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Solar urticaria in Korean patients
( Sung Min Kim ),( Young Ah Cho ),( Ji Su Lee ),( Ji Youn Hong ),( Jin Hee Kim ),( Joo Ran Hong ),( Hye In Cheon ),( Yang Won Lee ),( Yong Beom Choe ),( Kyu Joong Ahn ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Solar urticaria (SU) is an uncommon type of photodermatoses characterized by erythematous wheal with pruritus after sunlight exposure, which shows a female predominance. Only a few studies to analyze the clinical features of SU were reported in Asia. Objectives: We aimed to analyze the clinical and photobiological characteristics of SU in Korea. Methods: We retrospectively investigated the medical records of patients with SU who visited the department of dermatology, Konkuk university medical center from January 2005 to January 2020. Results: Of a total of 44 patients, 36 (81.8%) were male and 8 (18.2%) were female. The mean age at onset was 17.6 years (range, 5-47) and the mean threshold time was 19.7 minutes. Among 32 patients who underwent phototesting, the action spectrum most commonly implicated was ultraviolet (UV) A only in 12 (37.5%), and then visible light (415nm) only was responsible for SU in 8 (25.0%). Three patients (9.4%) were induced by both UVA and visible light (415nm). Even 4 patients (12.5%) were triggered by only natural sunlight. Serum immunoglobulin E levels were measured in 33 patients, and 17 (51.5%) showed values higher than normal. The treatment most widely used were oral antihistamine (43.2%), followed by phototherapy (13.6%). Conclusion: SU is a rare photodermatosis in Korea, which shows a male preponderance. In this study, UVA and visible light (415nm) were predominant action spectrum of SU.
Variations in Kiwifruit Microbiota across Cultivars and Tissues during Developmental Stages
Su-Hyeon Kim(Su-Hyeon Kim),Da-Ran Kim(Da-Ran Kim),Youn-Sig Kwak(Youn-Sig Kwak) 한국식물병리학회 2023 Plant Pathology Journal Vol.39 No.3
The plant microbiota plays a crucial role in promot-ing plant health by facilitating the nutrient acquisition, abiotic stress tolerance, biotic stress resilience, and host immune regulation. Despite decades of research efforts, the precise relationship and function between plants and microorganisms remain unclear. Kiwifruit (Actinidia spp.) is a widely cultivated horticultural crop known for its high vitamin C, potassium, and phytochemical content. In this study, we investigated the microbial communities of kiwifruit across different cultivars (cvs. Deliwoong and Sweetgold) and tissues at various developmental stages. Our results showed that the microbiota community similarity was confirmed be-tween the cultivars using principal coordinates analysis. Network analysis using both degree and eigenvector centrality indicated similar network forms between the cultivars. Furthermore, Streptomycetaceae was identi-fied in the endosphere of cv. Deliwoong by analyzing amplicon sequence variants corresponding to tissues with an eigenvector centrality value of 0.6 or higher. Our findings provide a foundation for maintaining ki-wifruit health through the analysis of its microbial com-munity.
Kim, Kyoung-Ran,Kim, Da-Rae,Lee, Taemin,Yhee, Ji Young,Kim, Byeong-Su,Kwon, Ick Chan,Ahn, Dae-Ro The Royal Society of Chemistry 2013 Chemical communications Vol.49 No.20
<P>A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. The drug delivered with the DNA nanoconstruct is considerably cytotoxic, whereas free doxorubicin is virtually non-cytotoxic for the drug-resistant cells. Thus, the DNA tetrahedron, made of the inherently natural and biocompatible material, can be a good candidate for the drug carrier to overcome MDR in cancer cells.</P> <P>Graphic Abstract</P><P>A DNA tetrahedron is employed for efficient delivery of doxorubicin into drug-resistant breast cancer cells. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c3cc38693g'> </P>
Kim, Hye Ran,Jin, Su Bong,Wen, Long,Choi, Yoon Seok,Choi, In Sik,Han, Jeon Geon American Scientific Publishers 2013 Journal of Nanoscience and Nanotechnology Vol.13 No.11
<P>ZnO has been studied as a strong candidate for high-quality TCO in accordance with increasing demand to replace ITO. The origin of n-doping in ZnO is not clearly understood, but recently, the H2 effect has received attention due to the role it plays in O-rich and O-poor conditions. In spite of recent rapid developments, controlling the electrical conductivity of ZnO has remained a major challenge. To control the electrical conductivity of ZnO, this study was performed using an FTS system with H2 and O2 addition at low processing temperature. The structural and electrical properties of ZnO thin films deposited at various H2 and O2 flow rates were investigated using XRD and a sheet resistance meter. In response to changes in H2 and O2 flow rates, the crystallization and related grain size of the ZnO films were somewhat changed. The sheet resistance increased from approximately 10(-1) to approximately 10(4) M ohm/sq. when the O2 flow rate was increased, and the resistance decreased from approximately 10(-1) to approximately 10(-4) M ohm/sq. when the H2 flow rate was increased. The increase of sheet resistance with O2 flow rates could be explained by decrease of oxygen vacancies. The decrease of sheet resistance with H2 flow rates could be explained by increase of the electrons from interstitial hydrogen atoms. The plasma characteristics were analyzed using optical emission spectroscopy (OES). But, the overall spectrum did not change with the H2 and O2 gas flow rates. So, the dramatic changes in the electrical properties of ZnO thin films could be considered to be a result of changes in chemical composition of the thin films rather than the plasma status.</P>
