Cu-Fe Bi-Functional Catalyst Synthesized by Solution Plasma for the Application in Li-air Battery

Ryo Takahashi,Helena Oi Lun Li,Nagahiro Saito 한국표면공학회 2013 한국표면공학회 학술발표회 초록집 Vol.2013 No.11

Robust, self-cleaning, amphiphobic coating with flower-like nanostructure on micro-patterned polymer substrate

Yao, Wenhui,Li, Lei,Li, Oi Lun,Cho, Young-Wook,Jeong, Myung-Yung,Cho, Young-Rae Elsevier 2018 Chemical Engineering Journal Vol.352 No.-

<P><B>Abstract</B></P> <P>Many superhydrophobic surfaces lose their repellency to water owing to the contamination of organic liquids or mechanical damage. Though amphiphobic coatings can repel both water and organic liquids, the poor mechanical and chemical stabilities significantly restrict their practical applications. Herein, we demonstrated a hydrothermal method to synthesize micro-patterned substrates bearing NiAl layered double hydroxide with flower-like nanostructures, which resemble the surface morphology of a lotus leaf. The surface was further modified by a low-surface-energy material of perfluorooctanoic acid through a solution immersion method. The binder-free coating formed in-situ on the substrate showed a good adhesion quality of 5B (ASTM D-3359). The coating possessed high repellency to different liquid droplets, including water, diiodomethane, ethylene glycol, soybean oil, etc., with surface tensions ranging from 72.7 to 22.4 mN m<SUP>−1</SUP>. Due to the excellent self-cleaning property, the contaminant on the surface was easily cleaned as the water droplet rolled off. Moreover, the coating exhibited good mechanical and chemical robustness in some extreme conditions, such as gas blowing, sea sand abrasion, and chemical immersion tests. These good performances made the coating possible to be applied widely in various practical applications.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Flower-like nanostructure of NiAl-LDH was synthesized on micro-patterned polymer. </LI> <LI> The hierarchical structure showed good amphiphobicity after fluorination. </LI> <LI> The amphiphobic surface possessed excellent self-cleaning performance. </LI> <LI> The amphiphobic surface exhibited good mechanical and chemical robustness. </LI> <LI> The coating can be used in anti-contaminant, self-cleaning, and biomedical device. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Effects of Ga-doping on the microstructure and magnetic properties of MnBi alloys

Yang, Yang,Kim, Jong-Woo,Si, Ping-Zhan,Qian, Hui-Dong,Shin, Yongho,Wang, Xinyou,Park, Jihoon,Li, Oi Lun,Wu, Qiong,Ge, Hongliang,Choi, Chul-Jin Elsevier 2018 JOURNAL OF ALLOYS AND COMPOUNDS Vol.769 No.-

<P><B>Abstract</B></P> <P>The low temperature phase Mn<SUB>55</SUB>Bi<SUB>45-<I>x</I> </SUB>Ga<SUB> <I>x</I> </SUB> (<I>x</I> = 0, 1, 3, 5, and 10) alloys were prepared by induction melting process with subsequent low temperature annealing. The effects of Ga-doping on the crystal structure and magnetic properties of the alloys were systematically studied. The room temperature coercivities of Mn<SUB>55</SUB>Bi<SUB>45-<I>x</I> </SUB>Ga<SUB> <I>x</I> </SUB> after ball milling increased from 1.43 T for <I>x</I> = 0 to 1.66 T for <I>x</I> = 5, while the saturation magnetization decreased from 60.7 Am<SUP>2</SUP>/kg (<I>x</I> = 0) to 45.1 Am<SUP>2</SUP>/kg (<I>x</I> = 5). The maximum energy product (<I>BH</I>)<SUB>max</SUB> of Mn<SUB>55</SUB>Bi<SUB>44</SUB>Ga powders reached 7.87 MGOe. The Curie temperature of the Mn<SUB>55</SUB>Bi<SUB>45-<I>x</I> </SUB>Ga<SUB> <I>x</I> </SUB> alloys increased from 633 K to 658 K with increasing Ga concentration in the range of 0 ≤ <I>x</I> ≤ 5.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Effects of doping Ga on the microstructural and magnetic properties of MnBi alloy. </LI> <LI> The MnBi-Ga powders are achieved by surfactant assisted high energy ball milling. </LI> <LI> The maximum energy produce (<I>BH</I>)<SUB>max</SUB> shows 7.87 MGOe for Mn<SUB>55</SUB>Bi<SUB>44</SUB>Ga sample. </LI> <LI> The coercivity of Mn<SUB>55</SUB>Bi<SUB>40</SUB>Ga<SUB>5</SUB> after ball milling reached 1.66 T at room temperature. </LI> <LI> The elevated curie temperature (<I>T</I> <SUB>c</SUB>) by doping Ga makes it a possible candidate for high temperature applications. </LI> </UL> </P>

