Rifampicin에 의한 것으로 추정되는 위막성 대장염1예

김수현,이은우,정종혁,문승현,김동한,양혁승,오영상,김호동,김도현,박혁,박정환,박경옥,이영직 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.2

Pseudomembranous colitis, caused by altering the normal colonic flora and allowing the multiplication of Clostridium difficile, is an deleterious adverse effect of antibiotics. But it is rarely reported by rifampicin. Rifampicin is one of the first line drug in the treatment of tuberculosis and many patients are exposed to its potential adverse effects. We experienced a patient that had abdominal discomfort and hematochezia due to pseudomembranous colitis after receiving antituberculous medication, and which was probably caused by rifampicin. A 82 years old man was admitted with abdominal discomfort and hematochezia for one week. On the past history he had been diagnosed as endobronchial tuberculosis about 4 months ago. Colonoscopy revealed multiple discrete whitish mucosal lesion on rectosigmoid colon, and histologic findings were consistent with pseudomembranous colitis. The antituberculous agents were discontinued and vancomycin was administered. The patient's symptoms were resolved within several days. There was no recurrence after reinstitution of the antituberculous agents excluding rifampicin. We report here on a case of pseudomembranous colitis probably due to rifampicin.

인체 대장암 및 자궁경부암에서 PCR-SSCP법을 이용한 Ki-ras 암유전자의 점돌연변이에 관한 연구

박영홍,백낙환,김현찬,김상효,홍관희,김기태,이기영 인제대학교 1994 仁濟醫學 Vol.15 No.2

인체 대장암 20례와 자궁경부암 10례의 암조직을 대상으로 c-Ki-ras 유전자 codon 12와 13에서의 점돌연변이를 알아보고자 polymerase chain reaction(PCR)과 single-strand conformation polymorphism(SSCP) 검사법을 시행하였다. 대장암의 경우 20례중 9례(45%)에서, 자궁경부암의 경우 10례중 1례(10%)에서 양성으로 나왔다. 대장암에서는 codon 12에서 GGT가 TGT로의 치환이 4례로서 가장 많았으며, AGT, CGT로의 치환이 각 1례였고 codon 13에서는 GGC가 GAC로의 치환이 2례, TGC로의 치환이 1례인 것으로 나타났다. 자궁경부암의 경우 codon 12에서 GGT가 AGT로의 치환이 1례인 것으로 나타났다. In an attempt to clarify the role of genetic alteration in the genesis of human colorectal and cervical cancers, tissue specimens from 20 patients with colorectal cancer and 10 patients with cervical cancer were examined for the presence of point mutation in K-ras2 exon 1 by single strand conformation polymorphism analysis of PCR product. Exon I of c-Ki-ras2 was amplified by polymerase chain reaction(PCR) and comparison was made between the normal and mutated genes by nondenaturing polyacrylamide gel electrophoresis(PAGE) of PCR product and nucleotide sequence analysis using asymmetric PCR with direct sequencing. Genomic DNA from white blood cells were used as normal control and those from A427 cell line were used as mutated control. 1.PCR product from A427 cell line showed a distinct migration shift pattern compared to the normal control in PAGE and the direct sequencing indicated that nucleotide sequence of codon 12 was mutated from GGT to GAT. In addition, there was a loss of normal allele in A427 cell line. 2.PCR product from 9 cases(45%) out of a 20 colon cancer patients showed migration shifts in PAGE, and all of these 9 patients invariably demonstrated mutation of ras gene, either in codon 12(6 cases:30%) or 13(3 cases:15%). The base substitutions in codon 12 were: from GGT to AGT(1), CGT(1), or TGT(4). Base changes in codon 13 were from GGC to TGC(1) or GAC(2). 3.PCR product from 1 cases(10%) out of a 10 cervical cancer patients showed migration shrifts in PAGE, Invariably demonstrated mutation of ras gene in codon 12. The base substitutions was from GGT to AGT(1) TQE incidence of point mutation of c-Ki-ras in colon cancer was high, however, it was low in cervical cancer, which showed the relation of ruts gene mutation with colon cancer. PCR -SSCP analysis is a simple, rapid and efficient method of detection of point mutation, especially when dealing with multiple samples.

