Hepatic Cirrhosis Occurring in a Young Woodchuck(Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus(WHV)

Kyu-shik Jeong,정원일,Jae-yong Chung,Mi-young An,Chae-yong Jung,Gyoung-jae Lee,Jong-soo Kang,Byeong-cheol Kang,Young-heun Jee,Bruce H Williams,Young-oh Kwon,Da-hee Jeong 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Cirrhosis Occurring in a Young Woodchuck (Marmota monax) Due to Vertical Transmission of Woodchuck Hepatitis Virus (WHV)Da-hee Jeong, Won-il Jeong, Jae-yong Chung, Mi-young An, Chae-yong Jung, Gyoung-jae Lee1, Jong-soo Kang1, Byeong-cheol Kang2, Young-heun Jee3, Bruce H Williams4, Young-oh Kwon5 and Kyu-shik Jeong*College of Veterinary Medicine, Kyungpook National University, Daegu 702-701, Korea1Shinwon Scientific Co., LTD, Research Institute, Suwon, Korea2Clinical Research Institute, Seoul National University, Seoul 110-744, Korea3College of Veterinary Medicine, Jeju National University, Jeju 690-756, Korea

제주형 작물재배용 비닐하우스의 모델개발 : 풍하중에 대한 수치해석

권기린,김용호,민창식 제주대학교 환경연구소 1998 환경연구논문집 : 제주대 Vol.6 No.-

An elastic analysis under wind load is performed for the double layered plastic greenhouse model developed particularly for minimizing damages under typhoons at Cheju Citrus Research Institute in Chejudo. General EVA frlm is used for the inner covering and for the outer covering the developed special film whch would break the wind pressure down is used. Based on the wind tunnel test. this special film will reduce effectively the wind speed by up to 86 to 98% under very controlled situation. Many more tests need to be performed to adopt the results to greenhouse analysis. Based on the elastic analysis performed in the study, the behavior of the greenhouse is changed dramatically due to the boundary conditions. Not like other researchers before we applied dead load of the concrete support at the ground pipe and fixed support boundary conditions at the 4 corner pipes. The analysis shows that the greenhouse is lifted and pulled the pipe out of the ground due to the sucking wind pressure. The behavior of the greenhouse is very much similar to that one real greenhouse failure. Therefore, not only we need to find the realistic boundary conditions for the supports, but also need to perform many more researches to find how to rest the pipe supports on the ground without losing economy.

Comb Transducer를 이용한 파이프 내 유도초음파 모드의 거동에 관한 연구

박익근,김용권,조윤호,안연식,조용상 한국비파괴검사학회 2004 한국비파괴검사학회지 Vol.24 No.2

발전설비의 보수검사에 적용하기 위한 예비 연구로 comb transducer를 이용한 파이프 내에서의 유도초음파 모드의 거동을 실험적으로 검증하였다. 유도초음파의 모드식별은 STFT와 WT에 의한 시간-주파수해석을 통하여 최적의 모드를 선정하였다. 시간-주파수해석과 이론적 해석 방법인 분산 곡선을 비교한 결과 잘 일치함을 알 수 있었으며, pitch-catch법과 선단부로부터 반사된 신호를 모두 분석한 결과 L(0,1) 모두가 다른 모드에 비해 모드변화에 의한 영향이 적었다. 따라서 L(0,1)을 최적의 모드로 선정하고, 결함위치를 추정한 결과 유용함을 알 수 있었다. A preliminary study of the behavior of ultrasonic guided wave mode in a pipe using a comb transducer for maintenance inspection of power plant facilities has been verified experimentally. The mode identification has been carried out in a pipe using the time-frequency analysis methods such as the wavelet transform(WT) and the short time Fourier transform (STFT), compared with theoretically calculated group velocity dispersion curves for longitudinal and flexural modes. The results are in good agreement with analytical predictions and show the effectiveness of using the time-frequency analysis method to identify the individual modes. It was found out that the longitudinal mode(0,l) is less affected by mode conversion compared with the other modes. Therefore, L(0,l) is selected as an optimal mode for the evaluation of the surface defect in a pipe.

대량의 각혈로 사망한 장티푸스 1예

한상우,유진홍,권순석,김성훈,박지찬,홍은정,최경성,박용완,장준희,안지원,박유경,강지영,박상미,신완식 대한감염학회 2004 감염과 화학요법 Vol.36 No.5

We experienced a 25 year-old male patient with typhoid fever complicated with massive hemoptysis. Pulmonary complication in typhoid fever is very rare and to our knowledge, there has been no report of hemoptysis as a main cause of death with this disease. We herein report a rare case of typhoid fever.