Impact of pillar configuration on the amphiphobicity of micro-patterned polymer surface

Yao, Wenhui,Li, Oi Lun,Kang, Young-Joon,Jeong, Myung-Yung,Cho, Young-Rae Elsevier 2018 Vacuum Vol.156 No.-

<P><B>Abstract</B></P> <P>Hydrophobic surfaces are easily contaminated by oil owing to its lower surface tension, which significantly limits their potential applications. In this study, micro-patterned surfaces with cylindrical or square pillar arrays were fabricated on a polycarbonate substrate by the thermal imprinting process. The geometry and size of the pillars were varied to obtain different samples, whereas the height of the pillars was kept constant. The surface of each micro-patterned sample was fluorinated with perfluorooctanoic acid. With the aim of characterizing the wetting behavior of the samples, droplets of water and oily liquids with different surface tensions were employed to measure the contact angles. In addition, the applicability of the Wenzel and Cassie equations for explaining the wetting mechanisms of droplets on the surfaces of the micro-patterned samples was systematically investigated. The prediction obtained using the Wenzel equation was found to differ considerably from the experimental results, whereas the Cassie equation was found to be acceptable for satisfactorily explaining the wetting behaviors of liquids on the micro-patterned samples. The main factor influencing the surface wettability of the micro-patterned sample was not the pillar geometry, but rather the pillar configuration, e.g., the solid area fraction, groove fraction, and spacing between pillars.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Micro-patterned surface with pillar array is formed by a thermal imprinting method. </LI> <LI> The micro-patterned surface is repellent to both water and oily liquids. </LI> <LI> Effect of pillar configuration on the amphiphobicity is studied. </LI> <LI> Wetting mechanism of liquid droplet on the micro-patterned surface is proposed. </LI> </UL> </P>

Oxymatrine Causes Hepatotoxicity by Promoting the Phosphorylation of JNK and Induction of Endoplasmic Reticulum Stress Mediated by ROS in LO2 Cells

Li-li Gu,Zhe-lun Shen,Yang-Lei Li,Yi-Qi Bao,Hong Lu 한국분자세포생물학회 2018 Molecules and cells Vol.41 No.5

Oxymatrine (OMT) often used in treatment for chronic hepatitis B virus infection in clinic. However, OMT–induced liver injury has been reported. In this study, we aim to investigate the possible mechanism of OMT-induced hepatotoxicity in human normal liver cells (L02). Exposed cells to OMT, the cell viability was decreased and apoptosis rate increased, the intracellular markers of oxidative stress were changed. Simultaneously, OMT altered apoptotic related proteins levels, including Bcl-2, Bax and pro-caspase-8/-9/-3. In addition, OMT enhanced the protein levels of endoplasmic reticulum (ER) stress makers (GRP78/Bip, CHOP, and cleaved-Caspase-4) and phosphorylation of c-Jun N-terminal kinase (p-JNK), as well as the mRNA levels of GRP78/Bip, CHOP, caspase-4, and ER stress sensors (IREI, ATF6, and PERK). Pre-treatment with Z-VAD-fmk, JNK inhibitor SP600125 and N-acetyl-l-cysteine (NAC), a ROS scavenger, partly improved the survival rates and restored OMT-induced cellular damage, and reduced caspase-3 cleavage. SP600125 or NAC reduced OMT-induced p-JNK and NAC significantly lowered caspase-4. Furthermore, 4-PBA, the ER stress inhibitor, weakened inhibitory effect of OMT on cells, on the contrary, TM worsen. 4-PBA also reduced the levels of p-JNK and cleaved-caspase-3 proteins. Therefore, OMT-induced injury in L02 cells was related to ROS mediated p-JNK and ER stress induction. Antioxidant, by inhibition of p-JNK or ER stress, may be a feasible method to alleviate OMT-induced liver injury.