유압 피스톤 펌프의 피스톤과 실린더 사이의 압력분포

김영환,박태조 경상대학교 생산기술연구소 2002 工學硏究院論文集 Vol.2 No.-

Under the tendency of higher speed and pressure requirements in hydraulic machinery, the clearance between piston and cylinder became gradually smaller. This results in many new tribological problems. Therefore exact understanding of oil pressure distribution in the clearance is vital for designers in reducing the energy losses due to friction and improving its reliability. This paper aimed at measuring oil pressure distribution in the clearance considering the effect of piston speed. We designed a piston-cylinder type test apparatus and measured oil pressure distributions accurately. The results showed that the pressure distributions are highly affected by the piston speed, and present experimental method can be used to enhance the performance of hydraulic piston pumps.

Dual-Phase 鋼의 變形에 關한 硏究

金榮煥,吳伊植 釜山工業大學校 1983 論文集 Vol.24 No.2

An investigation was made about the effect of wolume percent martensite on strength, ductility and the combination of daul-phase steel. The results obtained are as follows: 1) Yield ratios were increased with increasing volum percent martensite. 2) Dual-phase steel represented continuous yield behaviour. 3) The products of tensile strength and ductility (TS×EL) were almost constant and reprensented the linear relationship with increasinng volume percent martensite

자동차 변속기용 기어설계 프로그램 개발

김영환,박태조,문영재 慶尙大學校生産技術硏究所 1997 生産技術硏究所論文集 Vol.13 No.-

A new interactive computer program for design and examination of the automobile transmission gear is developed. The design data of a shifted helical gear sets are calculated and the contact ratio and the strength condition are examined. The involute curve and a root fillet of the designed tooth profile are graphically presented, and the informations for tooth profile such as root point, weakest section point, etc. are obtained. The whole engaging gear shape and contact state are certificated in Autocad. To check the lubrication conditions, the minimum film thickness is calculated and compared with the surface roughness data. Therefore the computer program made in this paper gives more improved practical tool in designing a automobile gear set.

노인의 정주환경 인식에 관한 연구

김수남,박영호,최창환 東亞大學校 建設技術硏究所 2007 硏究論文集 Vol.31 No.1

The purpose of this study is to not only clarify needs for physical environment improvement and participation in local community but also present results from actual field survey for establishing the policy for the elderly. With this purpose in mind, firstly, we attempt to consider personal characteristic. And then we analyzed the elderly residents' needs for the improvement of residential environment in local community. Second, we attempt to find out trends or settlement consciousness of the elderly and establish the policy considering environment improvement for the elderly. The results are as follows; 1) it is needed to work up to improve the basic actual settlement environment of the elderly, because they want to continually live in recent community. 2) in participation in local community, they are on negative lines and prefer to participation bring about incomes. 3) for the improvement of the quality of the settlement environment for the elderly in community, it is need to maintenance of the physical environment; especially mobility, welfare facilities, housing for the elderly.

황 첨착 활성탄에 의한 구리제거

김영환,박정훈,김정섭,유현철,이봉섭,곽명화,우성훈,박승조 東亞大學校 環境問題硏究所 2005 硏究報告 Vol.27 No.1

This study was carried out to remove copper ion in case of activated carbon impregnated sulphur(ACS) dose and different pH using activated carbon impregnated sulphur that prepared from activated carbon at sulphur dioxide atmosphere. Removal copper ion concentration was increased as increasing the ACS dose when copper ion concentration was 10 mg/L. Optimum dose of ACS 13.3 g ACS/L and maximum removal efficiency was 93%. The results obtained from adsorption experiment in the condition of ACS optimum dose when the pH was 3, 4, 5 respectively was pH 5 was excellent.

