홍삼 조사포닌 성분의 중추작용

이순철,이수정,정경수,유관희,김학성 충남대학교 약학대학 의약품개발연구소 1995 藥學論文集 Vol.11 No.-

The present study was undertaken to elucidate the characteristics of red ginseng total saponin in behavioral changes on ambulation, forced swim test and convulsion in mice. The ambulation and the duration of immobility on forced swim test were not affected by red ginseng total sapinin. On the other hand, the duration of immobility induced by DMI, PGL but not CIP was significantly decreased, and the onset of convulsion induced by pentylenetetrazole was significantly shortened by preadminstration of red ginseng total saponin. These results suggest that red ginseng total saponin component may play an important role in modulation synergism with drugs acting on depression and convulsion, and that the characteristics of synergetic effect induced by red ginseng total saponin potentiate the central norepinephrine neuron activity.

외상후 발작의 위험인자에 대한 조사

이재학,배학근,윤석만,도재원,이경석,윤일규,최순관,변박장 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Risk Factors for Posttraumatic Seizure The authors evaluate the risk factors for posttraumatic seizures. this prospective study was performed in a series of 470 head injured patient from January 1996 to Decomber 1998. The patients who were dead within 1 week of injury or children from 3 years old and under were excluded. There were 358 male and 112 female with a mean age of 35.2±22.8 years (range, 4-88 years). The results were as follows : 1). Of the 470 patients, pasttraumatic seizure occurred in 48 patients(10.2%): early seizure in 28(6%) and late seizure in 20 patients(4.2%). 2). The clinical risk factors for posttraumatic seizure were poor consciousness at admission, presence of brainstem herniation signs, poor GCS score, and posttraumatic amnesia more than 24 hours after trauma(p<0.001). 3). The radiological risk factors for posttraumatic seizure were subdural hematoma(p<0.001), intracerebral hematoma (p<0.02), mutiple intracranial CT lesions(p<0.001), or delayed lesions on follow-up CT scans(p<0.001). the incidence of seizure increased according to the severity of diffuse brain lesion(p<0.001), and the seizure rate in mass lesion was higher than that in diffuse lesion(p<0.001). 5). Hypoxia and coagulopathy had a statistically significant influence on posttraumatic seizure(p<0.05). Hypoxia had a infuence on occurrence of late seizure(p<0.05). 6). The incidence of posttraumatic seizure signiticantly increased in surgical group compared with coservative group(p<0.001) and significantly increased in patient who underwent decompressive craniectomy compared with those who underwent craniotomy(p<0.001) 7). Preventive administration of antiepileptic drugs decreased the incidence of early seizure, but did not affect on the reduction of late seizure. 8). Multivariate logistic regression analysis showed the subdural hematoma, GCS score, delayed lesion, and intracerebral hematoma in order of importance for seizure risk. in conclusion, the risk factors affecting on the occurrence of seizure were clinical status at admission, CT lesions, and severity of diffuse brain inJury. Considering that hypoxia affected on the late seizure, it is necessary to detect and treat it immediately after trauma. In addition, the patients who underwent decompressive craniectomy should be carefully followed to evaluate the risk of late seizure. Even though preventive administration of antiepileptic drugs had a tendency to decrease the incidence of early seizure, it is unclear whether administration of antiepileptic drugs can reduce the incidence of posttraumatic seizures. Prospective study will be needed in the selected patients.

몇 소나무類의 葉綠素 含量의 月別 變化

李慶學,金甲泰,朱洸영,曺炅眞,李敦求 서울大學校 農科大學 1985 서울대농학연구지 Vol.10 No.2

植物體는 生存 또는 生長을 위해 光合成作用을 하며, 綠色植物은 이를 위한 色素로서 葉綠體를 가지고 있다. 따라서 이의 含量은 生長能力이나 各種 stress에 대한 生理的 活成變化를 나타내는 指標로 이용되는데 이에 對한 硏究報告는 基礎的 資料로서의 重要性에도 불구하고 林木 특히 소나무類에 있어서는 극히 드물었다. 이에 서울大學交 農科大學 構內에 있는 소나무類 5樹種에 對한 針葉單位生重量當 葉綠素含量을 月別測定한 結果 樹種間의 含量差異는 뚜렷하니지 않았으나 測定時期間에는 差異를 보였다. 總葉綠素의 含量變化는 葉綠素 a의 含量變化에 起因하며 이는 여름철에는 높고 겨울철에는 낮았다. 또한 最大値는 2年生 針葉을 7, 8月에 測定했을 때 나타났다. 이러한 結果를 綜合해 볼 때 소나무類의 生理的 生活은 葉綠素 a와 密接한 關係를 갖고 있는 것으로 思料된다. To obtain the fundamental data about the chlorophyll contents of some conifers, monthly measurements of them per unit fresh weight(g) of needles were performed. The results were summarized as follows. 1. Difference of total chlorophyll contents between measuring times in a species was clear but not between species. Total chlorophyll content in summer showed high value and that in winter did low value. 2. In general, the total chlorophyll contents of the conifers showed the highest values in two-year-old needles, measured in July or August. 3. Monthly change of total chlorophyll contents was mainly due to that of the contents of chlorophyll a, and the contents of chlorophyll b was not varied greatly with measuring times. 4. It seems that the physiological activity of needles was closely related with the contents of chlorophyll a.

