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( Huei-fen Lo ),( Meng-chun Chi ),( Min-guan Lin ),( Yuan-gin Lan ),( Tzu-fan Wang ),( Long-liu Lin ) 한국미생물생명공학회(구 한국산업미생물학회) 2018 Journal of microbiology and biotechnology Vol.28 No.9
In the present study, the stabilizing effect of four different biological osmolytes on Bacillus licheniformis γ-glutamyl transpeptidase (BlGGT) was investigated. BlGGT appeared to be stable under temperatures below 40°C, but the enzyme retained less than 10% of its activity at 60°C. The tested osmolytes exhibited different degrees of effectiveness against temperature inactivation of BlGGT, and sucrose was found to be the most effective among these. The use of circular dichroism spectroscopy for studying the secondary structure of BlGGT revealed that the temperature-induced conformational change of the protein molecule could be prevented by the osmolytes. Consistently, the molecular structure of the enzyme was essentially conserved by the osmolytes at elevated temperatures as monitored by fluorescence spectroscopy. Sucrose was further observed to counteract guanidine hydrochloride (GdnHCl)- and urea-induced denaturation of BlGGT. Taken together, we observed evidently that some well-known biological osmolytes, especially sucrose, make a dominant contribution to the structural stabilization of BlGTT.
Gu, Yu-Lei,Lan, Chao,Pei, Hui,Yang, Shuang-Ning,Liu, Yan-Fen,Xiao, Li-Li Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15
Objective: To evaluate the application value of serum CA19-9, CEA, CA125 and CA242 in diagnosis and prognosis of pancreatic cancer cases treated with concurrent chemotherapy. Materials and Methods: 52 patients with pancreatic cancer, 40 with benign pancreatic diseases and 40 healthy people were selected. The electrochemiluminescence immunoassay method was used for detecting levels of CA19-9, CEA and CA125, and a CanAg CA242 enzyme linked immunoassay kit for assessing the level of CA242. The Kaplan-Meier method was used for analyzing the prognostic factors of patients with pancreatic cancer. The Cox proportional hazard model was applied for analyzing the hazard ratio (HR) and 95% confidential interval (CI) for survival time of patients with pancreatic cancer. Results: The levels of serum CA19-9, CEA, CA125 and CA242 in patients with pancreatic cancer were significantly higher than those in patients with benign pancreatic diseases and healthy people (P<0.001). The sensitivity of CA19-9 was the highest among these, followed by CA242, CA125 and CEA. The specificity of CA242 is the highest, followed by CA125, CEA and CA19-9. The sensitivity and specificity of joint detection of serum CA19-9, CEA, CA125and CA242 were 90.4% and 93.8%, obviously higher than single detection of those markers in diagnosis of pancreatic cancer. The median survival time of 52 patients with pancreatic cancer was 10 months (95% CI7.389~12.611).. Patients with the increasing level of serum CA19-9, CEA, CA125, CA242 had shorter survival times (P=0.047. 0.043, 0.0041, 0.029). COX regression analysis showed that CA19-9 was an independent prognostic factor for patients with pancreatic cancer (P=0.001, 95%CI 2.591~38.243). Conclusions: The detection of serum tumor markers (CA19.9, CEA, CA125 and CA242) is conducive to the early diagnosis of pancreatic cancer and joint detection of tumor markers helps improve the diagnostic efficiency. Moreover, CA19-9 is an independent prognostic factor for patients with pancreatic cancer.
Evaluating the effects of programs for reducing achievement gaps: a case study in Taiwan
Yao-Ting Sung,Fen-Lan Tseng,Nien-Ping Kuo,Tien-Ying Chang,Jia-Min Chiou 서울대학교 교육연구소 2014 Asia Pacific Education Review Vol.15 No.1
Considering that achievement gaps have become a serious educational problem worldwide, the Ministry of Education in Taiwan has been addressing a series of policies to reduce achievement gaps, but the effect of these policies has not yet been carefully examined. Therefore, the present study investigated current educational policies, achievement gap phenomenon, and its changing trends in the use of national standardized tests in Taiwan and evaluated the degree to which these policies are reducing the achievement gaps among Taiwanese students. Junior high school graduates who took the high school entrance examination between 2004 and 2010 were recruited to examine the associations between their academic achievements and variables such as socioeconomic status (SES), ethnicity, and school district. Time series analyses were conducted to determine the longitudinal trends for the achievement gaps. The results revealed that achievement gaps are decreasing among different ethnicities, but they are increasing among different SESs and school districts. These findings demonstrate some positive effects of the educational policies introduced in Taiwan, but also the need for further modification and precise implementation of these policies. Suggestions for implementing educational programs and policies to reduce achievement gaps are also presented.
