 1. The ratio of female to male was 1.4 : 1. 2. The age distribution of most patients was the period of 20 years thruogh 24 years. 3. The major reasons for seeking orthagnathic surgery were ethetic complanints(94.8%), and additional reason was functional complaints such as masticatory disturbances, phonetic disturbances, and TMJ discomfort. 4. In order to consult about orthognathic surgery, the patients first visited to the Dept. of oral and maxillofacial surgery at the ratio of 24.0%. 5. The ratio of the patients who underwent the presurgical orthodontic treatment was 79.5%, and the treatment usually required the period from 7 months to 18 months. 6. The setback amount was less than 10mm at the ratio of 85.8%. 7. The orthognathic operations which were practiced were usually composed of ramus osteotomy such as sagittal split ramus osteotomy and vertical ramus osteotomy and additional surgery on mandible at the ratio of 86.7%, and SSRO was done at the ratio of 62.5%, and EVRO was done at the ratio of 37.5%.

악관절 장애를 동반한 심한 안모 비대칭 환자의 치험례

이상철,오승환,김여갑,류동묵 大韓顎顔面成形再建外科學會 1992 Maxillofacial Plastic Reconstructive Surgery Vol.14 No.4

There are various modalities in the treatment of facial asymmetry, but in severe case with TMD by actively growing deformed condyle, the treatment choice is removing the condyle growth center and TMD symptom such as click or muscular discomfort. In our one case, the patient was complain of facial asymmetry . There are severe deformed condyle head with bird-head fashion and enlarged mandibular ramus and body vertically about 18 mm, overgrowthed Rt. mandible body horizontally about 20 mm. She had intermittent Lt. TMJ clicking and muscular discomfort. The author diagnosed it as Lt. hemimandibular hyper-plasia & R, hemimandibular elongation, a combintion form with TMD. the condyle was in active growing state in scintigraphic analysis. So we extirpated the deformed condyle by intrasoral sagittal split ramus osteotomy and reshaped the condyle and mandibular distal fragment extraorally. The distal fragment was readapted in glenoid fossa and fixated. In Rt. mandibular body area, autogenous onlay bone graft on the inferior border of mandible was performed to correct the asymmetry. The clicking and facial asymmetry was corrected and we report this results with other literature findings.

두개내 합병증을 유발한 저작극 농양

이상철,김여갑,류동목,이백수,최유성,한승완,오승환 大韓顎顔面成形再建外科學會 1996 Maxillofacial Plastic Reconstructive Surgery Vol.18 No.1

Although the use of the antibiotics has minimized the dangers of the spread of odontogenic infection to adjacent important organs, sometimes the fatal cases, such as Ludwig's angina, mediastinitis, intracranial complications from the odotogenic infection, may be occurred. The odontogenic infections or oral and maxillofacial region may involve the intracranial area through systemic circulation or by direct spread into the intracranial cavity. Headache, malaise, loss of appetite, chills, fever, vomiting, apathy, and irritability are usually followed by more specific involvement of the nervous system. We experienced one patient who died of intracranial complication from odontogenic infection. So we report the case and the literatures about intracranial involvements following odontogenic infections and dental procedures.

자동차 프런트 샤시 모듈 측정을 위한 머신 비전 시스템 개발

이동목,이광일,양승환 한국공작기계학회 2003 한국공작기계학회 춘계학술대회논문집 Vol.2003 No.-

Today, automobile world market is highly competitive. In order to strengthen the competitiveness, quality of automobile is recognized as important and efforts are being made to improve the quality of manufactured components. The directional ability of automobile has influence on driver directly and hence it must be solved on the preferential basis. In the present research, an automated vision system has been developed th inspect the front chassis module. To interpret the inspection data obtained for front chassis module, new interpreting algorithm have been developed. Previously the control of tolerance of front chassis module was done manually. With the help of the new algorithm developed, the dimension is calculated automatically to check whether the front chassis module is within the tolerance limit or not.