주야교대작업이 근로자의 심혈관계 질환의 위험인자에 미치는 영향

신재학,이중정,이경수,사공준,김창윤,정종학 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.1

지속적인 주야간 교대작업이 심혈관계 질환의 위험요인에 미치는 영향을 평가하고, 심혈관계 질환의 위험요인들 중 교대작업에 의해 민감하게 영향을 받는 요인들을 조사하고, 교대작업에 참여한 기간과 위험요인들과의 관계를 평가하기 위하여 울산시에 있는 모 자동차공장 생산직 근로자를 대상으로 1993년 4월 20일부터 2개월간에 걸쳐 단면조사를 시행하였다. 교대작업은 하루 2교대로 이루어지며 야간작업조와 주간작업조는 1주일 주기로 순환되었다. 근무기간 1년이상 80%이상을 교대작업에 참여했던 근로자 420명을 교대작업군으로, 교대작업에 참여한 경험이 전혀 없는 생산직 근로자 88명을 대조군으로 하여 연령, 성별, 최종 학력, 현 산업장에서의 근속기간, 입사전 경력, 현재 작업부서, 작업내용 및 직급을 자기기입식 설문지를 통하여 조사하였다. 교대작업에 관해서는 조사당시의 교대작업에 참여여부, 교대작업의 주기와 규칙성 여부, 입사후 지금까지 교대작업에 참여한 기간을 조사하였다. 심혈관계 질환의 위험요인들로서 혈압, 콜레스테롤치, 중성지방, apolipoprotein A-1과 B 등을 측정하였다. 위험요인들의 단순비교에 있어서는 수축기혈압은 교대작업군과 대조군이 각각 122.4±11.9mmHg, 120.0±11.4mmHg로 교대작업군에서 다소 높았고 이완기혈압도 각각 76.5±9.3mmHg, 75.9±9.1mmHg로서 교대작업군에서 다소 높았으나 유의한 차이는 없었다. 콜레스테롤치와 중성지방도 교대작업군에서 다소 높았으나 통계적으로 유의하지 않았다. Apolipoprotein B는 교대작업자가 101.8±19.9mg/dl로서 대조군의 94.2±26.5mg/dl에 비해 다소 높게 나타났으며 통계적으로도 경계역 유의성을 보였으나(p=0.057), apolipoprotein A-1은 apolipoprotein B에 비해 개인적인 변이가 크고 두 군간의 차이를 인정할 수 없었다. Apolipoprotein B와 apolipoprotein A-1의 비는 교대작업군이 0.73±0.20으로 대조군에 비해 높게 나타났다(p<0.05). 비체중은 두 군 모두 약 22로서 유의한 차이를 보이지 않았으나, 1주일 동안 규칙적인 운동을 하는 횟수는 대조군이 1.27±1.5회에 비해 교대작업자가 0.76±1.1회로서 유의하게 적었다(p<0.01). A형 행동양상을 가지는 비율은 교대작업자에서 58.8%로 주간작업자의 51.1%에 비해 다소 높았으나 통계적으로 유의하지는 않았다. 심혈관계 질환의 주된 위험인자들을 종속변수로 하고 교대작업과 다른 위험인자들을 독립변수로한 다중회귀분석에서는 수축기혈압을 종속변수로 채택하였을 때 가변수 교대작업은 회귀계수 2.668로서 수축기혈압을 증가시키는 것으로 나타났으며 (p=0.059), 비체중도 경계역 유의성을 보였다(p=0.053). 이완기혈압에 대한 다중회귀분석에서는 가변수인 교대작업이 유의한 영향을 미치지 않은 것으로 나타났으며, 비체중이 유의한 변수였다(p<0.01). 콜레스테롤치를 종속변수로 하여 실시한 다중회귀분석의 결과는 연령 및 비체중이 증가할수록 콜레스테롤치가 증가하는 경향을 보였으며 가변수인 교대작업이 콜레스테롤치를 증가시키나 통계적으로 유의하지는 않았다. 중성지방에 대한 다중회귀분석에서는 가변수 교대작업이 중성지방을 증가시키는 것으로 나타났으나 통계적으로 유의하지는 않았다. Apolipoprotein A-1의 경우 가변수 교대작업은 apolipoprotein A-1의 수준을 감소시키는 경향을 보였으나 통계적으로 유의하지는 않았다. 그 밖의 다른 변수들 중 apolipoprotein A-1의 수준에 영향을 미치는 변수는 없었다. Apolipoprotein B를 종속변수로한 다중회귀분석에서는 가변수 교대작업은 apolipoprotein B의 수준을 증가시키는 경향을 보였으나 통계적으로 유의하지는 않았다. Apolipoprotein B와 apolipoprotein A-1의 비를 종속변수로 한 다중회귀분석에서는 가변수 교대작업이 apolipoprotein B/Apo A-1을 증가시키는 변수였으며 통계적으로도 유의하였다(p<0.05). 교대작업군을 교대작업에 참여한 기간이 5년 미만인 군과 5년 이상인 군으로 나누어 비교하였을 때 콜레스테롤치, apolipoprotein B 및 Apo B/Apo A-1가 5년 미만의 교대작업군에 비해 5년 이상인 군이 유의하게 높게 나타났다(p<0.05). 교대작업기간이 위험요인에 미치는 영향을 보기 위해 가변수로 교대작업기간을 독립변수로 투입하여 다중회귀분석을 실시하였다. 콜레스테롤치를 종속변수로 한 다중회귀분석에서는 교대작업의 기간이 길수록 유의하게 증가하는 경향을 보였으며(p<0.05), apolipoprotein B도 교대작업의 기간이 길수록 다소 증가하는 경향을 보였으나 통계적으로 유의하지는 않았다. An investigation of effects of shift work on cardiovascular risk factors has been carried out on workers of a motor company in Ulsan, for 2 months from 20 April to 20 June, 1993. This cross-sectional survey was designed to compare the shift workers(n=420) with day workers(n=88). The study subjects were drawn from workers who were employed in twelve hour shift system. A control group who never experienced shift work was drawn from different sections of the factory. Each worker completed a medical and occupational questionnaire, and cardiovascular risk factors such as blood pressure, total cholesterol, triglyceride, apolipoprotein A-1 and B were measured. In univariate analysis, apolipoprotein B and the ratio of apolipoprotein B to apolipoprotein A-1 increased in shift workers. In multiple regression analysis for the systolic blood pressure, shift work was significant independent variable(p=0.059). In multiple regression analysis for the cholesterol, age and body mass index were significant independent variables(p<0.01), but shift work was not a statistically significant independent variable. In multiple regression analysis for the ratio of apolipoprotein B to apolipoprotein A-1, shift work was significant independent variable(p<0.05). Shift workers who have engaged in shift work more than 5 years have an excess of total cholesterol, apolipoprotein B and ratio of apolipoprotein B to apolipoprotein A-1 than those who have engaged in shift work less than 5 years (p<0.05). In multiple regression analysis for the cholesterol, duration of shift work was a significant independent variable(p=0.012). In multiple regression analysis for the apolipoprotein B and ratio of apolipoprotein B to apolipoprotein A-1, duration of shift work was not a significant independent variable.