Simple Joule-heating pyrolysis in air boosts capacitive performance of commercial carbon fiber cloth
Sun Xiaohao,Hou Shuai,Yuan Lan,Guo Fen 한국탄소학회 2022 Carbon Letters Vol.32 No.7
Commercial carbon fiber cloth (CFC) is treated by the Joule-heating pyrolysis method in air to boost its capacitive performance on the premise of energy- and time-saving considerations. A thermoelectric coupling model suitable for the Joule-heating pyrolysis is successfully established based on the comparisons between the simulated temperatures and actually measured ones. The temperature field on CFC surface induced by the Joule heat presents a concentric-ellipse shape that the temperature in the core is the maximal and gradually decays outward. Increasing the direct current (DC) voltage which is applied to the CFC from 1.0 to 6.0 V, the core temperature on the CFC surface can be raised from 31 to 519 °C. The specific surface area and hydrophilicity of the as-prepared porous CFC are greatly improved compared with the pristine one. Electrochemical test shows that the optimal Joule-heating pyrolysis parameters falls at 5.0 V and 12.5 min, and the areal specific capacitance of as-obtained CFC-5.0-12.5 is about 80 folds that of the pristine CFC. In addition to the much shorter preparation time, all the characteristics including areal specific capacitance, rate performance, and electrical conductivity of the Joule-heating pyrolyzed CFC are superior to those of the electrical furnace pyrolyzed counterpart. The aqueous symmetrical supercapacitor made of CFC-5.0-12.5 electrodes exhibits considerable power and energy densities with respect to the previously reported carbon electrode-based supercapacitors. For conductive precursors, the Joule-heating pyrolysis can be an ideal substitute for the traditional electric furnace pyrolysis.
Factors Related to Treatment Refusal in Taiwanese Cancer Patients
Chiang, Ting-Yu,Wang, Chao-Hui,Lin, Yu-Fen,Chou, Shu-Lan,Wang, Ching-Ting,Juang, Hsiao-Ting,Lin, Yung-Chang,Lin, Mei-Hsiang Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8
Background: Incidence and mortality rates for cancer have increased dramatically in the recent 30 years in Taiwan. However, not all patients receive treatment. Treatment refusal might impair patient survival and life quality. In order to improve this situation, we proposed this study to evaluate factors that are related to refusal of treatment in cancer patients via a cancer case manager system. Materials and Methods: This study analysed data from a case management system during the period from 2010 to 2012 at a medical center in Northern Taiwan. We enrolled a total of 14,974 patients who were diagnosed with cancer. Using the PRECEDE Model as a framework, we conducted logistic regression analysis to identify independent variables that are significantly associated with refusal of therapy in cancer patients. A multivariate logistic regression model was also applied to estimate adjusted the odds ratios (ORs) with 95% confidence intervals (95%CI). Results: A total of 253 patients (1.69%) refused treatment. The multivariate logistic regression result showed that the high risk factors for refusal of treatment in cancer patient included: concerns about adverse effects (p<0.001), poor performance(p<0.001), changes in medical condition (p<0.001), timing of case manager contact (p=.026), the methods by which case manager contact patients (p<0.001) and the frequency that case managers contact patients (${\geq}10times$) (p=0.016). Conclusions: Cancer patients who refuse treatment have poor survival. The present study provides evidence of factors that are related to refusal of therapy and might be helpful for further application and improvement of cancer care.
Liu, Ai Ling,Liao, Hong Qing,Li, Zhi Liang,Liu, Jun,Zhou, Cui Lan,Guo, Zi Fen,Xie, Hong Yan,Peng, Cui Ying Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.12
mTOR, the mammalian target of rapamycin, is a conserved serine/threonine kinase which belongs to the phosphatidyl-linositol kinase-related kinase (PIKK) family. It has two complexes called mTORC1 and mTORC2. It is well established that mTOR plays important roles in cell growth, proliferation and differentiation. Over-activation of the mTOR pathway is considered to have a relationship with the development of many types of diseases, including polycystic ovary syndrome (PCOS) and ovarian cancer (OC). mTOR pathway inhibitors, such as rapamycin and its derivatives, can directly or indirectly treat or relieve the symptoms of patients suffering from PCOS or OC. Moreover, mTOR inhibitors in combination with other chemical-molecular agents may have extraordinary efficacy. This paper will discuss links between mTOR signaling and PCOS and OC, and explore the mechanisms of mTOR inhibitors in treating these two diseases, with conclusions regarding the most effective therapeutic approaches.
Resistance Reduction Scheme for Tower Grounding with Conductive Cement
Lun Li,Tian Xu,Pei Feng,Liu Xin,Jia Lulu,Deng Chenxing,Wang Xing,Lan Fen,Cheng Hongbo 대한전기학회 2021 Journal of Electrical Engineering & Technology Vol.16 No.3
The construction conditions of transmission lines are becoming more and more diffi cult. It is necessary to fi nd new ways to reduce the grounding resistance of poles and towers at high soil resistivity and small construction area. Conductive cement samples with graphite, stainless steel fi bers, and their mixtures as conductive phases materials were prepared, the resistivity, fl exural strength and compressive strength were tested, compared and analyzed. The graphite and stainless steel fi ber conductive cement with better comprehensive performance was selected out for tower grounding. The application schemes of conductive cement for tower grounding were designed and compared, the partial wrapping scheme was selected and its application methods under diff erent soil resistivity was analyzed. The analysis results can provide theoretical basis and guidance for the application of conductive cement in transmission tower grounding, the feasibility of scheme is proved by the fi eld application.