항정신병약물을 처음으로 사용하는 초발 정신증 환자에서 나타나는 체중 및 대사성 지표의 변화 : 후향적 연구

김우진,심주철,공보금,강제욱,문정준,김정은,김민걸,박민경,김성진,김현정,정도운 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2

Objectives:This study was to identify weight & metabolic changes in first-episode psychotic patients with antipsychotics use and investigate the differences of weight & metabolic changes between first-episode psychotic patients and controls with antipsychotics use. Method:In this retrospective study, twenty eight first-episode psychotic patients and twenty eight controls with schizophrenia, schizoaffective or bipolar disorder defined by DSM-IV criteria were included. Information about demographic and clinical characteristics of the subjects was gathered from the medical records. Also body weight, sBP, dBP, fasting glucose, lipid profile and WBC count were evaluated before and after antipsychotics use. Rogistic regression was conducted to assess factors associated with weight gain. Results:First-episode psychotic patients showed more weight and BMI changes than controls after antipsychotics use, and these changes continue over 12 months. On the other hand, there were no significant factors associated with weight gain. Conclusion:The results of present study suggest that antispychotics is one of the major causes inducing weight gain of psychotic patients and antipsychotics-induced weight gain is more vulnerable to drug-naive first-episode psychotic patients.

Regional disparities in major cancer incidence in Korea, 1999-2018

Eun Hye Park(Eun Hye Park),Mee Joo Kang(Mee Joo Kang),Kyu-Won Jung(Kyu-Won Jung),Eun Hye Park(Eun Hye Park),E Hwa Yun(E Hwa Yun),Hye-Jin Kim(Hye-Jin Kim),Hyun-Joo Kong(Hyun-Joo Kong),Chang Kyun Choi(C 한국역학회 2023 Epidemiology and Health Vol.45 No.-

OBJECTIVES: This study investigated regional disparities in the incidence of 8 major cancers at the municipal level in Korea during 1999-2018 and evaluated the presence or absence of hot spots of cancer clusters during 2014-2018. METHODS: The Korea National Cancer Incidence Database was used. Age-standardized incidence rates were calculated by gender and region at the municipal level for 4 periods of 5 years and 8 cancer types. Regional disparities were calculated as both absolute and relative measures. The possibility of clusters was examined using global Moran’s I with a spatial weight matrix based on adjacency or distance. RESULTS: Regional disparities varied depending on cancer type and gender during the 20-year study period. For men, the regional disparities of stomach, colon and rectum, lung, and liver cancer declined, and those of thyroid and prostate cancer recently decreased, despite an overall increasing incidence. For women, regional disparities in stomach, colon and rectum, lung, liver, and cervical cancer declined, that of thyroid cancer recently decreased, despite an overall increasing incidence, and that of breast cancer steadily increased. In 2014-2018, breast cancer (I, 0.61; 95% confidence interval [CI], 0.53 to 0.70) showed a high probability of cancer clusters in women, and liver cancer (I, 0.48; 95% CI, 0.40 to 0.56) showed a high probability of cancer clusters in men. CONCLUSIONS: Disparities in cancer incidence that were not seen at the national level were discovered at the municipal level. These results could provide important directions for planning and implementing local cancer policies.