Kim, Kyung Ran,Lee, Su Young,Kang, Jee In,Kim, Bo Ra,Choi, Soo-Hee,Park, Jin Young,Lee, Eun,An, Suk Kyoon,Kwon, Jun Soo Blackwell Publishing Asia 2011 Early intervention in psychiatry Vol.5 No.2
<P>Aim: Recently, cognitive therapy in people at ultra-high risk (UHR) for psychosis has been reported to show modest treatment benefits. The aim of this study was to assess the feasibility and efficacy of cognitive therapy in reducing psychiatric symptoms in UHR people in Korea. Methods: We developed cognitive therapy for people at UHR for psychosis inspired by Morrison in 2004. Twenty-two UHR subjects were assigned to cognitive therapy, and 18 subjects completed the 10-session therapy. Psychopathology scores were assessed at baseline and post-treatment. Results: Cognitive therapy significantly reduced the severity of psychopathology including positive, negative and depressive symptoms. The within-group effect sizes indicated large treatment benefits for these psychopathologies. Conclusion: These findings suggest that cognitive therapy can be administered to people at UHR for psychosis in non-western culture.</P>
Evaluation of Salicornia herbacea as a Potential Antioxidant and Anti-Inflammatory Agent
Kim, You-Ah,Kong, Chang-Suk,Um, Young-Ran,Lim, Sun-Young,Yea, Sung-Su,Seo, Young-Wan The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.3
In this study, the antioxidant and anti-inflammatory activities of Salicornia herbacea were evaluated. The crude $CH_2Cl_2$/methanol extract of S. herbacea showed 52% and 86% scavenging activities of the authentic $ONOO^-$ and $ONOO^-$ from 3-morpholinosydnomimine (SIN-1) at a concentration of $50\;{\mu}g/mL$, respectively, and was subjected to a further fractionation with n-hexane, 85% aqueous methanol, n-butanol, and water. Additional purification of the n-butanol fraction revealed that the most potent scavenging activity led to the isolation of isorhamnetin 3-O-$\beta$-D-glucopyranoside as the active principle. The structure of isorhamnetin 3-O-$\beta$-D-glucopyranoside was elucidated by extensive two-dimensional nuclear magnetic resonance experiments such as $^1H$ correlation spectroscopy nuclear Overhauser effect spectroscopy, heteronuclear single quantum correlation, and heteronuclear multiple-bond correlation as well as by comparison with the published spectral data. Isorhamnetin 3-O-$\beta$-D-glucopyranoside exhibited dose-dependent scavenging activities of the authentic $ONOO^-$ and $ONOO^-$ from SIN-1. The electron spin resonance spin-trap techniques confirmed that reactive oxygen species, including the hydroxyl, superoxide, carbon-centered, and 1,1-diphenyl-2-picrylhydrazyl radicals, were actively quenched by addition of isorhamnetin 3-O-$\beta$-D-glucopyranoside. In addition, isorhamnetin 3-O-$\beta$-D-glucopyranoside suppressed the lipopolysaccharide-induced nitric oxide production and the expression of cytokines such as inducible nitric oxide synthase, tumor necrosis factor-a, and interleukin-$1{\beta}$ in Raw 264.7 cells. Findings from this study should underscore the nutraceutical value of S. herbacea-derived isorhamnetin 3-O-$\beta$-D-glucopyranoside as a potent antioxidative and anti-inflammatory agent via alleviation of radical-induced toxicities and pro-inflammatory responses.
FCP 17 : Extramammary paget disease with underlying syringoma
( Su Ran Hwang ),( Soo Han Woo ),( Dae Woo Kim ),( Joo Ik Kim ),( Chin Ho Rhee ),( Jin Park ),( Seok Kweon Yun ),( Han-uk Kim ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.1
Extramammary paget disease (EMPD) is a heterogenous condition representing either an in situ malignancy with apocrine differentiation or pagetoid spread of an underlying adnexal tumor or a non-cutaneous internal neoplasm. Concurrent involvement of the same area by EMPD and benign adnexal neoplasm is extremely rare. We describe a case of EMPD of the vulva with a benign underlying syringoma. A 69-year-old woman presented with a pruritic erythematous lesion on the left side of the vulva, which had been present for 3 years. Histopathological examination of biopsy specimen from the lesion revealed the presence of large pale cells with prominent nuclei, which were randomly dispersed throughout the epidermis. The dermis showed dilated cystic spaces lined by two layers of cuboidal cells and epithelial strands of similar cells with no evidence of atypia, and with no demonstrable continuity with epidermis. Some of the cysts had small comma-like tails, which gave them the appearance of tadpoles. A diagnosis of combined vulvar Paget’s disease and syringoma was rendered. This case is the first reported example of EMPD with a benign underlying syringoma, which is highly suspected to be coincidental association.