Genetic Relationship Analysis of Native Populations of Castanea mollissima BL. in Yan-Shan Area by AFLP

Li-Li Cheng,Shu-Chai Su,Ling Qin,Wei-Lun Yi,Jian-Li Liu 한국원예학회 2006 한국원예학회 기타간행물 Vol.- No.-

Oxymatrine Causes Hepatotoxicity by Promoting the Phosphorylation of JNK and Induction of Endoplasmic Reticulum Stress Mediated by ROS in LO2 Cells

Gu, Li-li,Shen, Zhe-lun,Li, Yang-Lei,Bao, Yi-Qi,Lu, Hong Korean Society for Molecular and Cellular Biology 2018 Molecules and cells Vol.41 No.5

Oxymatrine (OMT) often used in treatment for chronic hepatitis B virus infection in clinic. However, OMT-induced liver injury has been reported. In this study, we aim to investigate the possible mechanism of OMT-induced hepatotoxicity in human normal liver cells (L02). Exposed cells to OMT, the cell viability was decreased and apoptosis rate increased, the intracellular markers of oxidative stress were changed. Simultaneously, OMT altered apoptotic related proteins levels, including Bcl-2, Bax and pro-caspase-8/-9/-3. In addition, OMT enhanced the protein levels of endoplasmic reticulum (ER) stress makers (GRP78/Bip, CHOP, and cleaved-Caspase-4) and phosphorylation of c-Jun N-terminal kinase (p-JNK), as well as the mRNA levels of GRP78/Bip, CHOP, caspase-4, and ER stress sensors (IREI, ATF6, and PERK). Pre-treatment with Z-VAD-fmk, JNK inhibitor SP600125 and N-acetyl-l-cysteine (NAC), a ROS scavenger, partly improved the survival rates and restored OMT-induced cellular damage, and reduced caspase-3 cleavage. SP600125 or NAC reduced OMT-induced p-JNK and NAC significantly lowered caspase-4. Furthermore, 4-PBA, the ER stress inhibitor, weakened inhibitory effect of OMT on cells, on the contrary, TM worsen. 4-PBA also reduced the levels of p-JNK and cleaved-caspase-3 proteins. Therefore, OMT-induced injury in L02 cells was related to ROS mediated p-JNK and ER stress induction. Antioxidant, by inhibition of p-JNK or ER stress, may be a feasible method to alleviate OMT-induced liver injury.

Alanine Aminotransferase in Amphioxus: Presence, Localization and Up-regulation after Acute Lipopolysaccharide Exposure

Lun, Li-Min,Zhang, Shi-Cui,Liang, Yu-Jun Korean Society for Biochemistry and Molecular Biol 2006 Journal of biochemistry and molecular biology Vol.39 No.5

Alanine aminotransferase (AAT) is mainly synthesized in the liver, and its level in mammalian serum is elevated after acute phase induction. Here we demonstrated that sheep anti-human AAT antibody cross-reacted with amphioxus humoral fluids as well as human serum; and the concentration of AAT in the humoral fluids in amphioxus increased after the acute challenge with lipopolysaccharide, while the level of total proteins remains unchanged. These suggest the presence of the same acute phase response pattern in amphioxus, as observed in some mammalian species. Immunohistochemically, AAT was localized in the hepatic diverticulum, ovary and testis. It appears that the hepatic diverticulum in amphioxus is functionally homologous to the vertebrate liver in respect of AAT synthesis, supporting the hypothesis that the vertebrate liver evolved from the hepatic diverticulum of an amphioxus-like ancestor during early chordate evolution.