팩드레인재의 세립률 변화에 따른 배수효과에 관한 실험적 연구

공영주,임종철,박상욱,강연익 釜山大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.53 No.-

현재 팩드레인공법에서는 모래의 부족으로 인하여 많은 대체재료의 필요성이 절실해 지고 있다. 그러나 현재 국내에서 사용할 수 있는 드레인재로서의 적합성은 입도분포와 투수계수만으로 그 사용여부를 판단하고 있다. 본 논문에서는, 배수재인 모래의 세립률을 각각 1.5%, 30%, 60%로 인위적으로 달리한 실내모형실험을 통하여 그로 인한 압밀거동의 영향을 비교·고찰하였다. 압밀이 진행함에 따라 웰레지스턴스효과는 감소하는 경향을 보이면서, 시립률 30%는 세립률1.5%와 거의 비슷한 압밀진행 속도를 보임을 관찰할수 있었다. 이는 적당한 세립분이 함유된 배수재는 압밀거동에 있어서 필터의 역할을 하기 때문이라고 생각된다. 그러나, 종래의 규정대로라면 본 모형실험에 사용한 세립률30%는 세립률1.5%와 비슷한 압밀속도를 보임에도 불구하고 배수재의 규정에 벗어나기 때문에 사용할수 없는 재료가 된다. 따라서 배수재의 적합성 여부는 단순히 입도분포와 투수계수규정으로 판단할 것이 아니라 정확한 모형실험이나 현장실험을 통해서 판단해야 한다. Necessity of substitute materials is increasing owing to the lack of sand in pack drain method at present. But, the fitness of drain material which will be used in a country is decided by only grain distribution and permeability of drain materials. The consolidation behaviour by materials under the present design standard or not(the fine content 1.5%, 30%, 60% respectively) was compared through the laboratory model test. As consolidation progress, the well-resistance effect by fine content has the a tendency to decrease and the consolidation in fine grain ratio 30% is nearly the same to 1.5%. The reason is that the proper fine content inclusion in drain materials plays a filtering role which blocks the entrance of clay. But, although the fine content 30% is similar to 1.5% in consolidation velocity, it is unproper drain material in present drain regulation. Thus, the suitability of drain material should not be decided only by permeability and grain distribution. It should be decided by model test which takes account into filtering effect

Relationships among Nursing Students' Recognition, Perceived Usefulness, and Intention to Accept IoT

KANG, Ji-Yeon,KONG, Ye-Won,KIM, Eun-Bi,KIM, Eun-Ae,PARK, Sun-Joo,PARK, Jina,SEONG, Ji-Yeon,SON, Chae-Eun,LEE, Bo-Mi,KIM, Yunmi Korea FoodHealth Convergence Association 2021 식품보건융합연구 (KJFHC) Vol.7 No.1

The purpose of this study was to investigate the degree of recognition, perceived usefulness, and intention to accept the Internet of Things (IoT) in healthcare among nursing students, as well as to determine related factors. Through this study, we wanted to develop the basic research for the education related to the IoT in healthcare. In this study, data were collected from 348 nursing students using self-report online questionnaires, Naverform, and analyzed using the independent sample t-test, one-way analysis of variance, and Pearson correlation coefficients in SPSS version 26.0. The results of the study show that recognition of the IoT was correlated with its perceived usefulness (r=0.37; p<.001) and intention to accept the IoT (r=0.23 (p<.001). The strongest correlation was found between perceived usefulness of the IoT and intention to accept (r=0.67; p<.001). In conclusion, recognition of the IoT in healthcare affected its perceived usefulness, and a significant correlation was found between perceived usefulness of the IoT and intention to accept it. This study analyzed how much recognition, perceived usefulness, and intention to accept IoT in healthcare nursing students have. Based on these findings, we suggest that education related to the IoT in healthcare should be incorporated into the nursing curriculum.

Induction of the Glucose-regulated Proteins by Ca^2+-ATPase Inhibitors and Brefeldin A

Kang, Ho Sung,Park, Young Chul,Han, Song Iy,Kim, Byeong Gee,Kim, Chong-Rak,Lee, Kong-Joo,Kim, Han Do 이화여자대학교 생명과학연구소 1995 생명과학연구논문집 Vol.6 No.-

Glucose-regulated proteins (grp's) are a group of stress proteins whose syntheses are greatly enhanced when cells are exposed to stressful conditions including glucose stravation and Ca^2+ ionophore which perturbs intracellular Ca^2+ homeostasis. In this study, we examined the ability of endomembrane Ca^2+ -ATPase inhibitors, thapsigargin, 2,5-di(tert-butyl)-1,4-hydroquinone and cyclopiazonic acid, and brefeldin A, an inhibitor of intracellular protein transport, as inducers of grp's. The treatment of either Ca^2+-ATPase inhibitors or brefeldin A markedly increased the syntheses of grp's, whereas BAPTA-AM, a cell permeant Ca2+ chelator, did not induce the grp's. In addition, grp induction by Ca^2+-ATPase inhibitors was not inhibited by BAPTA-AM preloading which blocked increases in cytosolic Ca^2+, resulting from Ca^2+-ATPase inhibitor treatment. Thus, these results indicate that grp expression is closely coupled to the depletion of the intracellular Ca^2+ store as well as protein trafficking from the endoplasmic reticulum to Golgi.

