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      • 중복 원발암의 증례 1예: 위선암 및 방사선조사후 소장에서 발생한 혈관육종

        김강 ( Kang Kim1 ),김선희 ( Sun Hee Kim ),문진창 ( Jin Chang Moon ),박윤지 ( Yoon Ji Park ),박진경 ( Jin Kyung Park ),서승영 ( Seung Young Seo ),정래영 ( Lae Young Jung ),임호영 ( Ho Young Yhim ),곽재용 ( Jae Yong Kwak ) 전북대학교 의과학연구소 2011 全北醫大論文集 Vol.35 No.1

        Angiosarcomas are rare malignant neoplasms, which mainly occur on the skin and superficial tissue. Angiosarcoma in the small intestine after radiation therapy is very rare and there are less than 20 cases of small-intestine angiosarcoma after pelvic irradiation. We report a case of double cancer with gastric adenocarcinoma and postradiation angiosarcoma of the small intestine which has been diagnosed 20 years after pelvic irradiation therapy for uterine cervical cancer.

      • KCI등재

        Exploring potential biomarker responses to lithium in Daphnia magna from the perspectives of function and signaling networks

        Hyo Jeong Kim1,2,Jun Hyuek Yang,Hyun Soo Kim,Yeo Jin Kim,Wonhee Jang,Young Rok Seo,W. Jang,Y. R. Seo 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.1

        I ntensive usage of electronic appliances containing lithium batteries causes an accumulation of e-trash. Environmental exposure to lithium batteries contaminates ecosystems. In air and water, the batteries form lithium hydroxide (LiOH) on their surfaces. LiOH enters the aquatic environment and contaminates the aquatic ecosystem by being absorbed into biological organisms. In this study, in order to identify meaningful potential biomarkers that appear in response to lithium, we measured significantly up- and down-regulated genes after LiOH exposure by conducting a microarray. In addition, we explored the functions of differentially expressed daphnia genes, and we conducted a comparative analysis in other species, Daphnia spp. to humans, then analyzed the signaling pathways using the human gene set derived from daphnia sequences that are differentially expressed in response to LiOH using the NCBI-BLAST tool and Pathway studio. As a result, we identified signaling pathways and suggested several potential biomarkers that are up- or down-regulated in response to lithium. This study may contribute to the development of a biomonitoring system which can detect the ecotoxicity of lithium. Furthermore, lithium toxicity in humans can be predicted, so the study may also provide potential biomarkers of lithium exposure in humans.

      • SCIESCOPUSKCI등재

        Metagenomic Analysis of Fungal Communities Inhabiting the Fairy Ring Zone of Tricholoma matsutake

        ( Miae Kim1 ),( Hyeok Jun Yoon ),( Young Hyun You ),( Ye Eun Kim ),( Ju Ri Woo ),( Yeong Gyo Seo ),( Gyeong Min Lee ),( Young Ja Kim ),( Won Sik Kong ),( Jong Guk Kim ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.10

        Tricholoma matsutake, an ectomycorrhiza that has mutual relationships with the rootlet of Pinus denisflora, forms a fruiting body that serves as a valuable food in Asia. However, the artificial culture of this fungus has not been successful. Soil fungi, including T. matsutake, coexist with many other microorganisms and plants; therefore, complex microbial communities have an influence on the fruiting body formation of T. matsutake. Here, we report on the structures of fungal communities associated with the fairy ring of T. matsutake through the pyrosequencing method. Soil samples were collected inside the fairy ring zone, in the fairy ring zone, and outside the fairy ring zone. A total of 37,125 sequencing reads were obtained and 728 to 1,962 operational taxonomic units (OTUs) were observed in the sampling zones. The fairy ring zone had the lowest OTUs and the lowest fungal diversity of all sampling zones. The number of OTUs and fungal taxa inside and outside the fairy ring zone was, respectively, about 2 times and 1.5 times higher than the fairy ring. Taxonomic analysis showed that each sampling zone has different fungal communities. In particular, out of 209 genera total, 6 genera in the fairy ring zone, such as Hemimycena, were uniquely present and 31 genera, such as Mycena, Boletopsis, and Repetophragma, were specifically absent. The results of metagenomic analysis based on the pyrosequencing indicate a decrease of fungal communities in the fairy ring zone and changes of fungal communities depending on the fairy ring growth of T. matsutake.

