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강금석,남천석,김인덕,권륜희,이동찬,허예영,하배진 신라대학교 자연과학연구소 2007 自然科學論文集 Vol.16 No.-
The effects of Laminaria japonica fucoidan extract (LJFE) on the biochemical parameters of lipid-related function were investigated in liver and serum of CCl_(4)-treated rats. LJFE of 100 mg/kg concentration was intraperitoneally administered into rats at dose of 1.5 ml/kg for 14 days. On the day 15, 3.3 ml/kg of CCl_(4) dissolved in olive oil (1:1) was injected 12 hours before anesthetization. We examined the lipid-related functions and enzyme activitys by measuring the levels of total cholesterol (TC), triglyceride (TG), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH) in serum. The results showed that CCl_(4) treatment increased the high values of TG, LDH and ALP decreased the low values of TC but LJFE pretreatment decreased the high values of TG, LDH and ALP to the low values, increased the TC. It was suggested that LJFE can be used as the potential candidate for the lipid-metabolism natural supplement.
하배진,남천석,박은경,강금석 신라대학교 자연과학연구소 2006 自然科學論文集 Vol.15 No.-
In the present study the hepatoprotective and antioxidative effects of Epimedium koreanum (EK) and Salicornia herbacea (SH) were investigated against carbon tetrachloride (CCl_(4))-induced liver damage in rats. EK and SH (100 mg/kg) were administered into rats intraperitoneally (i.p) for 2 weeks. After CCl_(4) a dose of 3.3ml/kg was administered to induce hepatotoxicity. This antioxidative effects of EK and SH on CCl_(4) -treated rats were measured through the activity of Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) in serum and Superoxide dismutase (SOD), Catalase (CAT) in liver tissue. EK or SH-administered and CCl_(4) -treated (ECT or SCT) groups showed inhibitory effects in AST and ALT activities compared to CCl_(4) -treated control (CTC) group. SOD and CAT in ECT and SCT groups were increased compared to those of CTC group.
The Effects of Fucoidan Extracts on CCl4-Induced Liver Injury
Kum Suk Kang,김인덕,권륜희,Jin Young Lee,강재선,하배진 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.5
The aim of this study was to elucidate the antioxidant properties of fucoidan extracts (FE) against CCl4-induced oxidative stress by monitoring the levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Female, Sparague-Dowley rats were administered with FE (100 mg/kg daily) for 14 days and CCl4 on the 15’th day, 12 h before they were sacrificed. The levels of GOT, GPT, ALP and LDH in serum of rats, as well as the levels of MDA, SOD, CAT and GPx in total liver homogenate were analyzed. CCl4-treatment was found to increase the levels of GOT, GPT, ALP, LDH and MDA, as well as decrease levels of SOD, CAT and GPx significantly. The pre-treatment of rats with FE, however, suppressed the increment of levels of GOT, GPT, ALP, LDH and MDA, as well as recovered the levels of SOD, CAT and GPx in CCl4-treated rats. Moreover there was a significant decrease in incidences of necrosis and cirrhosis in the liver tissue of FE-treated rats. These results implied that FE possessed antioxidant properties against CCl4-induced oxidative stress.
Undaria pinnatifida Fucoidan Extract Protects against CCl₄-induced Oxidative Stress
Kum Suk Kang,김인덕,Ryun Hee Kwon,하배진 한국생물공학회 2008 Biotechnology and Bioprocess Engineering Vol.13 No.2
This study was performed to elucidate the effects of Undaria pinnatifida fucoidan extract (UPFE) in preventing CCl₄-induced oxidative stress. UPFE (100 mg/kg) was intraperitoneally administered to rats for 14 days. On day 15, CCl₄dissolved in olive oil (50% CCl₄) was injected 12 h before they were anesthetized and dissected. To measure UPFE-mediated antioxidation, we examined the levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), alkaline phosphatase (ALP), and lactate dehydrogenase (LDH) in serum, as well as malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in liver homogenates. CCl4 treatment markedly increased the levels of GOT, GPT, ALP, LDH, and MDA and significantly decreased levels of SOD, CAT, and GPx. UPFE pretreatment decreased levels of GOT, GPT, ALP, LDH, and MDA, by 62.8, 68.5, 41.9, 72.7, and 122%, respectively and increased those of SOD, CAT, and GPx by 111.1, 15.9, and 52.6%, respectively. These results showed that UPFE has antioxidant effects against CCl₄-induced oxidative stress.
