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( Kyu Yeon Hahn ),( Hyun Jik Lee ),( Chan Hyuk Park ),( Eun Hye Kim ),( Chung Nam Shim ),( Hyun Soo Jung ),( Hyuk Lee ),( Sung Kwan Shin ),( Sang Kil Lee ),( Yong Chan Lee ),( Jun Chul Park ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Post-endoscopic resection stricture is one of delayed complications of endoscopic submucosal dissection (ESD). Therefore, it is important to be aware of risk factors of stricture before performing ESD. Because early interventions including endoscopic balloon dilatation or local steroid injection is necessary to prevent severe stricture. The aim of this study is to determine the clinical factors associated with pyloric stricture after ESD in gastric neoplasm and risk factors of post-ESD stricture. Methods: A total 150 gastric neoplasms at prepylorus and pylorus treated by ESD between 2007 and 2012 at a single institution were reviewed. Post-ESD stricture which could not be passed by a standard endoscope was treated with endoscopic balloon dilation. Results: Antral deformity and sub-circumferential resection over 75% of the circumference are independent risk factors for post-endoscopic resection stricture and balloon dilation at prepylorus and pylorus. Eleven patients were received endoscopic balloon dilation (7. 2%) for treatment of post-ESD stricture. All 11 patients were successfully treated by endoscopic balloon dilation. Signifi cant differences between non balloon dilation group and dilation group were found in age (67. 4±10. 3 years vs. 73. 6±6. 0 years), pretreatment antral deformity (46. 4% vs. 81. 8%), tumor size (10. 8±5. 9mm vs. 23. 5±17. 5mm), the proportion of extension to the whole circumference of the lumen (=3/4: 90. 6% vs. 45. 5%, >3/4: 9. 4% vs. 54. 5%) and tumor location (anterior wall: 33. 6% vs. 9. 1%, greater curve: 15. 7% vs. 54. 5%). Multivariate analysis revealed that pretreatment antral deformity (odds ratio [OR]:10. 787; 95% confi dence interval [CI]:1. 235-94. 226, p=0. 031) and circumferential extension of > 3/4 (OR: 1. 121; 95% CI: 4. 041-1. 207. p=0. 003) were independent risk factors for post-endoscopic resection stricture. Conclusions:Antral deformity and sub-circumferential resection over 75% of the circumference are independent risk factors for post-endoscopic resection stricture and balloon dilation at prepylorus and pylorus.
Molecular Characterization of Apple stem grooving virus Isolated from Talaromyces flavus
Shim Hye-Kyung,Hwang Kyu-Hyon,Shim Chang-Ki,Son Su-Wan,Kim Dong-Giun,Choi Yong-Mun,Chung Young-Jae,Kim Dae-Hyun,Jee Hyeong-Jin,Lee Suk-Chan The Korean Society of Plant Pathology 2006 Plant Pathology Journal Vol.22 No.3
Talaromyces flavus mediates the transmission of Apple stem grooving virus (ASGV) to several host plants. The ASGV-F carried by T.flavus was partially purified from the fungus. Based on sequence analysis and homology searches, this is closely related to other ASGV strains isolated from host plants. The partially purified viral coat protein (CP) was separated on a 12% SDS-polyacrylamide gel and analyzed by Western blotting with an ASGV anti-serum. A single band at 28 kDa reacted with the ASGV anti-serum. The deduced amino acid sequence of the ORF-l showed conserved domains, including an NTP-binding helicase motif, GFAGSGKT. The amino acid sequences of the helicase and CP showed strong homology to other ASGV strains (98%). All ASGV isolated from plants and fungi had salt bridges composed of the CP and the GFAGSGKT motif of the helicase, which are commonly conserved in plant viruses. These results suggest that ASGV-F is one of ASGV strains isolated from T.flavus based on sequence similarity as well as the serological analysis of CP.
Kyu-Jin Shim,Chan-Shin Kang,Jong-Hee Chung,Hyun-Su Do 국제과학영재학회 2012 APEC Youth Scientist Journal Vol.4 No.-
Exercise has previously been shown to have positive effects on cognitive function; Cognitive function is known as having close relationship with specific Neuronal oscillation. Based on preceding researches, the current study examined the effect of exercise on the cognitive functions - learning, spatial memory and decision making process from the memory - with specially designed multi T-maze to escape from it with shorter time duration by memory. Besides different time decreases, the brain wave was collected during the maze task for analysis in such alteration of neuronal oscillation. As a result, we found that (1) the decrease in the time duration for escaping maze had statically significance and (2) some interesting neuronal oscillations related to cognitive function from previous researches were discovered. Thus we could conclude that exercise affects the development of spatial memory and task-solving ability and the neuronal oscillations on cognitive function.