地盤 掘鑿時의 地盤앵커에 의한 近接 構造物의 沈下 抑制 效果

강낙안,공영주,주인곤,임종철 釜山大學校生産技術硏究所 1996 生産技術硏究所論文集 Vol.50 No.-

지하구조물의 건설을 위한 깊은 굴착으로 인해 근접구조물에 많은 피해가 발생하고 있다. 피해를 일으키는 주된 원인은 흙막이 벽체의 수평변위에 의한 지반침하와 지하수위 저하나 진동등에 의한 압밀, 다짐 발생에 따른 지반침하 등이다. 지금까지 대부분의 연구는 현장계측을 이용하였으므로, 벽체의 변위와 지반침하에 영향을 미치는 많은 인자들 각각의 영향을 밝히기는 대단히 어려웠다. 본 연구에서는 실내 모형실험을 통하여 최종 굴착시의 주동파괴면 안쪽에 놓여있는 구조물의 침하를 최소화할 수 있는 지반앵커(1단, 2단)의 위치 및 간격을 결정하였다. 실험결과, 앵커 1단 설치, 앵커 2단 설치의 경우가 모두 앵커 깊이 비=0.4∼0.5일 때, 근접구조물의 침하가 최소가 되었다. 또, 지반 굴착시의 지반변형을 관찰하여 위의 사실을 확인하고, 지반 파괴면의 위치 및 형상을 구하였다. The structure is often deformed and damaged by deep excavation. This deformation and damage are mainly made by ground settlement(consolidation, compaction) owing to groundwater drop or vibration etc. and lateral movement of retaining wall. Then, most studies about deformation of ground have done by using results of site measurement, so it was very difficult to find each effect of many factors separately. The purpose of this study is to decide the location and interval of ground anchor( lst, 2nd ground anchor) to be able to minimize the settlement of adjacent structure located inside the active failure surface by model test at laboratory. As results of this model test, it was known that the depth ration of anchor to minimize the settlement of near-by structure was 0.4∼0.5, and by the observation of ground deformation during excavation, the direction and magnitude of displacement and the failure line could be known.

어머니의 취업과 아동의 언어발달과의 관계연구

강원경,김양희,서영숙,손화섭,이경진,이공주,이은미,이향은,어주경,조숙경 연세대학교 생활과학대학 1987 婦學 Vol.20 No.-

The purpose of this study was to investigate the relationship between mother's employment status and children's language development. The subjects were 56 mothers and their children at age 5 to 6 attending kindergarten in Seoul. A questionnaire was used to examine mother's communication style and an interveiw was used to assess children's language ability. Significant differences were found in children's language ability, specially in comprehension and expression, according to mother's communication style. There were no significant differences in children's language development and mother's communication style, according to mother's employment. Also, no significant differences were found in children's language development and mother's communication style, according to children's sex. It was concluded that mother's employment status did not directly affect children's language development.

Synthesis of 1,1-Dichloro-2,3,4,5-Tetraphenyl-1-Silacyclopenta-2,4-diene and Its Reaction with Alkali Metal: Evidence for the Formation of Silylanion

Joo, Wan-Chul,Park, Yoon-Chang,Kang, Suk-Ku,Hong, Jang-Hwan,Kong, Young-Kun Korean Chemical Society 1987 Bulletin of the Korean Chemical Society Vol.8 No.4

1,1-Dichloro-2,3,4,5-tetraphenyl-1-silacyclopenta- 2,4-diene was synthesized through the reaction of $SiCl_4$ with 1,4-dilithiotetraphenylbutadiene in 50% yield. From the reaction of this silole with metal, an air sensitive red-brownish solid was obtained. Treatment of this reaction product with $CH_3I\; and\; Me_3SiCl$ gave 1,1-dimethyl-2,3,4,5-tetraphenyl-1-silacyclopenta- 2,4-diene and 1,1-bis(trimethylsilyl)-2,3,4,5-tetraphenyl-1-silacyclopenta-2,4-diene, respectively. From these results, the formation of reactive 2,3,4,5-tetraphenyl-1-silacyclopenta-2,4-dienyl dianion was confirmed.

