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Kyunghwa Cho,Hee Geum Lee,Juan-Yu Piao,Su-Jung Kim,나혜경,서영준 대한암예방학회 2021 Journal of cancer prevention Vol.26 No.2
More than half of the world’s populations are considered to be infected by Helicobacter pylori. It causes a chronic inflammation of the stomach, which is implicated in the pathogenesis of gastric ulcer and cancer. Silibinin, a polyphenolic flavonoid derived from milk thistle, has been known for its hepatoprotective effects, and recent studies have revealed its chemopreventive potential. In the present study, we examined the anti-inflammatory effects of silibinin in human gastric cancer MKN-1 cells and in the stomach of C57BL/6 mice infected by H. pylori. Pretreatment with silibinin attenuated the up-regulation of COX-2 and inducible nitric oxide synthase (iNOS) in H. pylori-infected MKN-1 cells and mouse stomach. In addition, the elevated translocation and DNA binding of NF- κB and STAT3 induced by H. pylori infection were inhibited by silibinin treatment. Moreover, H. pylori infection in combination with high salt diet resulted in dysplasia and hyperplasia in mouse stomach, and these pathological manifestations were substantially mitigated by silibinin administration. Taken together, these findings suggest that silibinin exerts anti-inflammatory effects against H. pylori infection through suppression of NF-κB and STAT3 and subsequently, expression of COX-2 and iNOS. Key Words Helicobacter pylori, Silibinin, NF-κB, STAT3, Gastritis
조경화 ( Cho Kyunghwa ),권순정 ( Kwon Soonjung ),성민기 ( Sung Minki ),김선숙 ( Kim Sunsook ) 한국의료복지건축학회(구 한국의료복지시설학회) 2017 의료·복지 건축 Vol.23 No.2
Purpose: With the increasing of public-use facilities, there has been a growing concern over Indoor Air Quality(IAQ) of public-use facilities. Because the facilities are easy to be exposed to indoor air pollutants, they needs to be periodically managed the IAQ. Methods: In this study, indoor air pollutant concentrations of 24 vulnerable facilities were measured and compared. The measurements were conducted for pollutants which are defined in `IAQ Control In Public-Use Facilities, etc. Act`. We took two measurements, the first was carried out in summer and the second was proceeded in winter. We analyzed the values according to the type of facilities and pollutants. Results: There was a difference in pollutant concentrations by the season and in occurrence characteristics by the measurement spot. Therefore, we need to manage pollutant concentrations by characteristics of occurrence. Implications: Based on the comparative analysis of pollutant concentrations, we suggested cause and improvement strategies for IAQ management of Vulnerable facilities.
Q3과 Testlet Variance 레벨 간의 관계로 국부의존성 검사
조경화(Kyunghwa Cho),이승진(Seungjin Lee) 전남대학교 교육문제연구소 2020 교육연구 Vol.42 No.2
지역 독립성은 문항 반응 이론의 세 가지 필수적인 가정 중 하나입니다. 지역 독립성은 측정 문항이 다른 문항과 관련이 없음을 의미합니다. Q3는 국부의존성을 측정하기 위해 널리 사용되는 추정 지수입니다. testlet(하부검사)는 문항들의 그룹을 의미합니다. 예를 들어, 독해 시험에서 각 독해에 적용되는 문항들은 그 독해의 다른 문항들과 관계가 있을 수 있음을 나타냅니다. 이 연구의 목적은 시뮬레이션을 통해 Q3을 이용한 국부의존성과 probit 2PL모델을 이용한 testlet효과를 측정하고, Q3와 testlet 효과의 관계를 조사하는 것입니다. 이 연구에서 실행된 시뮬레이션의 결과, Q3와 testlet 효과는 긍정적인 관계를 가지는 것으로 나타났습니다. Local Item Independence is one of the essential assumptions in Item Response Theory. Local Item Independence means any item of the measurement is not related to another item. Q3 is a widely used estimation index to measure local item dependence. Testlet indicates the group of items to be applied to each reading passage in the reading comprehension test. The purpose of this study is to obtain local item dependence by Q3 and the testlet effect with the probit 2PL model and to investigate the relationship between Q3 and the testlet effect on passage-based testing with a simulation study. Based on the simulation results, the level of testlet effect had a positive relationship with Q3.