시간-주파수 해석법을 이용한 파이프 내 유도초음파 모드의 식별에 관한 연구

박익근,김용권,조윤호,안연식,조용상 한국비파괴검사학회 2004 학술대회 논문집 Vol.- No.-

발전설비의 보수검사에 적용하기 위한 예비 연구로 comb transducer를 이용한 파이프 내에서의 유도 초음파 모드의 거동을 실험적으로 검증하였다. 유도초음파의 모드식별은 STFT 와 WT에 의한 시간-주파수해석을 통하여 최적의 모드를 선정하였다. 시간-주파수해석과 이론적 해석 방법인 분산 곡선을 비교한 결과 잘 일치함을 알 수 있었으며, pitch-catch법과 선단부로부터 반사된 신호를 모드 분석한 결과 L(0,1) 모드가 다른 모드에 비해 모드변환에 의한 영향이 적었다. 따라서 L(0,1)을 최적의 모드로 선정하고, 결함위치를 추정한 결과 유용함을 알 수 있었다.

Case Reports : Isolated Cervical Lymph Node Sarcoidosis Presenting in an Asymptomatic Neck Mass; A Case Report

( Yong Shik Kwon ),( Hye In Jung ),( Hyun Jung Kim ),( Jin Wook Lee ),( Won Il Choi ),( Jin Young Kim ),( Byung Hak Rho ),( Hye Won Lee ),( Kun Young Kwon ) 대한결핵 및 호흡기학회 2013 Tuberculosis and Respiratory Diseases Vol.75 No.3

Sarcoidosis, a systemic granulomatous disease of unknown etiology. The presentation of sarcoidal granuloma in neck nodes without typical manifestations of systemic sarcoidosis is difficult to diagnose. We describe the case of a 37-year-old woman with an increasing mass on the right side of neck. The excisional biopsy from the neck mass showed noncaseating epithelioid cell granuloma of the lymph nodes. No evidence of mycobacterial or fungal infection was noted. Thoracic evaluations did not show enlargement of mediastinal lymph nodes or parenchymal abnormalities. Immunohistochemistry showed abundant expression of tumor necrosis factor-α in the granuloma. However, transforming growth factor-β was not expressed, although interleukin-1β was focally expressed. These immunohistochemical findings supported characterization of the granuloma and the diagnosis of sarcoidosis. Sarcoidosis can present with cervical lymph node enlargement without mediastinal or lung abnormality. Immunohistochemistry may support the diagnosis of sarcoidosis and characterization of granuloma.

Pneumonia Prevalence Upon Chest Radiography According to Vaccination Status Among Patients Under 50 Years of Age With Coronavirus Disease 2019

Kwon Yong Shik,Park Sun Hyo,Kim Hyun Jung,Park Jae Seok,Kim Mi-Ae,Kim Tae Hun,Lee Ji Yeon,Kim Jin Young 대한의학회 2024 Journal of Korean medical science Vol.39 No.6

Background: Coronavirus disease 2019 (COVID-19) vaccination is effective in preventing the disease transmission and progression. However, the relatively mild disease course of the omicron variant and the decrease in antibodies over time after vaccination raise questions about the effectiveness of vaccination, especially in young people. We compared the prevalence of pneumonia and chest X-ray severity score according to vaccination status among patients < 50 years old with COVID-19. Methods: From January 17 to March 17, 2022, 579 patients with COVID-19, who were < 50 years old and had a known vaccination history in our institution, were all included in this study. All patients underwent initial chest radiography, and follow-up chest radiographs were obtained every two days until discharge. Pneumonia was scored from the radiographs using the Brixia scoring system. The scores of the six lung zones were added for a total score ranging from 0 to 18. Patients were divided into four groups according to 10-year age intervals. Differences between groups were analyzed using the χ2 or Fisher’s exact tests for categorical variables and the Kruskal–Wallis test or analysis of variance for continuous variables. Results: Among patients aged 12–19 years, the prevalence of pneumonia did not differ depending on vaccination status (non-vaccinated vs. vaccinated, 1/47 [2.1%] vs. 1/18 [5.6%]; P = 0.577). Among patients in their 20s, the prevalence of pneumonia was significantly higher among nonvaccinated patients than among vaccinated patients (8/28, 28.6% vs. 7/138, 5.1%, P < 0.001), similar to patients in their 40s (32/52 [61.5%] vs. 18/138 [13.0%]; P < 0.001). The chest X-ray severity score was also significantly higher in non-vaccinated patients than that in vaccinated patients in their 20s to their 40s (P < 0.001), but not among patients aged 12–19 years (P = 0.678). Conclusion: In patients aged 20–49 years, vaccinated patients had a significantly lower prevalence of pneumonia and chest X-ray severity score than non-vaccinated patients.