      • KCI등재후보

        갑상선 미세유두상암의 임상적 특성

        안재현,최재영<SUP>1<.SUP>,박원서,송정윤,김용호,이상목,고석환,Jae Hyun Ahn,M.D.,Jae Young Choi,M.D.<SUP>1<.SUP>,Won Seo Park,M.D.,Jeong Yoon Song,M.D.,Yong Ho Kim,M.D.,Sang Mok Lee,M.D. and Suck Hwan Koh,M.D. 대한갑상선-내분비외과학회 2008 The Koreran journal of Endocrine Surgery Vol.8 No.2

        <B>Purpose:</B> PTMC is defined as a papillary thyroid cancer smaller than 10 mm in its greatest diameter. It is the most common form of differentiated thyroid cancer and its prognosis is known to be very favorable. The aim of this study is to identify its biologic behavior and to formulate a reasonable therapeutic strategy for the treatment of PTMC. <B>Methods:</B> 379 patients with papillary thyroid cancer were analyzed. Each patient was diagnosed preoperatively or postoperatively and treated between Jan. 2000 and Dec. 2007. Among these patients, 143 had been identified as having PTMC (37.7%) with a mean tumor size of 0.72 cm in diameter. <B>Results:</B> There were no significant differences of the clinical characteristics such as gender, age, the operative methods, or multicentricity between the PTMC group and the non-PTMC group, except for LN metastases. Also, there were fewer symptoms of palpable neck mass and preoperative findings such as capsular invasion and microcalcification in the PTMC group. We performed unilateral lobectomy with or without central compartment neck node dissection for the early stage diseases, but for the later stages of disease we performed near-total or total thyroidectomy with routine central compartment neck node dissection. And for the patients with lateral node enlargement, we performed ipsilateral modified radical neck dissection (MRND). <B>Conclusion:</B> This study shows that PTMC is quite similar to conventional papillary thyroid cancer in its biological behavior, and we conclude that total thyroidectomy with central compartment neck node dissection is the proper therapeutic strategy to treat PTMC. However, further study is necessary for identifying the low-risk and high-risk patients with PTMC. <B>(Ko</B><B></B><B>rean J Endocrine Surg 2008;8:101-105)</B>

      • KCI등재

        대성동 주민의 삶의 질 개선을 위한 공공 커뮤니티 서비스 디자인 -통일맞이 첫마을 대성동 프로젝트 사례를 중심으로-

        김유지(제1저자) ( You Ji Kim ),김서연(제2저자) ( Seo Yeon Kim ),박영준(제2저자) ( Young June Park ),이경민(제2저자) ( Kyung Min Lee ),김성우(교신저자) ( Sung Woo Kim ) 한국기초조형학회 2015 기초조형학연구 Vol.16 No.6

        본 연구의 목적은 DMZ내 유일한 민간 마을인 대성동 주민들의 삶의 질을 개선함과 동시에 남북 평화통일의 미래비전을 지향하는 아이디어를 창안하는 것이다. 대성동 주민의 삶의 질 개선은 2015년 행자부에서 마을의 노후화된 주택을 개량하는 과제로 시작되었다. 본 과제는 ‘정부3.0 국민디자인단’ 활동을 통해 서비스 디자인 관점에서 단순한 주택개량을 너머선 서비스 아이디어를 발굴하는 것을 목표로 한다. 전체적인 디자인 프로세스는 서비스 디자인 방법론에 기반 하였으며, ‘마을 삶의 질 개선’이란 측면에서 커뮤니티 디자인을 접목하여 진행하였다. 다양한 이해관계자와의 인터뷰를 통해본 연구의 큰 이해관계자를 ‘내부 주민’과 ‘외부 방문객’으로 정한 후 그들의 니즈와 핵심사항을 도출하였다. ‘남과 북’처럼 대립되는 요소를 연결시키고 소통하게 해주는 다리와 같은 개념을 본 연구의 디자인 프레임워크로 설정하였고, 문제해결을 위한 디자인 방향 키워드로 ‘역발상’, ‘조화’ 및 ‘미래지향’을 선정하였다. 이를 토대로 ‘내부 주민’에게는 부족한점을 채워주고 삶의 활력소가 되는 서비스 아이디어를, ‘외부 방문객’에게는 통일된 미래를 미리 만나봄과 동시에 이색적인 체험을 할 수 있는 관광 서비스 모델을 창안하였다. 결론적으로 커뮤니티 디자인이 접목된 서비스 디자인 특유의 생활밀착형 디자인 아이디어 발상을 통해 단순한 주택 개량을 넘어 삶의 질 향상에 기여하는 문화.사회.경제 등 다양한 측면에서의 요소를 발굴하였고, 동시에 분단과 통일이라는 대성동 마을 특유의 역사성과도 조화를 이루어내었다. The purpose of this study is to create service ideas regarding the vision for peaceful reunification in Korea and the improvement of life quality in the special community ‘Daesongdong’ - the only civilian habitation in DMZ. The effort from the Korean government to improve the quality of life in Daesongdong began by the Ministry of the Interior from 2015. Following that effort, this study aimed to expand ideas in a view of service design to generate solutions beyond just renovating current residences. The design process of the study was based on the service design process in mixture with community design. The two core stakeholders selected were ‘residents in Daesongdong’ representing ‘improving the quality of community life’ and ‘visitors to Daesongdong’ representing ‘towards peaceful unification of Korea.’ The design challenge was to harmonize these two rather separated themes. The concept behind the design framework was ‘bridge’ implying the connection of two opponents (South Korea and North Korea, separated past and reunited future, for instances.). Ideas were created with three design keywords in mind - harmony, towards future and reverse-thinking. As a result, a number of ideas in cultural, social, economical aspects beyond simple renovation of residences were produced and supported both themes in harmony.

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