Overview of Methodological Quality of Systematic Reviews about Gastric Cancer Risk and Protective Factors

Li, Lun,Ying, Xiang-Ji,Sun, Tian-Tian,Yi, Kang,Tian, Hong-Liang,Sun, Rao,Tian, Jin-Hui,Yang, Ke-Hu Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

Background and Objective: A comprehensive overall review of gastric cancer (GC) risk and protective factors is a high priority, so we conducted the present study. Methods: Systematic searches in common medical electronic databases along with reference tracking were conducted to include all kinds of systematic reviews (SRs) about GC risk and protective factors. Two authors independently selected studies, extracted data, and evaluated the methodological qualities and the quality of evidence using R-AMSTAR and GRADE approaches. Results: Beta-carotene below 20 mg/day, fruit, vegetables, non-fermented soy-foods, whole-grain, and dairy product were GC protective factors, while beta-carotene 20 mg/day or above, pickled vegetables, fermented soy-foods, processed meat 30g/d or above, or salty foods, exposure to alcohol or smoking, occupational exposure to Pb, overweight and obesity, helicobacter pylori infection were GC risk factors. So we suggested screening and treating H. pylori infection, limiting the amount of food containing risk factors (processed meat consumption, beta-carotene, pickled vegetables, fermented soy-foods, salty foods, alcohol), stopping smoking, avoiding excessive weight gain, avoidance of Pb, and increasing the quantity of food containing protective components (fresh fruit and vegetables, non-fermented soy-foods, whole-grain, dairy products). Conclusions: The conclusions and recommendations of our study were limited by including SRs with poor methodological bases and low quality of evidence, so that more research applying checklists about assessing the methodological qualities and reporting are needed for the future.

Maternal betaine supplementation ameliorates fatty liver disease in offspring mice by inhibiting hepatic NLRP3 inflammasome activation

Li Lun,Sun Liuqiao,Liang Xiaoping,Ou Qian,Tan Xuying,Li Fangyuan,Lai Zhiwei,Ding Chenghe,Chen Hangjun,Yu Xinxue,Wu Qiongmei,Wei Jun,Wu Feng,Wang Lijun 한국영양학회 2023 Nutrition Research and Practice Vol.17 No.6

BACKGROUND/OBJECTIVES: Previous research has shown maternal betaine supplementation alleviates fetal-derived hepatic steatosis. Therefore, this study examined the anti-inflammatory effect of maternal betaine intake in offspring mice and its mechanism. MATERIALS/METHODS: Female C57BL/6J mice and their offspring were randomly divided into 3 groups according to the treatment received during gestation and lactation: control diet (CD), fatty liver disease (FLD), and fatty liver disease + 1% betaine (FLD-BET). The FLD group was given a high-fat diet and streptozotocin (HFD + STZ), and the FLD-BET group was treated with HFD + STZ + 1% betaine. After weaning, the offspring mice were given a normal diet for 5 weeks and then dissected to measure the relevant indexes. RESULTS: Compared to the CD group, the offspring mice in the FLD group revealed obvious hepatic steatosis and increased serum levels of alanine aminotransferase, interleukin (IL)-6, and tumor necrosis factor (TNF)-α; maternal betaine supplementation reversed these changes. The hepatic mRNA expression levels of IL-6, IL-18, and Caspase-1 were significantly higher in the FLD group than in the CD group. Maternal betaine supplementation reduced the expression of IL-1β, IL-6, IL-18, and apoptosis-associated speck-like protein containing C-terminal caspase recruitment domain (ASC). Maternal betaine supplementation also reversed the increasing protein expressions of nitric oxide dioxygenase-like receptor family pyrin domain containing 3 (NLRP3), ASC, Caspase-1, IL-1β, and IL-18 in offspring mice exposed to HFD + STZ. Maternal betaine supplementation decreased the homocysteine (Hcy) and s-adenosine homocysteine (SAH) levels significantly in the livers. Furthermore, the hepatic Hcy concentrations showed significant inverse relationships with the mRNA expression of TNF-α, NLRP3, ASC, and IL-18. The hepatic SAH concentration was inversely associated with the IL-1β mRNA expression. CONCLUSIONS: The lipotropic and anti-inflammatory effect of maternal betaine supplementation may be associated with the inhibition of NLRP3 inflammasome in the livers of the offspring mice.