Ecopathological Analysis of Apple stem grooving virus-K Harboring Talaromyces flavus
Shim Hye-Kyung,Hwang Kyu-Hyon,Shim Chang-Ki,Hong Seung-Beom,Son Su-Wan,Kim Dong-Giun,Choi Yong-Mun,Chung Young-Jae,Kim Dae-Hyun,Jee Hyeong-Jin,Lee Suk-Chan The Korean Society of Plant Pathology 2006 Plant Pathology Journal Vol.22 No.3
Pear black necrotic leaf spot (PBNLS) on pear trees (Pyrus pyrifolia) is caused by a Korean isolate of Apple stem grooving virus (ASGV-K). Yellow spots were detected in Phaseolus vulgaris (kidney bean) and Chenopodium quinoa which were grown near the diseased pears in year 2000 through 2003. The ASGV-K, the causative agent of PBNLS, was detected from the symptoms of the diseased kidney bean plant and C. quinoa. ASGV-harboring fungi were also isolated from symptomatic plants and from soils surrounding the infected plants. The ASGV-harboring fungus was identified and characterized as Talaromyces flavus. Ecopathological studies showed that the number of ASGV-harboring fungi on the pear leaves was not correlated with differences in temperature or severity of symptoms. Additionally, there was no difference in fungus frequency among the orchard locations or different host plants. Although the frequency of fungi isolated from the soil was not affected by changes in temperature or location, the fungi occurred at higher densities in the rhizosphere than in the plants themselves.
Shim Hye-Kyung,Hwang Kyu-Hyon,Shim Chang-Ki,Son Su-Wan,Kim Dong-Giun,Choi Yong-Mun,Chung Young-Jae,Kim Dae-Hyun,Jee Hyeong-Jin,Lee Suk-Chan The Korean Society of Plant Pathology 2006 Plant Pathology Journal Vol.22 No.3
The pathogenicity to pear trees and other experimental hosts of the Apple stem grooving virus Korean isolate (ASGV-K) carried by a fungal vector, Talaromyces flavus was examined. ASGV-harboring T. flavus induced mild symptoms on virus-free pears. Symptom severity was intermediate between pears showing typical PBNLS and virus-free pears. Ten cultivars of Phaseolus vulgaris showed 35%-90% infectivity by direct infiltration into leaves and roots by ASGV-harboring T. flavus. Application of fungal cultures to soils showed 0%-70% infectivity depending on the P. vulgaris cultivar. Sap extracted from ASGV-infected Chenopodium quinoa induced similar symptoms on P. vulgaris at 25 days after inoculation. Similar symptoms were also detected on P. vulgaris which were inoculated with ASGV-harboring T.flavus. When healthy P. vulgaris leaves were challenged with sap extracted from P. vulgaris leaves infected with ASGV-harboring T. flavus, typical symptoms were observed. These data suggest that T. flavus mediates the transfer of ASGV to host plants.
