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Cadmium-induced biomarkers discovery and comparative network analysis in Daphnia magna
Jun Hyuek Yang,Hyo Jeong Kim,Sang Min Lee,Bo-Mi Kim,Young Rok Seo,Y. R. Seo 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.3
Exposure to cadmium is gradually increased and its toxicity can be fatal to organisms in aquatic environment. D. magna inhabits in water. It is recommended by OECD guideline to test toxicity of chemicals. Through acute immobilization test, we observed a mobility change of D. magna caused by cadmium chloride exposure. The EC50 value of cadmium chloride was 14.5 ppb. Using D. magna in EC50 value of cadmium, we conducted microarray analysis to investigate differential gene expression and found 247 up- and 146 down-regulated genes. We performed BLAST analysis to identify and understand the meaning of the microarray data in comparative genomics. Comparing common proteins in some species, potential biomarkers and functions are discovered through pathway analysis. Based on differential gene expression of cadmium-treated D. magna, potential biomarkers are identified and investigated by functional network of mammals including human through comparative genomic analysis.
Jun Hyuek Yang,Preeyaporn Koedrith,Doo Seok Kang,Nam Kook Kee,정종현,Cheol Min Lee,서영록,안연순 대한암예방학회 2019 Journal of cancer prevention Vol.24 No.3
Based on epidemiological studies, an International Agency for Research on Cancer Working Group determined that strong inorganic acid mists containing sulfuric acid are carcinogenic to human even though, sulfuric acid, per se, is not. Accumulative studies indicate that there is a link between chronic occupational exposure to sulfuric acid mists and an increased risk of laryngeal cancer. Unintended, acute exposure to sulfuric acid mists can cause corrosive damage to target tissues depending on the route of exposure. This review compares the toxicity and carcinogenicity of sulfuric acid mists compared to other strong inorganic acid mists. It also examines the routes and duration of exposure (short-term, prolonged, and long-term). In vivo evidence does not support or refute the carcinogenicity of sulfuric inorganic mists even though its co-carcinogenic or promoting potential has been considered. On the basis of existing evidence on sulfuric acid mist toxicity, we suggested a putative adverse outcome pathway (AOP) relevant to carcinogenicity caused by mists containing sulfuric acid. A possible key factor involved in sulfuric acid mist carcinogenesis is the genotoxic effects of low pH since it can increase instability in chromosomes and DNA. A putative AOP for sulfuric acid mist carcinogenicity would help generate better risk assessments and more accurate predictions regarding the risk of developing cancer due to prolonged exposure. Establishing an AOP would also be useful for future studies examining the carcinogenicity of other strong inorganic mists. (J Cancer Prev 2019;24:139-145)
Kang, Doo Seok,Yang, Jun Hyuek,Kim, Hyun Soo,Koo, Bon Kon,Lee, Cheol Min,Ahn, Yeon-Soon,Jung, Jong-Hyeon,Seo, Young Rok Korean Society of Cancer Prevention 2018 Journal of cancer prevention Vol.23 No.3
<P>As industry develops in modern society, many chemicals are being used. The safety of chemicals is an important issue because humans are constantly exposed to chemicals throughout their daily life. Through a risk assessment, the hazardous human effects of chemicals can be identified. Recently, the adverse outcome pathway (AOP) framework has been used to predict the adverse effects of chemicals. As a conceptual framework for organizing existing biological knowledge, the AOP consists of a molecular initiating event, key events, and an adverse outcome. These independent elements represent biological responses and are connected by key event relationships. This AOP framework provides intuitive hazard identification that can be helpful for carcinogenic risk assessment of chemicals. In this review, we introduce the application of the AOP framework to risk assessment for predicting carcinogenicity of chemicals and illustrate the utility of this approach for cancer prevention.</P>
Hyo Jeong Kim1,2,Jun Hyuek Yang,Hyun Soo Kim,Yeo Jin Kim,Wonhee Jang,Young Rok Seo,W. Jang,Y. R. Seo 대한독성 유전단백체 학회 2017 Molecular & cellular toxicology Vol.13 No.1
I ntensive usage of electronic appliances containing lithium batteries causes an accumulation of e-trash. Environmental exposure to lithium batteries contaminates ecosystems. In air and water, the batteries form lithium hydroxide (LiOH) on their surfaces. LiOH enters the aquatic environment and contaminates the aquatic ecosystem by being absorbed into biological organisms. In this study, in order to identify meaningful potential biomarkers that appear in response to lithium, we measured significantly up- and down-regulated genes after LiOH exposure by conducting a microarray. In addition, we explored the functions of differentially expressed daphnia genes, and we conducted a comparative analysis in other species, Daphnia spp. to humans, then analyzed the signaling pathways using the human gene set derived from daphnia sequences that are differentially expressed in response to LiOH using the NCBI-BLAST tool and Pathway studio. As a result, we identified signaling pathways and suggested several potential biomarkers that are up- or down-regulated in response to lithium. This study may contribute to the development of a biomonitoring system which can detect the ecotoxicity of lithium. Furthermore, lithium toxicity in humans can be predicted, so the study may also provide potential biomarkers of lithium exposure in humans.
아르고 플로트 구조해석 및 고압·수밀 실험에 관한 연구
이상범(Sang-Beom Lee),양영준(Young-Jun Yang),이동명(Dong-Myung Lee),권순홍(Sun-Hong Kwon),장원석(Won-Seok Jang),김정연(Jeong-Yeon Kim),박준수(Jun-Soo Park),최혁진(Hyuek-Jin Choi),오상우(Sang-Woo Oh) 대한조선학회 2011 대한조선학회 학술대회자료집 Vol.2011 No.6
The sea information such as temperature, salt and current has been a very important issue ever since the industrial revolution. Because variation of temperature and salt in sea are related with climate change of the earth. To measure the information of sea, there are many types of measure systems. However it is difficult to measure in deep water the reason why high pressure of water. The best way to measure sea information is ARGO Float ever now. This study presents the result of experiment of hyperbaric chamber and structural analysis for ARGO floats.