Treatment Outcomes after Discontinuation of Ethambutol due to Adverse Events in Mycobacterium avium Complex Lung Disease

Yong Shik Kwon,Byoung Soo Kwon,Ock-hwa Kim,Yea Eun Park,Tae Sun Shim,Yong Pil Chong,조경욱 대한의학회 2020 Journal of Korean medical science Vol.35 No.9

Background: Long-term administration of ethambutol (EMB) for Mycobacterium avium complex lung disease (MAC-LD) sometimes leads to permanent discontinuation of EMB due to various adverse events. This study aimed to investigate treatment outcomes after discontinuation of EMB. Methods: Among patients diagnosed with MAC-LD between January 2001 and December 2014, 508 patients whose treatment was initiated with standard regimen until May 2018 were enrolled at a tertiary referral center in Korea. Of these 508 patients, 60 (11.8%) discontinued EMB due to various adverse effects. Among these 60 patients, treatment outcomes were analyzed for 44 patients by comparing their outcomes with those of matched subjects who received the standard treatment regimen without EMB discontinuation. Results: The mean age of the 60 patients who discontinued EMB was 64.4 years. Ocular toxicity was the most common cause of discontinuation of EMB (75.0%, 45/60). The mean duration of EMB administration before its discontinuation was 7.0 ± 4.6 months. The treatment failure rate of the 44 patients with EMB discontinuation analyzed for treatment outcome was 29.6%, which was higher than that of the matched patients who received the standard regimen (18.3%), although the difference was not significant (P = 0.095). Of these 44 patients, EMB was substituted with later-generation fluoroquinolone in 23 patients, and the treatment failure rate of these 23 patients was significantly higher than that of the matched patients who received the standard regimen (39.1% vs. 19.3%, P = 0.045). Conclusion: These findings suggest that treatment outcomes are unsatisfactory in patients with MAC-LD who discontinue EMB owing to adverse events. Notably, there was a statistically significant high failure rate in patients who were prescribed fluoroquinolone to replace EMB.

Comparison of Baseline Characteristics and Clinical Courses between Patients with First Positive and Re-detection PCR for SARS-CoV-2

( Yong Shik Kwon ),( Sun Hyo Park ),( Hyun Jung Kim ),( Jae Seok Park ),( Ji Yeon Lee ),( Mi-ri Hyun ),( Hyun Ah Kim ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-

Background Many patients with re-detected polymerase chain reaction (PCR) for SARS-CoV-2 were identified and then they were admitted again, although they were recovered after treatment. The Results of the viral culture among the re-detected patients were revealed as no-growth for SARS-CoV-2, and cases that re-detected patients transmit SARS-CoV-2 to other patients have not been identified, contagious risk and clinical features of them are unknown. We investigated the baseline characteristics and clinical courses between the first positive and re-detected patients for SARS-CoV-2. Methods From 22 February 2020 to 30 April 2020, 826 patients diagnosed as first positive patients, 171 patients were identified as re-detected patients. The medical records were retrospectively reviewed. Among these two groups, clinical characteristics including initial symptoms, rates of aggravation to severe pneumonia (clinical signs of pneumonia plus one of the following: respiratory rate > 30 breaths/min, severe respiratory distress or SpO2 ≤ 90% on room air), transfer to intensive care unit, and mechanical ventilator, continuous renal replacement therapy, extracorporeal membrane oxygenation usage were compared. Results Re-detected group was significantly younger than first positive group (median 46 years vs 56 years, p<0.001). More than half (100/171, 58.5%) of the re-detected patients were asymptomatic, while 26.2% (216/826) of first positive group were asymptomatic (p<0.001). Patient who progress to severe pneumonia were significantly lower in re- detected group than the first positive group (4.1% vs 17.5%, p<0.001). None of the patients in re-detected group had admitted ICU, needed mechanical ventilator, continuous renal replacement therapy, and extracorporeal membrane oxygenation. None of the re- detected patients were dead. However, 19 patients (2.3%) were dead in first-positive group. Conclusion More than half of the re-detected patients were asymptomatic and had favorable outcome than first positive group.

Isolated Cervical Lymph Node Sarcoidosis Presenting in an Asymptomatic Neck Mass: A Case Report

Kwon, Yong Shik,Jung, Hye In,Kim, Hyun Jung,Lee, Jin Wook,Choi, Won-Il,Kim, Jin Young,Rho, Byung Hak,Lee, Hye Won,Kwon, Kun Young The Korean Academy of Tuberculosis and Respiratory 2013 Tuberculosis and Respiratory Diseases Vol.75 No.3

Sarcoidosis, a systemic granulomatous disease of unknown etiology. The presentation of sarcoidal granuloma in neck nodes without typical manifestations of systemic sarcoidosis is difficult to diagnose. We describe the case of a 37-year-old woman with an increasing mass on the right side of neck. The excisional biopsy from the neck mass showed noncaseating epithelioid cell granuloma of the lymph nodes. No evidence of mycobacterial or fungal infection was noted. Thoracic evaluations did not show enlargement of mediastinal lymph nodes or parenchymal abnormalities. Immunohistochemistry showed abundant expression of tumor necrosis factor-${\alpha}$ in the granuloma. However, transforming growth factor-${\beta}$ was not expressed, although interleukin-$1{\beta}$ was focally expressed. These immunohistochemical findings supported characterization of the granuloma and the diagnosis of sarcoidosis. Sarcoidosis can present with cervical lymph node enlargement without mediastinal or lung abnormality. Immunohistochemistry may support the diagnosis of sarcoidosis and characterization of granuloma.