재발된 고혈압성 뇌실질내 출혈

배학근,정두신,도재원,이경석,윤일규 대한신경외과학회 1999 Journal of Korean neurosurgical society Vol.28 No.3

60세 이상 환자의 척추수술

윤석만,이경석,도재원,배학근,윤일규 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

Objective: Advances in surgical technique, anesthesia and perioperative patient management, coupled with the rapid increase in the population of patients reaching their 60s or older, have led to a signiticant rise in spinal precedures. The objective of this study was to evaluate frequency of the disease, surgical results and postoperative complications of the aged patients who underwent spinal surgeries. Methods : We reviewed all spinal procedures for spinal lesions including degenerative diseases, trauma, tumor and others in patients aged 60 years or older between January 1 1994 and October 1 1998(56 men and 26 women), retrospectively. Final outcome was assessed by telephone interview with the patient or the family in 67.1%(55/82). Results : There were 56 male patients and 26 female patients. There were 57 cases of degenerative diseases, 14 cases of trauma, 5 cases of metastaisis, 4 cases of infection and 2 cases of others. According to the level of surgical procedures, there were 20 cases fo cervical spine, 8 cases of thoracic spine, 54 cases of lumbar spine. Postoperaive complications included the following(17/82): 7 dural tears, 2 sepsis, 2 nerve root injury and 6 others. There were no operation-related deaths. During follow up period, ten patients(12.2%) had died, 45 patients(54.9%) were contacted and 27 patients(32.9%) could not be located. Mean follow up period for the 45 patients contacted was 26.1±15.7 months. Of the 45 persons contacted, 34(75.6%) reported improvement, 6(13.3%) no change and 5(11.1%) aggravation of their preoperative symptoms. Conclusion: Spine surgery in patients aged 60 years or older has higher complication rate compare to the younger but it is reasonable to consider the surgical procedures even in the elderly if it is needed. We should give attention not to tear the dura during the surgical procedures, especially in the elderly.