Shim, Man Kyu,Park, Jooho,Yoon, Hong Yeol,Lee, Sangmin,Um, Wooram,Kim, Jong-Ho,Kang, Sun-Woong,Seo, Joung-Wook,Hyun, Soo-Wang,Park, Jae Hyung,Byun, Youngro,Kwon, Ick Chan,Kim, Kwangmeyung Elsevier 2019 Journal of controlled release Vol.294 No.-
<P><B>Abstract</B></P> <P>Cancer nanomedicine using nanoparticle-based delivery systems has shown outstanding promise in recent decades for improving anticancer treatment. However, limited targeting efficiency, low drug loading efficiency and innate toxicity of nanoparticles have caused severe problems, leaving only a few available in the clinic. Here, we newly developed carrier-free nanoparticles of cathepsin B-cleavable peptide (Phe-Arg-Arg-Gly; FRRG)-conjugated doxorubicin (DOX) prodrug (FRRG-DOX) that formed a stable nanoparticle structure with an average diameter of 213 nm in aqueous condition. The carrier-free nanoparticles of FRRG-DOX induced cytotoxicity against cathepsin B-overexpressed tumor cells whereas the toxicity was minimized in normal cells. In particular, the FRRG-DOX nanoparticles showed the successful tumor-targeting ability and enhanced therapeutic efficiency in human colon adenocarcinoma (HT-29) tumor-bearing mice <I>via</I> enhanced permeation and retention (EPR) effect. Furthermore, FRRG-DOX nanoparticles did not present any severe toxicity, such as non-specific cell death and cardiac toxicity, in normal tissues due to minimal expression of cathepsin B. This carrier-free nanoparticles of FRRG-DOX can solve the unavoidable problems of current nanomedicine, such as lower targeting efficiency, toxicity of nanoparticles themselves, and difficulty in mass production that are fatally caused by natural and synthetic nano-sized carriers.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
심기환,박석규,손태화,김명찬,강신권 한국농화학회 1984 Applied Biological Chemistry (Appl Biol Chem) Vol.27 No.1
Volatiles from Mallus pumila Miller Var. Fuji, Ralls Janet and Jonathan during maturity were examined. The volatiles of apples were collected by the headspace trapping method using. Tenax GC and identified by gas liquid chromatography and GC-mass spectrometry. Among over 34 GLC peaks, 23 esters, 9 alcohols and 2 aldehydes were identified. The quantity of volatiles produced was increased in proportion to the degree of maturity, and 1-butanol, isobutyl butyrate, 2-pentanol, ethyl valerate and hexanal were major.
A Cooperative Metabolic Syndrome Estimation With High Precision Sensing Unit
Youn, Chan-Hyun,Shim, Eun Bo,Lim, Soo,Cho, Young Min,Hong, Hyuck Ki,Choi, Yeon Shik,Park, Hyo-Derk,Lee, Hong Kyu IEEE 2011 IEEE Transactions on Biomedical Engineering Vol.58 No.3
<P>In this letter, we discuss a sensor-integrated system model for metabolic syndrome prediction with workflow system. This model measures not only a cell temperature variation using invasive method but also controlling simulation for metabolic syndrome prediction. To identify the system realization, we discuss the schemes for predicting metabolic syndrome from measurement of mitochondrial activity by using high precision sensors and integrated simulation model of human energetic under high performance workflow computing environment. To predict metabolic syndrome, we built a sensor-integrated chamber that had network interface to deliver analysis results of human cells, annotation data from public hospital, and metabolic data. Using the proposed system, we showed the possibility to evaluate the functionality of human mitochondria and analyze energy metabolism.</P>
Myung Kyu Oh,Du Hyun Kim,Myung Ki Kim,Ie Sung Shim,Young Chan Cho,Im Soo Choi,Yeon Gyu Kim,Sae Jun Yang,Young Tae Lee,Sang Hyun Park 한국육종학회 2007 한국육종학회지 Vol.39 No.2
Nitrogen (N) fertilization is essential for alleviating nutrient deficiencies of the world’s population by increasing rice production, one of the most important food crops of our time. Here we established an in vivo hydroponics rice seedling culture system to investigate the physio-biochemical and molecular responses of various rice genotypes to low nitrogen application. Yoshida’s nutrient solution (YS) was used to grow rice seedlings, and at three-week-old the seedlings manifested highly stable and reproducible symptoms, such as reduced shoot growth and length. Out of 12 genetically selected or tested genotypes, almost all (11 genotypes) showed varied degrees of growth reduction response to applied nitrogen (4 and 40 ppm N for treatment and control, respectively), but SR19663-B-B-34-3-3-3-1 showed similar growth as the control though its leaf width was smaller than the control. The leaves of a 11 representative low nitrogen-responsive genotype as BG90-2 were sampled for revealing the protein profiles between low and normal (control) nitrogen application by using two-dimensional gel electrophoresis (2-DGE) followed by staining of separated proteins with silver. Fifty differentially expressed silver stained protein spots were excised from 2-D gels and 41 proteins identified using high-throughput mass spectrometry (MS) using matrix-assisted laser desorption/ionization-time of flight-MS and nano electrospray ionization liquid chromatography tandem MS. These proteins could be assigned as major (energy metabolism, photosynthesis and oxidative stress) and minor functional categories, revealing many novel low N-responsive proteins, including those having energy/photosynthesis, and defense/stress, and iron homeostasis-related functions.