Induction of the Glucose-regulated Proteins by Ca^(2+)-ATPase Inhibitors and Brefeldin A

Kang, Ho Sung,Park, Young Choul,Han, Song Iy,Kim, Byeong Gee,Kim, Chong-Rak,Lee, Kong-Joo,Kim, Han Do 부산대학교 기초과학연구소 1995 부산대학교 기초과학연구소 연구논문집 Vol.15 No.-

Glucose-regulated proteins (grp's) are a group of stress proteins whose syntheses are greatly enhanced when cells are exposed to stressful conditions including glucose stravation and Ca²^(+) ionophore which perturbs intracellular Ca²^(+) homeostasis. In this study, we examned the ability of endomembrane Ca²^(+)-ATPase inhibitors, thapsigargin, 2.5-di(tert-butyl)-1,4-hycroquinone and cyclopiazonic acid, and brefeldin A, an inhibitor of intracellular protein transport, as inducers of grp's. The treatment of either Ca²^(+)-ATPase inhibitors or brefeldin A markedly incresed the syntheses of grp's, whereas BAPTA-AM, a cell permeant Ca²^(+) chelator, did not induce the grp's. In addition, grp induction by Ca²^(+)-ATPase inhibitors was not inhibited by BAPTA-AM preloading which blocked increases in cytosolic Ca²^(+), resulting from Ca²^(+)-ATPase inhibitor treatment. Thus, these results indicate that grp expression is closely coupled to the depletion of the intracellular Ca²^(+) store as well as protein trafficking from the endoplasmic reticulum to Glogi.

GO-26 : Cutoff value of pre- and post-cone HR-HPV load predicting residual/recurrent disease after conization in high-grade intraepithelial neoplasia and microinvasive

( Joo Hyuk Son ),( Seong Woo Kang ),( Tae Wook Kong ),( Jiheum Paek ),( Suk Joon Chang ),( Hee Sug Ryu ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

목적: The aim of this study was to analyze clinico-pathologic factors and the optimal cut-off value of high-risk human papillomavirus (HR-HPV) load for predicting high-grade residual/recurrent disease after the conization in cervical intraepithelial neoplasia (CIN 2-3), adenocarcinoma in situ (AIS), and microinvasive carcinoma of the uterine cervix (MICA). 방법: We retrospectively reviewed data from 701 patients with CIN 2-3, AIS, and MICA who underwent conization between September 2003 and June 2012. Receiver-operating characteristic curve analysis was used to find out the optimal cut-off value of HR-HPV load for predicting residual/ recurrent disease. Clinico-pathologic variables, including resection margin and HR-HPV load, were evaluated as possible predictors of residual/ recurrent disease. 결과: At a cut-off value of 1.16 RLU/CO for post-cone HR-HPV load, the sensitivity was 88.2% and the specificity was 98.3%. Multivariate analysis demonstrated that abnormal post- cone cytology (p=0.001, OR = 83.808, 95% CI = 6.688 ? 1050.232), positive endocervical margin (p<0.001, OR = 80.478, 95% CI = 7.421 ? 872.732), and positive post-cone HR HPV (p<0.001, OR = 79.660, 95% CI = 8.539 ? 743.129) were significantly associated with residual/recurrent disease. The post-cone HR-HPV positivity was observed more in the patients who showed positive endocervical margin than in the patients with positive ectocervical margin (32.6% vs. 5.3%, p=0.002). 결론: Positive post-cone HR-HPV was, not a high pre-cone HR-HPV load, a significant risk factor for predicting residual/recurrent disease. Patients with positive endocervical margin showed not only the post-cone HR-HPV positivity but also the residual/recurrent disease after the conization. Therefore, complete assessment of the endocervical margin status is necessary to determine residual/recurrent disease.