CA 125치가 증가된 난소종괴 환자에서 악성 감별을 위한 CA 15-3과 TAG 72의 효용성

이수미,김영탁,정동근,남주현,목정은 울산대학교 의과대학 1992 울산의대학술지 Vol.1 No.1

The purpose of our study was to evaluate whether the combined use of serum tumor markers, CA 15-3 and TAG 72 could improve the efficacy for discriminating malignant from benign ovarian masses in patients with elevated serum CA 125 levels. Serum CA 15-3 and TAG 72 were preoperatively measured by immunoradiometric assay in 78 patients with pelvic masses who had elevated serum CA 125 levels above 35 U/ml. In 32 patients with epithelial ovarian cancers, serum CA 125 levels were elevated above 65 U/ml in 97% and serum CA 15-3(>30U/ml) and TAG 72(>10 u/ml) levels were elevated in 59% and 50%, respectively, suggesting relatively low sensitivity of CA 15-3 and TAG 72. However, in 41 patients with benign ovarian tumors, elevations of these two markers were detected only in 7% and 5%, respectively, and particularly, both markers were not elevated among all the aptients over 50 years of age. Coordinate elevations of CA 125(>35U/ml) and CA 15-3(>30U/ml) or TAG 72(>10 U/ml) could discriminate epithelial ovarian cancers from benign masses with a sensitivity of 72% and specificity of 90%. Among patients over 50 years of age, sensitivity and specificity were increased to 79% and 100%, respectively. It is concluded that the combined use of CA 15-3 and TAG 72 with CA 125 could obtain an improved efficacy for discrimination of epithelial ovarian cancer, especially among patients over 50 years of age.

Biocompatible Osteoconductive Polymer와 吸收性 Hydroxyapatite가 骨化에 미치는 影響에 關한 硏究 : A HISTOLOGICAL STUDY

李敏汀,李相喆,柳東睦 慶熙大學校 齒科大學 1995 慶熙齒大論文集 Vol.17 No.2

The purpose of this study was to observe the osteogenic effects of biocompatible osteoconductive polymer(BOP D.T.I. Co., U.S.A.) and resorbable HA(Osteogen ; Impladent Co., U.S.A.) in bony defected area In order to perform this study, 30 male rabbits, weighing about 2.5kg were selected. The 3x5x7mm sized defects were made on the both sides of the mandibular body and the defect was filled with blood clot in control group and with resorbable HA and BOP respectively in experimental groups. All experimental animals were sacrificed at the 3rd day and the 1st, 2nd, 4th and 6th week after operation. The mandibular body and surrounding tissues were removed out, deminerahzed, dehydrated and embedded. The histological observation of the specimens in light microscopic level was performed after Azan staining. The results were as follows 1. Osteoblasts were observed after a eek both in control group and experimental groups, and fibrous tissues were formed in bony defected area. Especially, new bone formation was observed earlier in BOP experimental group than in any other groups. 2. New bone formation was developed from the adjacent normal bone to bony defected area both in control group and experimental groups. And in experimental groups, new bone was infiltrated rapidly into the graft material than in control group and large amount of bone formation was observed. 3. Both in two experimental groups, the resorption pattern of the graft material was observed after 2 weeks, an materials were almost disappeared after 4 weeks. 4. After 6 weeks, bony defected area was occupied with new bone both in control group and in experimental groups, but bony density in experimental groups was higher than in control group, especially in BOP experimental group which showed more mature heating state.

자동차 프런트 샤시 모듈 측정을 위한 머신 비전 시스템 개발

이동목,이광일,양승한 한국공작기계학회 2004 한국생산제조학회지 Vol.13 No.3

Today, automobile world market is highly competitive. In order to strengthen the competitiveness, quality of automobile is recognized as important and efforts are being made to improve the quality of manufactured components. The directional ability of automobile has influence on driver directly and hence it must be solved on the preferential basis. In the present research, an automated vision system has been developed to inspect the front chassis module. To interpret the inspection data obtained for front chassis module, new interpreting algorithm have been developed. Previously the control of tolerance of front chassis module was done manually. With the help of the new algorithm developed, the dimension is calculated automatically to check whether the front chassis module is within the tolerance limit or not.