논에서 벼 대체작물 재배가 토양 물리화학성과 작물 수량에 미치는 효과
한경화 ( Kyunghwa Han ),조현준 ( Hyunjun Cho ),조희래 ( Heerae Cho ),이협성 ( Hyubsung Lee ),옥정훈 ( Junghun Ok ),서미진 ( Mijin Seo ),정강호 ( Kangho Jung ),장용선 ( Yongseon Zhang ),서영호 ( Youngho Seo ) 한국환경농학회 2017 한국환경농학회지 Vol.36 No.2
논에서 대체작물의 재배에 따른 토양 물리화학성과 작물수량의 변화를 살펴보기 위하여 하성충적지에 분포된 규암미사질 양토의 배수 약간양호인 토양에서 콩, 레드클로버, 공심채를 대체작물로 재배하여 3년간 경작시험을 수행하였다. 경작처리는 콩-벼-벼, 콩-콩-벼, 레드클로버-레드클로버-벼, 레드클로버-벼-벼, 공심채-공심채-벼, 공심채-벼-벼 작부체계로, 3년차에는 모든 처리에서 논으로 복원한 다음 벼를 재배하여 토양 물리화학성과 작물 수량을 조사하였다. 앞그루가 밭일 때 토양의 용적밀도와 경도, 수분함량이 감소하였고 공극률은 증가하였다. 대체작물을 2년 재배하였을 때에 1년 재배하였을 때보다 토양 입단량과 감수심이 높았다. 토양 유기물 함량은 레드클로버와 공심채를 2년 동안 재배하였을 때 높았다. 3년차에 유효인산과 치환성 칼리 함량, 토양CEC는 앞그루가 콩이었을 때 높았다. 대체작물의 1년차 생산성은 공심채가 레드클로버보다 높았으나, 2년차에는 반대였다. 3년차의 벼 수량은 앞그루가 콩과 레드클로버일 때가 공심채일 때보다 높았다. BACKGROUND:Cultivation of alternative crops in paddy fields is necessary because of the decrease in rice consumption and the increase in excess stock of rice. The studywas conducted to investigate the effects of alternative crops cultivation in paddy fields on soil physico-chemical characteristics and crop yield. METHODS AND RESULTS: Soybean (Glycine max), red-clover (Trifolium pratense), and water convolvulus (Ipomoea aquatica) were selected for alternative crops in the first and/or second year and ricewas planted in the third year.When alternative cropswere cultivated in the previous year, soil bulk density, soil hardness, and water content were lower than those for rice cultivation. Water-depth decreasing rate and aggregate content were greater for the upland-upland-paddy cropping system than upland-paddy-paddy cropping system. Cultivation of red-clover andwater convolvulus for two years resulted in the high soil organic matter content. In the third year, available phosphate, exchangeable potassium, and soil cation exchange capacity were relatively high when soybean was cultivated in the previous year. In the first year, water convolvulus cultivation showed greater productivity than red-clover cultivation while the opposite pattern was found in the second year. Rice yield in the third year was greater for soybean or red-clover as a previous crop than for water convolvulus as a previous crop. CONCLUSION: The results suggest that cultivation of alternative crops in paddy fields can improve soil physical properties including bulk density, hardness, water content, and aggregate content as well as rice productivity.
밭 토양에서 유기물 자원의 시용이 작물 수량 및 토양 물리성에 미치는 영향
한경화(Kyunghwa Han),정강호(Kangho Jung),조희래(Heerae Cho),이협성(Hyubsung Lee),옥정훈(Junghun Ok),장용선(Yongseon Zhang),김기선(Gisun Kim),서영호(Youngho Seo) 유기성자원학회 2017 유기물자원화 Vol.25 No.4
농경지에 유기물 자원을 시용하면 지력이 높아져서 작물의 수량이 높아진다. 본 연구의 목적은 유기물 자원을 밭 토양에 시용하였을 때 작물 수량 및 토양 물리성에 미치는 영향을 유기물 자원별로 비교하고자 하였다. 콩을 평야지인 수원의 사양토와 식양토 포장에서 재배하였으며, 온도 영향을 살펴보기 위하여 고랭지 평창의 사양토 포장에서도 수행하였다. 시험에 쓰인 유기물 자원은 볏짚퇴비, 돈분톱밥퇴비, 계분톱밥퇴비, 코코피트였으며, 콩 파종 전에 탄소 기준으로 동등한 수준으로 시용하였다. 무기질비료의 시용량은 토양검정한 분석치를 고려하여 결정하였다. 유기물 자원의 분해 특성을 살펴보기 위하여 항온배양실험을 실내에서 사양토 를 대상으로 수행하였다. 분해 속도는 볏짚퇴비가 가장 높았으며, 돈분톱밥퇴비, 코코피트 순이었다. 유기물 자원의 시용에 따른 콩 수량의 증가 효과는 사양토에 비해서 식양토에서 높았다. 기상 비율의 증가 효과도 식양토에서 뚜렷하였다. 반면에 토양 입단 안정성의 증가 효과는 사양토에서 비교적 높았다. 볏짚퇴비가 모든 토양에서 콩 수량의 증가 효과가 가장 높았다. 코코피트의 콩 수량 증가 및 토양 물리성 개선 효과는 다른 유기물 자원에 비해서 높지 않았다. 따라서 밭작물 수량의 증대 및 토양 물리성의 개선을 위해서는 축분퇴비 등 다른 유기물 자원에 비해서 볏짚퇴비가 적합하였다. Application of organic resources to agricultural land can increase crop yield by improving soil characteristics. The objective of this study was to evaluate effect of crop yield and soil physical properties including aggregate stability to application of organic resources in upland. The soybean was cultivated in a sandy loam field and a clay loam field located at Suwon and a sandy loam field located at Pyeongchang. The organic resources used in this study were rice straw compost (RSC), composted pig manure with sawdust (CPIG), composted poultry manure with sawdust (CPM), and cocopeat applied before sowing crop. Application rate of organic resources was determined based on carbon content and water content. The inorganic fertilizers were applied based on soil testing. In addition, the decomposition of RSC, CPIG, and cocopeat was characterized by isothermal incubation with sandy loam soil. The decomposition rate was highest for RSC followed by CPIG and cocopeat. Organic resource application increased yield of soybean, which effect was greater in clay loam than in sandy loam. In addition, increase in gas phase proportion by organic resource application was distinct in clay loam soil compared with sandy loam soil. In terms of aggregate stability, increasing effect was more obvious in sandy loam soils than in a clay loam soil. The highest yield was observed in RSC treatment plots for all the fields. Improvement of soybean yield and soil physical characteristics by cocopeat was not as much as that of the other organic resources. The results implied that RSC could be recommended for promoting aggregate stability and crop yield in upland cultivation.