자발성 뇌지주막하 출혈 환자에서 최초 뇌실 크기의 임상적 의의

신일영,윤일규,윤석만,도재원,이경석,배학근,최순관,변박장 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.1

The purpose of this study is to invesetigate the clinical significance of initial enlargement of ventricle in the patients who had aneurysmal SAH. Of the total 821 patients with aneursmal SAH who were registerd in SAH data bank system between 1989-1999, 307 patients who had been already measured in the size of ventricle at the time of admission, were studied retrospectively. The size of ventricle was calculated by bifrontal index. Normal size of ventricle was defined as 30% or less, mild enlargement was defined as 31 to 39%, and moderate enlargement of vertricle was defined as more than 39% in bifrontal index. The sizes of ventricle using bifrontal index were analysed according to the age, sex, blood pressure, consciousness at admission, medical history of hypertension, location of ruptured aneurysm, Fisher's grade on CT(computerized tomography) scan at the time of admission, cerebral vasospasm, intraventricular hemorrhage (IVH), performance of external ventricular drainage (EVD), and prognosis at discherge. Chi-square test and ANONA were used in the statistical evaluation. The results were as follows : 1) Of the 307 patients, 235(76.5%) had a mild to moderate enlargement of ventricle at the time of admission (more than 30% in bifrontal index). 2) The size of ventricle was enlarged according to the increase of age (p<0.05). 3) In the patients who had ruptured aneurysm on anterior cerebral artery, the size of ventricle significantly increased and showed a higher incidence in mild enlargement compared with moderate enlargement of ventricle (p<0.05). 4) The size of ventricle increased in th patients who had IVH and the EVD was more frequently performed in th patients who had the enlarged ventricle associated with IVH (p<0.05). 5) In the patients who had high Fisher's grade, the size of ventricle had a tendency to increase, but there was no statistical significance. 6) In the patients who had poor prognosis, the size of ventricle had a tendency to increase, but there was no statistical significance. Conclusively, the initial size of ventricle was enlarged in th aged patients, ruptured aneurysm on anterior communicating artery, high FIsher's grade, patients associated with IVH. Considering those factors, prediction for the enlargement of ventricle size may help to treat the patients suffering aneurysmal SAH.

두개강내 원발성 흑색종 2례

이흥선,배학근,도재원,이경석,윤일규,이인수,배원경,김의한 대한신경외과학회 1990 Journal of Korean neurosurgical society Vol.19 No.8-9

Primary malignant melanoma arising from the leptomeninges is a rare entity. We report two cases of primary intracranial melanorna developed in one aged 65 years female and the other 70 years male. One case died 2 years after the operation, and the other case is still living more than 1 year after operation. Both cases seem to have a relatively long survival. The literature on this subject is briefly reviewed.

Morphologlcal Characters of Superior Populus albaxPopulus glandulosa F1 Clones under Intensive Culture

Kyeong Hack Lee,Don Koo Lee 한국육종학회 1984 한국육종학회 학술발표회 발표요지 Vol.16 No.1

Pharmacokinetics of LB20304, a New Fluoroquinolone, in Rats and Dogs

Seo, Mi-Kyeong,Lee, Sun-Hwa,Choi, Yun-Jeong,Jeong, Yi-Na,Lee, Sung-Hack,Kim, In-Chull,Lee, Yong-Hee The Pharmaceutical Society of Korea 1996 Archives of Pharmacal Research Vol.19 No.5

The pharmacokinetics of LB20304 was investigated following intravenous (IV) and oral administration to rats and dogs. Additionally, in vitro metabolism and serum protein binding studies were also conducted. The total body clearance, apparent volume of distribution, terminal half-life, and extent of bioavailability were 21.8 ml/min/kg, 2265 ml/kg, 93.6 min, and 30.8% for rats; and 7.95 ml/min/kg, 4144 ml/kg, 363 min, and 81.1% for dogs, respectively. LB20304 was stable in the liver microsome containing NADPH generating system and its serum protein binding was 58.5-65.8% for rats, 19.1-29.6% for dogs, and 56.9-59.6% for humans. Its tissue concentration levels in lever, stomach, small intestine, and kidney were 9.5 to 26.1 times greater than plasma level, but the concentration in testis was quite low and that in brain was negligible in rats. The 48 hr urinary recovery of the dose was 44% for IV dosing and 14% for oral dosing, shereas the 48 hr biliary recovery of the dose was 6.4% for IV dosing and 4.5% for oral dosing in rats. In summary, the pharmacokinetic properties of LB20304 were characterized by its good oral absorption, long plasma half-life, and good tissue distribution.