하악골에 발생한 거대한 cemento-ossifying fibroma의 치험례

이상철,권용대,이백수,김여갑,류동목,박종오 大韓顎顔面成形再建外科學會 2000 Maxillofacial Plastic Reconstructive Surgery Vol.22 No.1

The cemento-ossifying filbroma is a well-demarcated and occasionally encapsulated neoplasm composed of fibrous tissue that contains varying amounts of calcified tissue resembling bone, cementum, or both. The greatest number of cases are encountered during the third and fourth decades of life and there is a definite female predilection, with female-to-male ratios as high as 5 : 1 being reported. The mandible is involved far more than the maxilla, and 90 percent of all cases are located in the mandible. The mandibular premolar-molar area is the most common site. Radiographically, the lesion is most often well defined and unilocular. Depending on the amount of calcified produced in the tumor, it may appear as completely radiolucent : more often it shows varying degrees of radiopacity. Some lesions may be largely radiopaque with a radiolucent halo. On microscopic study, the tumor is composed of fibrous tissue of varying degrees of cellularity containing calcified material. This may be in the form of trabeculae of osteoid and bone or basophilic ovoid calcifications that resemble cementum-like material. Admixture of the two types of calcifications are commonly seen. On this case, large cemento-ossifying fibroma has grown in the mandible and this lesion was treated by complete surgical excision and posterior iliac bone graft. A review of literature and a report of a case of cemento-ossifying fibroma are presented.

법랑아세포종에서 apoptosis 연관 인자 발현과 apoptitic index

목동진,박진배,윤혜경,김우형,이희철 인제대학교 백병원 2002 仁濟醫學 Vol.23 No.4

Objective : Ameloblastoma is a common odontogenic benign tumor of the jaw bone. However, it might be able to infiltrate into the adjacent tissue, causing bony destruction and high recurrent rate. The aim of this study is to understand the biologic behavior of ameloblastoma through immunohistochemi cal stainings for apoptosis-related markers of bcl-2, box and caspase-3, examining the apoptosis index and simultanecusly. performing the same tests on MIB-1, which is a marker of cell-proliferationg capacity and p53, which is related with tumor malignancy, and also study the differences between the above marker's expressions and their relationships. Methods and Material : The 39 cases of ameloblastoma were used after the surgery conducted at the Pusan Back Hospital and the Pusan University Hospital during the period from January 1991 to June 2001. The clinical parameters were recorded by patent's age, sex, location of tumor, treatment modality, radiologic findings and recurrences. Based on hematoxylin & eosin findings, they were histologicaly subdivided into follicular and non-follicular. Immunohistochemical stainings for bcl-2, bax, caspase-3. p53 and MIB-1 and TdT-mediated dUTP-biotin nick end labelling method for apoptosis were performed and also statistical analyses were conducted between clinicopathologic parameters and expressions for bcl-2, bax, caspase-3, p53 and MIB-1 and apoptosis. Results : six(15.4%) recurrences were found out of 39 cases. For the patient's age of 40 and above, found a higher recurrence rate(p=0.0182) and multilocular on X-ray(p=0.0640), but there were no significant differences between recurrence rate, sex, location of tumor, treatment modality and histologic subtype. Apoptosis was found in 10(25.6%) of 39 cases and bcl-2 was(20.5%), bax was 21(53.8%), caspase-3 was 19(48.7%). the positive reaction for p53 was 13 cases(33.3%) and 5(12.8) cases for MIB-1. In the positive case of apoptosis and MIB=1, both of them have showed an increasing tendency of high recurrence, but there were no statistical significance. It showed no significant relationship between expression rates of bcl-2, bax, caspase-3 and p53 and recurrence rate. In follicular type, bcl-2 and p53 positive reaction revealed increasing tendency, however, no significant relationship between radiological finding, expressions of apoptosis, bax, caspase-3 and MIB-1 and histologic subtype has found. No significant relationship between apoptosis and apoptosis-related markers as bcl-2, bax, and caspase-3 expressions has found. There was a significant relationship between bcl-2 and p53 expressions(p<0.01), but no significant differences of apoptosis and expressions of bax and caspase-3 according to p53 and MIB-1 expressions have noted. Conclusion : Apoptosis-related bcl-2, bax, caspase-3 expressions and p53 and MIB-1 expressions are involved in the development of ameloblastoma and high recurrent rate is related to the age of more than 40 years, multichambered lesion and the positive reaction for apoptosis and MIB-1. These finding suggest that patient's age, radiologic findings, apoptosis and proliferation activity of ameloblastoma could be useful markers to predict recurrence.