The Effects of Fucoidan Extracts on $CCl_4$-Induced Liver Injury
Kang, Kum-Suk,Kim, In-Deok,Kwon, Ryun-Hee,Lee, Jin-Young,Kang, Jae-Seon,Ha, Bae-Jin 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.5
The aim of this study was to elucidate the antioxidant properties of fucoidan extracts (FE) against $CCl_4$-induced oxidative stress by monitoring the levels of glutamate oxaloacetate transaminase (GOT), glutamate pyruvate transaminase (GPT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx). Female, Sparague-Dowley rats were administered with FE (100 mg/kg daily) for 14 days and $CCl_4$ on the 15'th day, 12 h before they were sacrificed. The levels of GOT, GPT, ALP and LDH in serum of rats, as well as the levels of MDA, SOD, CAT and GPx in total liver homogenate were analyzed. $CCl_4$-treatment was found to increase the levels of GOT, GPT, ALP, LDH and MDA, as well as decrease levels of SOD, CAT and GPx significantly. The pre-treatment of rats with FE, however, suppressed the increment of levels of GOT, GPT, ALP, LDH and MDA, as well as recovered the levels of SOD, CAT and GPx in CCl4-treated rats. Moreover there was a significant decrease in incidences of necrosis and cirrhosis in the liver tissue of FE-treated rats. These results implied that FE possessed antioxidant properties against $CCl_4$-induced oxidative stress.
갈파래 추출 분획물의 CCl₄ 독성에 대한 항산화 효과
남천석(Chun Suk Nam),강금석(Kum Suk Kang),하종명(Jong-Myung Ha),이상현(Sang-Hyeon Lee),이재화(Jae Hwa Lee),이동근(Dong Geun Lee),장정수(Jeong Su Jang),강환열(Hwan Yul Kang),하배진(Bae Jin Ha) 한국독성학회 2006 Toxicological Research Vol.22 No.4
This study was to investigate the preventive effects in anti-oxidation of Ulva lactuca extract fractions (ULEF) against CCl₄ toxification in liver total homogenate and mitochondrial fraction of ULEF-pretreated and carbon tetrachloride (CCl₄)-posttreated rats. ULEF was intraperitoneally administered into rats at dose of 1 ml/kg for 14 days. On the day 15, 3.3 ㎖/㎏ of CCl₄ dissolved in olive oil (1 : 1) was injected 12 hr before anesthetization. Activities of superoxide dismutase (SOD) in mitochondrial fraction were measured and catalase (CAT), glutathione peroxidase (GPx), malondialdehyde (MDA) in liver total homogenate. SOD, CAT and GPx were higher in the ULEF-pretreated and CCl₄-posttreated group than those in the CCl₄-posttreated group, and the pretreatment of ULEF decreased MDA. These results showed that the pretreatment of ULEF had the preventive role in the activities of anti-oxidative enzymes, SOD, CAT and GPx
Кан Кум Сук(Kang Kum Suk) 경북대학교 러시아-유라시아 연구소 2022 러시아유라시아연구 Vol.8 No.-
В статье рассматриваются особенности медицинского дискурса, который обусловлен статусно-ролевыми характеристиками участников данного вида дискурса. Для оказания воздействующего эффекта на реципиентов в медицинском дискурсе используются различные виды рекламной печатной продукции, в текстах которых реализуются стратегии и тактики, нацеленные на привлечение клиентов путем ознакомления со спектром оказываемых клиникой услуг. Лексические средства, вербализующие воздействующие стратегии и тактики, способствуют созданию определенного имиджа медицинской клиники, а также влияют на выбор клиентом (потенциальным пациентом) пакета медицинских услуг. The article discusses the features of medical discourse, which is conditioned by the status-role characteristics of participants in this type of discourse. To have an influencing effect on recipients, various types of printed advertising products are used in medical discourse, in the texts of which strategies and tactics are implemented aimed at attracting customers by familiarizing themselves with the range of services provided by the clinic. Lexical means that verbalize influencing strategies and tactics contribute to the creation of a certain image of a medical clinic, and also influence the choice of a client (potential patient) package of medical services.