陸上競技(體育科) 種目別 評占基準에 關한 一硏究 : 投擲競技를 中心으로 Centering on the Throwing Test

金永煥 慶北大學校 師範大學 1974 敎育硏究誌 Vol.16 No.-

This study attempts to investigate the Scientific ality as well as relialility of evaluation Standard value which had been employed in our physical education department up to the present time. 1. The highest records of students abilities measured for the last seven years (1967-1973) were statistically treated. 2. Kinds of exercises and the number of participants. a. Shot put (male 189/female 47) b. Discus throw (male 171/female 43) c. Javelin throw (male 171/female 40) 3. The statistical results of investigating the old and new standard value show that males Suffer a loss whereas females gain a benifit. 4. this new evaluation standard value will be applied to our students from the school year of 1974.

네트워크를 근간으로하는 분산 시스템을 위한 CNU File Server의 구현

김봉환,황영원,이광일,김상하 충남대학교 자연과학연구소 1993 忠南科學硏究誌 Vol.20 No.1

A file server provides remote centralized storage of data to computers connected to it via a communication network: it facilitates data sharing among autonomous computers and support of inexpensive computers that have limited or no secondary storage. The prototype of CNU File Server(CNUFS) is designed, and the implementation aspacts and initial experiences with applications are discussed in this paper.

주정폐수의 혐기성 소화처리시와 포기처리시 처리특성에 관한 연구

金煥起,李城白,黃譚勇 全北大學校 附設 都市및環境硏究所 1996 都市 및 環境硏究 Vol.11 No.1

The wastewater of alcohol manufactory plant has very high suspended soild and BOD concentration, acidity, and high temperture. Thus most of the plants drive on anaerobic digestion method of biological treatment because of using a lot of generated methane gas and possible to disinfect pathogenic bacteria in sluge and wastewater. But because of the problem in the concentration of anaerobic treatment water, second treatment is necessary 2-step activated treatment for increasing treatment efficiency. The purpose of this study was performed to know a difference between last 1-step digestion 1-step aeration treatment and 2-step digestion 2-step aeration treatment with retention time in digestion and aerator. The obtained results can be summarized as follows; 1. The concentration characteristic of alchohol production wastewater was analyzed COD 50,000∼80,000㎎/ℓ, BOD 22,000∼41,000㎎/ℓ, SS 20,000∼45,000㎎/ℓ, pH 4.1∼4.2, and 75∼80℃ according to the raw material of alchohol. 2. In case of the anaerobic digestion method of rice-barley wastewater, average COD removal rate of 2-step digestion appeared to 91.9% compared to average COD removal rate 59.3% on 1-step digestion. It is necessary to drive above 20 day of retention time in metane degestor because of increasing organic load causing the decrease of pH and the increase of VFA/COD within aerator. 3. Alcohol wastewater of tapioka is generally much treatment efficiency of 2-step digestion than that of 1-step digestion, but below 2.7㎏-COD/㎥·d of COD bulk load showed the possibility of treatment at 1-step and 2-step digestion method. 4. Amount of gas generation in anaerobic digestion was almost similar at 1-step and 2-step digestion. 5. In the result of aerobic treatment, treatment efficiency of 2-step consecutive aeration was highly about 3% compared to 1-step combined aeration and in the condition of COD 4,000㎎/ℓ, COD load 800㎏ -COD/d, COD volume-load 0.8㎏-COD/㎥·d were difficult two treatment methods both. 6. pH and VFA concentrations are considered as important factors to determine VFA restriction and the harmfulness of fatty acid was seemed to be related to pH. VFA in 1-step digestion appeared strong change with the increase of input wastewater quantity, but 2-step digestion was treated to stable change in output COD 1,230∼2,246㎎/ℓ.